DE60219500T2 - Neue phenylethanolaminverbindungen mit erregender wirkung an beta2-akzeptor und verfahren zu deren herstellung - Google Patents

Neue phenylethanolaminverbindungen mit erregender wirkung an beta2-akzeptor und verfahren zu deren herstellung Download PDF

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Publication number
DE60219500T2
DE60219500T2 DE60219500T DE60219500T DE60219500T2 DE 60219500 T2 DE60219500 T2 DE 60219500T2 DE 60219500 T DE60219500 T DE 60219500T DE 60219500 T DE60219500 T DE 60219500T DE 60219500 T2 DE60219500 T2 DE 60219500T2
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DE
Germany
Prior art keywords
compounds
carbon atoms
formula
amino
chloro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60219500T
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German (de)
English (en)
Other versions
DE60219500D1 (de
Inventor
Maosheng Cheng
Li Pan
Lei Ji
Li Zhang
Jianmin Shen
Guilan Song
Zhiqing Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Jinzhou Jiutai Pharmaceutical Co Ltd China Jinzhou
Jinzhou Jiutai Pharmaceutical Co Ltd
Shenyang Pharmaceutical University
Original Assignee
Jinzhou Jiutai Pharmaceutical Co Ltd China Jinzhou
Jinzhou Jiutai Pharmaceutical Co Ltd
Shenyang Pharmaceutical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jinzhou Jiutai Pharmaceutical Co Ltd China Jinzhou, Jinzhou Jiutai Pharmaceutical Co Ltd, Shenyang Pharmaceutical University filed Critical Jinzhou Jiutai Pharmaceutical Co Ltd China Jinzhou
Publication of DE60219500D1 publication Critical patent/DE60219500D1/de
Application granted granted Critical
Publication of DE60219500T2 publication Critical patent/DE60219500T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/68—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60219500T 2001-09-30 2002-09-25 Neue phenylethanolaminverbindungen mit erregender wirkung an beta2-akzeptor und verfahren zu deren herstellung Expired - Lifetime DE60219500T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNB011282347A CN1276911C (zh) 2001-09-30 2001-09-30 具有β2－受体兴奋作用的新型苯乙醇胺类化合物及其制法
CN01128234 2001-09-30
PCT/CN2002/000676 WO2003093219A1 (fr) 2001-09-30 2002-09-25 Nouveaux composes de phenylethanolamine ayant une fonction d'excitation d'un $g(b)2-accepteur et leur procede de preparation

Publications (2)

Publication Number Publication Date
DE60219500D1 DE60219500D1 (de) 2007-05-24
DE60219500T2 true DE60219500T2 (de) 2007-12-13

Family

ID=4668112

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60219500T Expired - Lifetime DE60219500T2 (de) 2001-09-30 2002-09-25 Neue phenylethanolaminverbindungen mit erregender wirkung an beta2-akzeptor und verfahren zu deren herstellung

Country Status (12)

Country Link
US (1) US7098364B2 (xx)
EP (1) EP1439164B1 (xx)
JP (1) JP3990399B2 (xx)
CN (1) CN1276911C (xx)
AT (1) ATE359261T1 (xx)
AU (1) AU2002338124A1 (xx)
DE (1) DE60219500T2 (xx)
DK (1) DK1439164T3 (xx)
ES (1) ES2284926T3 (xx)
HK (1) HK1064664A1 (xx)
RU (1) RU2264382C1 (xx)
WO (1) WO2003093219A1 (xx)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100497296C (zh) * 2006-07-07 2009-06-10 沈阳药科大学 旋光活性的苯乙醇胺类化合物及其制法
CN100431535C (zh) * 2006-09-18 2008-11-12 锦州九泰药业有限责任公司 一种盐酸川丁特罗气雾剂
EP1969929A1 (de) 2007-03-12 2008-09-17 Bayer CropScience AG Substituierte Phenylamidine und deren Verwendung als Fungizide
CN102477000B (zh) * 2010-11-24 2013-11-06 沈阳药科大学 一种苯乙醇胺类化合物的合成方法
US9784726B2 (en) 2013-01-08 2017-10-10 Atrogi Ab Screening method, a kit, a method of treatment and a compound for use in a method of treatment
CN106279018B (zh) * 2015-06-26 2019-01-29 沈阳药科大学 β2-受体兴奋剂及其制备方法和应用
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714740D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB202205895D0 (en) 2022-04-22 2022-06-08 Atrogi Ab New medical uses

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4028398A1 (de) * 1990-09-07 1992-03-12 Thomae Gmbh Dr K Phenylethanolamine, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SG55296A1 (en) * 1996-04-12 1998-12-21 Kissei Pharmaceutical Phenylethalolaminotetralincarboxamide derivatives
CN1237574A (zh) * 1998-05-29 1999-12-08 中国科学院成都有机化学研究所 合成苯乙醇胺类化合物的方法

Also Published As

Publication number Publication date
RU2264382C1 (ru) 2005-11-20
DK1439164T3 (da) 2007-08-20
RU2004112212A (ru) 2005-09-10
EP1439164B1 (en) 2007-04-11
EP1439164A1 (en) 2004-07-21
EP1439164A4 (en) 2005-12-21
DE60219500D1 (de) 2007-05-24
ATE359261T1 (de) 2007-05-15
CN1276911C (zh) 2006-09-27
ES2284926T3 (es) 2007-11-16
HK1064664A1 (en) 2005-02-04
AU2002338124A1 (en) 2003-11-17
US7098364B2 (en) 2006-08-29
AU2002338124A8 (en) 2003-11-17
JP2005519989A (ja) 2005-07-07
US20040266867A1 (en) 2004-12-30
WO2003093219A1 (fr) 2003-11-13
JP3990399B2 (ja) 2007-10-10
CN1408703A (zh) 2003-04-09

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