DE60215042T2 - Benzazole derivate zur behandlung von scleroderma - Google Patents
Benzazole derivate zur behandlung von scleroderma Download PDFInfo
- Publication number
- DE60215042T2 DE60215042T2 DE60215042T DE60215042T DE60215042T2 DE 60215042 T2 DE60215042 T2 DE 60215042T2 DE 60215042 T DE60215042 T DE 60215042T DE 60215042 T DE60215042 T DE 60215042T DE 60215042 T2 DE60215042 T2 DE 60215042T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- group
- benzothiazol
- scleroderma
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01000727 | 2001-12-07 | ||
| EP01000727 | 2001-12-07 | ||
| PCT/EP2002/013857 WO2003047570A1 (en) | 2001-12-07 | 2002-12-06 | Benzazole derivatives for the treatment of scleroderma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60215042D1 DE60215042D1 (de) | 2006-11-09 |
| DE60215042T2 true DE60215042T2 (de) | 2007-10-04 |
Family
ID=8176107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60215042T Expired - Lifetime DE60215042T2 (de) | 2001-12-07 | 2002-12-06 | Benzazole derivate zur behandlung von scleroderma |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US7776854B2 (https=) |
| EP (1) | EP1450792B1 (https=) |
| JP (2) | JP4589002B2 (https=) |
| AT (1) | ATE340572T1 (https=) |
| AU (1) | AU2002352227B2 (https=) |
| CA (1) | CA2468826C (https=) |
| DE (1) | DE60215042T2 (https=) |
| DK (1) | DK1450792T3 (https=) |
| ES (1) | ES2268127T3 (https=) |
| IL (1) | IL162259A0 (https=) |
| PT (1) | PT1450792E (https=) |
| SI (1) | SI1450792T1 (https=) |
| WO (1) | WO2003047570A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5021307B2 (ja) * | 2003-09-12 | 2012-09-05 | メルク セローノ ソシエテ アノニム | 糖尿病治療のためのベンゾチアゾール誘導体 |
| US7878978B2 (en) | 2004-03-18 | 2011-02-01 | University Of Pittsburgh- Of The Commonwealth System Of Higher Education | Use of relaxin to increase arterial compliance |
| US20070203134A1 (en) * | 2004-09-10 | 2007-08-30 | Applied Research Systems Ars Holding N.V. | Benzimidazole Acetonitriles |
| US7838522B2 (en) | 2004-11-17 | 2010-11-23 | Ares Trading S.A. | Benzothiazole formulations and use thereof |
| JP5144271B2 (ja) * | 2004-11-17 | 2013-02-13 | アレス トレーディング ソシエテ アノニム | ベンゾチアゾ−ル製剤、及びそれらの使用 |
| KR20080044836A (ko) | 2005-07-15 | 2008-05-21 | 라보라뚜와르 세로노 에스. 에이. | 자궁내막증 치료용 ｊｎｋ 억제제 |
| BRPI0613042A2 (pt) | 2005-07-15 | 2010-12-14 | Serono Lab | inibidores de jnk para o tratamento de endometriose |
| WO2007141224A2 (en) * | 2006-06-02 | 2007-12-13 | Laboratoires Serono Sa | Jnk inhibitors for treatment of skin diseases |
| US20080305186A1 (en) * | 2007-06-11 | 2008-12-11 | Board Of Regents, The University Of Texas System | Method and Composition for the Treatment of Cardiac Hypertrophy |
| JP2011520902A (ja) * | 2008-05-16 | 2011-07-21 | コーセラ，インコーポレーテッド | 創傷の治癒を促進する方法 |
| US8680076B2 (en) | 2010-10-25 | 2014-03-25 | Signal Pharmaceuticals, Llc | Methods of treatment, improvement and prevention using haloaryl substituted aminopurines |
| WO2014114186A1 (zh) * | 2013-01-24 | 2014-07-31 | 山东亨利医药科技有限责任公司 | Jnk抑制剂 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0666812B2 (ja) | 1988-01-11 | 1994-08-24 | 日本電気株式会社 | パケット交換方法並びにパケット交換装置 |
| US5985592A (en) | 1997-06-05 | 1999-11-16 | Dalhousie University | Uses for pentoxifylline or functional derivatives/metabolites thereof |
| WO2000075118A1 (en) * | 1999-06-03 | 2000-12-14 | Vertex Pharmaceuticals Incorporated | INHIBITORS OF c-JUN N-TERMINAL KINASES (JNK) |
| EP1110957A1 (en) | 1999-12-24 | 2001-06-27 | Applied Research Systems ARS Holding N.V. | Benzazole derivatives and their use as JNK modulators |
| US20020111353A1 (en) * | 2000-12-05 | 2002-08-15 | Mark Ledeboer | Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases |
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2002
- 2002-12-06 AT AT02787919T patent/ATE340572T1/de active
- 2002-12-06 DE DE60215042T patent/DE60215042T2/de not_active Expired - Lifetime
- 2002-12-06 IL IL16225902A patent/IL162259A0/xx unknown
- 2002-12-06 JP JP2003548825A patent/JP4589002B2/ja not_active Expired - Lifetime
- 2002-12-06 AU AU2002352227A patent/AU2002352227B2/en not_active Expired
- 2002-12-06 CA CA2468826A patent/CA2468826C/en not_active Expired - Lifetime
- 2002-12-06 SI SI200230413T patent/SI1450792T1/sl unknown
- 2002-12-06 EP EP02787919A patent/EP1450792B1/en not_active Expired - Lifetime
- 2002-12-06 US US10/496,785 patent/US7776854B2/en not_active Expired - Lifetime
- 2002-12-06 PT PT02787919T patent/PT1450792E/pt unknown
- 2002-12-06 DK DK02787919T patent/DK1450792T3/da active
- 2002-12-06 ES ES02787919T patent/ES2268127T3/es not_active Expired - Lifetime
- 2002-12-06 WO PCT/EP2002/013857 patent/WO2003047570A1/en not_active Ceased
-
2010
- 2010-06-02 JP JP2010127168A patent/JP2010248205A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DK1450792T3 (da) | 2007-01-29 |
| DE60215042D1 (de) | 2006-11-09 |
| JP2005515994A (ja) | 2005-06-02 |
| AU2002352227A1 (en) | 2003-06-17 |
| PT1450792E (pt) | 2006-12-29 |
| SI1450792T1 (sl) | 2006-12-31 |
| CA2468826A1 (en) | 2003-06-12 |
| JP2010248205A (ja) | 2010-11-04 |
| ES2268127T3 (es) | 2007-03-16 |
| IL162259A0 (en) | 2005-11-20 |
| US20050119277A1 (en) | 2005-06-02 |
| US7776854B2 (en) | 2010-08-17 |
| WO2003047570A1 (en) | 2003-06-12 |
| AU2002352227B2 (en) | 2007-11-01 |
| CA2468826C (en) | 2011-11-01 |
| EP1450792B1 (en) | 2006-09-27 |
| ATE340572T1 (de) | 2006-10-15 |
| JP4589002B2 (ja) | 2010-12-01 |
| EP1450792A1 (en) | 2004-09-01 |
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Owner name: LABORATOIRES SERONO S.A., COINSINS, VAUD, CH |