DE60213986T2 - Neuen reagenzien in chemilumineszenz-nachweisverfahren - Google Patents

Neuen reagenzien in chemilumineszenz-nachweisverfahren Download PDF

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Publication number
DE60213986T2
DE60213986T2 DE60213986T DE60213986T DE60213986T2 DE 60213986 T2 DE60213986 T2 DE 60213986T2 DE 60213986 T DE60213986 T DE 60213986T DE 60213986 T DE60213986 T DE 60213986T DE 60213986 T2 DE60213986 T2 DE 60213986T2
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DE
Germany
Prior art keywords
precursor
group
leaving group
light
emitting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60213986T
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German (de)
English (en)
Other versions
DE60213986D1 (de
Inventor
Dieter Heindl
Rupert Herrmann
Hans-Peter Josel
Erasmus Huber
Ursula Klause
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Roche Diagnostics GmbH
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Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
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Publication of DE60213986D1 publication Critical patent/DE60213986D1/de
Publication of DE60213986T2 publication Critical patent/DE60213986T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/904—Oxidation - reduction indicators
DE60213986T 2001-06-01 2002-05-28 Neuen reagenzien in chemilumineszenz-nachweisverfahren Expired - Lifetime DE60213986T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01112879 2001-06-01
EP01112879 2001-06-01
PCT/EP2002/005855 WO2002099097A1 (en) 2001-06-01 2002-05-28 Novel compounds for chemiluminescense procedures

Publications (2)

Publication Number Publication Date
DE60213986D1 DE60213986D1 (de) 2006-09-28
DE60213986T2 true DE60213986T2 (de) 2007-09-06

Family

ID=8177561

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60213986T Expired - Lifetime DE60213986T2 (de) 2001-06-01 2002-05-28 Neuen reagenzien in chemilumineszenz-nachweisverfahren

Country Status (9)

Country Link
US (1) US7332354B2 (pt-PT)
EP (1) EP1397488B1 (pt-PT)
JP (1) JP2004535423A (pt-PT)
AT (1) ATE336572T1 (pt-PT)
AU (1) AU2002310743A1 (pt-PT)
CA (1) CA2448824A1 (pt-PT)
DE (1) DE60213986T2 (pt-PT)
ES (1) ES2271263T3 (pt-PT)
WO (1) WO2002099097A1 (pt-PT)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2989446B1 (de) * 2013-04-24 2018-10-03 Euroimmun Medizinische Labordiagnostika AG Verfahren zur automatisierten auswertung von inkubierten immunblotstreifen

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10022078B2 (en) 2004-07-13 2018-07-17 Dexcom, Inc. Analyte sensor
DE10303265A1 (de) * 2003-01-28 2004-07-29 Roche Diagnostics Gmbh Fluorimetrische Bestimmung von Analyten durch ein intramolekulares Quencher-Fluorophor-Konjugat
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US7654956B2 (en) 2004-07-13 2010-02-02 Dexcom, Inc. Transcutaneous analyte sensor
US20090053747A1 (en) * 2007-08-21 2009-02-26 Mattingly Phillip G Measurement of Haloperoxidase Activity With Chemiluminescent Detection
US20090148871A1 (en) * 2007-12-10 2009-06-11 Mattingly Phillip G Interdependent Assays for Detecting Two or More Analytes of Interest in A Test Sample
CN102378750A (zh) * 2009-03-31 2012-03-14 东丽株式会社 发光元件材料前体和其制造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537877A1 (de) * 1985-10-24 1987-04-30 Geiger Reinhard Luciferin-derivate und immunoassays unter einsatz derartiger luciferin-derivate
ES2063735T3 (es) * 1986-10-22 1995-01-16 Abbott Lab Sales de acridinio quimioluminiscentes.
EP0511366A1 (en) * 1990-11-21 1992-11-04 Beckman Instruments, Inc. Chemiluminescent compounds
US5344928A (en) 1991-04-26 1994-09-06 Takeda Chemical Industries, Ltd. Phenothiazine derivatives, their production and use
US5593845A (en) * 1993-05-17 1997-01-14 Lumigen, Inc. Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
US5491072A (en) 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
BE1008216A4 (fr) * 1994-01-25 1996-02-20 Biocode Sa Derives chemoluminescents heterocycliques.
US5589328A (en) * 1994-08-04 1996-12-31 Mahant; Vijay K. Chemiluminescence assays based on indoxyl substrates, thioindoxyl substrates and other substrates
KR100259761B1 (ko) 1996-03-15 2000-07-01 타이도 나오카타 에스에이치기 표지용시약, 그의 제조방법 및 이를 이용한 표지법
BE1011206A4 (fr) 1997-06-11 1999-06-01 Biocode Sa Derives chimioluminescents heterocycliques.
EP1203091B1 (en) * 1999-07-30 2005-03-16 Bayer Corporation Chemiluminescent substrates of hydrolytic enzymes such as phosphatases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2989446B1 (de) * 2013-04-24 2018-10-03 Euroimmun Medizinische Labordiagnostika AG Verfahren zur automatisierten auswertung von inkubierten immunblotstreifen

Also Published As

Publication number Publication date
JP2004535423A (ja) 2004-11-25
AU2002310743A1 (en) 2002-12-16
US7332354B2 (en) 2008-02-19
ATE336572T1 (de) 2006-09-15
WO2002099097A8 (en) 2003-03-06
ES2271263T3 (es) 2007-04-16
EP1397488A1 (en) 2004-03-17
DE60213986D1 (de) 2006-09-28
EP1397488B1 (en) 2006-08-16
CA2448824A1 (en) 2002-12-12
WO2002099097A1 (en) 2002-12-12
US20040214999A1 (en) 2004-10-28

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