DE60213541T2 - Discodermolid-Analoga und ihre pharmazeutische Verwendung - Google Patents

Discodermolid-Analoga und ihre pharmazeutische Verwendung Download PDF

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Publication number
DE60213541T2
DE60213541T2 DE60213541T DE60213541T DE60213541T2 DE 60213541 T2 DE60213541 T2 DE 60213541T2 DE 60213541 T DE60213541 T DE 60213541T DE 60213541 T DE60213541 T DE 60213541T DE 60213541 T2 DE60213541 T2 DE 60213541T2
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DE
Germany
Prior art keywords
alkyl
formula
hours
och
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60213541T
Other languages
German (de)
English (en)
Other versions
DE60213541D1 (de
Inventor
Kenneth Walter Mountain Lakes Bair
Frederick Ray Morristown Kinder jr.
Timothy Michael Sparta Ramsey
Michael Lloyd Randolph Sabio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE60213541D1 publication Critical patent/DE60213541D1/de
Publication of DE60213541T2 publication Critical patent/DE60213541T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
DE60213541T 2001-11-16 2002-11-15 Discodermolid-Analoga und ihre pharmazeutische Verwendung Expired - Lifetime DE60213541T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33239901P 2001-11-16 2001-11-16
US332399P 2001-11-16
US34339401P 2001-12-21 2001-12-21
US343394P 2001-12-21

Publications (2)

Publication Number Publication Date
DE60213541D1 DE60213541D1 (de) 2006-09-14
DE60213541T2 true DE60213541T2 (de) 2007-10-04

Family

ID=26988201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60213541T Expired - Lifetime DE60213541T2 (de) 2001-11-16 2002-11-15 Discodermolid-Analoga und ihre pharmazeutische Verwendung

Country Status (9)

Country Link
US (2) US6833367B2 (enExample)
EP (1) EP1312608B1 (enExample)
JP (1) JP4410986B2 (enExample)
AT (1) ATE334977T1 (enExample)
CY (1) CY1106201T1 (enExample)
DE (1) DE60213541T2 (enExample)
DK (1) DK1312608T3 (enExample)
ES (1) ES2267928T3 (enExample)
PT (1) PT1312608E (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005084349A2 (en) * 2004-03-02 2005-09-15 Kosan Biosciences, Inc. Compounds useful for the synthesis of (+)-discodermolide and methods therefor
US7214708B2 (en) * 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs
FR2951720B1 (fr) * 2009-10-28 2011-12-16 Pf Medicament Molecules polyketides comme agents anticancereux
WO2012002741A2 (en) * 2010-07-01 2012-01-05 Yuhan Corporation Process for the preparation of hmg-coa reductase inhibitors and intermediates thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5010099A (en) * 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use
US5681847A (en) * 1995-12-05 1997-10-28 Harbor Branch Oceanographic Institution, Inc. Methods of using discodermolide compounds
US6242616B1 (en) * 1996-12-03 2001-06-05 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US6870058B2 (en) 1996-12-03 2005-03-22 The Trustees Of The University Of Pennsylvania Compounds which mimic the chemical and biological properties of discodermolide
US6096904A (en) 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
US6127406A (en) 1998-10-09 2000-10-03 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds and methods of use
CA2401160C (en) * 2000-03-01 2009-09-08 Harbor Branch Oceanographic Institution, Inc. Biologically active analogs of discodermolide

Also Published As

Publication number Publication date
DK1312608T3 (da) 2006-11-27
US7148218B2 (en) 2006-12-12
EP1312608A2 (en) 2003-05-21
JP2003160575A (ja) 2003-06-03
ES2267928T3 (es) 2007-03-16
EP1312608B1 (en) 2006-08-02
ATE334977T1 (de) 2006-08-15
US20030153601A1 (en) 2003-08-14
JP4410986B2 (ja) 2010-02-10
US20050080080A1 (en) 2005-04-14
EP1312608A3 (en) 2003-06-18
US6833367B2 (en) 2004-12-21
CY1106201T1 (el) 2011-06-08
DE60213541D1 (de) 2006-09-14
PT1312608E (pt) 2006-12-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN