DE69904294T2 - Cytotoxische tris oxazole makrolide - Google Patents

Cytotoxische tris oxazole makrolide

Info

Publication number
DE69904294T2
DE69904294T2 DE69904294T DE69904294T DE69904294T2 DE 69904294 T2 DE69904294 T2 DE 69904294T2 DE 69904294 T DE69904294 T DE 69904294T DE 69904294 T DE69904294 T DE 69904294T DE 69904294 T2 DE69904294 T2 DE 69904294T2
Authority
DE
Germany
Prior art keywords
represents hydrogen
lower alkyl
oxazole
macrolides
macrolide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69904294T
Other languages
English (en)
Other versions
DE69904294D1 (de
Inventor
Tatsuo Higa
Gravalos Dolores Garcia
Jose Luis Fernandez-Puentes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Instituto Biomar SA
Original Assignee
Instituto Biomar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituto Biomar SA filed Critical Instituto Biomar SA
Application granted granted Critical
Publication of DE69904294D1 publication Critical patent/DE69904294D1/de
Publication of DE69904294T2 publication Critical patent/DE69904294T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69904294T 1998-01-27 1999-01-27 Cytotoxische tris oxazole makrolide Expired - Lifetime DE69904294T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9801741.1A GB9801741D0 (en) 1998-01-27 1998-01-27 New cytotoxic tris (oxazole)-containing macrolides
PCT/GB1999/000277 WO1999037653A1 (en) 1998-01-27 1999-01-27 New cytotoxic tris(oxazole)-containing macrolides

Publications (2)

Publication Number Publication Date
DE69904294D1 DE69904294D1 (de) 2003-01-16
DE69904294T2 true DE69904294T2 (de) 2003-08-21

Family

ID=10825984

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69904294T Expired - Lifetime DE69904294T2 (de) 1998-01-27 1999-01-27 Cytotoxische tris oxazole makrolide

Country Status (21)

Country Link
US (1) US6391900B1 (de)
EP (1) EP1051420B1 (de)
JP (1) JP4511027B2 (de)
KR (1) KR20010034413A (de)
CN (1) CN1131869C (de)
AT (1) ATE229024T1 (de)
AU (1) AU760184B2 (de)
BR (1) BR9907748A (de)
CA (1) CA2319032C (de)
CZ (1) CZ291931B6 (de)
DE (1) DE69904294T2 (de)
DK (1) DK1051420T3 (de)
ES (1) ES2186324T3 (de)
GB (1) GB9801741D0 (de)
HU (1) HUP0101321A3 (de)
IL (1) IL137545A0 (de)
MX (1) MXPA00007381A (de)
PL (1) PL342040A1 (de)
PT (1) PT1051420E (de)
RU (1) RU2217433C2 (de)
WO (1) WO1999037653A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100471727B1 (ko) * 2002-10-14 2005-02-21 학교법인 포항공과대학교 이속사졸린 고리와 불소를 포함하는 거대고리 화합물 및그의 제조방법
CN100360515C (zh) * 2004-04-09 2008-01-09 中国科学院上海药物研究所 抗肿瘤活性成份陵水醇、制备方法和用途
KR20110043653A (ko) * 2008-07-03 2011-04-27 파르마 마르 에스.에이. 항종양 마크롤라이드
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6256493A (ja) * 1985-09-06 1987-03-12 Yamanouchi Pharmaceut Co Ltd カビラマイド類
US5760065A (en) 1994-09-13 1998-06-02 Kyowa Hakko Kogyo Co., Ltd. Anti-HIV agent

Also Published As

Publication number Publication date
US6391900B1 (en) 2002-05-21
RU2217433C2 (ru) 2003-11-27
JP4511027B2 (ja) 2010-07-28
BR9907748A (pt) 2000-10-17
EP1051420A1 (de) 2000-11-15
PT1051420E (pt) 2003-02-28
CA2319032C (en) 2009-09-08
HUP0101321A2 (hu) 2001-09-28
IL137545A0 (en) 2001-07-24
EP1051420B1 (de) 2002-12-04
KR20010034413A (ko) 2001-04-25
WO1999037653A1 (en) 1999-07-29
AU760184B2 (en) 2003-05-08
MXPA00007381A (es) 2002-06-04
CN1131869C (zh) 2003-12-24
PL342040A1 (en) 2001-05-21
DE69904294D1 (de) 2003-01-16
HUP0101321A3 (en) 2002-06-28
ES2186324T3 (es) 2003-05-01
CZ291931B6 (cs) 2003-06-18
JP2002501074A (ja) 2002-01-15
GB9801741D0 (en) 1998-03-25
ATE229024T1 (de) 2002-12-15
DK1051420T3 (da) 2002-12-30
AU2431999A (en) 1999-08-09
CN1320127A (zh) 2001-10-31
CA2319032A1 (en) 1999-07-29
CZ20002754A3 (cs) 2002-02-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition