DE60212415T2 - Die verwendung von einer 4-pyridylmethylphtalazine enthaltenden kombination zur behandlung von tumoren - Google Patents
Die verwendung von einer 4-pyridylmethylphtalazine enthaltenden kombination zur behandlung von tumoren Download PDFInfo
- Publication number
- DE60212415T2 DE60212415T2 DE60212415T DE60212415T DE60212415T2 DE 60212415 T2 DE60212415 T2 DE 60212415T2 DE 60212415 T DE60212415 T DE 60212415T DE 60212415 T DE60212415 T DE 60212415T DE 60212415 T2 DE60212415 T2 DE 60212415T2
- Authority
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- Germany
- Prior art keywords
- day
- administered
- phthalazine
- pyridylmethyl
- chloroanilino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 239000000825 pharmaceutical preparation Substances 0.000 description 1
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- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 229940117820 purinethol Drugs 0.000 description 1
- 229960004622 raloxifene Drugs 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 229940089617 risedronate Drugs 0.000 description 1
- 229960000759 risedronic acid Drugs 0.000 description 1
- VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 description 1
- 229950009213 rubitecan Drugs 0.000 description 1
- 229940076279 serotonin Drugs 0.000 description 1
- 229940112726 skelid Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229960003454 tamoxifen citrate Drugs 0.000 description 1
- FQZYTYWMLGAPFJ-OQKDUQJOSA-N tamoxifen citrate Chemical compound [H+].[H+].[H+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 FQZYTYWMLGAPFJ-OQKDUQJOSA-N 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229960003433 thalidomide Drugs 0.000 description 1
- 229940034915 thalomid Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940044693 topoisomerase inhibitor Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 1
- 230000004614 tumor growth Effects 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 229960001771 vorozole Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31869401P | 2001-09-12 | 2001-09-12 | |
| US33102501P | 2001-09-12 | 2001-09-12 | |
| US318694P | 2001-09-12 | ||
| US331025P | 2001-09-12 | ||
| US32204401P | 2001-09-14 | 2001-09-14 | |
| US322044P | 2001-09-14 | ||
| US38816302P | 2002-06-12 | 2002-06-12 | |
| US388163P | 2002-06-12 | ||
| PCT/EP2002/010194 WO2003022282A1 (en) | 2001-09-12 | 2002-09-11 | Use of 4-pyridylmethylphthalazines for cancer treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60212415D1 DE60212415D1 (de) | 2006-07-27 |
| DE60212415T2 true DE60212415T2 (de) | 2006-11-23 |
Family
ID=27502161
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60212415T Expired - Lifetime DE60212415T2 (de) | 2001-09-12 | 2002-09-11 | Die verwendung von einer 4-pyridylmethylphtalazine enthaltenden kombination zur behandlung von tumoren |
| DE60231068T Expired - Lifetime DE60231068D1 (de) | 2001-09-12 | 2002-09-11 | Die Verwendung von 4-Pyridylmethylphthalazinen zur Behandlung von Nierentumoren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60231068T Expired - Lifetime DE60231068D1 (de) | 2001-09-12 | 2002-09-11 | Die Verwendung von 4-Pyridylmethylphthalazinen zur Behandlung von Nierentumoren |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20040258770A1 (enExample) |
| EP (1) | EP1427420B1 (enExample) |
| JP (1) | JP2005502690A (enExample) |
| KR (1) | KR20040029172A (enExample) |
| CN (1) | CN1330308C (enExample) |
| AT (2) | ATE329597T1 (enExample) |
| AU (2) | AU2002342678B2 (enExample) |
| BR (1) | BR0212446A (enExample) |
| CA (1) | CA2457848A1 (enExample) |
| CO (1) | CO5560545A2 (enExample) |
| CY (1) | CY1105189T1 (enExample) |
| DE (2) | DE60212415T2 (enExample) |
| DK (1) | DK1427420T3 (enExample) |
| ES (2) | ES2266590T3 (enExample) |
| HR (1) | HRP20040241A2 (enExample) |
| IL (1) | IL160382A0 (enExample) |
| NO (1) | NO327358B1 (enExample) |
| NZ (1) | NZ531484A (enExample) |
| PL (1) | PL367349A1 (enExample) |
| PT (1) | PT1427420E (enExample) |
| RS (1) | RS16804A (enExample) |
| WO (1) | WO2003022282A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0223341D0 (en) * | 2002-10-08 | 2002-11-13 | Groningen Acad Ziekenhuis | Organic compounds |
| JP2006514991A (ja) * | 2002-12-27 | 2006-05-18 | シエーリング アクチエンゲゼルシャフト | 新規医薬組合せ |
| EP1631278A4 (en) * | 2003-05-20 | 2006-09-20 | Aronex Pharmaceuticals Inc | COMBINED CHEMOTHERAPY COMPRISING CAPECITABINE AND A COMPLEX BASED ON LIPOSOMIC PLATINUM |
| MXPA06003163A (es) * | 2003-09-23 | 2006-06-05 | Novartis Ag | Combinacion de un inhibidor de receptor de vegf con un agente quimioterapeutico. |
| GB0610925D0 (en) * | 2006-06-02 | 2006-07-12 | Novartis Ag | Use of vascular endothelial growth factor receptor inhibitors for the treatment of cancer |
| KR101037292B1 (ko) * | 2010-09-03 | 2011-05-27 | (주)슈추어 | 신발 장식구 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996005176A1 (en) * | 1994-08-09 | 1996-02-22 | Eisai Co., Ltd. | Fused pyridazine compound |
| DE69709319T2 (de) * | 1996-03-05 | 2002-08-14 | Astrazeneca Ab, Soedertaelje | 4-anilinochinazolin derivate |
| US6096904A (en) * | 1996-12-03 | 2000-08-01 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| CO4950519A1 (es) * | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
-
2002
- 2002-09-11 BR BR0212446-7A patent/BR0212446A/pt not_active IP Right Cessation
- 2002-09-11 AT AT02779338T patent/ATE329597T1/de not_active IP Right Cessation
- 2002-09-11 ES ES02779338T patent/ES2266590T3/es not_active Expired - Lifetime
- 2002-09-11 RS YUP-168/04A patent/RS16804A/sr unknown
- 2002-09-11 IL IL16038202A patent/IL160382A0/xx not_active IP Right Cessation
- 2002-09-11 CN CNB028178831A patent/CN1330308C/zh not_active Expired - Fee Related
- 2002-09-11 DE DE60212415T patent/DE60212415T2/de not_active Expired - Lifetime
- 2002-09-11 NZ NZ531484A patent/NZ531484A/en not_active IP Right Cessation
- 2002-09-11 KR KR10-2004-7003645A patent/KR20040029172A/ko not_active Abandoned
- 2002-09-11 AU AU2002342678A patent/AU2002342678B2/en not_active Ceased
- 2002-09-11 PT PT02779338T patent/PT1427420E/pt unknown
- 2002-09-11 PL PL02367349A patent/PL367349A1/xx not_active Application Discontinuation
- 2002-09-11 DK DK02779338T patent/DK1427420T3/da active
- 2002-09-11 CA CA002457848A patent/CA2457848A1/en not_active Abandoned
- 2002-09-11 JP JP2003526411A patent/JP2005502690A/ja active Pending
- 2002-09-11 EP EP02779338A patent/EP1427420B1/en not_active Expired - Lifetime
- 2002-09-11 US US10/489,751 patent/US20040258770A1/en not_active Abandoned
- 2002-09-11 HR HR20040241A patent/HRP20040241A2/hr not_active Application Discontinuation
- 2002-09-11 ES ES06114903T patent/ES2320922T3/es not_active Expired - Lifetime
- 2002-09-11 DE DE60231068T patent/DE60231068D1/de not_active Expired - Lifetime
- 2002-09-11 AT AT06114903T patent/ATE421880T1/de not_active IP Right Cessation
- 2002-09-11 WO PCT/EP2002/010194 patent/WO2003022282A1/en not_active Ceased
-
2004
- 2004-02-27 CO CO04017661A patent/CO5560545A2/es active IP Right Grant
- 2004-03-05 NO NO20040973A patent/NO327358B1/no not_active IP Right Cessation
-
2006
- 2006-08-09 AU AU2006203428A patent/AU2006203428B2/en not_active Ceased
- 2006-08-31 CY CY20061101239T patent/CY1105189T1/el unknown
-
2009
- 2009-04-15 US US12/423,843 patent/US20090196871A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PL367349A1 (en) | 2005-02-21 |
| AU2002342678B2 (en) | 2006-08-24 |
| ATE329597T1 (de) | 2006-07-15 |
| JP2005502690A (ja) | 2005-01-27 |
| NZ531484A (en) | 2007-02-23 |
| CN1553803A (zh) | 2004-12-08 |
| ATE421880T1 (de) | 2009-02-15 |
| CN1330308C (zh) | 2007-08-08 |
| WO2003022282A1 (en) | 2003-03-20 |
| CY1105189T1 (el) | 2010-03-03 |
| NO327358B1 (no) | 2009-06-15 |
| US20040258770A1 (en) | 2004-12-23 |
| CA2457848A1 (en) | 2003-03-20 |
| HRP20040241A2 (en) | 2005-04-30 |
| EP1427420A1 (en) | 2004-06-16 |
| EP1427420B1 (en) | 2006-06-14 |
| PT1427420E (pt) | 2006-10-31 |
| ES2320922T3 (es) | 2009-05-29 |
| KR20040029172A (ko) | 2004-04-03 |
| IL160382A0 (en) | 2004-07-25 |
| NO20040973L (no) | 2004-06-03 |
| BR0212446A (pt) | 2004-08-17 |
| ES2266590T3 (es) | 2007-03-01 |
| US20090196871A1 (en) | 2009-08-06 |
| DE60231068D1 (de) | 2009-03-19 |
| AU2006203428A1 (en) | 2006-08-31 |
| RS16804A (sr) | 2007-02-05 |
| DK1427420T3 (da) | 2006-10-02 |
| AU2006203428B2 (en) | 2009-06-04 |
| CO5560545A2 (es) | 2005-09-30 |
| DE60212415D1 (de) | 2006-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
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| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |