DE60210989T2 - Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen - Google Patents

Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen Download PDF

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Publication number
DE60210989T2
DE60210989T2 DE60210989T DE60210989T DE60210989T2 DE 60210989 T2 DE60210989 T2 DE 60210989T2 DE 60210989 T DE60210989 T DE 60210989T DE 60210989 T DE60210989 T DE 60210989T DE 60210989 T2 DE60210989 T2 DE 60210989T2
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Prior art keywords
gpr86
adp
activity
cells
polypeptide
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Expired - Lifetime
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DE60210989T
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English (en)
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DE60210989D1 (de
Inventor
Didier Communi
Nathalie Suarez
Michel Detheux
Stephane Brezillon
Vincent Lannoy
Marc Parmentier
Jean-Marie Boeynaems
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Ogeda SA
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Euroscreen SA
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP

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DE60210989T 2001-08-07 2002-08-06 Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen Expired - Lifetime DE60210989T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US924125 2001-08-07
US09/924,125 US6946244B2 (en) 2001-08-07 2001-08-07 Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13)
PCT/EP2002/008761 WO2003014731A2 (en) 2001-08-07 2002-08-06 The natural ligand for orphan g protein coupled receptor gpr86 and methods of use

Publications (2)

Publication Number Publication Date
DE60210989D1 DE60210989D1 (de) 2006-06-01
DE60210989T2 true DE60210989T2 (de) 2006-12-14

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DE60210989T Expired - Lifetime DE60210989T2 (de) 2001-08-07 2002-08-06 Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen

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US (3) US6946244B2 (enExample)
EP (1) EP1421377B1 (enExample)
JP (1) JP4372545B2 (enExample)
AT (1) ATE324585T1 (enExample)
CA (1) CA2453486C (enExample)
DE (1) DE60210989T2 (enExample)
DK (1) DK1421377T3 (enExample)
ES (1) ES2262819T3 (enExample)
WO (1) WO2003014731A2 (enExample)

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WO2004015422A2 (en) * 2002-08-05 2004-02-19 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with ovarian cancer g-protein coupled receptor 1 (ogr-1)
GB2394286A (en) * 2002-09-17 2004-04-21 Innovab Ltd An assay for adp using an adp binding protein
WO2004082571A2 (en) * 2003-03-18 2004-09-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 86 (gpr86)
GB0312845D0 (en) * 2003-06-04 2003-07-09 Paradigm Therapeutics Ltd Use of componds in medicine
GB0312844D0 (en) * 2003-06-04 2003-07-09 Paradigm Therapeutics Ltd Use of compounds in medicine
JP4926952B2 (ja) * 2004-07-01 2012-05-09 武田薬品工業株式会社 Ｇｐｒ８６受容体の使用
WO2006003422A1 (en) * 2004-07-01 2006-01-12 Paradigm Therapeutics Limited Use of the receptor gpr86
ES2322727B1 (es) * 2005-07-28 2010-04-22 Universidad Del Pais Vasco Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares.
US20090306009A1 (en) 2005-12-06 2009-12-10 P2-Science Aps Modulation of the P2Y2 Receptor Pathway
GB0817166D0 (en) 2008-09-19 2008-10-29 Medical Res Council Sensor
ES2912453T3 (es) 2016-05-06 2022-05-26 Inst Nat Sante Rech Med Composiciones farmacéuticas para el tratamiento de la leucemia mieloide aguda (LMA) quimiorresistente

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US6162899A (en) 1997-10-23 2000-12-19 Smithkline Beecham Corporation Human HNEAA81 receptor
CA2239255A1 (en) 1997-10-23 1999-04-23 Smithkline Beecham Corporation Cdna clone hneaa81 that encodes a human 7-transmembrane receptor
CA2348377C (en) * 1998-11-20 2008-12-02 Arena Pharmaceuticals, Inc. Human orphan g protein-coupled receptors
US6689866B1 (en) * 1999-03-09 2004-02-10 Curagen Corporation Polynucleotides and proteins encoded thereby
US6863889B2 (en) * 1999-03-09 2005-03-08 Curagen Corporation Polynucleotides and proteins encoded thereby
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
US20030059878A1 (en) 2001-07-06 2003-03-27 Tanabe Seiyaku Co., Ltd Novel purinoceptor and gene thereof

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JP4372545B2 (ja) 2009-11-25
US7422846B2 (en) 2008-09-09
CA2453486A1 (en) 2003-02-20
US6946244B2 (en) 2005-09-20
WO2003014731B1 (en) 2004-03-25
JP2005500053A (ja) 2005-01-06
US20060078918A1 (en) 2006-04-13
WO2003014731A2 (en) 2003-02-20
US20040005629A1 (en) 2004-01-08
CA2453486C (en) 2011-09-27
US20030050235A1 (en) 2003-03-13
WO2003014731A3 (en) 2004-02-19
ATE324585T1 (de) 2006-05-15
DK1421377T3 (da) 2006-08-28
DE60210989D1 (de) 2006-06-01
EP1421377B1 (en) 2006-04-26
EP1421377A2 (en) 2004-05-26
ES2262819T3 (es) 2006-12-01

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