DE60210989D1 - Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen - Google Patents

Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen

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Publication number
DE60210989D1
DE60210989D1 DE60210989T DE60210989T DE60210989D1 DE 60210989 D1 DE60210989 D1 DE 60210989D1 DE 60210989 T DE60210989 T DE 60210989T DE 60210989 T DE60210989 T DE 60210989T DE 60210989 D1 DE60210989 D1 DE 60210989D1
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DE
Germany
Prior art keywords
ligand
coupled receptor
protein coupled
gpr86
receptor gpr86
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60210989T
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English (en)
Other versions
DE60210989T2 (de
Inventor
Didier Communi
Nathalie Suarez
Michel Detheux
Stephane Brezillon
Vincent Lannoy
Marc Parmentier
Jean-Marie Boeynaems
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ogeda SA
Original Assignee
Euroscreen SA
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Filing date
Publication date
Application filed by Euroscreen SA filed Critical Euroscreen SA
Publication of DE60210989D1 publication Critical patent/DE60210989D1/de
Application granted granted Critical
Publication of DE60210989T2 publication Critical patent/DE60210989T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • G—PHYSICS
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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    • G01—MEASURING; TESTING
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD, ATP

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  • Health & Medical Sciences (AREA)
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  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
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  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Tropical Medicine & Parasitology (AREA)
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DE60210989T 2001-08-07 2002-08-06 Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen Expired - Lifetime DE60210989T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US924125 2001-08-07
US09/924,125 US6946244B2 (en) 2001-08-07 2001-08-07 Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13)
PCT/EP2002/008761 WO2003014731A2 (en) 2001-08-07 2002-08-06 The natural ligand for orphan g protein coupled receptor gpr86 and methods of use

Publications (2)

Publication Number Publication Date
DE60210989D1 true DE60210989D1 (de) 2006-06-01
DE60210989T2 DE60210989T2 (de) 2006-12-14

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DE60210989T Expired - Lifetime DE60210989T2 (de) 2001-08-07 2002-08-06 Der ligand für den g-protein gekoppelten rezeptor gpr86 und seine verwendungen

Country Status (9)

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US (3) US6946244B2 (de)
EP (1) EP1421377B1 (de)
JP (1) JP4372545B2 (de)
AT (1) ATE324585T1 (de)
CA (1) CA2453486C (de)
DE (1) DE60210989T2 (de)
DK (1) DK1421377T3 (de)
ES (1) ES2262819T3 (de)
WO (1) WO2003014731A2 (de)

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AU2003266238A1 (en) * 2002-08-05 2004-02-25 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with ovarian cancer g-protein coupled receptor 1 (ogr-1)
GB2394286A (en) * 2002-09-17 2004-04-21 Innovab Ltd An assay for adp using an adp binding protein
WO2004082571A2 (en) * 2003-03-18 2004-09-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 86 (gpr86)
GB0312844D0 (en) * 2003-06-04 2003-07-09 Paradigm Therapeutics Ltd Use of compounds in medicine
GB0312845D0 (en) * 2003-06-04 2003-07-09 Paradigm Therapeutics Ltd Use of componds in medicine
AU2005258934A1 (en) * 2004-07-01 2006-01-12 Paradigm Therapeutics Limited Use of the receptor GPR86
JP4926952B2 (ja) * 2004-07-01 2012-05-09 武田薬品工業株式会社 Ｇｐｒ８６受容体の使用
ES2322727B1 (es) 2005-07-28 2010-04-22 Universidad Del Pais Vasco Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares.
EP2036567A3 (de) 2005-12-06 2009-12-09 P2-Science APS Modulation des p2y2-Rezeptorpfads
GB0817166D0 (en) 2008-09-19 2008-10-29 Medical Res Council Sensor
ES2912453T3 (es) 2016-05-06 2022-05-26 Inst Nat Sante Rech Med Composiciones farmacéuticas para el tratamiento de la leucemia mieloide aguda (LMA) quimiorresistente

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US6162899A (en) 1997-10-23 2000-12-19 Smithkline Beecham Corporation Human HNEAA81 receptor
CA2239255A1 (en) 1997-10-23 1999-04-23 Smithkline Beecham Corporation Cdna clone hneaa81 that encodes a human 7-transmembrane receptor
DK1133559T3 (da) * 1998-11-20 2006-04-10 Arena Pharm Inc Human-G-protein-koblet orphan receptor RUP3
US6689866B1 (en) * 1999-03-09 2004-02-10 Curagen Corporation Polynucleotides and proteins encoded thereby
US6863889B2 (en) * 1999-03-09 2005-03-08 Curagen Corporation Polynucleotides and proteins encoded thereby
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
US20030059878A1 (en) 2001-07-06 2003-03-27 Tanabe Seiyaku Co., Ltd Novel purinoceptor and gene thereof

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Publication number Publication date
ES2262819T3 (es) 2006-12-01
WO2003014731A3 (en) 2004-02-19
EP1421377A2 (de) 2004-05-26
US20040005629A1 (en) 2004-01-08
EP1421377B1 (de) 2006-04-26
DK1421377T3 (da) 2006-08-28
US6946244B2 (en) 2005-09-20
JP2005500053A (ja) 2005-01-06
DE60210989T2 (de) 2006-12-14
WO2003014731B1 (en) 2004-03-25
US20030050235A1 (en) 2003-03-13
ATE324585T1 (de) 2006-05-15
CA2453486C (en) 2011-09-27
US20060078918A1 (en) 2006-04-13
US7422846B2 (en) 2008-09-09
WO2003014731A2 (en) 2003-02-20
JP4372545B2 (ja) 2009-11-25
CA2453486A1 (en) 2003-02-20

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