DK1421377T3 - Naturlig ligand for den orphane G-proteinkoblede receptor GPR86 og metoder til anvendelse - Google Patents

Naturlig ligand for den orphane G-proteinkoblede receptor GPR86 og metoder til anvendelse

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Publication number
DK1421377T3
DK1421377T3 DK02748870T DK02748870T DK1421377T3 DK 1421377 T3 DK1421377 T3 DK 1421377T3 DK 02748870 T DK02748870 T DK 02748870T DK 02748870 T DK02748870 T DK 02748870T DK 1421377 T3 DK1421377 T3 DK 1421377T3
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DK
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Prior art keywords
orphan
protein
methods
coupled receptor
natural ligand
Prior art date
Application number
DK02748870T
Other languages
Danish (da)
English (en)
Inventor
Didier Communi
Nathalie Suarez
Michel Detheux
Stephane Brezillon
Vincent Lannoy
Marc Parmentier
Jean-Marie Boeynaems
Original Assignee
Euroscreen Sa
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Publication of DK1421377T3 publication Critical patent/DK1421377T3/da

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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G01N33/5735—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes co-enzymes or co-factors, e.g. NAD or ATP

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DK02748870T 2001-08-07 2002-08-06 Naturlig ligand for den orphane G-proteinkoblede receptor GPR86 og metoder til anvendelse DK1421377T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/924,125 US6946244B2 (en) 2001-08-07 2001-08-07 Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13)

Publications (1)

Publication Number Publication Date
DK1421377T3 true DK1421377T3 (da) 2006-08-28

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DK02748870T DK1421377T3 (da) 2001-08-07 2002-08-06 Naturlig ligand for den orphane G-proteinkoblede receptor GPR86 og metoder til anvendelse

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US (3) US6946244B2 (enExample)
EP (1) EP1421377B1 (enExample)
JP (1) JP4372545B2 (enExample)
AT (1) ATE324585T1 (enExample)
CA (1) CA2453486C (enExample)
DE (1) DE60210989T2 (enExample)
DK (1) DK1421377T3 (enExample)
ES (1) ES2262819T3 (enExample)
WO (1) WO2003014731A2 (enExample)

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AU2003266238A1 (en) * 2002-08-05 2004-02-25 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with ovarian cancer g-protein coupled receptor 1 (ogr-1)
GB2394286A (en) * 2002-09-17 2004-04-21 Innovab Ltd An assay for adp using an adp binding protein
WO2004082571A2 (en) * 2003-03-18 2004-09-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 86 (gpr86)
GB0312844D0 (en) * 2003-06-04 2003-07-09 Paradigm Therapeutics Ltd Use of compounds in medicine
GB0312845D0 (en) * 2003-06-04 2003-07-09 Paradigm Therapeutics Ltd Use of componds in medicine
AU2005258934A1 (en) 2004-07-01 2006-01-12 Paradigm Therapeutics Limited Use of the receptor GPR86
JP4926952B2 (ja) * 2004-07-01 2012-05-09 武田薬品工業株式会社 Ｇｐｒ８６受容体の使用
ES2322727B1 (es) 2005-07-28 2010-04-22 Universidad Del Pais Vasco Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares.
EP2036567A3 (en) 2005-12-06 2009-12-09 P2-Science APS Modulation of the P2Y2 receptor pathway
GB0817166D0 (en) * 2008-09-19 2008-10-29 Medical Res Council Sensor
US11376269B2 (en) 2016-05-06 2022-07-05 Inserm Pharmaceutical compositions for the treatment of chemoresistant acute myeloid leukemia (AML)

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US6162899A (en) * 1997-10-23 2000-12-19 Smithkline Beecham Corporation Human HNEAA81 receptor
CA2239255A1 (en) * 1997-10-23 1999-04-23 Smithkline Beecham Corporation Cdna clone hneaa81 that encodes a human 7-transmembrane receptor
ATE301673T1 (de) * 1998-11-20 2005-08-15 Arena Pharm Inc Menschliche, an ein g-protein gekoppelter rezeptor rup3 ohne bekannten ligand
US6863889B2 (en) * 1999-03-09 2005-03-08 Curagen Corporation Polynucleotides and proteins encoded thereby
US6689866B1 (en) * 1999-03-09 2004-02-10 Curagen Corporation Polynucleotides and proteins encoded thereby
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides
US20030059878A1 (en) * 2001-07-06 2003-03-27 Tanabe Seiyaku Co., Ltd Novel purinoceptor and gene thereof

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EP1421377A2 (en) 2004-05-26
WO2003014731A3 (en) 2004-02-19
CA2453486A1 (en) 2003-02-20
US20040005629A1 (en) 2004-01-08
US20030050235A1 (en) 2003-03-13
US7422846B2 (en) 2008-09-09
DE60210989D1 (de) 2006-06-01
ATE324585T1 (de) 2006-05-15
ES2262819T3 (es) 2006-12-01
US20060078918A1 (en) 2006-04-13
DE60210989T2 (de) 2006-12-14
WO2003014731A2 (en) 2003-02-20
JP4372545B2 (ja) 2009-11-25
WO2003014731B1 (en) 2004-03-25
US6946244B2 (en) 2005-09-20
JP2005500053A (ja) 2005-01-06
CA2453486C (en) 2011-09-27
EP1421377B1 (en) 2006-04-26

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