DE60203734D1 - Herstellung von alpha-tocopherol - Google Patents

Herstellung von alpha-tocopherol

Info

Publication number
DE60203734D1
DE60203734D1 DE60203734T DE60203734T DE60203734D1 DE 60203734 D1 DE60203734 D1 DE 60203734D1 DE 60203734 T DE60203734 T DE 60203734T DE 60203734 T DE60203734 T DE 60203734T DE 60203734 D1 DE60203734 D1 DE 60203734D1
Authority
DE
Germany
Prior art keywords
solvent
acid
mixture
alpha
rac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60203734T
Other languages
English (en)
Other versions
DE60203734T2 (de
Inventor
Werner Bonrath
Carl Burdick
Thomas Netscher
Frank Schager
Dominik Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Application granted granted Critical
Publication of DE60203734D1 publication Critical patent/DE60203734D1/de
Publication of DE60203734T2 publication Critical patent/DE60203734T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrane Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60203734T 2001-10-31 2002-10-23 Herstellung von alpha-tocopherol Expired - Lifetime DE60203734T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01125966 2001-10-31
EP01125966 2001-10-31
PCT/EP2002/011819 WO2003037883A1 (en) 2001-10-31 2002-10-23 Manufacture of alpha- tocopherol

Publications (2)

Publication Number Publication Date
DE60203734D1 true DE60203734D1 (de) 2005-05-19
DE60203734T2 DE60203734T2 (de) 2006-02-09

Family

ID=8179127

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60203734T Expired - Lifetime DE60203734T2 (de) 2001-10-31 2002-10-23 Herstellung von alpha-tocopherol

Country Status (8)

Country Link
US (1) US7626046B2 (de)
EP (1) EP1446398B1 (de)
JP (1) JP2005507422A (de)
CN (1) CN1271065C (de)
AT (1) ATE293108T1 (de)
DE (1) DE60203734T2 (de)
ES (1) ES2239260T3 (de)
WO (1) WO2003037883A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE378325T1 (de) 2002-11-21 2007-11-15 Dsm Ip Assets Bv Herstellung von tocoferylazetaten
WO2004063182A1 (en) * 2003-01-13 2004-07-29 Dsm Ip Assets B.V. PROCESS FOR THE MANUFACTURE OF α-TOCOPHERYL ACETATE
WO2005026181A2 (en) * 2003-09-15 2005-03-24 Dsm Ip Assets B.V. A NEW ROUTE TO α-TOCOPHEROL, α-TOCOPHERYL ALKANOATES AND PRECURSORS THEREOF
WO2005026142A2 (en) * 2003-09-15 2005-03-24 Dsm Ip Assets B.V. Synthesis of alpha-tocopheryl alkanoates and precursors thereof
CN111065634A (zh) 2017-07-12 2020-04-24 帝斯曼知识产权资产管理有限公司 用于制备α-生育酚的中间体的新型合成
CN113640395A (zh) * 2020-04-27 2021-11-12 深圳波顿香料有限公司 电子烟油中的生育酚乙酸酯的合相色谱分析方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208334A (en) 1978-12-22 1980-06-17 Hoffmann-La Roches Inc. Process for preparation of α-tocopherol
US6369242B2 (en) 2000-03-17 2002-04-09 Roche Vitamins Inc. Tocopherol manufacture by tris(perfluorohydrocarbylsulphonyl) methane or metal methides thereof

Also Published As

Publication number Publication date
CN1271065C (zh) 2006-08-23
DE60203734T2 (de) 2006-02-09
ATE293108T1 (de) 2005-04-15
US7626046B2 (en) 2009-12-01
WO2003037883A1 (en) 2003-05-08
CN1578777A (zh) 2005-02-09
EP1446398B1 (de) 2005-04-13
US20050187393A1 (en) 2005-08-25
ES2239260T3 (es) 2005-09-16
JP2005507422A (ja) 2005-03-17
EP1446398A1 (de) 2004-08-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition