KR970069965A - 2-메틸-1, 4-나프토퀴논(비타민 k_3)의 제조방법 - Google Patents
2-메틸-1, 4-나프토퀴논(비타민 k_3)의 제조방법 Download PDFInfo
- Publication number
- KR970069965A KR970069965A KR1019960012872A KR19960012872A KR970069965A KR 970069965 A KR970069965 A KR 970069965A KR 1019960012872 A KR1019960012872 A KR 1019960012872A KR 19960012872 A KR19960012872 A KR 19960012872A KR 970069965 A KR970069965 A KR 970069965A
- Authority
- KR
- South Korea
- Prior art keywords
- methyl
- naphthoquinone
- reaction
- producing
- dehydrogenation
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/69—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to carbon-to-carbon double or triple bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C46/00—Preparation of quinones
- C07C46/02—Preparation of quinones by oxidation giving rise to quinoid structures
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
본 발명은 2-메틸-1,4-벤조퀴논과 1,3-부타디엔을 순한 산화제겸 용매인 N,N-디메틸술폭사이드 존재하에서 루이스산 및 브뢴스테인드산 촉매를 사용하여 동일반응기에서 [2+4]딜즈-알더 반응 및 산화성 탈수소화 반응을 연속적으로시켜 높은 수율로 2-메틸-1,4-나프토퀴논(비타민 K3)을 제조하는 방법에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (5)
- 2-메틸-1,4-벤조퀴논과 1,3-부타디엔을 [2+4]딜즈-알더 반응시켜서 얻은 2-메틸-4a,5,8,8a-테트라하히드로-1,4-나프토퀴논을 산촉매 존재하에 탈수소화하여 2-메틸-1,4-나프토퀴논을 제조하는 방법에 있어서, [2+4]딜즈-알더 반응의 반응용매겸 탈수소화제로 N,N-디메틸술폭사이드를 사용하고 탈수소화 반응 촉매로 루이스산 또는 브뢴스테드산을 사용하여 [2+4]딜즈-알더 반응과 탈수소화 반응을 동일 반응기내에서 연속적으로 이행시켜 2-메틸-1,4-나프토퀴논을 제조하는 방법.
- 제1항에 있어서, 루이스산으로 SnCl4,·nH2O, FeCl3·nH2O, AlCl3, BF3또는 브뢴스테드산으로 유기산을 탈수소화 반응 촉매로 사용하여 2-메틸-1,4-나프토퀴논을 제조하는 방법.
- 제1항에 있어서, 탈수소 반응 촉매를 2-메틸-1,4-벤조퀴논에 대하여 1~70wt% 사용하여 2-메틸-1,4-나프토퀴논을 제조하는 방법.
- 제1항에 있어서, [2+4]딜즈-알더 반응과 탈수소화 반응온도가 100~180℃ 2-메틸-1,4-나프토퀴논을 제조하는 방법.
- 제1항에 있어서, N,N-디메틸술폭사이드와 유기용매와의 혼합용매를 반응용매로 사용하여 2-메틸-1,4-나프토퀴논을 제조하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019960012872A KR0178456B1 (ko) | 1996-04-25 | 1996-04-25 | 2-메틸-1,4-나프토퀴논(비타민 k3)의 제조방법 |
US08/758,921 US5770774A (en) | 1996-04-25 | 1996-12-02 | Method for preparing 2-methyl-1,4-naphthoquinone (vitamin K3) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019960012872A KR0178456B1 (ko) | 1996-04-25 | 1996-04-25 | 2-메틸-1,4-나프토퀴논(비타민 k3)의 제조방법 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR970069965A true KR970069965A (ko) | 1997-11-07 |
KR0178456B1 KR0178456B1 (ko) | 1999-05-15 |
Family
ID=19456680
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960012872A KR0178456B1 (ko) | 1996-04-25 | 1996-04-25 | 2-메틸-1,4-나프토퀴논(비타민 k3)의 제조방법 |
Country Status (2)
Country | Link |
---|---|
US (1) | US5770774A (ko) |
KR (1) | KR0178456B1 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100901443B1 (ko) * | 2007-03-20 | 2009-06-08 | 주식회사 비즈모델라인 | 자동차 번호를 이용한 무선결제 시스템 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7595378B2 (en) | 2001-06-13 | 2009-09-29 | Genmab A/S | Human monoclonal antibodies to epidermal growth factor receptor (EGFR) |
WO2006113479A2 (en) * | 2005-04-15 | 2006-10-26 | Albert Einstein College Of Medicine Of Yeshiva University | Vitamin k for prevention and treatment of skin rash secondary to anti-egfr therapy |
US9428582B2 (en) * | 2006-07-03 | 2016-08-30 | Genmab A/S | Method of treating rash in patients undergoing anti-EGFR therapy |
US7840340B2 (en) * | 2007-04-13 | 2010-11-23 | United Parcel Service Of America, Inc. | Systems, methods, and computer program products for generating reference geocodes for point addresses |
US8815953B2 (en) * | 2008-03-13 | 2014-08-26 | Spectrum Pharmaceuticals, Inc. | Formulations of vitamin K analogs for topical use |
EP2345631A1 (en) * | 2010-01-13 | 2011-07-20 | Lonza Ltd. | Yield-efficient process for the production of highly pure 2-methyl-1,4-naphthoquinone and its derivatives |
CN102557913A (zh) * | 2010-12-31 | 2012-07-11 | 新疆大学 | 2-吡喃酮一锅法合成羟基取代1,4-萘醌 |
WO2014039917A1 (en) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Benzoquinone derivatives for treating oxidative stress disorders |
CN111689844B (zh) * | 2020-07-30 | 2023-06-13 | 能特科技有限公司 | 一种2-甲基-1,4-萘醌新型生产工艺 |
CN115805096B (zh) * | 2023-02-07 | 2023-05-12 | 浙江新和成股份有限公司 | 一种非均相氮掺杂碳材料负载钴催化剂及维生素k3的生产工艺 |
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1996
- 1996-04-25 KR KR1019960012872A patent/KR0178456B1/ko not_active IP Right Cessation
- 1996-12-02 US US08/758,921 patent/US5770774A/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100901443B1 (ko) * | 2007-03-20 | 2009-06-08 | 주식회사 비즈모델라인 | 자동차 번호를 이용한 무선결제 시스템 |
Also Published As
Publication number | Publication date |
---|---|
KR0178456B1 (ko) | 1999-05-15 |
US5770774A (en) | 1998-06-23 |
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