DE602007008826D1 - Verfahren zur feststellung von oxidativem stress - Google Patents
Verfahren zur feststellung von oxidativem stressInfo
- Publication number
- DE602007008826D1 DE602007008826D1 DE602007008826T DE602007008826T DE602007008826D1 DE 602007008826 D1 DE602007008826 D1 DE 602007008826D1 DE 602007008826 T DE602007008826 T DE 602007008826T DE 602007008826 T DE602007008826 T DE 602007008826T DE 602007008826 D1 DE602007008826 D1 DE 602007008826D1
- Authority
- DE
- Germany
- Prior art keywords
- oxidative stress
- concentration
- ophthalmic acid
- measuring blood
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000036542 oxidative stress Effects 0.000 title abstract 3
- JCMUOFQHZLPHQP-UHFFFAOYSA-N L-L-Ophthalmic acid Natural products OC(=O)CNC(=O)C(CC)NC(=O)CCC(N)C(O)=O JCMUOFQHZLPHQP-UHFFFAOYSA-N 0.000 abstract 3
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 3
- 108010088490 ophthalmic acid Proteins 0.000 abstract 3
- JCMUOFQHZLPHQP-BQBZGAKWSA-N ophthalmic acid Chemical compound OC(=O)CNC(=O)[C@H](CC)NC(=O)CC[C@H](N)C(O)=O JCMUOFQHZLPHQP-BQBZGAKWSA-N 0.000 abstract 3
- HVVLQPOCRDLFGA-UHFFFAOYSA-N ophthalmic acid Natural products CCC(NC(=O)C(N)CCC(=O)O)C(=O)NCC(=O)O HVVLQPOCRDLFGA-UHFFFAOYSA-N 0.000 abstract 3
- 230000003078 antioxidant effect Effects 0.000 abstract 2
- 230000035882 stress Effects 0.000 abstract 2
- 108010024636 Glutathione Proteins 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 230000017119 detection of oxidative stress Effects 0.000 abstract 1
- 238000001647 drug administration Methods 0.000 abstract 1
- 229960003180 glutathione Drugs 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 230000017074 necrotic cell death Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000000451 tissue damage Effects 0.000 abstract 1
- 231100000827 tissue damage Toxicity 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2430/00—Assays, e.g. immunoassays or enzyme assays, involving synthetic organic compounds as analytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006012955A JP4840804B2 (ja) | 2006-01-20 | 2006-01-20 | 酸化ストレスの判定方法 |
| PCT/JP2007/050517 WO2007083632A1 (ja) | 2006-01-20 | 2007-01-16 | 酸化ストレスの判定方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602007008826D1 true DE602007008826D1 (de) | 2010-10-14 |
Family
ID=38287585
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602007008826T Active DE602007008826D1 (de) | 2006-01-20 | 2007-01-16 | Verfahren zur feststellung von oxidativem stress |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7964177B2 (de) |
| EP (1) | EP1975621B1 (de) |
| JP (1) | JP4840804B2 (de) |
| AT (1) | ATE479900T1 (de) |
| DE (1) | DE602007008826D1 (de) |
| WO (1) | WO2007083632A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2009048081A1 (ja) * | 2007-10-12 | 2011-02-24 | 公立大学法人横浜市立大学 | 脂肪性肝疾患の診断方法、診断装置、診断プログラム及び脂肪性肝疾患用治療薬のスクリーニング方法 |
| JP5676275B2 (ja) * | 2008-12-24 | 2015-02-25 | 学校法人慶應義塾 | 酸化ストレス検出用マーカー、肝臓疾患マーカー及び医薬品の検定方法 |
| WO2010146064A1 (en) * | 2009-06-16 | 2010-12-23 | B.R.A.H.M.S Gmbh | Diagnostical use of peroxiredoxin 4 |
| KR101867808B1 (ko) | 2010-06-18 | 2018-06-18 | 각고호우징 게이오기주크 | 간장질환 마커, 그 측정방법, 장치 및 의약품의 검정방법 |
| JP2012171911A (ja) * | 2011-02-22 | 2012-09-10 | Kao Corp | Ｐｐａｒ活性化剤 |
| US8937213B2 (en) | 2011-05-21 | 2015-01-20 | Christopher E. Hopkins | Transgenic biosensors |
| WO2012178030A2 (en) * | 2011-06-24 | 2012-12-27 | Applied Isotope Technologies, Inc. | Accurate measurement of glutathione for disease diagnosis and drug metabolite screening |
| WO2013005790A1 (ja) * | 2011-07-07 | 2013-01-10 | 味の素株式会社 | 生体酸化の評価方法、生体酸化評価装置、生体酸化評価方法、生体酸化評価プログラム、生体酸化評価システム、情報通信端末装置、および生体酸化の予防・改善物質の探索方法 |
| JP6173667B2 (ja) * | 2012-09-20 | 2017-08-02 | ヒューマン・メタボローム・テクノロジーズ株式会社 | 代謝物の抽出方法 |
| WO2016077467A1 (en) * | 2014-11-11 | 2016-05-19 | The Johns Hopkins University | Biomarkers useful in the treatment of subjects having diseases of the eye |
| JP6889439B2 (ja) * | 2017-02-21 | 2021-06-18 | 学校法人産業医科大学 | 放射線被ばくの判定方法 |
| WO2019060623A1 (en) | 2017-09-20 | 2019-03-28 | Nacuity Pharmaceuticals, Inc. | PROCESS FOR THE SYNTHESIS OF N-ACETYLCYSTEINE AMIDE AND ITS DERIVATIVES |
| US11548851B2 (en) | 2017-09-20 | 2023-01-10 | Nacuity Pharmaceuticals, Inc. | Method for preparation of n-acetyl cysteine amide and derivatives thereof |
| US11091433B2 (en) | 2017-09-20 | 2021-08-17 | Nacuity Pharmaceutials, Inc. | Method for preparation of N-acetyl cysteine amide and derivatives thereof |
| US20190135741A1 (en) | 2017-11-09 | 2019-05-09 | Nacuity Pharmaceuticals, Inc. | Methods of Making Deuterium-Enriched N-acetylcysteine Amide (D-NACA) and (2R, 2R')-3,3'-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress |
| KR102177291B1 (ko) * | 2018-12-21 | 2020-11-10 | 이화여자대학교 산학협력단 | 산화적 스트레스 수준을 측정하는 방법 |
| US11766413B2 (en) | 2019-01-11 | 2023-09-26 | Nacuity Pharmaceuticals, Inc. | Treatment of age-related macular degeneration, glaucoma, and diabetic retinopathy with n-acetylcysteine amide (NACA) or (2R,2R′)-3,3′-disulfanediyl BIS(2-acetamidopropanamide)(DiNACA) |
| KR102383788B1 (ko) * | 2020-06-12 | 2022-04-05 | 이화여자대학교 산학협력단 | 신체적 스트레스 상태를 평가하는 방법 |
| KR102450159B1 (ko) * | 2021-01-07 | 2022-09-30 | 계명대학교 산학협력단 | 담즙 내 철 의존성 세포사멸 또는 프레닐화 관련 바이오마커 및 이의 용도 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1180198A (ja) | 1997-09-04 | 1999-03-26 | Nof Corp | ジヒドロピリジン構造を特異的に認識するモノクローナル抗体、ハイブリッド細胞およびモノクローナル抗体の製造方法 |
| JP2002517724A (ja) | 1998-05-29 | 2002-06-18 | 日研フード株式会社 | 酸化ストレス評価のための健康指標としての酸化ストレス診断分析図の使用及びヒトにおける酸化ストレスの抑制 |
| JP3856961B2 (ja) * | 1998-08-27 | 2006-12-13 | 利充 丹羽 | 酸化ストレスの測定方法 |
| DE10021737C2 (de) | 2000-05-04 | 2002-10-17 | Hermann Haller | Verfahren und Vorrichtung zur qualitativen und/oder quantitativen Bestimmung eines Protein- und/oder Peptidmusters einer Flüssigkeitsprobe, die dem menschlichen oder tierischen Körper entnommen wird |
| JP3341765B1 (ja) | 2001-07-25 | 2002-11-05 | 学校法人慶應義塾 | 陰イオン性化合物の分離分析方法及び装置 |
| JP3998245B2 (ja) | 2002-03-19 | 2007-10-24 | ヤマサ醤油株式会社 | 酸化アポリポタンパク質ａｉ及びそれを含有する酸化リポタンパク質の測定法及びキット |
| JP2003310621A (ja) | 2002-04-19 | 2003-11-05 | Nikken Foods Co Ltd | 酸化ストレス特性の診断分析図、これを用いた酸化ストレス特性の診断方法及び機能性食品の評価・開発方法並びに酸化ストレス特性の改善に用いられる機能性食品 |
| JP3735816B2 (ja) | 2002-12-09 | 2006-01-18 | 日研フード株式会社 | 酸化ストレス評価のための健康指標としての酸化ストレス診断分析図を使用して酸化ストレスを評価する方法 |
| WO2005052575A1 (en) * | 2003-11-28 | 2005-06-09 | Pfizer Limited | Molecular markers of oxidative stress |
-
2006
- 2006-01-20 JP JP2006012955A patent/JP4840804B2/ja active Active
-
2007
- 2007-01-16 DE DE602007008826T patent/DE602007008826D1/de active Active
- 2007-01-16 US US12/161,203 patent/US7964177B2/en active Active
- 2007-01-16 AT AT07706844T patent/ATE479900T1/de not_active IP Right Cessation
- 2007-01-16 EP EP07706844A patent/EP1975621B1/de active Active
- 2007-01-16 WO PCT/JP2007/050517 patent/WO2007083632A1/ja active Application Filing
-
2011
- 2011-04-22 US US13/092,420 patent/US8309056B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20110259743A1 (en) | 2011-10-27 |
| EP1975621B1 (de) | 2010-09-01 |
| US8309056B2 (en) | 2012-11-13 |
| JP2007192746A (ja) | 2007-08-02 |
| EP1975621A1 (de) | 2008-10-01 |
| JP4840804B2 (ja) | 2011-12-21 |
| US7964177B2 (en) | 2011-06-21 |
| EP1975621A4 (de) | 2009-02-11 |
| US20090029409A1 (en) | 2009-01-29 |
| ATE479900T1 (de) | 2010-09-15 |
| WO2007083632A1 (ja) | 2007-07-26 |
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