DE602006007148D1 - Neue imidazolcarboxamid-derivate als fructose-1,6-bisphosphatase-hemmer und pharmazeutische zusammensetzungen damit - Google Patents
Neue imidazolcarboxamid-derivate als fructose-1,6-bisphosphatase-hemmer und pharmazeutische zusammensetzungen damitInfo
- Publication number
- DE602006007148D1 DE602006007148D1 DE602006007148T DE602006007148T DE602006007148D1 DE 602006007148 D1 DE602006007148 D1 DE 602006007148D1 DE 602006007148 T DE602006007148 T DE 602006007148T DE 602006007148 T DE602006007148 T DE 602006007148T DE 602006007148 D1 DE602006007148 D1 DE 602006007148D1
- Authority
- DE
- Germany
- Prior art keywords
- fructose
- pharmaceutical compositions
- carboxamide derivatives
- bisphosphatase inhibitors
- compositions therewith
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0508211A FR2889190A1 (fr) | 2005-08-01 | 2005-08-01 | Nouveaux derives d'imidazoles carboxamides comme inhibiteurs de fructose -1,6-biphosphatase et compositions pharmaceutiques les contenant |
PCT/EP2006/006643 WO2007014619A1 (en) | 2005-08-01 | 2006-07-07 | Novelimidazolecarboxamide derivatives as fructose-1,6-bisphosphatase inhibitors, and pharmaceutical compositions comprising same |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006007148D1 true DE602006007148D1 (de) | 2009-07-16 |
Family
ID=36168401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006007148T Active DE602006007148D1 (de) | 2005-08-01 | 2006-07-07 | Neue imidazolcarboxamid-derivate als fructose-1,6-bisphosphatase-hemmer und pharmazeutische zusammensetzungen damit |
Country Status (16)
Country | Link |
---|---|
US (1) | US8362057B2 (de) |
EP (1) | EP1910310B1 (de) |
JP (1) | JP5026421B2 (de) |
KR (1) | KR20080033489A (de) |
CN (1) | CN101233114A (de) |
AR (1) | AR055202A1 (de) |
AT (1) | ATE432925T1 (de) |
AU (1) | AU2006275172B2 (de) |
BR (1) | BRPI0614496A2 (de) |
CA (1) | CA2617282C (de) |
DE (1) | DE602006007148D1 (de) |
ES (1) | ES2326237T3 (de) |
FR (1) | FR2889190A1 (de) |
MX (1) | MX2008001489A (de) |
WO (1) | WO2007014619A1 (de) |
ZA (1) | ZA200801945B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2889190A1 (fr) | 2005-08-01 | 2007-02-02 | Merck Sante Soc Par Actions Si | Nouveaux derives d'imidazoles carboxamides comme inhibiteurs de fructose -1,6-biphosphatase et compositions pharmaceutiques les contenant |
EP2061767B1 (de) | 2006-08-08 | 2014-12-17 | Sanofi | Arylaminoaryl-alkyl-substituierte Imidazolidin-2,4-dione, Verfahren zu ihrer Herstellung, diese Verbindungen enthaltende Arzneimittel und ihre Verwendung |
EP2102199B1 (de) * | 2006-12-04 | 2011-04-27 | AstraZeneca AB | Antibakterielle polycyclische harnstoffverbindungen |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
DE102007047738A1 (de) * | 2007-10-05 | 2009-04-09 | Merck Patent Gmbh | Imidazolderivate |
US20110129440A1 (en) * | 2007-10-29 | 2011-06-02 | Schering Corporation | Heterocyclic Urea and Thiourea Derivatives and Methods of Use Thereof |
MX2010005714A (es) * | 2007-11-30 | 2010-07-01 | Hoffmann La Roche | Compuestos de piridina. |
TW201014822A (en) | 2008-07-09 | 2010-04-16 | Sanofi Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
DK2470552T3 (en) | 2009-08-26 | 2014-02-17 | Sanofi Sa | NOVEL, CRYSTALLINE, heteroaromatic FLUORGLYCOSIDHYDRATER, MEDICINES COVERING THESE COMPOUNDS AND THEIR USE |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120053A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2714668B9 (de) * | 2011-05-23 | 2017-06-14 | Merck Patent GmbH | Thiazolderivate |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (de) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren |
CN105338812A (zh) * | 2013-03-15 | 2016-02-17 | 怀特黑德生物医学研究院 | 苯并咪唑衍生物及其用途 |
EP4197596A1 (de) | 2021-12-15 | 2023-06-21 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Imidazolderivate zur behandlung und prophylaxe von infektionskrankheiten |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5658889A (en) * | 1989-01-24 | 1997-08-19 | Gensia Pharmaceuticals, Inc. | Method and compounds for aica riboside delivery and for lowering blood glucose |
US5628889A (en) * | 1994-09-06 | 1997-05-13 | International Business Machines Corporation | High power capacity magnetron cathode |
AU1811397A (en) * | 1996-02-29 | 1997-09-16 | Kissei Pharmaceutical Co. Ltd. | Imidazole derivatives and vascular wall thickening inhibitor |
JPH11147823A (ja) * | 1997-11-17 | 1999-06-02 | Kissei Pharmaceut Co Ltd | 血管新生阻害剤 |
CN1215076C (zh) * | 1998-09-09 | 2005-08-17 | 症变治疗公司 | 新的果糖1,6-二磷酸酶的杂芳族抑制剂 |
WO2001060819A1 (fr) | 2000-02-18 | 2001-08-23 | Kirin Beer Kabushiki Kaisha | Nouveaux composes d'isoxazole et de thiazole et leur utilisation en tant que medicaments |
EP1752450A1 (de) * | 2005-08-01 | 2007-02-14 | Merck Sante | Imidazolderivate als Fruktose-1,6-biphosphataseinhibitoren und pharmazeutische Zusammensetzungen diese enthaltend |
FR2889190A1 (fr) | 2005-08-01 | 2007-02-02 | Merck Sante Soc Par Actions Si | Nouveaux derives d'imidazoles carboxamides comme inhibiteurs de fructose -1,6-biphosphatase et compositions pharmaceutiques les contenant |
-
2005
- 2005-08-01 FR FR0508211A patent/FR2889190A1/fr active Pending
-
2006
- 2006-07-07 ES ES06776141T patent/ES2326237T3/es active Active
- 2006-07-07 CN CNA2006800281348A patent/CN101233114A/zh active Pending
- 2006-07-07 AT AT06776141T patent/ATE432925T1/de not_active IP Right Cessation
- 2006-07-07 US US11/997,514 patent/US8362057B2/en not_active Expired - Fee Related
- 2006-07-07 BR BRPI0614496-9A patent/BRPI0614496A2/pt not_active Application Discontinuation
- 2006-07-07 CA CA2617282A patent/CA2617282C/en not_active Expired - Fee Related
- 2006-07-07 KR KR1020087005113A patent/KR20080033489A/ko not_active Application Discontinuation
- 2006-07-07 JP JP2008524380A patent/JP5026421B2/ja not_active Expired - Fee Related
- 2006-07-07 EP EP06776141A patent/EP1910310B1/de not_active Not-in-force
- 2006-07-07 DE DE602006007148T patent/DE602006007148D1/de active Active
- 2006-07-07 WO PCT/EP2006/006643 patent/WO2007014619A1/en active Application Filing
- 2006-07-07 AU AU2006275172A patent/AU2006275172B2/en not_active Ceased
- 2006-07-07 MX MX2008001489A patent/MX2008001489A/es not_active Application Discontinuation
- 2006-07-31 AR ARP060103321A patent/AR055202A1/es unknown
-
2008
- 2008-02-29 ZA ZA200801945A patent/ZA200801945B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FR2889190A1 (fr) | 2007-02-02 |
AR055202A1 (es) | 2007-08-08 |
AU2006275172B2 (en) | 2011-11-24 |
EP1910310B1 (de) | 2009-06-03 |
KR20080033489A (ko) | 2008-04-16 |
CA2617282A1 (en) | 2007-02-08 |
ES2326237T3 (es) | 2009-10-05 |
JP5026421B2 (ja) | 2012-09-12 |
CN101233114A (zh) | 2008-07-30 |
CA2617282C (en) | 2014-09-09 |
ZA200801945B (en) | 2009-08-26 |
BRPI0614496A2 (pt) | 2011-03-29 |
AU2006275172A1 (en) | 2007-02-08 |
MX2008001489A (es) | 2008-02-15 |
WO2007014619A1 (en) | 2007-02-08 |
JP2009502992A (ja) | 2009-01-29 |
US20080207720A1 (en) | 2008-08-28 |
EP1910310A1 (de) | 2008-04-16 |
US8362057B2 (en) | 2013-01-29 |
ATE432925T1 (de) | 2009-06-15 |
WO2007014619A8 (en) | 2007-11-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE602006007148D1 (de) | Neue imidazolcarboxamid-derivate als fructose-1,6-bisphosphatase-hemmer und pharmazeutische zusammensetzungen damit | |
ATE492545T1 (de) | Verbindungen und zusammensetzungen als proteinkinase-hemmer | |
ATE518860T1 (de) | Pyrroloä2,3-büpyridinderivate als proteinkinaseinhibitoren | |
LTC2091918I2 (lt) | Junginiai ir kompozicijos, kaip proteinkinazės inhibitoriai | |
DE602007014374D1 (de) | Ä4,5'ü-bipyrimidinyl-6,4'-diaminderivate als proteinkinase-hemmer | |
ATE543825T1 (de) | Spiro-oxindolverbindungen und ihre verwendungen als therapeutische mittel | |
BRPI0614205A2 (pt) | composto, composição farmacêutica, e, uso de composto | |
ATE525374T1 (de) | Heteroarylsubstituierte pyrroloä2,3-büpyridine und pyrroloä2,3-büpyrimidine als januskinaseinhibitoren | |
ATE492544T1 (de) | Pyrazol-substituierte aminoheteroarylverbindungen als proteinkinasehemmer | |
ATE400271T1 (de) | Aryl-pyridinderivate als 11-beta-hsd1-hemmer | |
ATE420076T1 (de) | Indozolonderivate als 11b-hsd1-inhibitoren | |
DK2783682T3 (da) | Farmaceutisk sammensætning omfattende pimobendan | |
DE502006004750D1 (de) | 2,4-diamino-pyrimidine als aurora inhibitoren | |
BRPI0618904A2 (pt) | composto, composição farmacêutica, e, uso do composto | |
RU2398586C3 (ru) | Фармацевтическая композиция | |
DE602005020465D1 (de) | Enantiomerenreine aminoheteroaryl-verbindungen als proteinkinasehemmer | |
DE602005005456D1 (de) | Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen | |
CL2007000161A1 (es) | Compuestos derivados de 2,4-dioxoimidazolidina sustituida, inhibidores de proteinas cinasas; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer. | |
ATE404564T1 (de) | Diazepinoindolderivate als kinaseinhibitoren | |
EP1871910A4 (de) | Zusammensetzungen und verfahren zur verbesserung der wirkstoffempfindlichkeit und behandlung wirkstoffresistenter infektionen und krankheiten | |
BRPI0607198A2 (pt) | composição, uso da composição método de tratamento doenças, e, embalagem farmacêutica | |
ATE453384T1 (de) | Neue dosierformulierung | |
ATE509011T1 (de) | Pyrimidinderivate als 11beta-hsd1-inhibitoren | |
DE602005014646D1 (de) | Substituierte propenylpiperazinderivate als neue inhibitoren von histondeacetylase | |
DK1587478T3 (da) | Farmaceutisk sammensætning |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |