DE602004024900D1 - Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren - Google Patents
Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahrenInfo
- Publication number
- DE602004024900D1 DE602004024900D1 DE602004024900T DE602004024900T DE602004024900D1 DE 602004024900 D1 DE602004024900 D1 DE 602004024900D1 DE 602004024900 T DE602004024900 T DE 602004024900T DE 602004024900 T DE602004024900 T DE 602004024900T DE 602004024900 D1 DE602004024900 D1 DE 602004024900D1
- Authority
- DE
- Germany
- Prior art keywords
- diseases
- compounds
- isoindol
- dihydro
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- PXZQEOJJUGGUIB-UHFFFAOYSA-N isoindolin-1-one Chemical class C1=CC=C2C(=O)NCC2=C1 PXZQEOJJUGGUIB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 3
- 238000011321 prophylaxis Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Manufacturing & Machinery (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Ceramic Engineering (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Structural Engineering (AREA)
- Materials Engineering (AREA)
- Neurology (AREA)
- Obesity (AREA)
- Inorganic Chemistry (AREA)
- Orthopedic Medicine & Surgery (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49787803P | 2003-08-25 | 2003-08-25 | |
| US10/926,238 US7320992B2 (en) | 2003-08-25 | 2004-08-24 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
| PCT/US2004/027595 WO2005021532A1 (en) | 2003-08-25 | 2004-08-25 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004024900D1 true DE602004024900D1 (de) | 2010-02-11 |
Family
ID=34228620
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004024900T Expired - Lifetime DE602004024900D1 (de) | 2003-08-25 | 2004-08-25 | Substituierte 2,3-dihydro-1h-isoindol-1-one derivate und anwendungsverfahren |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7320992B2 (https=) |
| EP (1) | EP1664027B1 (https=) |
| JP (1) | JP2007503450A (https=) |
| AT (1) | ATE453636T1 (https=) |
| AU (1) | AU2004269000A1 (https=) |
| CA (1) | CA2534570A1 (https=) |
| DE (1) | DE602004024900D1 (https=) |
| ES (1) | ES2337062T3 (https=) |
| MX (1) | MXPA06001923A (https=) |
| WO (1) | WO2005021532A1 (https=) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080011199A (ko) * | 2005-04-19 | 2008-01-31 | 교와 핫꼬 고교 가부시끼가이샤 | 질소 함유 복소환 화합물 |
| WO2006134989A1 (ja) * | 2005-06-15 | 2006-12-21 | Kyowa Hakko Kogyo Co., Ltd. | 含窒素複素環化合物 |
| UA91560C2 (ru) * | 2005-08-31 | 2010-08-10 | Селджин Корпорэйшн | Соединения ряда изоиндолимидов, их композиция и применение |
| US7989461B2 (en) | 2005-12-23 | 2011-08-02 | Amgen Inc. | Substituted quinazolinamine compounds for the treatment of cancer |
| US8110681B2 (en) * | 2006-03-17 | 2012-02-07 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compounds for the treatment of spinal muscular atrophy and other uses |
| PE20080695A1 (es) | 2006-04-27 | 2008-06-28 | Banyu Pharma Co Ltd | Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel |
| EP2046753A2 (en) * | 2006-07-06 | 2009-04-15 | Brystol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
| NZ578096A (en) * | 2007-01-10 | 2011-11-25 | Albany Molecular Res Inc | 5-pyridinone substituted indazoles |
| EP2114940A1 (en) * | 2007-02-09 | 2009-11-11 | AstraZeneca AB | Aza-isoindolones and their use as metabotropic glutamate receptor potentiators - 613 |
| MX2009010082A (es) | 2007-03-20 | 2009-10-19 | Celgene Corp | Derivados y composiciones que comprenden isoindolina 4'-o-sustituida y metodos para utilizar la misma. |
| CN101861311A (zh) * | 2007-07-21 | 2010-10-13 | 阿尔巴尼分子研究公司 | 5-吡啶酮取代的吲唑 |
| TW200918062A (en) * | 2007-09-12 | 2009-05-01 | Wyeth Corp | Azacyclylisoquinolinone and-isoindolinone derivatives as histamine-3 antagonists |
| EP2215074B1 (en) * | 2007-09-27 | 2014-02-19 | The United States of America, as Represented by the Secretary, Department of Health and Human Services | Isoindoline compounds for the treatment of spinal muscular atrophy and other uses |
| WO2009054332A1 (ja) * | 2007-10-23 | 2009-04-30 | Banyu Pharmaceutical Co., Ltd. | ピリドン置換ジヒドロピラゾロピリミジノン誘導体 |
| KR101068835B1 (ko) * | 2007-10-26 | 2011-09-30 | 한국과학기술연구원 | 베타-아밀로이드 집적체 및 피브릴에 우수한 결합 친화도를가지는 이소인돌론 화합물 및 이의 제조 방법 |
| JP5632612B2 (ja) * | 2007-12-05 | 2014-11-26 | あすか製薬株式会社 | ラクタム化合物又はその塩及びppar活性化剤 |
| US20110092452A1 (en) * | 2008-03-05 | 2011-04-21 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| BRPI0912383A2 (pt) | 2008-05-08 | 2015-07-28 | Basf Se | Processo para preparar aril carboxamidas |
| GB0811643D0 (en) * | 2008-06-25 | 2008-07-30 | Cancer Rec Tech Ltd | New therapeutic agents |
| EP2414353A1 (en) | 2009-04-01 | 2012-02-08 | Basf Se | Isoxazoline compounds for combating invertebrate pests |
| JP5744019B2 (ja) * | 2009-07-14 | 2015-07-01 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | 選択的parp−1阻害を有する3−オキソ−2,3−ジヒドロ−1h−イソインドール−4−カルボキサミド |
| CN102596963A (zh) * | 2009-09-10 | 2012-07-18 | 诺瓦提斯公司 | 二环杂芳基的醚衍生物 |
| IL266563B (en) | 2009-10-06 | 2022-09-01 | Millennium Pharm Inc | Heterocyclic compounds useful as pdk1 inhibitors |
| US8440710B2 (en) | 2009-10-15 | 2013-05-14 | Hoffmann-La Roche Inc. | HSL inhibitors useful in the treatment of diabetes |
| NZ601267A (en) * | 2009-12-23 | 2014-03-28 | Takeda Pharmaceutical | Fused heteroaromatic pyrrolidinones as syk inhibitors |
| EP2723739B1 (en) | 2011-06-22 | 2016-08-24 | Takeda Pharmaceutical Company Limited | Substituted 6-aza-isoindolin-1-one derivatives |
| WO2013056015A1 (en) | 2011-10-14 | 2013-04-18 | Incyte Corporation | Isoindolinone and pyrrolopyridinone derivatives as akt inhibitors |
| WO2013129622A1 (ja) | 2012-03-02 | 2013-09-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
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-
2004
- 2004-08-24 US US10/926,238 patent/US7320992B2/en not_active Expired - Lifetime
- 2004-08-25 DE DE602004024900T patent/DE602004024900D1/de not_active Expired - Lifetime
- 2004-08-25 WO PCT/US2004/027595 patent/WO2005021532A1/en not_active Ceased
- 2004-08-25 ES ES04782152T patent/ES2337062T3/es not_active Expired - Lifetime
- 2004-08-25 MX MXPA06001923A patent/MXPA06001923A/es not_active Application Discontinuation
- 2004-08-25 EP EP04782152A patent/EP1664027B1/en not_active Expired - Lifetime
- 2004-08-25 AU AU2004269000A patent/AU2004269000A1/en not_active Abandoned
- 2004-08-25 AT AT04782152T patent/ATE453636T1/de not_active IP Right Cessation
- 2004-08-25 JP JP2006524818A patent/JP2007503450A/ja not_active Withdrawn
- 2004-08-25 CA CA002534570A patent/CA2534570A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007503450A (ja) | 2007-02-22 |
| US7320992B2 (en) | 2008-01-22 |
| ATE453636T1 (de) | 2010-01-15 |
| EP1664027A1 (en) | 2006-06-07 |
| US20050054670A1 (en) | 2005-03-10 |
| EP1664027B1 (en) | 2009-12-30 |
| AU2004269000A1 (en) | 2005-03-10 |
| WO2005021532A1 (en) | 2005-03-10 |
| CA2534570A1 (en) | 2005-03-10 |
| ES2337062T3 (es) | 2010-04-20 |
| MXPA06001923A (es) | 2006-05-17 |
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