DE602004017918D1 - Anionenbindende Polymere und ihre Verwendung - Google Patents

Anionenbindende Polymere und ihre Verwendung

Info

Publication number
DE602004017918D1
DE602004017918D1 DE602004017918T DE602004017918T DE602004017918D1 DE 602004017918 D1 DE602004017918 D1 DE 602004017918D1 DE 602004017918 T DE602004017918 T DE 602004017918T DE 602004017918 T DE602004017918 T DE 602004017918T DE 602004017918 D1 DE602004017918 D1 DE 602004017918D1
Authority
DE
Germany
Prior art keywords
anion
binding polymers
binding
cases
polymers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602004017918T
Other languages
English (en)
Inventor
Eric Connor
Dominique Charmot
Ting Han Chang
Florence Roger
Gerrit Klaerner
Hoai Son Nguyen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ilypsa Inc
Original Assignee
Ilypsa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/701,385 external-priority patent/US7385012B2/en
Priority claimed from US10/806,495 external-priority patent/US7335795B2/en
Application filed by Ilypsa Inc filed Critical Ilypsa Inc
Publication of DE602004017918D1 publication Critical patent/DE602004017918D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/74Synthetic polymeric materials
    • A61K31/785Polymers containing nitrogen
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F26/00Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F26/06Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02Polyamines
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02Polyamines
    • C08G73/0206Polyalkylene(poly)amines
    • C08G73/0213Preparatory process
    • C08G73/022Preparatory process from polyamines and epihalohydrins
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L39/00Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions of derivatives of such polymers
    • C08L39/02Homopolymers or copolymers of vinylamine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Steroid Compounds (AREA)
DE602004017918T 2003-11-03 2004-11-03 Anionenbindende Polymere und ihre Verwendung Active DE602004017918D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/701,385 US7385012B2 (en) 2003-11-03 2003-11-03 Polyamine polymers
US10/806,495 US7335795B2 (en) 2004-03-22 2004-03-22 Crosslinked amine polymers
US10/965,044 US7459502B2 (en) 2003-11-03 2004-10-13 Pharmaceutical compositions comprising crosslinked polyamine polymers

Publications (1)

Publication Number Publication Date
DE602004017918D1 true DE602004017918D1 (de) 2009-01-02

Family

ID=34557428

Family Applications (5)

Application Number Title Priority Date Filing Date
DE602004017918T Active DE602004017918D1 (de) 2003-11-03 2004-11-03 Anionenbindende Polymere und ihre Verwendung
DE602004006892T Active DE602004006892T2 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendungen
DE602004014527T Active DE602004014527D1 (de) 2003-11-03 2004-11-03 Polyamin-polymere
DE602004023661T Active DE602004023661D1 (de) 2003-11-03 2004-11-03 Anionbindende Polymere sowie deren Verwendung
DE112004002099T Withdrawn DE112004002099T5 (de) 2003-11-03 2004-11-03 Anionen bindende Polymere und Verwendungen davon

Family Applications After (4)

Application Number Title Priority Date Filing Date
DE602004006892T Active DE602004006892T2 (de) 2003-11-03 2004-11-03 Anionenbindende polymere und ihre verwendungen
DE602004014527T Active DE602004014527D1 (de) 2003-11-03 2004-11-03 Polyamin-polymere
DE602004023661T Active DE602004023661D1 (de) 2003-11-03 2004-11-03 Anionbindende Polymere sowie deren Verwendung
DE112004002099T Withdrawn DE112004002099T5 (de) 2003-11-03 2004-11-03 Anionen bindende Polymere und Verwendungen davon

Country Status (18)

Country Link
US (1) US7459502B2 (de)
EP (5) EP1854826B1 (de)
JP (3) JP3996944B2 (de)
KR (1) KR101052581B1 (de)
AT (5) ATE398636T1 (de)
AU (1) AU2004285609B2 (de)
BR (1) BRPI0416172A (de)
CA (1) CA2542730C (de)
CY (3) CY1107728T1 (de)
DE (5) DE602004017918D1 (de)
DK (3) DK1682606T3 (de)
ES (4) ES2287806T3 (de)
GB (1) GB2426248B (de)
HK (1) HK1101697A1 (de)
PL (3) PL1854826T3 (de)
PT (3) PT1854826E (de)
SI (3) SI2009042T1 (de)
WO (2) WO2005041900A2 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6733780B1 (en) 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20040161474A1 (en) * 2002-05-24 2004-08-19 Moerck Rudi E. Rare earth metal compounds methods of making, and methods of using the same
US20060083791A1 (en) * 2002-05-24 2006-04-20 Moerck Rudi E Rare earth metal compounds methods of making, and methods of using the same
US7381428B2 (en) 2003-08-26 2008-06-03 Shire International Licensing B.V. Stabilized lanthanum carbonate compositions
SI2172205T1 (sl) * 2003-08-26 2014-10-30 Shire Biopharmaceuticals Holdings Ireland Limited Farmacevtska formulacija obsegajoča lantanove spojine
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7767768B2 (en) * 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
CA2583548A1 (en) * 2004-10-15 2006-04-27 Altairnano, Inc. Phosphate binder with reduced pill burden
US20060177415A1 (en) * 2004-11-01 2006-08-10 Burke Steven K Once a day formulation for phosphate binders
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
ITME20040015A1 (it) * 2004-12-07 2005-03-07 Vincenzo Savica Chewing gum, caramelle gommose, pastiglie, compresse a lento rilascio di chelanti fosfato e/o fosforo salivare e capsule a lento rilascio di chelanti fosfato e/o fosforo a livello gastroenterico.
US20080069860A1 (en) * 2005-08-17 2008-03-20 Allison Wren Hyperphosphatemia in domestic animals: compositions and methods of treatment
WO2007022445A2 (en) * 2005-08-17 2007-02-22 Altairnano, Inc. Treatment of chronic renal failure and other conditions in domestic animals: compositions and methods
US8986669B2 (en) 2005-09-02 2015-03-24 Genzyme Corporation Method for removing phosphate and polymer used therefore
US8114393B2 (en) * 2005-09-14 2012-02-14 Wisconsin Alumni Research Foundation Methods and compositions for phosphate binding
US8158117B2 (en) 2005-09-14 2012-04-17 Wisconsin Alumni Research Foundation Methods and compositions for phosphate binding
CN103027896B (zh) * 2005-09-15 2016-01-20 基酶有限公司 胺聚合物的小袋制剂
AU2012205214B2 (en) * 2005-09-15 2015-05-21 Genzyme Corporation Formulation for Amine Polymers
KR20080057319A (ko) * 2005-09-30 2008-06-24 일립사, 인코포레이티드 가교 쉘을 갖는 코어-쉘 복합체의 제조 방법, 및 이로부터수득되는 코어-쉘 복합체
WO2007041569A1 (en) * 2005-09-30 2007-04-12 Ilypsa, Inc. Methods and compositions for selectively removing potassium ion from the gastrointestinal tract of a mammal
WO2007076874A1 (en) * 2006-01-05 2007-07-12 Lifecycle Pharma A/S Disintegrating loadable tablets
US20070177866A1 (en) * 2006-01-31 2007-08-02 Yoshizo Fujimoto Camera extension arm
US7749536B2 (en) * 2006-02-14 2010-07-06 Teva Pharmaceutical Industries Ltd. Pharmaceutical formulations of aliphatic amine polymers and methods for their manufacture
CN100398112C (zh) * 2006-03-24 2008-07-02 辽宁诺康生物制药有限责任公司 一种治疗血磷酸盐过多症的药物及其制备方法
EP2016114A2 (de) * 2006-05-05 2009-01-21 Genzyme Corporation Aminkondensationspolymere als phosphatkomplexbildner
BRPI0715053A2 (pt) * 2006-07-18 2013-03-19 Genzyme Corp composiÇço farmacÊutica, mÉtodo para tratar doenÇas, e, polÍmero
BRPI0717008A2 (pt) * 2006-09-01 2014-01-21 Usv Ltd Processo para o preparo de cloridrato de sevelamer e formulação do mesmo
US7964182B2 (en) * 2006-09-01 2011-06-21 USV, Ltd Pharmaceutical compositions comprising phosphate-binding polymer
WO2008042222A2 (en) 2006-09-29 2008-04-10 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) * 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
JP2010519298A (ja) * 2007-02-23 2010-06-03 ゲンズイメ コーポレーション アミンポリマー組成物
EP2131820A1 (de) * 2007-03-08 2009-12-16 Genzyme Corporation Sulfonpolymerzusammensetzungen
EP2152277A1 (de) * 2007-04-27 2010-02-17 Genzyme Corporation Amido-amin-dendrimer-zusammensetzungen
RU2010104673A (ru) * 2007-07-11 2011-08-20 Торэй Индастриз, Инк. (Jp) Сшитый полиаллиламин или его соль присоединения кислоты и его применение для медицинских целей
EP2016947A1 (de) * 2007-07-17 2009-01-21 Chemo Ibérica, S.A. Neuartiges Verfahren zur Herstellung vernetzter Poly(allylamin-)Polymere in einem einzigen Schritt
WO2009023544A2 (en) * 2007-08-10 2009-02-19 Ilypsa, Inc. Dosage unit anion-exchange polymer pharmaceutical compositions
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
JP5332520B2 (ja) * 2007-11-07 2013-11-06 アステラス製薬株式会社 医薬用錠剤
WO2009097127A1 (en) * 2008-01-31 2009-08-06 Genzyme Corporation Pharmaceutical compositions
US20110142952A1 (en) * 2008-06-20 2011-06-16 Harris David J Pharmaceutical Compositions
KR20110119714A (ko) * 2009-01-22 2011-11-02 유에스브이 리미티드 포스페이트 결합 폴리머를 포함하는 약학적 조성물
IT1394299B1 (it) * 2009-05-12 2012-06-06 Chimico Internaz Spa Lab Procedimento per la preparazione di sevelamer
AU2011220748B2 (en) * 2010-02-24 2015-11-05 Relypsa, Inc. Amine polymers for use as bile acid sequestrants
JP5964247B2 (ja) * 2010-02-24 2016-08-03 レリプサ, インコーポレイテッド 胆汁酸捕捉剤として使用するためのポリイミダゾール
BR112012021444A2 (pt) * 2010-02-24 2016-05-31 Relypsa Inc polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas.
CA2798081C (en) 2010-05-12 2024-02-13 Spectrum Pharmaceuticals, Inc. Lanthanum carbonate hydroxide, lanthanum oxycarbonate and methods of their manufacture and use
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US10369529B2 (en) 2012-01-30 2019-08-06 California Institute Of Technology Mixed matrix membranes with embedded polymeric particles and networks and related compositions, methods, and systems
US9302922B2 (en) 2012-01-30 2016-04-05 California Institute Of Technology Filtration membranes and related compositions, methods and systems
EP2557074A1 (de) 2011-08-11 2013-02-13 Astellas Pharma Inc. Verfahren zur Herstellung von N,N,N',N'-tetrakis(3-aminpropyl)-1,4-butanediamin
EP2875064B1 (de) 2012-07-19 2019-06-26 Ecolab USA Inc. Hocheffiziente nassfestharze aus neuen vernetzern
KR20150130492A (ko) * 2013-03-15 2015-11-23 젠자임 코포레이션 개선된 최종 당화 산물(age) 전구체의 격리제
RU2728778C2 (ru) 2013-06-05 2020-07-31 Трисида, Инк. Протон-связывающие полимеры для перорального введения
US10435528B2 (en) 2013-09-17 2019-10-08 Aquanano Llc High-capacity anion exchange materials
JP5843986B2 (ja) * 2014-03-25 2016-01-13 アステラス製薬株式会社 粒状医薬組成物
WO2016043808A1 (en) 2014-09-17 2016-03-24 Aquanano Llc High-capacity anion exchange material
JP6903576B2 (ja) 2014-12-10 2021-07-14 トリシダ・インコーポレイテッドTricida, Inc. 経口投与用プロトン結合ポリマー
EP3280461B1 (de) * 2015-04-06 2020-06-17 3M Innovative Properties Company Entfernbare filmbildende gelzusammensetzungen und verfahren zu deren auftragung
CA2987852C (en) * 2015-05-29 2023-03-14 Georgia-Pacific Chemicals Llc High efficiency wet strength resins from new cross-linkers
MX2018013476A (es) * 2016-05-06 2019-03-28 Tricida Inc Composiciones para tratar trastornos acido-base.
AU2017388956A1 (en) 2016-12-28 2019-07-11 Fujifilm Corporation Emulsion of nitrogen atom-containing polymer or salt thereof, production method therefor, and production method for particles
CN107141408A (zh) * 2017-06-12 2017-09-08 厦门建霖健康家居股份有限公司 一种抗菌聚合物及其制备方法
US10934380B1 (en) 2017-09-25 2021-03-02 Tricida, Inc. Crosslinked poly(allylamine) polymer pharmaceutical compositions
EP3698799B1 (de) * 2017-10-16 2022-01-26 FUJIFILM Corporation Mittel zur behandlung von hyperphosphatämie
WO2019078198A1 (ja) 2017-10-16 2019-04-25 富士フイルム株式会社 高リン血症治療剤および粒子
CA3080651A1 (en) 2017-11-03 2019-05-09 Tricida, Inc. Compositions for and method of treating acid-base disorders
JP2021093979A (ja) * 2019-12-18 2021-06-24 太陽化学株式会社 難水溶性物質含有組成物
CN111521705B (zh) * 2020-05-05 2021-04-20 大连润生康泰医学检验实验室有限公司 一种血清中胆汁酸的富集方法
WO2023064357A1 (en) * 2021-10-13 2023-04-20 Tricida, Inc. Pharmaceutical compositions for the treatment of lithiasis disorders
CN115260355A (zh) * 2022-05-16 2022-11-01 江苏中天药业有限公司 一种阴离子交换树脂、其制备方法、该树脂与药物的复合物和其掩味制剂

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US814789A (en) 1904-12-21 1906-03-13 Edward D Mackintosh Drawing and plotting device.
US3308020A (en) * 1961-09-22 1967-03-07 Merck & Co Inc Compositions and method for binding bile acids in vivo including hypocholesteremics
US3499960A (en) * 1965-01-25 1970-03-10 Merck & Co Inc Palatable coated particles of an anion exchange resin
US3692895A (en) * 1970-09-08 1972-09-19 Norman A Nelson Method of reducing hypercholesteremia in humans employing a copolymer of polyethylenepolyamine and a bifunctional substance, such as epichlorohydria
US3974272A (en) * 1972-09-01 1976-08-10 Merck & Co., Inc. Palatable cholestyramine coacervate compositions
US4027009A (en) * 1973-06-11 1977-05-31 Merck & Co., Inc. Compositions and methods for depressing blood serum cholesterol
US3930810A (en) * 1974-07-31 1976-01-06 Universal Oil Products Company Additives for petroleum distillates
US4015939A (en) * 1976-05-12 1977-04-05 Bio-Rad Laboratories, Inc. Competitive binding thyroid assay with improved bound-free separation step
US4135880A (en) * 1977-08-19 1979-01-23 Bio-Rad Laboratories, Inc. Folate assay with ion exchange resin bound-free separation
US4410688A (en) * 1981-04-29 1983-10-18 Allied Corporation Macromolecular highly branched homogeneous compound
US4558120A (en) * 1983-01-07 1985-12-10 The Dow Chemical Company Dense star polymer
US4568737A (en) * 1983-01-07 1986-02-04 The Dow Chemical Company Dense star polymers and dendrimers
US4737550A (en) * 1983-01-07 1988-04-12 The Dow Chemical Company Bridged dense star polymers
US4631337A (en) * 1983-01-07 1986-12-23 The Dow Chemical Company Hydrolytically-stable dense star polyamine
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
JPS6090243A (ja) * 1983-10-25 1985-05-21 Nitto Boseki Co Ltd 小球状モノアリルアミン橋かけ重合体の製造方法
US4587329A (en) * 1984-08-17 1986-05-06 The Dow Chemical Company Dense star polymers having two dimensional molecular diameter
US4599400A (en) * 1984-12-18 1986-07-08 The Dow Chemical Company Star/comb-branched polyamide
US4747881A (en) * 1985-02-05 1988-05-31 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
US4734200A (en) * 1986-04-04 1988-03-29 Advanced Separation Technologies Incorporated Process for removal of fluoride and phosphorus-type contaminants from acidic wastewater
IT1190349B (it) * 1986-06-16 1988-02-16 Prodotti Formenti Srl Composizioni farmaceutiche ad attivita' sequestrante degli acidi biliari contenenti colestiramina quale principio attivo,e procedimento per prepararle
US5338532A (en) * 1986-08-18 1994-08-16 The Dow Chemical Company Starburst conjugates
US5807582A (en) * 1988-08-26 1998-09-15 Pharmacia & Upjohn Company Fine-beaded colestipol hydrochloride and pharmaceutically elegant dosage forms made therefrom
GB8829088D0 (en) 1988-12-13 1989-01-25 Smith Kline French Lab Compounds
US5091175A (en) * 1990-05-14 1992-02-25 Erbamont Inc. Pharmaceutical composition containing bile acid sequestrant enclosed in a size-exclusion membrane
FR2680791B1 (fr) * 1991-08-30 1994-09-09 Bp Chemicals Snc Procede de fabrication d'un polymere reticule et utilisation du polymere.
US5530092A (en) * 1992-01-13 1996-06-25 Dsm N.V. Dendritic macromolecule and the preparation thereof
BE1007260A3 (nl) 1993-07-08 1995-05-02 Dsm Nv Werkwijze voor het bereiden van een dendritisch macromolekuul.
US5380522A (en) * 1992-08-11 1995-01-10 Day; Charles E. Method for treatment of irritable bowel syndrome
US5451397A (en) * 1992-12-21 1995-09-19 Rohm And Haas Company Bile acid sequestrant
CA2153151A1 (en) * 1993-02-17 1994-09-01 Robert Charles Hider Polymeric compounds
US5487888A (en) * 1993-05-20 1996-01-30 Geltex, Inc. Iron-binding polymers for oral administration
US5618530A (en) * 1994-06-10 1997-04-08 Geltex Pharmaceuticals, Inc. Hydrophobic amine polymer sequestrant and method of cholesterol depletion
US5607669A (en) * 1994-06-10 1997-03-04 Geltex Pharmaceuticals, Inc. Amine polymer sequestrant and method of cholesterol depletion
US6129910A (en) * 1993-06-02 2000-10-10 Geltex Pharmaceuticals, Inc. Water-insoluble noncrosslinked bile acid sequestrants
CA2129079C (en) * 1993-08-03 2006-01-17 Tatsuo Nomura Orally administrable cholesterol lowering agent
US5667775A (en) * 1993-08-11 1997-09-16 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
US5414068A (en) 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
WO1995020619A1 (en) 1994-01-28 1995-08-03 Dsm N.V. Dendritic macromolecule and a process for the preparation thereof
BE1008134A3 (nl) 1994-03-16 1996-01-23 Dsm Nv Bereiding van stervormig vertakte polymeren.
TW474813B (en) * 1994-06-10 2002-02-01 Geltex Pharma Inc Alkylated composition for removing bile salts from a patient
GB9503061D0 (en) * 1995-02-16 1995-04-05 British Tech Group Polymeric compounds
US6060604A (en) * 1995-03-31 2000-05-09 Florida State University Pharmaceutical compounds comprising polyamines substituted with electron-affinic groups
NL1001973C2 (nl) * 1995-12-21 1997-06-24 Stork Friesland Bv Semipermeabel composietmembraan.
DE69705877T2 (de) * 1996-03-05 2002-06-06 Mitsubishi Chemical Corp., Tokio/Tokyo Verwendung von Anionenaustauscherharzen zur Herstellung eines Arzneimittels zur Behandlung der Hyperphosphatemie
US6034129A (en) * 1996-06-24 2000-03-07 Geltex Pharmaceuticals, Inc. Ionic polymers as anti-infective agents
US6180094B1 (en) * 1996-07-19 2001-01-30 Nikken Chemicals Co., Ltd. Remedies for hyperphosphatemia
JP4358303B2 (ja) * 1996-10-23 2009-11-04 ダウ グローバル テクノロジーズ インコーポレイティド 食物ホスフェート又はオキサレート吸収を低下させるための水溶性ポリマー
TW592727B (en) 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
JP2003183168A (ja) * 1997-04-04 2003-07-03 Chugai Pharmaceut Co Ltd リン酸結合性ポリマー含有製剤
US6423754B1 (en) * 1997-06-18 2002-07-23 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with polyallylamine polymers
US6007803A (en) * 1997-09-19 1999-12-28 Geltex Pharmaceuticals, Inc. Ionic polymers as toxin binding agents
US20040170600A1 (en) * 1997-10-22 2004-09-02 Jaime Simon Water-soluble polymers for the reduction of dietary phosphate or oxalate absorption
US5985938A (en) * 1997-11-05 1999-11-16 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
US6726905B1 (en) * 1997-11-05 2004-04-27 Genzyme Corporation Poly (diallylamines)-based phosphate binders
US6566407B2 (en) * 1997-11-05 2003-05-20 Geltex Pharmaceuticals, Inc. Method for reducing oxalate
NZ505123A (en) * 1997-12-19 2003-07-25 Smithkline Beecham Corp Process for manufacturing bite-dispersion tablets by compressing medicaments and other ingredients into granulates then compressing the granulates and other ingredients into tablets, and the tablets thereof
US6333051B1 (en) * 1998-09-03 2001-12-25 Supratek Pharma, Inc. Nanogel networks and biological agent compositions thereof
TW568788B (en) 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
JP3363143B2 (ja) * 1998-10-12 2003-01-08 中外製薬株式会社 リン酸結合性ポリマー粒子
US6361768B1 (en) * 1998-12-29 2002-03-26 Pmd Holdings Corp. Hydrophilic ampholytic polymer
US6180754B1 (en) * 1999-09-03 2001-01-30 The Dow Chemical Company Process for producing cross-linked polyallylamine polymer
US6362266B1 (en) * 1999-09-03 2002-03-26 The Dow Chemical Company Process for reducing cohesiveness of polyallylamine polymer gels during drying
US20020054903A1 (en) * 1999-10-19 2002-05-09 Joseph Tyler Direct compression polymer tablet core
US6733780B1 (en) * 1999-10-19 2004-05-11 Genzyme Corporation Direct compression polymer tablet core
US20040059065A1 (en) * 2000-03-09 2004-03-25 Takeshi Goto Crosslinked anion-exchange resin or salt thereof
DE10011481A1 (de) * 2000-03-09 2001-10-18 Fresenius Hemocare Gmbh Adsorbens zum Absenken der Konzentration von Fibrinogen und/oder Fibrin, Verwendung des Adsorbens zur Herstellung eines Adsorbers und Adsorber mit dem Adsorbens
US6844372B2 (en) * 2000-03-09 2005-01-18 Hisamitsu Pharmaceutical Co., Inc. Crosslinked anion-exchange resin or salt thereof and phosphorus adsorbent comprising the same
WO2001068106A1 (fr) * 2000-03-13 2001-09-20 Hisamitsu Pharmaceutical Co., Inc. Prophylactiques et/ou remedes pour hyperphosphatemie
US6471968B1 (en) * 2000-05-12 2002-10-29 Regents Of The University Of Michigan Multifunctional nanodevice platform
MY133977A (en) * 2000-06-16 2007-11-30 Nippon Catalytic Chem Ind Crosslinked polymers containing tertiary amine and/or quaternary ammonium salt structures, processes for making and uses thereof
DE60132256T2 (de) * 2000-11-20 2008-12-24 Sorbent Therapeutics, Inc., Vernon Hills Wasserabsorbierende polymere und deren verwendung
WO2002066543A1 (en) * 2001-02-16 2002-08-29 Genzyme Corporation Method of drying a material having a cohesive phase
WO2002085379A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for improving vascular access in patients with vascular shunts
AU2002257147B9 (en) * 2001-04-18 2005-08-18 Genzyme Corporation Methods of treating syndrome X with aliphatic polyamines
WO2002085383A1 (en) * 2001-04-18 2002-10-31 Genzyme Corporation Method for reducing copper levels and treating copper toxicosis
JP2004528332A (ja) * 2001-04-18 2004-09-16 ジェンザイム コーポレーション 痛風を治療する方法および尿酸を結合する方法
AU2002257145B2 (en) * 2001-04-18 2005-06-02 Genzyme Corporation Method for lowering serum glucose
WO2002085380A1 (en) * 2001-04-18 2002-10-31 Geltex Pharmaceuticals, Inc. Method for treating gout and reducing serum uric acid
US6600011B2 (en) * 2001-10-09 2003-07-29 Genzyme Corporation Process for purification and drying of polymer hydrogels
JP3931639B2 (ja) * 2001-11-19 2007-06-20 セイコーエプソン株式会社 インクジェットプリンタに使用するための水性インク組成物
WO2004037274A1 (en) * 2002-10-22 2004-05-06 Genzyme Corporation Amine polymers for promoting bone formation
DE10305807A1 (de) 2003-02-12 2004-08-26 Basf Ag Polymethylenamine und Verfahren zu deren Herstellung
US7449605B2 (en) * 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) * 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7385012B2 (en) * 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US20050276781A1 (en) * 2004-06-09 2005-12-15 Ross Edward A Molecularly imprinted phosphate binders for therapeutic use

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