DE602004017487D1 - Antiangiogene peptide vom n-terminus von endostatin - Google Patents
Antiangiogene peptide vom n-terminus von endostatinInfo
- Publication number
- DE602004017487D1 DE602004017487D1 DE602004017487T DE602004017487T DE602004017487D1 DE 602004017487 D1 DE602004017487 D1 DE 602004017487D1 DE 602004017487 T DE602004017487 T DE 602004017487T DE 602004017487 T DE602004017487 T DE 602004017487T DE 602004017487 D1 DE602004017487 D1 DE 602004017487D1
- Authority
- DE
- Germany
- Prior art keywords
- endostatin
- terminus
- peptides
- antiangiogenic peptides
- nucleic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 108010079505 Endostatins Proteins 0.000 title abstract 2
- 102400001047 Endostatin Human genes 0.000 title 1
- 230000001772 anti-angiogenic effect Effects 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 108091005461 Nucleic proteins Proteins 0.000 abstract 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49926403P | 2003-08-29 | 2003-08-29 | |
US53921304P | 2004-01-26 | 2004-01-26 | |
PCT/US2004/028143 WO2005021756A1 (en) | 2003-08-29 | 2004-08-30 | Anti-angiogenic peptides from the n-terminus of endostatin |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004017487D1 true DE602004017487D1 (de) | 2008-12-11 |
Family
ID=34278655
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004015142T Active DE602004015142D1 (de) | 2003-08-29 | 2004-08-30 | Antiangiogene peptide zur behandlung oder vorbeugung von endometriose |
DE602004017487T Active DE602004017487D1 (de) | 2003-08-29 | 2004-08-30 | Antiangiogene peptide vom n-terminus von endostatin |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004015142T Active DE602004015142D1 (de) | 2003-08-29 | 2004-08-30 | Antiangiogene peptide zur behandlung oder vorbeugung von endometriose |
Country Status (10)
Country | Link |
---|---|
US (1) | US7645735B2 (de) |
EP (2) | EP1687426B1 (de) |
JP (2) | JP2007529410A (de) |
KR (1) | KR20070030159A (de) |
AT (2) | ATE401400T1 (de) |
AU (2) | AU2004285847A1 (de) |
CA (2) | CA2537179A1 (de) |
DE (2) | DE602004015142D1 (de) |
IL (1) | IL173952A0 (de) |
WO (2) | WO2005042566A2 (de) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2537179A1 (en) | 2003-08-29 | 2005-03-10 | Children's Medical Center Corporation | Anti-angiogenic peptides from the n-terminus of endostatin |
US7524811B2 (en) | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
CN100475270C (zh) * | 2006-01-20 | 2009-04-08 | 清华大学 | 一种治疗肿瘤的药物及其应用 |
CN100398557C (zh) * | 2006-04-05 | 2008-07-02 | 中国药科大学 | 血管生成抑制多肽及其制备方法和应用 |
CN100427503C (zh) * | 2006-09-08 | 2008-10-22 | 哈尔滨医科大学 | 内皮抑制素小分子多肽及编码该多肽的核苷酸序列和互补链 |
JP2010504359A (ja) | 2006-09-20 | 2010-02-12 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | 局部麻酔および/または疼痛緩和のための、揮発性麻酔剤を送達するための方法 |
CA2712731C (en) | 2008-01-22 | 2016-05-03 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
US8507441B2 (en) * | 2009-10-22 | 2013-08-13 | University of Pittsburgh—Of the Commonwealth Systems of Higher Education | Use of endostatin peptides for the treatment of fibrosis |
US10960382B2 (en) | 2013-11-18 | 2021-03-30 | Indian Oil Corporation Limited | Catalyst for enhancing liquid yield in thermal coking process |
EP3071671A1 (de) | 2013-11-18 | 2016-09-28 | Indian Oil Corporation Limited | Verfahren und system zur verbesserung der flüssigkeitsausbeute von schweren kohlenwasserstoffeinsätzen |
CN113943365B (zh) * | 2015-07-27 | 2023-12-08 | 上海贺普药业股份有限公司 | 一种肿瘤抑制肽 |
RU2711085C1 (ru) * | 2019-08-12 | 2020-01-15 | федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Полипептид для ингибирования миграции и инвазии рака предстательной железы |
IT202100023357A1 (it) | 2021-09-09 | 2023-03-09 | Cheirontech S R L | Peptidi con attività anti-angiogenica |
CN113845582B (zh) * | 2021-10-15 | 2022-05-27 | 南京市妇幼保健院 | 内源性多肽在制备预防或治疗子宫内膜癌靶向药物中的应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6346510B1 (en) * | 1995-10-23 | 2002-02-12 | The Children's Medical Center Corporation | Therapeutic antiangiogenic endostatin compositions |
US5854205A (en) | 1995-10-23 | 1998-12-29 | The Children's Medical Center Corporation | Therapeutic antiangiogenic compositions and methods |
JP3840262B2 (ja) * | 1995-10-23 | 2006-11-01 | ザ チルドレンズ メディカル センター コーポレイション | 治療用の抗血管新生組成物および方法 |
WO1998005293A2 (en) * | 1996-08-02 | 1998-02-12 | The Children's Medical Center Corporation | Method of regulating the female reproductive system through angiogenesis inhibitors |
CA2307792C (en) * | 1997-10-31 | 2007-06-26 | Children's Medical Center Corporation | Method for regulating size and growth of vascularized normal tissue |
CA2313705A1 (en) * | 1997-12-08 | 1999-06-17 | Beth Israel Deaconess Medical Center | Restin and methods of use thereof |
US6653098B1 (en) * | 1998-02-23 | 2003-11-25 | G. D. Searle & Co. | Method of producing mouse and human endostatin |
AU3199999A (en) * | 1998-03-24 | 1999-10-18 | Children's Medical Center Corporation | Endostatin derived peptides with anti-angiogenic and anti-cancer activity |
KR20010052566A (ko) * | 1998-06-03 | 2001-06-25 | 윌리엄 뉴 | 엔도스타틴 단백질을 포함하는 단백질 올리고머 조성물 및이의 사용방법 |
DK1107989T3 (da) * | 1998-08-25 | 2010-05-25 | Merck Patent Gmbh | Ekspression og eksport af angiostatin og endostatin som immunfusiner |
US7317003B2 (en) * | 1998-09-04 | 2008-01-08 | National University Of Singapore | Small peptides having anti-angiogenic and endothelial cell inhibition activity |
AU4342000A (en) * | 1999-04-13 | 2000-11-14 | Merck & Co., Inc. | Soluble recombinant endostatin and method of making same from (streptomyces sp) |
IT1312077B1 (it) | 1999-04-15 | 2002-04-04 | Univ Degli Studi Milano | Polipeptidi ad attivita' antiangiogenica. |
WO2000067771A1 (en) * | 1999-05-06 | 2000-11-16 | The Burnham Institute | Antiangiogenic endostatin peptides, endostatin variants and methods of use |
AU2002224403A1 (en) * | 2000-10-13 | 2002-04-22 | Entremed, Inc | Endostatin and pitslre protein kinases as angiogenesis-inhibiting peptides and method of use |
ITMI20010394A1 (it) * | 2001-02-27 | 2002-08-27 | Univ Degli Studi Milano | Peptidi ad attivita' antiangiogenica |
AU2003244516A1 (en) * | 2002-02-07 | 2003-09-02 | Novozymes Delta Limited | Hiv inhibiting proteins |
US7524811B2 (en) * | 2003-08-29 | 2009-04-28 | Children's Medical Center Corporation | Anti-angiogenic peptides from the N-terminus of endostatin |
CA2537179A1 (en) | 2003-08-29 | 2005-03-10 | Children's Medical Center Corporation | Anti-angiogenic peptides from the n-terminus of endostatin |
-
2004
- 2004-08-30 CA CA002537179A patent/CA2537179A1/en not_active Abandoned
- 2004-08-30 AT AT04816838T patent/ATE401400T1/de not_active IP Right Cessation
- 2004-08-30 KR KR1020067004199A patent/KR20070030159A/ko not_active Application Discontinuation
- 2004-08-30 DE DE602004015142T patent/DE602004015142D1/de active Active
- 2004-08-30 WO PCT/US2004/028476 patent/WO2005042566A2/en active Application Filing
- 2004-08-30 EP EP04816838A patent/EP1687426B1/de not_active Not-in-force
- 2004-08-30 DE DE602004017487T patent/DE602004017487D1/de active Active
- 2004-08-30 WO PCT/US2004/028143 patent/WO2005021756A1/en active Application Filing
- 2004-08-30 CA CA002537236A patent/CA2537236A1/en not_active Abandoned
- 2004-08-30 AU AU2004285847A patent/AU2004285847A1/en not_active Abandoned
- 2004-08-30 AU AU2004269399A patent/AU2004269399A1/en not_active Abandoned
- 2004-08-30 EP EP04782583A patent/EP1668129B1/de not_active Not-in-force
- 2004-08-30 JP JP2006524956A patent/JP2007529410A/ja active Pending
- 2004-08-30 AT AT04782583T patent/ATE412745T1/de not_active IP Right Cessation
- 2004-08-30 JP JP2006524938A patent/JP2007525972A/ja active Pending
-
2006
- 2006-02-27 IL IL173952A patent/IL173952A0/en unknown
- 2006-02-28 US US11/364,887 patent/US7645735B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2005021756A1 (en) | 2005-03-10 |
CA2537179A1 (en) | 2005-03-10 |
JP2007525972A (ja) | 2007-09-13 |
IL173952A0 (en) | 2006-07-05 |
JP2007529410A (ja) | 2007-10-25 |
AU2004285847A1 (en) | 2005-05-12 |
KR20070030159A (ko) | 2007-03-15 |
WO2005042566A2 (en) | 2005-05-12 |
CA2537236A1 (en) | 2005-05-12 |
ATE412745T1 (de) | 2008-11-15 |
AU2004269399A1 (en) | 2005-03-10 |
US7645735B2 (en) | 2010-01-12 |
EP1687426B1 (de) | 2008-07-16 |
US20060258583A1 (en) | 2006-11-16 |
EP1687426A2 (de) | 2006-08-09 |
DE602004015142D1 (de) | 2008-08-28 |
EP1668129B1 (de) | 2008-10-29 |
ATE401400T1 (de) | 2008-08-15 |
WO2005042566A3 (en) | 2005-10-06 |
EP1668129A1 (de) | 2006-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |