DE60138390D1 - Estrogen-17-sulphamate zur hemmung von steroid sulfatase - Google Patents

Estrogen-17-sulphamate zur hemmung von steroid sulfatase

Info

Publication number
DE60138390D1
DE60138390D1 DE60138390T DE60138390T DE60138390D1 DE 60138390 D1 DE60138390 D1 DE 60138390D1 DE 60138390 T DE60138390 T DE 60138390T DE 60138390 T DE60138390 T DE 60138390T DE 60138390 D1 DE60138390 D1 DE 60138390D1
Authority
DE
Germany
Prior art keywords
group
sulphamate
modulator
compound
estrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60138390T
Other languages
English (en)
Inventor
Barry Victor Lloyd Potter
Michael John Reed
Atul Purohit
Matthew Paul Leese
Bertrand Leblond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterix Ltd
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of DE60138390D1 publication Critical patent/DE60138390D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
DE60138390T 2000-08-18 2001-08-17 Estrogen-17-sulphamate zur hemmung von steroid sulfatase Expired - Lifetime DE60138390D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0020498.2A GB0020498D0 (en) 2000-08-18 2000-08-18 Compound
PCT/GB2001/003688 WO2002016392A1 (en) 2000-08-18 2001-08-17 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase

Publications (1)

Publication Number Publication Date
DE60138390D1 true DE60138390D1 (de) 2009-05-28

Family

ID=9897954

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60138390T Expired - Lifetime DE60138390D1 (de) 2000-08-18 2001-08-17 Estrogen-17-sulphamate zur hemmung von steroid sulfatase

Country Status (12)

Country Link
US (3) US7119081B2 (de)
EP (4) EP1311532B1 (de)
JP (3) JP5074655B2 (de)
AT (1) ATE428720T1 (de)
AU (3) AU2001278629A1 (de)
CY (1) CY1109130T1 (de)
DE (1) DE60138390D1 (de)
DK (1) DK1311532T3 (de)
ES (1) ES2323630T3 (de)
GB (1) GB0020498D0 (de)
PT (1) PT1311532E (de)
WO (3) WO2002016392A1 (de)

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US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
GB0020498D0 (en) * 2000-08-18 2000-10-11 Sterix Ltd Compound
GB0113920D0 (en) 2001-06-07 2001-08-01 Sterix Ltd Composition
US8026229B2 (en) 2001-08-13 2011-09-27 Sterix Limited Antitumor-active 2-alkoxyestradiol sulfamates
EP1358882A1 (de) * 2002-04-30 2003-11-05 Schering Aktiengesellschaft Verwendung von Prodrogue von Estriol sulfamate zur Behandlung von autoimmunischen Erkrankungen
DE10307105A1 (de) * 2003-02-19 2004-09-09 Schering Ag Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate
JP4719144B2 (ja) * 2003-03-24 2011-07-06 ステリックス リミテッド ステロイドスルファターゼのインヒビターとしてのエストロゲン誘導体
GB0306717D0 (en) * 2003-03-24 2003-04-30 Sterix Ltd Compound
GB0306718D0 (en) 2003-03-24 2003-04-30 Sterix Ltd Compound
GB0505541D0 (en) * 2005-03-17 2005-04-27 Novartis Ag Organic compounds
GB0702446D0 (en) * 2007-02-08 2007-03-21 Sterix Ltd Composition
US9284345B2 (en) * 2007-04-12 2016-03-15 Endorecherche, Inc. 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators
US20100204146A1 (en) 2007-09-17 2010-08-12 Preglem S.A. Treatment of Oestrogen Dependant Conditions in Pre-menopausal Women
WO2014124412A2 (en) * 2013-02-11 2014-08-14 President And Fellows Of Harvard College Methods and compounds for the inhibition of cellular proliferation
ES2514140B1 (es) * 2013-03-26 2015-08-03 Universidad Pablo De Olavide Uso del inhibidor de sulfatasas esteroideas STX64 para el tratamiento del envejecimiento
US11548893B2 (en) 2017-07-15 2023-01-10 Arisan Therapeutics Inc. Enantiomerically pure adamantane carboxamides for the treatment of filovirus infection

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AU2001278629A1 (en) 2002-03-04
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EP1311533A1 (de) 2003-05-21
EP1311532B1 (de) 2009-04-15
US20030225051A1 (en) 2003-12-04
PT1311532E (pt) 2009-06-01
WO2002016393A1 (en) 2002-02-28
EP1311534A1 (de) 2003-05-21
US20060281719A1 (en) 2006-12-14
AU2001278631A1 (en) 2002-03-04
ATE428720T1 (de) 2009-05-15
US7067503B2 (en) 2006-06-27
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AU2001278638A1 (en) 2002-03-04
CY1109130T1 (el) 2014-07-02
JP4958377B2 (ja) 2012-06-20
GB0020498D0 (en) 2000-10-11
ES2323630T3 (es) 2009-07-22
EP1311532A1 (de) 2003-05-21
JP2004511441A (ja) 2004-04-15
US7119081B2 (en) 2006-10-10
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