WO2002032409A3 - Use of compound in the manufacture of a pharmaceutical for inhibiting steroid sulphatase and steroid dehydrogenase activity - Google Patents
Use of compound in the manufacture of a pharmaceutical for inhibiting steroid sulphatase and steroid dehydrogenase activity Download PDFInfo
- Publication number
- WO2002032409A3 WO2002032409A3 PCT/GB2001/004645 GB0104645W WO0232409A3 WO 2002032409 A3 WO2002032409 A3 WO 2002032409A3 GB 0104645 W GB0104645 W GB 0104645W WO 0232409 A3 WO0232409 A3 WO 0232409A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- steroid
- compound
- pharmaceutical
- group
- manufacture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002210687A AU2002210687A1 (en) | 2000-10-20 | 2001-10-18 | Use of compound in the manufacture of a pharmaceutical for inhibiting steroid sulphatase and steroid dehydrogenase activity |
JP2003536257A JP4553586B2 (en) | 2001-10-18 | 2002-10-17 | Steroid compounds for inhibiting steroid sulfatase |
AT06000817T ATE408615T1 (en) | 2001-10-18 | 2002-10-17 | STEROIDAL COMPOUNDS FOR INHIBITING STEROID SULFOTASE |
EP06000817A EP1657247B1 (en) | 2001-10-18 | 2002-10-17 | Steroidal compounds for inhibiting steroid sulphotase |
ES06000817T ES2314760T3 (en) | 2001-10-18 | 2002-10-17 | STEROID COMPOUNDS FOR THE INHIBITION OF STEROID SULPHATASE. |
DK02801418T DK1448592T3 (en) | 2001-10-18 | 2002-10-17 | Steroidal compounds for inhibiting steroid sulfatases |
CA2463227A CA2463227C (en) | 2001-10-18 | 2002-10-17 | Steroidal compounds for inhibiting steroid sulphotase |
EP02801418A EP1448592B1 (en) | 2001-10-18 | 2002-10-17 | Steroidal compounds for inhibiting steroid sulphatase |
ES02801418T ES2258174T3 (en) | 2001-10-18 | 2002-10-17 | STEROID COMPOUNDS FOR THE INHIBITION OF STEROID SULPHATASE. |
DE60229009T DE60229009D1 (en) | 2001-10-18 | 2002-10-17 | Steroidal compounds for the inhibition of steroid sulfotase |
PCT/GB2002/004686 WO2003033518A1 (en) | 2001-10-18 | 2002-10-17 | Steroidal compounds for inhibiting steroid sulphatase |
DE60209811T DE60209811T2 (en) | 2001-10-18 | 2002-10-17 | STEROIDAL COMPOUNDS FOR INHIBITING STEROIDSULFATASES |
AT02801418T ATE319734T1 (en) | 2001-10-18 | 2002-10-17 | STEROIDAL COMPOUNDS FOR INHIBITING STEROID SULFATASES |
PT02801418T PT1448592E (en) | 2001-10-18 | 2002-10-17 | STEROID COMPOUNDS FOR INHIBITION OF STEROID SULFATASE |
US10/825,758 US7098218B2 (en) | 2001-10-18 | 2004-04-16 | Steroidal compounds for inhibiting steroid sulphatase |
US11/329,982 US7276513B2 (en) | 2001-10-18 | 2006-01-11 | Steroidal compounds for inhibiting steroid sulphatase |
HK06107131.9A HK1084955A1 (en) | 2001-10-18 | 2006-06-22 | Steroidal compounds for inhibiting steroid sulphotase |
US11/855,603 US8124614B2 (en) | 2001-10-18 | 2007-09-14 | Steroidal compounds for inhibiting steroid sulphatase |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0025788.1A GB0025788D0 (en) | 2000-10-20 | 2000-10-20 | Use |
GB0025788.1 | 2000-10-20 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2002/004686 Continuation-In-Part WO2003033518A1 (en) | 2001-10-18 | 2002-10-17 | Steroidal compounds for inhibiting steroid sulphatase |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002032409A2 WO2002032409A2 (en) | 2002-04-25 |
WO2002032409A3 true WO2002032409A3 (en) | 2002-08-08 |
Family
ID=9901713
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2001/004645 WO2002032409A2 (en) | 2000-10-20 | 2001-10-18 | Use of compound in the manufacture of a pharmaceutical for inhibiting steroid sulphatase and steroid dehydrogenase activity |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2002210687A1 (en) |
GB (1) | GB0025788D0 (en) |
WO (1) | WO2002032409A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003033518A1 (en) * | 2001-10-18 | 2003-04-24 | Sterix Limited | Steroidal compounds for inhibiting steroid sulphatase |
DE60229009D1 (en) | 2001-10-18 | 2008-10-30 | Sterix Ltd | Steroidal compounds for the inhibition of steroid sulfotase |
GB0127923D0 (en) | 2001-11-21 | 2002-01-16 | Sterix Ltd | Compound |
AU2002339192A1 (en) * | 2001-11-21 | 2003-06-10 | Sterix Limited | 1,2,4-triazole derivatives containing a sulphamate group as aromatase inhibitors |
DE10307103A1 (en) * | 2003-02-19 | 2004-09-09 | Schering Ag | Anti-tumor effective 2-substituted D-homostra-1,3,5 (10) -trien-3-yl sulfamate |
GB0306718D0 (en) | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
AU2004238395A1 (en) * | 2003-05-13 | 2004-11-25 | Cryptopharma Pty Ltd | Estratriene derivatives |
US7419972B2 (en) | 2004-07-02 | 2008-09-02 | Schering Ag | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
DE102004032674A1 (en) * | 2004-07-02 | 2006-01-26 | Schering Ag | New 2-substituted Estra-1,3,5 (10) -triene-17-ones as inhibitors of 17β-hydroxysteroid dehydrogenase type 1 |
US8030298B2 (en) | 2005-05-26 | 2011-10-04 | Abbott Products Gmbh | 17β-HSD1 and STS inhibitors |
GB0604142D0 (en) | 2006-03-01 | 2006-04-12 | Sterix Ltd | Compound |
CA2671075A1 (en) * | 2006-11-30 | 2008-06-05 | Solvay Pharmaceuticals Gmbh | Substituted estratrien derivatives as 17beta hsd inhibitors |
US8288367B2 (en) | 2006-11-30 | 2012-10-16 | Solvay Pharmaceuticals Gmbh | Substituted estratriene derivatives as 17BETA HSD inhibitors |
EP2207544A2 (en) | 2007-09-17 | 2010-07-21 | PregLem S.A. | Treatment of oestrogen dependant conditions in pre-menopausal women |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4429398A1 (en) * | 1994-08-09 | 1996-02-15 | Jenapharm Gmbh | Pharmaceutical compositions with Estra 1,3,5 (10) triene derivatives |
WO1998024802A2 (en) * | 1996-12-05 | 1998-06-11 | Imperial College Of Science Technology And Medicine | Compound |
US5880115A (en) * | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
US5891620A (en) * | 1994-11-11 | 1999-04-06 | Imperial College Of Science, Technology And Medicine | Steroid sulfatase assay |
GB2331987A (en) * | 1997-12-04 | 1999-06-09 | Imperial College | Polycyclic sulphamate oxime inhibitors of oestrone sulphatase |
US6046186A (en) * | 1997-12-24 | 2000-04-04 | Sri International | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use |
WO2001051055A2 (en) * | 2000-01-14 | 2001-07-19 | Sterix Limited | Pharmaceutical compositions containing steroidal structures and uses thereof |
-
2000
- 2000-10-20 GB GBGB0025788.1A patent/GB0025788D0/en not_active Ceased
-
2001
- 2001-10-18 WO PCT/GB2001/004645 patent/WO2002032409A2/en active Application Filing
- 2001-10-18 AU AU2002210687A patent/AU2002210687A1/en not_active Abandoned
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4429398A1 (en) * | 1994-08-09 | 1996-02-15 | Jenapharm Gmbh | Pharmaceutical compositions with Estra 1,3,5 (10) triene derivatives |
US5891620A (en) * | 1994-11-11 | 1999-04-06 | Imperial College Of Science, Technology And Medicine | Steroid sulfatase assay |
WO1998024802A2 (en) * | 1996-12-05 | 1998-06-11 | Imperial College Of Science Technology And Medicine | Compound |
US5880115A (en) * | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
GB2331987A (en) * | 1997-12-04 | 1999-06-09 | Imperial College | Polycyclic sulphamate oxime inhibitors of oestrone sulphatase |
US6046186A (en) * | 1997-12-24 | 2000-04-04 | Sri International | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use |
WO2001051055A2 (en) * | 2000-01-14 | 2001-07-19 | Sterix Limited | Pharmaceutical compositions containing steroidal structures and uses thereof |
Non-Patent Citations (3)
Title |
---|
CIOBANU L C ET AL: "Potent Inhibition of Steroid Sulfatase Activity by 3-O-Sulfamate 17alpha-Benzyl(or 4'-tert-butylbenzyl)estra-1,3,5(10)-trienes: Combination of Two Substituents at Position C3 and C17alpha of Estradiol", J. MED. CHEM., vol. 42, 1999, pages 2280 - 2286, XP002190754 * |
LI P-K ET AL: "Development of potent non-estrogenic estrone sulfatase inhibitors", STEROIDS: STRUCTURE, FUNCTION, AND REGULATION, ELSEVIER SCIENCE PUBLISHERS, NEW YORK, NY, US, vol. 63, no. 7-8, 8 July 1998 (1998-07-08), pages 425 - 432, XP004127380, ISSN: 0039-128X * |
TREMBLAY M R ET AL: "OVERVIEW OF A RATIONAL APPROACH TO DESIGN TYPE I 17BETA-HYDROXYSTEROID DEHYDROGENASE INHIBITORS WITHOUT ESTROGENIC ACTIVITY: CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION", JOURNAL OF STEROID BIOCHEMISTRY, PERGAMON PRESS PLC, GB, vol. 66, no. 4, 1998, pages 179 - 191, XP001055919, ISSN: 0022-4731 * |
Also Published As
Publication number | Publication date |
---|---|
AU2002210687A1 (en) | 2002-04-29 |
GB0025788D0 (en) | 2000-12-06 |
WO2002032409A2 (en) | 2002-04-25 |
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