DE60136701D1 - Der mevalonatunabhängige isoprenoidbiosyntheseweg - Google Patents

Der mevalonatunabhängige isoprenoidbiosyntheseweg

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Publication number
DE60136701D1
DE60136701D1 DE60136701T DE60136701T DE60136701D1 DE 60136701 D1 DE60136701 D1 DE 60136701D1 DE 60136701 T DE60136701 T DE 60136701T DE 60136701 T DE60136701 T DE 60136701T DE 60136701 D1 DE60136701 D1 DE 60136701D1
Authority
DE
Germany
Prior art keywords
variants
biosynthesis
isoprenoid biosynthesis
isoprenoids
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60136701T
Other languages
English (en)
Inventor
Adelbert Bacher
Meinhart H Zenk
Petra Adam
Wolfgang Eisenreich
Monika Fellermeier
Stefan Hecht
Felix Rohdich
Christoph A Schuhr
Juraithip Wungsintaweekul
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Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60136701D1 publication Critical patent/DE60136701D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
    • C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
    • C12N15/8274—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for herbicide resistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen
DE60136701T 2000-06-05 2001-06-01 Der mevalonatunabhängige isoprenoidbiosyntheseweg Expired - Lifetime DE60136701D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10027821A DE10027821A1 (de) 2000-06-05 2000-06-05 Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
PCT/EP2001/006255 WO2001094561A2 (en) 2000-06-05 2001-06-01 The non-mevalonate isoprenoid pathway

Publications (1)

Publication Number Publication Date
DE60136701D1 true DE60136701D1 (de) 2009-01-08

Family

ID=7644765

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10027821A Withdrawn DE10027821A1 (de) 2000-06-05 2000-06-05 Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
DE60136701T Expired - Lifetime DE60136701D1 (de) 2000-06-05 2001-06-01 Der mevalonatunabhängige isoprenoidbiosyntheseweg

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE10027821A Withdrawn DE10027821A1 (de) 2000-06-05 2000-06-05 Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg

Country Status (6)

Country Link
US (2) US7288367B2 (de)
EP (1) EP1287145B1 (de)
AT (1) ATE415479T1 (de)
AU (1) AU2001274084A1 (de)
DE (2) DE10027821A1 (de)
WO (1) WO2001094561A2 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60036477T2 (de) 1999-08-04 2008-06-12 Bacher, Adelbert, Prof. Dr.med. Dr.rer.nat. Isoprenoid biosynthese
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US6660507B2 (en) * 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
ATE371729T1 (de) * 2001-05-15 2007-09-15 Adelbert Bacher Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase
PT1408984E (pt) 2001-07-20 2008-12-26 Bioagency Ag Compostos organofosforosos para activar células t gama/delta
BR122021005304B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Hospedeiro recombinante que compreende genes recombinantes para produção de esteviol ou glicosídeo de esteviol, ácido nucleico, método para produzir esteviol, glicosídeo de esteviol ou composição de glicosídeo de esteviol e método para sintetizar esteviol ou glicosídeo de esteviol
CN103732753B (zh) 2011-08-08 2018-03-30 埃沃尔瓦公司 甜菊醇糖苷类的重组生产
CA3171770A1 (en) 2013-02-06 2014-08-14 Evolva Sa Methods for improved production of rebaudioside d and rebaudioside m
EP2954061B1 (de) 2013-02-11 2023-11-22 Evolva SA Effiziente herstellung von steviolglycosiden in rekombinanten wirtszellen
MX2017001859A (es) 2014-08-11 2017-04-11 Evolva Sa Produccion de glicosidos de esteviol en hospederos recombinantes.
SG11201701677UA (en) 2014-09-09 2017-04-27 Evolva Sa Production of steviol glycosides in recombinant hosts
CA2973674A1 (en) 2015-01-30 2016-08-04 Evolva Sa Production of steviol glycosides in recombinant hosts
US10604743B2 (en) 2015-03-16 2020-03-31 Dsm Ip Assets B.V. UDP-glycosyltransferases
WO2017025362A1 (en) 2015-08-07 2017-02-16 Evolva Sa Production of steviol glycosides in recombinant hosts
CA3020671A1 (en) 2016-04-13 2017-10-19 Evolva Sa Production of steviol glycosides in recombinant hosts
EP3458599A1 (de) 2016-05-16 2019-03-27 Evolva SA Herstellung von steviolglycosiden in rekombinanten wirten
EP3535406A1 (de) 2016-11-07 2019-09-11 Evolva SA Herstellung von steviolglycosiden in rekombinanten wirten

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3587718T2 (de) 1984-03-06 1994-08-04 Mgi Pharma Inc Herbizide Resistenz in Pflanzen.
GB9315751D0 (en) 1993-07-30 1993-09-15 Zeneca Ltd Dna,dna constructs,cells and plants derived therefrom
US5885782A (en) 1994-09-13 1999-03-23 Nce Pharmaceuticals, Inc. Synthetic antibiotics
US6107071A (en) 1996-09-24 2000-08-22 Smithkline Beecham Corporation Histidinol dehydrogenase
US5858367A (en) 1997-03-27 1999-01-12 Case Western Reserve University Methods for screening for antimicrobials utilizing AarC and compositions thereof
WO1999011757A1 (en) 1997-09-02 1999-03-11 Washington State University Research Foundation NUCLEIC AND AMINO ACID SEQUENCES FOR A NOVEL TRANSKETOLASE FROM $i (MENTHA PIPERITA)
DE19752700A1 (de) 1997-11-28 1999-06-02 Hoechst Schering Agrevo Gmbh 1-Desoxy-D-xylulose-5-phosphat Synthase, Verfahren zur Identifizierung von Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase und Effektoren der 1-Desoxy-D-xylulose-5-phosphat Synthase
CA2328157A1 (en) 1998-04-14 1999-10-21 Jomaa Hassan Method for identifying chemical active agents and active agents for inhibiting the 1-desoxy-d-xylulose-5-phosphate biosynthetic pathway
WO1999058649A1 (en) * 1998-05-13 1999-11-18 University Of Maryland Methods of modifying the production of isopentenyl pyrophosphate, dimethylallyl pyrophosphate and/or isoprenoids
SK3922001A3 (en) 1998-09-22 2001-09-11 Jomaa Pharmaka Gmbh Genes of the 1-desoxy-d-xylulose biosynthetic pathway
JP2002532101A (ja) * 1998-12-14 2002-10-02 バッハー，アーデルバート テルペノイド類生合成阻害剤のためのスクリーニング
JP2003500073A (ja) * 1999-05-21 2003-01-07 ヨマー、ファルマカ、ゲゼルシャフト、ミット、ベシュレンクテル、ハフツング イソプレノイドの濃度を変更するためのデオキシ−ｄ−キシルロースホスフェート生合成経路の遺伝子の使用
DE60036477T2 (de) 1999-08-04 2008-06-12 Bacher, Adelbert, Prof. Dr.med. Dr.rer.nat. Isoprenoid biosynthese
DE10021688A1 (de) 2000-05-05 2001-11-15 Hassan Jomaa Gene des 1-Desoxy-D-xylulose-Biosynthesewegs
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
AU2001290522B2 (en) 2000-08-07 2006-11-30 Monsanto Technology Llc Methyl-D-erythritol phosphate pathway genes
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
ATE371729T1 (de) 2001-05-15 2007-09-15 Adelbert Bacher Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase
AU2002322265A1 (en) 2001-06-18 2003-01-02 Structural Genomix Crystals and structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase mecps

Also Published As

Publication number Publication date
WO2001094561A2 (en) 2001-12-13
EP1287145A2 (de) 2003-03-05
US7288367B2 (en) 2007-10-30
DE10027821A1 (de) 2001-12-06
ATE415479T1 (de) 2008-12-15
AU2001274084A1 (en) 2001-12-17
US20040072142A1 (en) 2004-04-15
WO2001094561A3 (en) 2002-05-30
EP1287145B1 (de) 2008-11-26
US20090199313A1 (en) 2009-08-06

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