ATE371729T1 - Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase - Google Patents

Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase

Info

Publication number
ATE371729T1
ATE371729T1 AT02748701T AT02748701T ATE371729T1 AT E371729 T1 ATE371729 T1 AT E371729T1 AT 02748701 T AT02748701 T AT 02748701T AT 02748701 T AT02748701 T AT 02748701T AT E371729 T1 ATE371729 T1 AT E371729T1
Authority
AT
Austria
Prior art keywords
erythritol
methyl
crystal structure
synthase
cytidine
Prior art date
Application number
AT02748701T
Other languages
English (en)
Inventor
Adelbert Bacher
Stefan Hecht
Robert Huber
Johannes Kaiser
Felix Rohdich
Stefan Steinbacher
Original Assignee
Adelbert Bacher
Max Planck Gesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001123597 external-priority patent/DE10123597A1/de
Application filed by Adelbert Bacher, Max Planck Gesellschaft filed Critical Adelbert Bacher
Application granted granted Critical
Publication of ATE371729T1 publication Critical patent/ATE371729T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y406/00—Phosphorus-oxygen lyases (4.6)
    • C12Y406/01—Phosphorus-oxygen lyases (4.6.1)
    • C12Y406/01012—2-C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase (4.6.1.12)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT02748701T 2001-05-15 2002-05-13 Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase ATE371729T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001123597 DE10123597A1 (de) 2001-05-15 2001-05-15 Kristallstruktur der 2C-Methyl-D-erythritol 2,4-cyclodiphosphat Synthase
US29387501P 2001-05-25 2001-05-25

Publications (1)

Publication Number Publication Date
ATE371729T1 true ATE371729T1 (de) 2007-09-15

Family

ID=26009297

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02748701T ATE371729T1 (de) 2001-05-15 2002-05-13 Kristallstruktur der 2c-methyl-d-erythritol-2,4- cyclodiphosphat-synthase

Country Status (6)

Country Link
US (1) US20040226502A1 (de)
EP (1) EP1390488B1 (de)
AT (1) ATE371729T1 (de)
AU (1) AU2002319171A1 (de)
DE (1) DE60222115T2 (de)
WO (1) WO2002092800A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6280300A (en) 1999-08-04 2001-03-05 Adelbert Bacher Isoprenoid biosynthesis
DE10027821A1 (de) * 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
WO2004072276A1 (en) * 2003-02-14 2004-08-26 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Crystal structure of 2-c-methyl-d-erythritol 4-phosphate synthase in complex with inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9315751D0 (en) * 1993-07-30 1993-09-15 Zeneca Ltd Dna,dna constructs,cells and plants derived therefrom
US5885782A (en) * 1994-09-13 1999-03-23 Nce Pharmaceuticals, Inc. Synthetic antibiotics
US6183121B1 (en) * 1997-08-14 2001-02-06 Vertex Pharmaceuticals Inc. Hepatitis C virus helicase crystals and coordinates that define helicase binding pockets
DE10027821A1 (de) * 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
DE10201458A1 (de) * 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
AU2002322265A1 (en) * 2001-06-18 2003-01-02 Structural Genomix Crystals and structure of 2c-methyl-d-erythritol 2,4-cyclodiphosphate synthase mecps

Also Published As

Publication number Publication date
AU2002319171A1 (en) 2002-11-25
EP1390488B1 (de) 2007-08-29
US20040226502A1 (en) 2004-11-18
DE60222115D1 (en) 2007-10-11
EP1390488A2 (de) 2004-02-25
DE60222115T2 (de) 2008-05-21
WO2002092800A2 (en) 2002-11-21
WO2002092800A3 (en) 2003-08-21

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Legal Events

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