DE60132079T2 - Verfahren zur Herstellung eines Ersatzkonstrukts für Ligamente - Google Patents
Verfahren zur Herstellung eines Ersatzkonstrukts für Ligamente Download PDFInfo
- Publication number
- DE60132079T2 DE60132079T2 DE60132079T DE60132079T DE60132079T2 DE 60132079 T2 DE60132079 T2 DE 60132079T2 DE 60132079 T DE60132079 T DE 60132079T DE 60132079 T DE60132079 T DE 60132079T DE 60132079 T2 DE60132079 T2 DE 60132079T2
- Authority
- DE
- Germany
- Prior art keywords
- cells
- ligament
- matrix
- dimensional
- acl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 34
- 210000003041 ligament Anatomy 0.000 title claims abstract description 28
- 230000008569 process Effects 0.000 title claims description 11
- 238000002360 preparation method Methods 0.000 title claims description 4
- 239000000463 material Substances 0.000 claims abstract description 13
- 230000008439 repair process Effects 0.000 claims abstract description 11
- 210000004027 cell Anatomy 0.000 claims description 48
- 210000001264 anterior cruciate ligament Anatomy 0.000 claims description 33
- 239000011159 matrix material Substances 0.000 claims description 30
- 238000009987 spinning Methods 0.000 claims description 19
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 229920005594 polymer fiber Polymers 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 5
- 238000002513 implantation Methods 0.000 claims description 4
- 239000004753 textile Substances 0.000 claims description 4
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- 239000000835 fiber Substances 0.000 abstract description 42
- 210000001519 tissue Anatomy 0.000 description 23
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- 239000003658 microfiber Substances 0.000 description 16
- 229920000954 Polyglycolide Polymers 0.000 description 15
- 210000002950 fibroblast Anatomy 0.000 description 14
- 239000000243 solution Substances 0.000 description 14
- 229920000747 poly(lactic acid) Polymers 0.000 description 13
- 238000004626 scanning electron microscopy Methods 0.000 description 8
- 108010067306 Fibronectins Proteins 0.000 description 7
- 102000016359 Fibronectins Human genes 0.000 description 7
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- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Natural products OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 5
- 239000000969 carrier Substances 0.000 description 5
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 3
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical class CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
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- 229920001436 collagen Polymers 0.000 description 3
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- 229920000544 Gore-Tex Polymers 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 239000012876 carrier material Substances 0.000 description 2
- 210000000845 cartilage Anatomy 0.000 description 2
- 239000006143 cell culture medium Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
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- 230000006378 damage Effects 0.000 description 2
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- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 238000004128 high performance liquid chromatography Methods 0.000 description 2
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- 208000014674 injury Diseases 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000000399 orthopedic effect Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 210000002303 tibia Anatomy 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 210000000689 upper leg Anatomy 0.000 description 2
- 208000025674 Anterior Cruciate Ligament injury Diseases 0.000 description 1
- 229920000049 Carbon (fiber) Polymers 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 1
- 206010061223 Ligament injury Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000906034 Orthops Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
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- 238000003556 assay Methods 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 239000004917 carbon fiber Substances 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 230000021164 cell adhesion Effects 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000001086 cytosolic effect Effects 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000012606 in vitro cell culture Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000036244 malformation Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 230000004660 morphological change Effects 0.000 description 1
- 230000005804 musculo-skeletal problem Effects 0.000 description 1
- 238000011587 new zealand white rabbit Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 210000000426 patellar ligament Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 229920000151 polyglycol Polymers 0.000 description 1
- 239000010695 polyglycol Substances 0.000 description 1
- 238000012667 polymer degradation Methods 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 238000002278 reconstructive surgery Methods 0.000 description 1
- 238000009877 rendering Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000009864 tensile test Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/08—Muscles; Tendons; Ligaments
Landscapes
- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Lining Or Joining Of Plastics Or The Like (AREA)
- Footwear And Its Accessory, Manufacturing Method And Apparatuses (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19199900P | 2000-03-24 | 2000-03-24 | |
| US191999P | 2000-03-24 | ||
| PCT/US2001/009079 WO2001072241A1 (en) | 2000-03-24 | 2001-03-22 | Ligament replacement constructs and methods for production and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60132079D1 DE60132079D1 (de) | 2008-02-07 |
| DE60132079T2 true DE60132079T2 (de) | 2008-12-18 |
Family
ID=22707811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60132079T Expired - Lifetime DE60132079T2 (de) | 2000-03-24 | 2001-03-22 | Verfahren zur Herstellung eines Ersatzkonstrukts für Ligamente |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1272127B1 (enExample) |
| JP (2) | JP4452426B2 (enExample) |
| AT (1) | ATE381912T1 (enExample) |
| AU (2) | AU2001249322B2 (enExample) |
| CA (1) | CA2403983C (enExample) |
| DE (1) | DE60132079T2 (enExample) |
| DK (1) | DK1272127T3 (enExample) |
| ES (1) | ES2299481T3 (enExample) |
| WO (1) | WO2001072241A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020133229A1 (en) | 2000-03-24 | 2002-09-19 | Laurencin Cato T. | Ligament and tendon replacement constructs and methods for production and use thereof |
| US20030212456A1 (en) * | 2002-05-09 | 2003-11-13 | John Lipchitz | Implant for tissue repair |
| US8177839B2 (en) * | 2006-12-27 | 2012-05-15 | Shriners Hospitals For Children | Woven and/or braided fiber implants and methods of making same |
| EP2131880B1 (en) | 2007-02-20 | 2012-08-08 | Shriners Hospitals for Children | In vivo hydraulic fixation including bio-rivets using biocompatible expandable fibers |
| JP5492097B2 (ja) | 2008-02-22 | 2014-05-14 | マイメディクス，インコーポレイテッド | 手首、手及びその他の靱帯置換術又は修復術のために適切なバイオステープル |
| EP2291143B1 (en) | 2008-05-16 | 2020-07-08 | Mimedx, Inc. | Medical constructs of twisted lengths of collagen fibers and methods of making same |
| CA2740008C (en) | 2008-10-09 | 2017-01-31 | Mimedx, Inc. | Methods of making biocomposite medical constructs and related constructs including artificial tissues, vessels and patches |
| JP5653418B2 (ja) | 2009-05-22 | 2015-01-14 | ソフト ティシュー リジェネレイション， インコーポレイテッド | 靱帯および腱の再生のための力学的に応答可能な足場 |
| US9757132B2 (en) * | 2010-03-24 | 2017-09-12 | Biorez, Inc. | Mechanically competent scaffold for rotator cuff and tendon augmentation |
| CA2829339C (en) | 2011-03-08 | 2018-10-16 | Mimedx, Inc. | Collagen fiber ribbons with integrated fixation sutures and methods of making the same |
| US9694106B2 (en) | 2011-07-11 | 2017-07-04 | Mimedx Group, Inc. | Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods |
| US8986378B2 (en) | 2011-11-02 | 2015-03-24 | Mimedx Group, Inc. | Implantable collagen devices and related methods and systems of making same |
| US9433489B2 (en) | 2013-03-12 | 2016-09-06 | Soft Tissue Regeneration, Inc. | Absorbable synthetic braided matrix for breast reconstruction and hernia repair |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4792336A (en) * | 1986-03-03 | 1988-12-20 | American Cyanamid Company | Flat braided ligament or tendon implant device having texturized yarns |
| US5263984A (en) * | 1987-07-20 | 1993-11-23 | Regen Biologics, Inc. | Prosthetic ligaments |
| EP0306018A1 (en) * | 1987-09-04 | 1989-03-08 | Bio-Products, Inc. | Tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers |
| US5078744A (en) * | 1987-09-04 | 1992-01-07 | Bio-Products, Inc. | Method of using tendon/ligament substitutes composed of long, parallel, non-antigenic tendon/ligament fibers |
| US5376118A (en) * | 1989-05-10 | 1994-12-27 | United States Surgical Corporation | Support material for cell impregnation |
| JP3493199B2 (ja) * | 1993-07-07 | 2004-02-03 | スミス アンド ネフュー ピーエルシー | 埋込型プロステーシス、キットおよびそれを製造するための装置 |
| EP0677297B1 (en) * | 1993-09-24 | 2000-12-13 | Takiron Co. Ltd. | Implantation material |
| GB2282328B (en) * | 1993-09-29 | 1997-10-08 | Johnson & Johnson Medical | Absorbable structures for ligament and tendon repair |
| JPH10505250A (ja) * | 1994-06-06 | 1998-05-26 | ケース ウエスターン リザーブ ユニバーシティ | 組織再生のためのバイオマトリックス |
| US5718012A (en) * | 1996-05-28 | 1998-02-17 | Organogenesis, Inc. | Method of strength enhancement of collagen constructs |
| CA2252860C (en) * | 1996-05-28 | 2011-03-22 | 1218122 Ontario Inc. | Resorbable implant biomaterial made of condensed calcium phosphate particles |
-
2001
- 2001-03-22 EP EP01922531A patent/EP1272127B1/en not_active Expired - Lifetime
- 2001-03-22 WO PCT/US2001/009079 patent/WO2001072241A1/en not_active Ceased
- 2001-03-22 DK DK01922531T patent/DK1272127T3/da active
- 2001-03-22 AT AT01922531T patent/ATE381912T1/de active
- 2001-03-22 AU AU2001249322A patent/AU2001249322B2/en not_active Ceased
- 2001-03-22 CA CA002403983A patent/CA2403983C/en not_active Expired - Lifetime
- 2001-03-22 DE DE60132079T patent/DE60132079T2/de not_active Expired - Lifetime
- 2001-03-22 ES ES01922531T patent/ES2299481T3/es not_active Expired - Lifetime
- 2001-03-22 AU AU4932201A patent/AU4932201A/xx active Pending
- 2001-03-22 JP JP2001570204A patent/JP4452426B2/ja not_active Expired - Fee Related
-
2007
- 2007-06-20 JP JP2007161999A patent/JP4897583B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2403983C (en) | 2008-02-12 |
| WO2001072241A1 (en) | 2001-10-04 |
| AU2001249322B2 (en) | 2004-10-14 |
| DK1272127T3 (da) | 2008-04-28 |
| EP1272127B1 (en) | 2007-12-26 |
| DE60132079D1 (de) | 2008-02-07 |
| JP4897583B2 (ja) | 2012-03-14 |
| CA2403983A1 (en) | 2001-10-04 |
| JP4452426B2 (ja) | 2010-04-21 |
| JP2007289727A (ja) | 2007-11-08 |
| EP1272127A4 (en) | 2004-03-03 |
| EP1272127A1 (en) | 2003-01-08 |
| AU4932201A (en) | 2001-10-08 |
| ES2299481T3 (es) | 2008-06-01 |
| JP2003530912A (ja) | 2003-10-21 |
| ATE381912T1 (de) | 2008-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |