DE60128451D1 - Beschichtung welche ein anhaften von endothelzellen stimuliert - Google Patents

Beschichtung welche ein anhaften von endothelzellen stimuliert

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Publication number
DE60128451D1
DE60128451D1 DE60128451T DE60128451T DE60128451D1 DE 60128451 D1 DE60128451 D1 DE 60128451D1 DE 60128451 T DE60128451 T DE 60128451T DE 60128451 T DE60128451 T DE 60128451T DE 60128451 D1 DE60128451 D1 DE 60128451D1
Authority
DE
Germany
Prior art keywords
stent
coating
luminal
exterior surface
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60128451T
Other languages
English (en)
Other versions
DE60128451T2 (de
Inventor
Michael John Kutryk
Robert John Cottone
Stephen Maxwell Rowland
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orbus Medical Technologies Inc
Original Assignee
Orbus Medical Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26885401&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60128451(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Orbus Medical Technologies Inc filed Critical Orbus Medical Technologies Inc
Application granted granted Critical
Publication of DE60128451D1 publication Critical patent/DE60128451D1/de
Publication of DE60128451T2 publication Critical patent/DE60128451T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Families Citing this family (230)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU716005B2 (en) 1995-06-07 2000-02-17 Cook Medical Technologies Llc Implantable medical device
US6638237B1 (en) * 1999-08-04 2003-10-28 Percardia, Inc. Left ventricular conduits and methods for delivery
US7220276B1 (en) * 2000-03-06 2007-05-22 Surmodics, Inc. Endovascular graft coatings
US8460367B2 (en) * 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
CN100506293C (zh) * 2000-03-15 2009-07-01 祥丰医疗有限公司 促进内皮细胞粘附的涂层
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US9320829B2 (en) * 2000-03-15 2016-04-26 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20070055367A1 (en) * 2000-03-15 2007-03-08 Orbus Medical Technologies, Inc. Medical device with coating that promotes endothelial cell adherence and differentiation
US8088060B2 (en) 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20030229393A1 (en) * 2001-03-15 2003-12-11 Kutryk Michael J. B. Medical device with coating that promotes cell adherence and differentiation
US20050271701A1 (en) * 2000-03-15 2005-12-08 Orbus Medical Technologies, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US6854467B2 (en) * 2000-05-04 2005-02-15 Percardia, Inc. Methods and devices for delivering a ventricular stent
US8632583B2 (en) 2011-05-09 2014-01-21 Palmaz Scientific, Inc. Implantable medical device having enhanced endothelial migration features and methods of making the same
US20020032478A1 (en) * 2000-08-07 2002-03-14 Percardia, Inc. Myocardial stents and related methods of providing direct blood flow from a heart chamber to a coronary vessel
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
US8192484B2 (en) 2000-12-12 2012-06-05 Cardiatis S.A. Stent for blood flow improvement
US6976990B2 (en) * 2001-01-25 2005-12-20 Percardia, Inc. Intravascular ventriculocoronary bypass via a septal passageway
DE10122806A1 (de) * 2001-05-10 2002-11-14 Holger Kiesewetter Verfahren zum Nachweis von Blutzell-Antigenen und gegen diese gerichtete Antikörper
US8889169B2 (en) * 2001-05-11 2014-11-18 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
US7666462B2 (en) * 2001-05-11 2010-02-23 Exogenesis Corporation Method of controlling a drug release rate
US7923055B2 (en) 2001-05-11 2011-04-12 Exogenesis Corporation Method of manufacturing a drug delivery system
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US8715312B2 (en) 2001-07-20 2014-05-06 Microvention, Inc. Aneurysm treatment device and method of use
US7572288B2 (en) 2001-07-20 2009-08-11 Microvention, Inc. Aneurysm treatment device and method of use
US8252040B2 (en) 2001-07-20 2012-08-28 Microvention, Inc. Aneurysm treatment device and method of use
US20030036698A1 (en) * 2001-08-16 2003-02-20 Robert Kohler Interventional diagnostic catheter and a method for using a catheter to access artificial cardiac shunts
WO2003049795A2 (en) * 2001-09-28 2003-06-19 Boston Scientific Limited Medical devices comprising nanocomposites
AU2002359340A1 (en) * 2001-10-31 2003-05-12 Ventrigraft Inc Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo
US20030109824A1 (en) * 2001-11-07 2003-06-12 Microvena Corporation Distal protection device with local drug delivery to maintain patency
US7172758B2 (en) 2002-01-29 2007-02-06 Colb A Mark Endothelialization of vascular surfaces
IL162803A0 (en) * 2002-02-06 2005-11-20 Orbus Medical Technologies Inc Medical device with coating that promotes endothelial cell adherence and differentiation
US7008397B2 (en) * 2002-02-13 2006-03-07 Percardia, Inc. Cardiac implant and methods
US7758889B1 (en) 2002-07-24 2010-07-20 Luna Innovations Incorporated Fullerenes in targeted therapies
US20080193490A1 (en) * 2002-02-14 2008-08-14 Andreas Hirsch Use of Carbon Nanotube for Drug Delivery
US20030215454A1 (en) * 2002-03-01 2003-11-20 Colb A. Mark Binding of red blood cells to exposed subendothelial surfaces to impede platelet deposition thereon and/or for use in targeted drug delivery thereto
US6905667B1 (en) 2002-05-02 2005-06-14 Zyvex Corporation Polymer and method for using the polymer for noncovalently functionalizing nanotubes
AU2003237128A1 (en) * 2002-05-03 2003-11-17 Duke University Carbon nanotubules for storage of nitric oxide
EP1364663A1 (de) * 2002-05-21 2003-11-26 Commonwealth Scientific And Industrial Research Organisation Okulare Vorrichtungen mit funktionalisierter Oberfläche mit adhäsiven Eigenschaften
JP2005531391A (ja) * 2002-06-27 2005-10-20 微創医療器械(上海)有限公司 薬剤放出ステント
US8679517B2 (en) 2002-09-26 2014-03-25 Palmaz Scientific, Inc. Implantable materials having engineered surfaces made by vacuum deposition and method of making same
CA2499976C (en) 2002-09-26 2013-06-11 Advanced Bio Prosthetic Surfaces, Ltd. Implantable materials having engineered surfaces and method of making same
US8268340B2 (en) 2002-09-26 2012-09-18 Advanced Bio Prosthetic Surfaces, Ltd. Implantable materials having engineered surfaces and method of making same
US7162308B2 (en) 2002-11-26 2007-01-09 Wilson Greatbatch Technologies, Inc. Nanotube coatings for implantable electrodes
US7060684B1 (en) 2002-12-16 2006-06-13 Quijano Rodolfo C Device for treating diabetes and methods thereof
US7311727B2 (en) * 2003-02-05 2007-12-25 Board Of Trustees Of The University Of Arkansas Encased stent
CA2513443A1 (en) * 2003-02-26 2004-09-10 Medivas, Llc Bioactive stents and methods for use thereof
US7074294B2 (en) * 2003-04-17 2006-07-11 Nanosys, Inc. Structures, systems and methods for joining articles and materials and uses therefor
US20050221072A1 (en) * 2003-04-17 2005-10-06 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
US7056409B2 (en) * 2003-04-17 2006-06-06 Nanosys, Inc. Structures, systems and methods for joining articles and materials and uses therefor
US20050038498A1 (en) * 2003-04-17 2005-02-17 Nanosys, Inc. Medical device applications of nanostructured surfaces
US20060122596A1 (en) * 2003-04-17 2006-06-08 Nanosys, Inc. Structures, systems and methods for joining articles and materials and uses therefor
US7579077B2 (en) * 2003-05-05 2009-08-25 Nanosys, Inc. Nanofiber surfaces for use in enhanced surface area applications
WO2005005679A2 (en) * 2003-04-28 2005-01-20 Nanosys, Inc. Super-hydrophobic surfaces, methods of their construction and uses therefor
TWI427709B (zh) * 2003-05-05 2014-02-21 Nanosys Inc 用於增加表面面積之應用的奈米纖維表面
US7803574B2 (en) 2003-05-05 2010-09-28 Nanosys, Inc. Medical device applications of nanostructured surfaces
ES2333427T3 (es) 2003-05-16 2010-02-22 Cinvention Ag Procedimiento de recubrimiento de sustratos con material basado en carbono.
JP2004344469A (ja) * 2003-05-23 2004-12-09 Terumo Corp 体内埋込医療器具
WO2005016414A2 (en) * 2003-08-13 2005-02-24 The Children's Hospital Of Philadelphia Use of receptor sequences for immobilizing gene vectors on surfaces
US20050124896A1 (en) * 2003-08-25 2005-06-09 Jacob Richter Method for protecting implantable sensors and protected implantable sensors
US20060188486A1 (en) * 2003-10-14 2006-08-24 Medivas, Llc Wound care polymer compositions and methods for use thereof
US20050096509A1 (en) * 2003-11-04 2005-05-05 Greg Olson Nanotube treatments for internal medical devices
WO2005044361A1 (en) 2003-11-07 2005-05-19 Merlin Md Pte Ltd Implantable medical devices with enhanced visibility, mechanical properties and biocompatibility
US20060085062A1 (en) * 2003-11-28 2006-04-20 Medlogics Device Corporation Implantable stent with endothelialization factor
US20090118817A1 (en) * 2005-06-16 2009-05-07 Mayo Foundation For Medical Education And Research Magnetic Medical Apparatus, Kits, and Methods
US8465453B2 (en) * 2003-12-03 2013-06-18 Mayo Foundation For Medical Education And Research Kits, apparatus and methods for magnetically coating medical devices with living cells
JP4618997B2 (ja) * 2003-12-09 2011-01-26 テルモ株式会社 ステントおよびその製造方法
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
US8025960B2 (en) 2004-02-02 2011-09-27 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US20110039690A1 (en) 2004-02-02 2011-02-17 Nanosys, Inc. Porous substrates, articles, systems and compositions comprising nanofibers and methods of their use and production
US20050175667A1 (en) * 2004-02-10 2005-08-11 Wenda Carlyle Use of endothelin antagonists to prevent restenosis
TW200539841A (en) * 2004-03-10 2005-12-16 Orbus Medical Technologies Inc Progenitor endothelial cell capturing with a drug eluting implantable medical device
SG133420A1 (en) * 2005-12-13 2007-07-30 Merlin Md Pte Ltd An endovascular device with membrane having permanently attached agents
US8715340B2 (en) * 2004-03-31 2014-05-06 Merlin Md Pte Ltd. Endovascular device with membrane
US8915952B2 (en) 2004-03-31 2014-12-23 Merlin Md Pte Ltd. Method for treating aneurysms
US8500751B2 (en) 2004-03-31 2013-08-06 Merlin Md Pte Ltd Medical device
US8163269B2 (en) * 2004-04-05 2012-04-24 Carpenter Kenneth W Bioactive stents for type II diabetics and methods for use thereof
US20060013855A1 (en) * 2004-04-05 2006-01-19 Medivas, Llc Bioactive stents for type II diabetics and methods for use thereof
US20050234545A1 (en) * 2004-04-19 2005-10-20 Yea-Yang Su Amorphous oxide surface film for metallic implantable devices and method for production thereof
CA2563329C (en) * 2004-04-30 2016-01-26 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US20050260355A1 (en) * 2004-05-20 2005-11-24 Jan Weber Medical devices and methods of making the same
US20050260557A1 (en) * 2004-05-21 2005-11-24 Mary Zacour Method of quantifying the cell-binding properties of a medical device
WO2005120549A2 (en) * 2004-06-07 2005-12-22 Conor Medsystems, Inc. Local delivery of growth factors for stem cell transplantation
EP2138195A3 (de) * 2004-06-16 2010-07-21 Affinergy Inc. Grenzflächenbiomaterialien zur Förderung der Anhaftung von Zielanalyten
US20060093642A1 (en) * 2004-11-03 2006-05-04 Ranade Shrirang V Method of incorporating carbon nanotubes in a medical appliance, a carbon nanotube medical appliance, and a medical appliance coated using carbon nanotube technology
GB2420976B (en) * 2004-11-19 2006-12-20 Zvi Finkelstein Therapeutic implant
US8609123B2 (en) * 2004-11-29 2013-12-17 Advanced Cardiovascular Systems, Inc. Derivatized poly(ester amide) as a biobeneficial coating
AU2005314263B2 (en) * 2004-12-08 2011-05-19 Shire Regenerative Medicine, Inc. Methods and compositions for enhancing vascular access
US20060136042A1 (en) * 2004-12-22 2006-06-22 Scimed Life Systems, Inc. Vulnerable plaque stent
CA2509083A1 (en) * 2004-12-22 2006-06-22 Merlin Md Pte Ltd A medical device
US8158410B2 (en) * 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20070003589A1 (en) * 2005-02-17 2007-01-04 Irina Astafieva Coatings for implantable medical devices containing attractants for endothelial cells
EP1848470A2 (de) * 2005-02-17 2007-10-31 Abbott Cardiovascular Systems, Inc. Beschichtungen für implantierbare medizinische vorrichtungen mit lockmitteln für endothelzellen
WO2006099020A2 (en) * 2005-03-09 2006-09-21 The University Of Tennessee Research Foundation Barrier stent and use thereof
DE602006014814D1 (de) 2005-04-21 2010-07-22 Massachusetts Inst Technology Materialien und verfahren zur änderung einer immunreaktion auf exogene und endogene immunogene, einschliesslich genidentischer und nicht-genidentischer zellen, gewebe oder organe
US8414907B2 (en) * 2005-04-28 2013-04-09 Warsaw Orthopedic, Inc. Coatings on medical implants to guide soft tissue healing
US9119901B2 (en) * 2005-04-28 2015-09-01 Warsaw Orthopedic, Inc. Surface treatments for promoting selective tissue attachment to medical impants
ES2263382B1 (es) * 2005-05-16 2007-11-16 Fundacion Para La Investigacion Biomedica Del Hospital Gregorio Marañon Matriz artificial de gel de fibrina endotelizada superproductora de factores proangiogenicos.
AU2006262682B2 (en) 2005-06-21 2012-07-05 Shire Regenerative Medicine, Inc. Methods and compositions for enhancing vascular access
CA2623239C (en) * 2005-09-22 2016-07-12 Medivas, Llc Solid polymer delivery compositions and methods for use thereof
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−(α−アミノ)−ジオール−ジエステル含有ポリ(エステルアミド)およびポリ(エステルウレタン)組成物および使用の方法
AU2006304229A1 (en) 2005-10-13 2007-04-26 Synthes Gmbh Drug-impregnated encasement
US20070196423A1 (en) * 2005-11-21 2007-08-23 Med Institute, Inc. Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
US20100204783A1 (en) * 2005-12-06 2010-08-12 Helen Marie Nugent Methods and compositions for enhancing vascular access
EP1962894A4 (de) * 2005-12-07 2012-11-14 Medivas Llc Verfahren zum zusammensetzen einer polymer-zusammensetzung zur abgabe eines biologischen mittels
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US7531505B2 (en) * 2006-01-11 2009-05-12 Affinergy, Inc. Compositions and methods for promoting attachment of cells of endothelial cell lineage to medical devices
US7807624B2 (en) * 2006-01-11 2010-10-05 Affinergy, Inc. Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20100023101A1 (en) * 2006-02-03 2010-01-28 University Of Wollongong Biocompatible composites
US20070191766A1 (en) * 2006-02-10 2007-08-16 Boston Scientific Scimed, Inc. Balloon catheter having nanotubes
EP1983929B1 (de) * 2006-02-13 2011-11-23 Merlin MD PTE Ltd Endovaskuläre vorrichtung mit membran
US20070203564A1 (en) * 2006-02-28 2007-08-30 Boston Scientific Scimed, Inc. Biodegradable implants having accelerated biodegradation properties in vivo
US20070225795A1 (en) * 2006-03-24 2007-09-27 Juan Granada Composite vascular prosthesis
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
CA2649672C (en) * 2006-05-02 2015-07-07 Medivas, Llc Delivery of ophthalmologic agents to the exterior or interior of the eye
EP2021141A4 (de) * 2006-05-09 2013-07-03 Medivas Llc Biologisch abbaubare wasserlösliche polymere
US7572625B2 (en) * 2006-05-18 2009-08-11 Boston Scientific Scimed, Inc. Medical devices coated with drug carrier macromolecules
ES2732255T3 (es) * 2006-06-13 2019-11-21 Alchimedics Endoprótesis de elución de fármaco con una capa de liberación biodegradable fijada con un recubrimiento de imprimación electroinjertado
US20080108138A1 (en) * 2006-06-13 2008-05-08 Vermette Patrick Bioactive compositions and their use in cell patterning
US8535372B1 (en) * 2006-06-16 2013-09-17 Abbott Cardiovascular Systems Inc. Bioabsorbable stent with prohealing layer
US8066753B2 (en) * 2006-07-06 2011-11-29 Robert Kipperman Specialized catheter and method for placement in a bifurcated vessel
US7824438B2 (en) * 2006-07-06 2010-11-02 Robert Kipperman Method for placement of a stent assembly in a bifurcated vessel
EP2054537A2 (de) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprothese mit dreidimensionaler desintegrationssteuerung
US20080085293A1 (en) * 2006-08-22 2008-04-10 Jenchen Yang Drug eluting stent and therapeutic methods using c-Jun N-terminal kinase inhibitor
WO2008030388A2 (en) 2006-09-06 2008-03-13 Boston Scientific Scimed, Inc. Medical devices having a coating for promoting endothelial cell adhesion
US8808726B2 (en) 2006-09-15 2014-08-19 Boston Scientific Scimed. Inc. Bioerodible endoprostheses and methods of making the same
JP2010503485A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 医療用デバイスおよび同デバイスの製造方法
EP2399616A1 (de) 2006-09-15 2011-12-28 Boston Scientific Scimed, Inc. Biologisch erodierbare Endoprothese mit biostabilen anorganischen Schichten
ATE517590T1 (de) 2006-09-15 2011-08-15 Boston Scient Ltd Biologisch erodierbare endoprothesen
CA2663762A1 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
WO2008039521A2 (en) * 2006-09-26 2008-04-03 Nmt Medical, Inc. Method for modifying a medical implant surface for promoting tissue growth
US20100028402A1 (en) * 2006-10-25 2010-02-04 Marina Dobrovolskaia Nanoparticle-based anticoagulant
US20100092532A1 (en) * 2006-11-07 2010-04-15 Helen Marie Nugent Materials and Methods for Treating and Managing Angiogenesis-Mediated Diseases
ATE488259T1 (de) 2006-12-28 2010-12-15 Boston Scient Ltd Bioerodierbare endoprothesen und herstellungsverfahren dafür
BRPI0807177B8 (pt) * 2007-01-30 2021-06-22 Univ Pittsburgh dispositivo de enxerto de tecido tubular e método de preparação do mesmo
US20080311172A1 (en) * 2007-04-25 2008-12-18 Schapira Jay N Programmed-release, nanostructured biological construct
US8257304B2 (en) * 2007-06-01 2012-09-04 Tyco Healthcare Group Lp Extension tubes for balloon catheters
US20100070020A1 (en) 2008-06-11 2010-03-18 Nanovasc, Inc. Implantable Medical Device
ES2381641T3 (es) * 2007-06-13 2012-05-30 Pervasis Therapeutics, Inc. Métodos y dispositivos para la administración mínimamente invasiva de composiciones fluidas que contienen células
US9023094B2 (en) 2007-06-25 2015-05-05 Microvention, Inc. Self-expanding prosthesis
CA2709412A1 (en) * 2007-07-24 2009-01-29 Medivas, Llc Biodegradable cationic polymer gene transfer compositions and methods of use
US20090043380A1 (en) * 2007-08-09 2009-02-12 Specialized Vascular Technologies, Inc. Coatings for promoting endothelization of medical devices
US20090043330A1 (en) * 2007-08-09 2009-02-12 Specialized Vascular Technologies, Inc. Embolic protection devices and methods
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
JP5356239B2 (ja) 2007-09-28 2013-12-04 テルモ株式会社 生体内留置物
CN101172168B (zh) * 2007-10-10 2010-06-02 大连理工大学 胺糖聚糖负载cd133抗体的金属血管支架涂层与制法
US20090112239A1 (en) * 2007-10-31 2009-04-30 Specialized Vascular Technologies, Inc. Sticky dilatation balloon and methods of using
US8319002B2 (en) 2007-12-06 2012-11-27 Nanosys, Inc. Nanostructure-enhanced platelet binding and hemostatic structures
WO2009073854A1 (en) 2007-12-06 2009-06-11 Nanosys, Inc. Resorbable nanoenhanced hemostatic structures and bandage materials
WO2009089340A1 (en) * 2008-01-09 2009-07-16 Innovative Health Technologies, Llc Implant pellets and methods for performing bone augmentation and preservation
JP5435878B2 (ja) * 2008-02-12 2014-03-05 富士フイルム株式会社 断片化抗体を標識物質に固定した標識粒子
US20110190251A1 (en) * 2008-03-03 2011-08-04 Kepley Christopher L Method for inhibiting the build-up of arterial plaque by administering fullerenes
WO2009114089A2 (en) * 2008-03-03 2009-09-17 Luna Innovations Incorporated Using fullerenes to enhance and stimulate hair growth
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US20100022940A1 (en) * 2008-07-25 2010-01-28 Medtronic Vascular, Inc. Percutaneously Introduceable Shunt Devices and Methods
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2326356B1 (de) 2008-08-07 2017-10-11 Exogenesis Corporation Medizinische vorrichtung für knochenimplantat und verfahren zur herstellung einer derartigen vorrichtung
US20100036482A1 (en) * 2008-08-07 2010-02-11 Exogenesis Corporation Drug delivery system and method of manufacturing thereof
WO2010019716A1 (en) * 2008-08-13 2010-02-18 Medivas, Llc Aabb-poly(depsipeptide) biodegradable polymers and methods of use
US8642063B2 (en) 2008-08-22 2014-02-04 Cook Medical Technologies Llc Implantable medical device coatings with biodegradable elastomer and releasable taxane agent
US8262692B2 (en) * 2008-09-05 2012-09-11 Merlin Md Pte Ltd Endovascular device
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
WO2010054121A2 (en) * 2008-11-07 2010-05-14 Specialized Vascular Technologies, Inc. Extracellular matrix modulating coatings for medical devices
US8540889B1 (en) 2008-11-19 2013-09-24 Nanosys, Inc. Methods of generating liquidphobic surfaces
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
EP2403438B1 (de) * 2009-03-04 2021-04-21 Peytant Solutions, Inc. Mit amniongewebehaltigem material modizifierte stents und zugehörige verfahren
US8574612B2 (en) * 2009-03-04 2013-11-05 Boston Scientific Scimed, Inc. Medical devices having a coating of biologic macromolecules
WO2010132707A1 (en) * 2009-05-14 2010-11-18 Orbusneich Medical, Inc. Self-expanding stent with polygon transition zone
US8382818B2 (en) 2009-07-02 2013-02-26 Tryton Medical, Inc. Ostium support for treating vascular bifurcations
JP5782029B2 (ja) * 2009-08-12 2015-09-24 デューク ユニバーシティーDuke University 細胞でコーティングされた移植可能デバイス
US9446051B2 (en) * 2009-10-19 2016-09-20 The Population Council, Inc. Neuroprotection and myelin repair using nestorone®
CA2777551C (en) 2009-10-19 2015-12-22 The Population Council, Inc. Neuroprotection and myelin repair using nestorone
JP2013509258A (ja) 2009-10-28 2013-03-14 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 生体浸食性ラップおよびそのための使用
CA2784021C (en) 2009-12-16 2018-03-20 Neograft Technologies, Inc. Graft devices and methods of use
WO2011082227A1 (en) 2009-12-29 2011-07-07 Boston Scientific Scimed, Inc. High strength low opening pressure stent design
EP2519188A4 (de) 2009-12-31 2017-03-22 Neograft Technologies, Inc. Transplantatvorrichtungen und verfahren zur herstellung
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
WO2012012407A2 (en) 2010-07-19 2012-01-26 Neograft Technologies, Inc. Graft devices and methods of use
US9861814B2 (en) * 2010-12-23 2018-01-09 Medtronic, Inc. Medical electrical lead having biological surface and methods of making and using same
KR101770827B1 (ko) * 2011-03-10 2017-08-23 서울대학교산학협력단 혈관내피 전구세포를 선택적으로 포획할 수 있는 스텐트 및 이의 제조 방법
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US8728563B2 (en) 2011-05-03 2014-05-20 Palmaz Scientific, Inc. Endoluminal implantable surfaces, stents, and grafts and method of making same
CA2835427A1 (en) 2011-05-11 2012-11-15 Microvention, Inc. Device for occluding a lumen
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
WO2012175748A1 (en) 2011-06-23 2012-12-27 Dsm Ip Assets B.V. Micro- or nanoparticles comprising a biodegradable polyesteramide copolymer for use in the delivery of bioactive agents
WO2013016349A2 (en) 2011-07-25 2013-01-31 Neograft Technologies, Inc. Vessel treatment methods and devices for use in a graft device
GB201114293D0 (en) 2011-08-19 2011-10-05 Univ Edinburgh Endothelial polymers
US9381112B1 (en) 2011-10-06 2016-07-05 William Eric Sponsell Bleb drainage device, ophthalmological product and methods
ITVI20110310A1 (it) * 2011-11-29 2013-05-30 Ehsan Bahrami Rivestimento combinatorio comprendente due proteine chimeriche per aumentare l'attrazione di cellule endoteliali e cellule progenitrici endoteliali su una superficie metallica
US8632489B1 (en) 2011-12-22 2014-01-21 A. Mateen Ahmed Implantable medical assembly and methods
TWI590843B (zh) 2011-12-28 2017-07-11 信迪思有限公司 膜及其製造方法
ES2943709T3 (es) 2012-04-06 2023-06-15 Merlin Md Pte Ltd Dispositivos para tratar un aneurisma
US10500077B2 (en) 2012-04-26 2019-12-10 Poseidon Medical Inc. Support for treating vascular bifurcations
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
WO2014204708A1 (en) 2013-06-21 2014-12-24 DePuy Synthes Products, LLC Films and methods of manufacture
US11266395B2 (en) 2014-06-17 2022-03-08 Ganihand, LLC Devices and methods to provide hands free scleral depression during ophthalmic procedures
CN104383609B (zh) * 2014-11-07 2016-09-14 浙江大学 一种可调控细胞粘附的材料在筛选内皮细胞和平滑肌细胞中的应用
WO2016077410A1 (en) * 2014-11-11 2016-05-19 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Super elastic, bioabsorbable endovascular devices
CA2969171C (en) 2014-12-18 2023-12-12 Dsm Ip Assets B.V. Drug delivery system for delivery of acid sensitive drugs
WO2017100927A1 (en) 2015-12-15 2017-06-22 Neovasc Tiara Inc. Transseptal delivery system
US10342899B2 (en) 2015-12-19 2019-07-09 Cardiac Pacemakers, Inc. Biologically inert coating for implantable medical devices
CA3007670A1 (en) 2016-01-29 2017-08-03 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
WO2017214550A1 (en) 2016-06-09 2017-12-14 Haimachek, Inc. Collector for detection and reversible capturing of cells from body fluids in vivo
WO2017218787A1 (en) 2016-06-16 2017-12-21 Cardiac Pacemakers, Inc. Hydrophilization and antifouling of enhanced metal surfaces
EP3496771B1 (de) 2016-08-09 2023-01-04 Cardiac Pacemakers, Inc. Funktionalisiertes peg für implantierbare medizinische vorrichtungen
US20180206851A1 (en) * 2016-10-19 2018-07-26 Daniel E. Walzman Hydrogel intrasaccular occlusion device
AU2017361296B2 (en) 2016-11-21 2022-09-29 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US10603485B2 (en) 2016-11-28 2020-03-31 Boston Scientific Neuromodulation Corporation Features in increased surface area on neuromodulation leads
CN108619581A (zh) * 2017-03-21 2018-10-09 微创心脉医疗科技(上海)有限公司 药物涂层、介入医疗器械及褪黑素在药物涂层中的应用
CN110545754B (zh) * 2017-04-13 2022-06-28 祥丰医疗私人有限公司 具有涂层的医疗设备以及治疗或预防血管病症的用途
US10433852B2 (en) 2017-05-08 2019-10-08 William Z. H'Doubler Aortic occlusion balloon apparatus, system and method of making
US10856984B2 (en) 2017-08-25 2020-12-08 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US11864728B2 (en) * 2017-12-28 2024-01-09 Cilag Gmbh International Characterization of tissue irregularities through the use of mono-chromatic light refractivity
DE102018110591B4 (de) * 2018-05-03 2022-11-03 Acandis Gmbh Medizinische Vorrichtung mit Fibrinbeschichtung, System und Set mit einer derartigen Vorrichtung sowie Herstellverfahren
IL311092A (en) * 2018-08-31 2024-04-01 Wisconsin Alumni Res Found Fabrication of vascular grafts seeded with arterial endothelial cells
JP7260930B2 (ja) 2018-11-08 2023-04-19 ニオバスク ティアラ インコーポレイテッド 経カテーテル僧帽弁人工補綴物の心室展開
AU2020233892A1 (en) 2019-03-08 2021-11-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
JP7438236B2 (ja) 2019-04-01 2024-02-26 ニオバスク ティアラ インコーポレイテッド 制御可能に展開可能な補綴弁
CA3136334A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
WO2020236931A1 (en) 2019-05-20 2020-11-26 Neovasc Tiara Inc. Introducer with hemostasis mechanism
US11311376B2 (en) 2019-06-20 2022-04-26 Neovase Tiara Inc. Low profile prosthetic mitral valve
CN110917410B (zh) * 2019-11-14 2020-11-24 浙江大学 一种基于双层异相结构的心血管支架涂层及其制备方法
EP4101479A4 (de) * 2020-02-06 2023-06-21 Shin-Etsu Chemical Co., Ltd. Angiogenese-vorrichtung
CN113713172B (zh) * 2021-09-08 2023-04-11 深圳清华大学研究院 原位促内皮化涂层及其制备方法

Family Cites Families (165)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3523807A (en) 1966-11-25 1970-08-11 Mihaly Gerendas Method of making a cross-linked fibrin prosthesis
JPS5313915B2 (de) 1973-01-25 1978-05-13
US4515160A (en) 1982-04-23 1985-05-07 Medtronic, Inc. Cardiac pacemaker synchronized programming
US4487715A (en) 1982-07-09 1984-12-11 The Regents Of The University Of California Method of conjugating oligopeptides
US4548736A (en) 1983-08-29 1985-10-22 Wisconsin Alumni Research Foundation Preparation of protein films
US4553974A (en) 1984-08-14 1985-11-19 Mayo Foundation Treatment of collagenous tissue with glutaraldehyde and aminodiphosphonate calcification inhibitor
US4889808A (en) * 1985-10-01 1989-12-26 American Home Products Method of enchancing t-PA and SCU-PA production
JPS62235568A (ja) * 1985-12-05 1987-10-15 ドクタ− ミユ−ラ−−リ−ルハイム ケ−ジ− バイオロジツシエ ラボラトリ−ン 表面に共有結合した抗体によつて生化学的に活性化されてなる担体
US4962091A (en) 1986-05-23 1990-10-09 Syntex (U.S.A.) Inc. Controlled release of macromolecular polypeptides
US4920016A (en) 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US4795459A (en) 1987-05-18 1989-01-03 Rhode Island Hospital Implantable prosthetic device with lectin linked endothelial cells
US4886062A (en) * 1987-10-19 1989-12-12 Medtronic, Inc. Intravascular radially expandable stent and method of implant
ES2076970T3 (es) 1988-10-28 1995-11-16 Terumo Corp Material medico antitrombotico, organo interno artificial y metodo para la produccion de material medico antitrombotico.
US5043165A (en) 1988-12-14 1991-08-27 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs
US5011778A (en) * 1989-05-23 1991-04-30 Otsuka Pharmaceutical Co., Ltd. Monoclonal antibodies directed to IL-1 activated endothelial cells and medicaments employing the monoclonal antibodies
US5635386A (en) 1989-06-15 1997-06-03 The Regents Of The University Of Michigan Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture
JPH0366384A (ja) 1989-08-04 1991-03-22 Senjiyu Seiyaku Kk 生理活性物質放出制御システム
US5674848A (en) 1989-08-14 1997-10-07 The Regents Of The University Of California Bioreactor compositions with enhanced cell binding
US5635482A (en) 1989-08-14 1997-06-03 The Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
US5059166A (en) 1989-12-11 1991-10-22 Medical Innovative Technologies R & D Limited Partnership Intra-arterial stent with the capability to inhibit intimal hyperplasia
US5674192A (en) * 1990-12-28 1997-10-07 Boston Scientific Corporation Drug delivery
US5199939B1 (en) 1990-02-23 1998-08-18 Michael D Dake Radioactive catheter
DE69110787T2 (de) 1990-02-28 1996-04-04 Medtronic, Inc., Minneapolis, Minn. Intraluminale prothese mit wirkstoffeluierung.
US7189410B1 (en) * 1990-11-27 2007-03-13 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5492890A (en) * 1990-12-03 1996-02-20 The Scripps Research Institute Polypeptides for promoting cell attachment
DE4202282A1 (de) * 1991-01-29 1992-08-20 Fuji Photo Film Co Ltd Lichtempfindliches uebertragungsmaterial und bilderzeugungsverfahren
US5198263A (en) 1991-03-15 1993-03-30 The United States Of America As Represented By The United States Department Of Energy High rate chemical vapor deposition of carbon films using fluorinated gases
US5199942A (en) 1991-06-07 1993-04-06 Immunex Corporation Method for improving autologous transplantation
US5302168A (en) 1991-09-05 1994-04-12 Hess Robert L Method and apparatus for restenosis treatment
US5811447A (en) * 1993-01-28 1998-09-22 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US6515009B1 (en) * 1991-09-27 2003-02-04 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5464450A (en) 1991-10-04 1995-11-07 Scimed Lifesystems Inc. Biodegradable drug delivery vascular stent
GB9203037D0 (en) * 1992-02-11 1992-03-25 Salutar Inc Contrast agents
US5302166A (en) * 1992-02-21 1994-04-12 Optima Industries, Inc. Tool changer
US5310669A (en) 1992-06-22 1994-05-10 The Trustees Of Dartmouth College Fullerene coated surfaces and uses thereof
US6306421B1 (en) * 1992-09-25 2001-10-23 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5292813A (en) 1992-10-02 1994-03-08 Exxon Research & Engineering Co. Fullerene-grafted polymers and processes of making
US5981568A (en) * 1993-01-28 1999-11-09 Neorx Corporation Therapeutic inhibitor of vascular smooth muscle cells
US5338571A (en) 1993-02-10 1994-08-16 Northwestern University Method of forming self-assembled, mono- and multi-layer fullerene film and coated substrates produced thereby
US5464650A (en) 1993-04-26 1995-11-07 Medtronic, Inc. Intravascular stent and method
US5641466A (en) 1993-06-03 1997-06-24 Nec Corporation Method of purifying carbon nanotubes
US5558903A (en) 1993-06-10 1996-09-24 The Ohio State University Method for coating fullerene materials for tribology
US6120764A (en) 1993-06-24 2000-09-19 Advec, Inc. Adenoviruses for control of gene expression
AU7515294A (en) 1993-07-28 1995-02-28 Fred Hutchinson Cancer Research Center Creating novel hematopoietic cell lines by expressing altered retinoic acid receptors
US5543328A (en) * 1993-08-13 1996-08-06 Genetic Therapy, Inc. Adenoviruses having modified fiber proteins
WO1995005843A1 (en) 1993-08-25 1995-03-02 Systemix, Inc. Method for producing a highly enriched population of hematopoietic stem cells
US6323184B1 (en) * 1993-10-15 2001-11-27 Thomas Jefferson University Arteriovenous and venous graft treatments: methods and compositions
JPH09511666A (ja) 1994-04-08 1997-11-25 アトリックス・ラボラトリーズ・インコーポレイテッド 医療装置で使用する付随的ポリマー系
US5536641A (en) 1994-05-17 1996-07-16 Memorial Sloane Kittering Cancer Center Monoclonal antibody specific for vascular endothelial cell antigen endoglyx-1 and uses thereof for detection of, and isolation of, vascular endothelial cells
GB9413029D0 (en) 1994-06-29 1994-08-17 Common Services Agency Stem cell immobilisation
US6249703B1 (en) 1994-07-08 2001-06-19 Medtronic, Inc. Handheld patient programmer for implantable human tissue stimulator
AU700584C (en) 1994-08-12 2002-03-28 Meadox Medicals, Inc. Vascular graft impregnated with a heparin-containing collagen sealant
US6342390B1 (en) * 1994-11-23 2002-01-29 The United States Of America As Represented By The Secretary Of Health And Human Services Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
US6281015B1 (en) 1994-12-16 2001-08-28 Children's Medical Center Corp. Localized delivery of factors enhancing survival of transplanted cells
US6231600B1 (en) 1995-02-22 2001-05-15 Scimed Life Systems, Inc. Stents with hybrid coating for medical devices
DE69618938T2 (de) 1995-03-28 2002-10-31 Fidia Advanced Biopolymers, S.R.L. Nanosphären mit einem biokompatiblen polysaccharid
US6120536A (en) * 1995-04-19 2000-09-19 Schneider (Usa) Inc. Medical devices with long term non-thrombogenic coatings
US6099562A (en) * 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5807398A (en) * 1995-04-28 1998-09-15 Shaknovich; Alexander Shuttle stent delivery catheter
US5780436A (en) 1995-05-01 1998-07-14 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US5661127A (en) 1995-05-01 1997-08-26 The Regents Of The University Of California Peptide compositions with growth factor-like activity
US5603722A (en) 1995-06-06 1997-02-18 Quanam Medical Corporation Intravascular stent
US5824299A (en) * 1995-06-22 1998-10-20 President & Fellows Of Harvard College Modulation of endothelial cell proliferation with IP-10
US5830879A (en) * 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor
US5874500A (en) * 1995-12-18 1999-02-23 Cohesion Technologies, Inc. Crosslinked polymer compositions and methods for their use
US6090618A (en) * 1996-10-07 2000-07-18 Arch Development Corporation DNA constructs and viral vectors comprising a smooth muscle promoter
US5669924A (en) * 1995-10-26 1997-09-23 Shaknovich; Alexander Y-shuttle stent assembly for bifurcating vessels and method of using the same
US5865723A (en) 1995-12-29 1999-02-02 Ramus Medical Technologies Method and apparatus for forming vascular prostheses
US6033582A (en) * 1996-01-22 2000-03-07 Etex Corporation Surface modification of medical implants
WO1997029802A2 (en) 1996-02-20 1997-08-21 Advanced Bionics Corporation Improved implantable microstimulator and systems employing the same
AU724277B2 (en) * 1996-03-06 2000-09-14 Hyperion Catalysis International, Inc. Functionalised nanotubes
AUPN855496A0 (en) * 1996-03-07 1996-04-04 Unisearch Limited Prevention of proliferation of vascular cells
US20040072768A1 (en) * 1996-03-07 2004-04-15 Khachigian Levon Michael Inhibition of proliferation of cells
JPH09249751A (ja) * 1996-03-14 1997-09-22 Collagn Corp 架橋生体物質組成物を調製するための疎水性架橋剤の使用
US6790606B1 (en) * 1996-03-15 2004-09-14 Munin Corporation Extracellular matrix signaling molecules
DK0888452T3 (da) * 1996-03-15 2004-06-14 Munin Corp Human CYR61, et ekstracellulært matrix-signalmolekyle
GB9606188D0 (en) 1996-03-23 1996-05-29 Danbiosyst Uk Pollysaccharide microspheres for the pulmonary delivery of drugs
GB9606452D0 (en) 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds
US5843633A (en) 1996-04-26 1998-12-01 Amcell Corporation Characterization of a human hematopoietic progenitor cell antigen
US6455678B1 (en) 1996-04-26 2002-09-24 Amcell Corporation Human hematopoietic stem and progenitor cell antigen
US6143037A (en) * 1996-06-12 2000-11-07 The Regents Of The University Of Michigan Compositions and methods for coating medical devices
US6013780A (en) * 1996-09-06 2000-01-11 Technion Research & Development Co. Ltd. VEGF145 expression vectors
CA2270154A1 (en) 1996-10-25 1998-04-30 The Government Of The United States Of America As Represented By The Sec Retary, Department Of Health And Human Services Methods and compositions for inhibiting inflammation and angiogenesis comprising a mammalian cd97 alpha subunit
US6500421B1 (en) 1996-11-04 2002-12-31 St. Jude Children's Research Hospital In vivo selection of primitive hematopoietic cells
US5980887A (en) 1996-11-08 1999-11-09 St. Elizabeth's Medical Center Of Boston Methods for enhancing angiogenesis with endothelial progenitor cells
AU5173598A (en) 1996-11-08 1998-06-10 Ikonos Corporation Method for coating substrates
US5749890A (en) * 1996-12-03 1998-05-12 Shaknovich; Alexander Method and system for stent placement in ostial lesions
US5753088A (en) 1997-02-18 1998-05-19 General Motors Corporation Method for making carbon nanotubes
US6258939B1 (en) 1997-03-10 2001-07-10 The Regents Of The University Of California PSCA antibodies and hybridomas producing them
US6238872B1 (en) * 1997-04-01 2001-05-29 S.E.T.-Smart Endolumenal Technologies Ltd. Targeted therapy to a biomedical device
US20020032315A1 (en) * 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
US6273913B1 (en) 1997-04-18 2001-08-14 Cordis Corporation Modified stent useful for delivery of drugs along stent strut
US6077987A (en) 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
US5880090A (en) * 1997-09-19 1999-03-09 The Hope Heart Institute Treatment of vascular graft implants with G-CSF
US6440734B1 (en) 1998-09-25 2002-08-27 Cytomatrix, Llc Methods and devices for the long-term culture of hematopoietic progenitor cells
US8257725B2 (en) * 1997-09-26 2012-09-04 Abbott Laboratories Delivery of highly lipophilic agents via medical devices
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
US5980565A (en) 1997-10-20 1999-11-09 Iowa-India Investments Company Limited Sandwich stent
DE69840671D1 (de) 1997-11-14 2009-04-30 Cedars Sinai Medical Center Transfektion und transfer nicht humaner männlicher keimzellen zur generierung transgener nicht humaner säugetiere
US20020056148A1 (en) 1997-11-14 2002-05-09 Readhead Carol W. Transfection, storage and transfer of male germ cells for generation of selectable transgenic stem cells
US6197586B1 (en) 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6468244B1 (en) 1997-12-19 2002-10-22 James E. Leone Catheter system having fullerenes and method
US20020051762A1 (en) 1998-01-23 2002-05-02 Shahin Rafii Purified populations of endothelial progenitor cells
US6541116B2 (en) 1998-01-30 2003-04-01 Advanced Cardiovascular Systems, Inc. Superoxide dismutase or superoxide dismutase mimic coating for an intracorporeal medical device
US20030125615A1 (en) 1998-02-05 2003-07-03 Yitzhack Schwartz Homing of autologous cells to a target zone in tissue using active therapeutics or substances
US6140127A (en) 1998-02-18 2000-10-31 Cordis Corporation Method of coating an intravascular stent with an endothelial cell adhesive five amino acid peptide
US6676937B1 (en) 1998-03-09 2004-01-13 Caritas St. Elizabeth's Medical Center Of Boston Inc. Compositions and methods for modulating vascularization
US6482406B1 (en) 1999-03-26 2002-11-19 Duncan J. Stewart Cell-based gene therapy for the pulmonary system
MXPA00010110A (es) 1998-04-17 2002-08-06 Angiogenix Inc Factores angiogenicos terapeuticos y metodos para su uso.
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US6153252A (en) 1998-06-30 2000-11-28 Ethicon, Inc. Process for coating stents
WO2000001410A1 (en) * 1998-07-06 2000-01-13 Beth Israel Deaconess Medical Center Methods of inhibiting proliferative diseases by inhibiting tgf-beta mediated angiogenesis
US6387663B1 (en) * 1998-07-31 2002-05-14 University Of Southern California Targeting pharmaceutical agents to injured tissues
CA2279476C (en) 1998-07-31 2011-09-27 Stemcell Technologies Inc. Novel antibody composition for isolating human cells from human-murine chimeric hematopoietic cell suspensions
JP2000086699A (ja) 1998-09-07 2000-03-28 Seikagaku Kogyo Co Ltd 細胞表面抗原cd14を認識する新規なモノクローナル抗体
US6607724B2 (en) * 1998-10-08 2003-08-19 Children's Hospital Compositions and methods for inhibiting angiogenesis
US6375680B1 (en) * 1998-12-01 2002-04-23 St. Jude Medical, Inc. Substrates for forming synthetic tissues
US7122635B2 (en) * 1999-01-06 2006-10-17 University Of Southern California Method and composition for angiogenesis inhibition
DE19903385A1 (de) 1999-01-29 2000-08-03 Max Delbrueck Centrum Mittel zur Prävention von In-Stent Restenosen und postoperativen Entzündungen
US6544541B1 (en) * 1999-06-02 2003-04-08 Cardiovascular Solutions, Inc. Devices and compounds for treating arterial restenosis
AU781470B2 (en) * 1999-06-07 2005-05-26 Baxter Aktiengesellschaft Targeted angiogenesis
US6258121B1 (en) 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US6371980B1 (en) 1999-08-30 2002-04-16 Cardiovasc, Inc. Composite expandable device with impervious polymeric covering and bioactive coating thereon, delivery apparatus and method
US6159531A (en) 1999-08-30 2000-12-12 Cardiovasc, Inc. Coating having biological activity and medical implant having surface carrying the same and method
US6503273B1 (en) * 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
WO2001065934A2 (en) * 2000-03-09 2001-09-13 Lee Walters Applications of immune system tolerance to treatment of various diseases
US20160287708A9 (en) * 2000-03-15 2016-10-06 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US9320829B2 (en) * 2000-03-15 2016-04-26 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20030229393A1 (en) * 2001-03-15 2003-12-11 Kutryk Michael J. B. Medical device with coating that promotes cell adherence and differentiation
US20070141107A1 (en) * 2000-03-15 2007-06-21 Orbusneich Medical, Inc. Progenitor Endothelial Cell Capturing with a Drug Eluting Implantable Medical Device
US9522217B2 (en) 2000-03-15 2016-12-20 Orbusneich Medical, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
US8088060B2 (en) * 2000-03-15 2012-01-03 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US8460367B2 (en) * 2000-03-15 2013-06-11 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20050271701A1 (en) 2000-03-15 2005-12-08 Orbus Medical Technologies, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
CN100506293C (zh) * 2000-03-15 2009-07-01 祥丰医疗有限公司 促进内皮细胞粘附的涂层
HUP0300810A2 (hu) * 2000-07-20 2003-08-28 M.G.V.S. Ltd. Mesterséges értranszplantátum, valamint ennek létrehozása és alkalmazása
US6607720B1 (en) 2000-09-05 2003-08-19 Yong-Fu Xiao Genetically altered mammalian embryonic stem cells, their living progeny, and their therapeutic application for improving cardiac function after myocardial infarction
US6548025B1 (en) 2000-11-08 2003-04-15 Illinois Institute Of Technology Apparatus for generating odor upon electronic signal demand
US6471980B2 (en) 2000-12-22 2002-10-29 Avantec Vascular Corporation Intravascular delivery of mycophenolic acid
US6613083B2 (en) * 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
WO2002092108A1 (en) 2001-05-11 2002-11-21 Children's Medical Center Corporation ¨ Methods for assessing antiangiogenic agents
US20030157071A1 (en) 2001-05-31 2003-08-21 Wolfe M. Michael Treatment or replacement therapy using transgenic stem cells delivered to the gut
DE10148828B4 (de) * 2001-10-04 2005-05-19 Avontec Gmbh Modulation der Expression STAT-1-abhängiger Gene
AU2002359340A1 (en) * 2001-10-31 2003-05-12 Ventrigraft Inc Methods and device compositions for the recruitment of cells to blood contacting surfaces in vivo
US7172758B2 (en) * 2002-01-29 2007-02-06 Colb A Mark Endothelialization of vascular surfaces
AUPS078002A0 (en) * 2002-02-27 2002-03-21 Unisearch Limited Dnazyme therapeutics
US20030181973A1 (en) 2002-03-20 2003-09-25 Harvinder Sahota Reduced restenosis drug containing stents
JP4136434B2 (ja) 2002-04-17 2008-08-20 進 清野 インスリン産生細胞の誘導
KR20050010827A (ko) 2002-05-20 2005-01-28 오르버스 메디칼 테크놀로지즈 인코포레이티드 약물 용리 이식성 의료 장치
EP1410812A1 (de) 2002-10-14 2004-04-21 EC (European Community) Funktionalisierung von Stents mit Lipasen
EP2198976A3 (de) * 2002-11-07 2014-08-20 Abbott Laboratories Verfahren zum Laden eines förderlichen Wirkstoffs in eine Prothese durch Flüssigkeitsstrahlanwendung
US20060223756A1 (en) * 2002-12-18 2006-10-05 Gene Liau Endothelial cell specifically binding peptides
US7186882B2 (en) * 2003-03-18 2007-03-06 Nasrin Mesaeli Transgenic mouse over-expressing calreticulin (CRT) in vascular smooth muscle cells
US20050107870A1 (en) * 2003-04-08 2005-05-19 Xingwu Wang Medical device with multiple coating layers
US20050149174A1 (en) 2003-12-18 2005-07-07 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20050187607A1 (en) * 2004-02-20 2005-08-25 Akhtar Adil J. Drug delivery device
US8431145B2 (en) * 2004-03-19 2013-04-30 Abbott Laboratories Multiple drug delivery from a balloon and a prosthesis
EP2301619B1 (de) * 2004-03-19 2017-05-10 Abbott Laboratories Abgabe mehrerer Arzneimittel aus einem Ballon und Prothese
CA2563329C (en) 2004-04-30 2016-01-26 Orbus Medical Technologies, Inc. Medical device with coating for capturing genetically-altered cells and methods for using same
CN101631513B (zh) * 2006-10-20 2013-06-05 奥巴斯尼茨医学公司 可生物吸收的聚合物组合物和医疗设备
US7959942B2 (en) * 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
US8026382B2 (en) * 2007-05-18 2011-09-27 Heidi Kay Lipid raft, caveolin protein, and caveolar function modulation compounds and associated synthetic and therapeutic methods
WO2009130296A2 (en) * 2008-04-25 2009-10-29 Morphosys Ag Anti-alk1 antibodies and uses thereof
US9217042B2 (en) * 2012-10-23 2015-12-22 Abbott Cardiovascular Systems Inc. Method of reducing MACE in diabetic patients subsequent to stent placement

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US20130035755A1 (en) 2013-02-07
US9072723B2 (en) 2015-07-07
US20070156232A1 (en) 2007-07-05
CN1418115A (zh) 2003-05-14
KR20030001378A (ko) 2003-01-06
JP5675744B2 (ja) 2015-02-25
US20020049495A1 (en) 2002-04-25
AU2001245734A1 (en) 2001-09-24
US20150352261A1 (en) 2015-12-10
US20150352263A1 (en) 2015-12-10
US7803183B2 (en) 2010-09-28
US9555166B2 (en) 2017-01-31
WO2001068158A1 (en) 2001-09-20
EP1263484B1 (de) 2007-05-16
ATE362382T1 (de) 2007-06-15
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JP2003526477A (ja) 2003-09-09
ES2283398T3 (es) 2007-11-01
US7037332B2 (en) 2006-05-02
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JP2013046771A (ja) 2013-03-07
CN100506293C (zh) 2009-07-01
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