DE60123074D1 - Modulation von gamma-secretase aktivität - Google Patents
Modulation von gamma-secretase aktivitätInfo
- Publication number
- DE60123074D1 DE60123074D1 DE60123074T DE60123074T DE60123074D1 DE 60123074 D1 DE60123074 D1 DE 60123074D1 DE 60123074 T DE60123074 T DE 60123074T DE 60123074 T DE60123074 T DE 60123074T DE 60123074 D1 DE60123074 D1 DE 60123074D1
- Authority
- DE
- Germany
- Prior art keywords
- app
- gamma
- secretase
- assay
- cells expressing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Holo Graphy (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20350600P | 2000-05-11 | 2000-05-11 | |
US203506P | 2000-05-11 | ||
PCT/US2001/015089 WO2001085924A2 (en) | 2000-05-11 | 2001-05-09 | MODULATION OF η-SECRETASE ACTIVITY |
EP01935260.8A EP1305406B2 (de) | 2000-05-11 | 2001-05-09 | Modulation von gamma-secretase aktivität |
Publications (3)
Publication Number | Publication Date |
---|---|
DE60123074D1 true DE60123074D1 (de) | 2006-10-26 |
DE60123074T2 DE60123074T2 (de) | 2007-03-01 |
DE60123074T3 DE60123074T3 (de) | 2015-01-29 |
Family
ID=22754280
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60123074.4T Expired - Lifetime DE60123074T3 (de) | 2000-05-11 | 2001-05-09 | Modulation von gamma-secretase aktivität |
Country Status (8)
Country | Link |
---|---|
US (2) | US6579689B2 (de) |
EP (1) | EP1305406B2 (de) |
JP (1) | JP2003532413A (de) |
AT (1) | ATE339496T1 (de) |
AU (1) | AU2001261368A1 (de) |
DE (1) | DE60123074T3 (de) |
DK (1) | DK1305406T4 (de) |
WO (1) | WO2001085924A2 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004505608A (ja) * | 2000-04-03 | 2004-02-26 | ブリストル−マイヤーズ スクイブ カンパニー | 機能的に活性なガンマ−セクレターゼタンパク質複合体の単離およびその活性およびインヒビターの検出法 |
US20030022251A1 (en) * | 2001-07-04 | 2003-01-30 | Boehringer Ingelheim Pharma Kg | Gamma-secretase in vitro screening assay |
WO2003057165A2 (en) * | 2002-01-04 | 2003-07-17 | The Rockefeller University | COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS |
CN1319987C (zh) * | 2002-04-24 | 2007-06-06 | 森启 | γ-分泌酶抑制剂 |
AU2006203819A1 (en) * | 2005-01-07 | 2006-07-13 | Roskamp Research Llc | Compounds for inhibiting beta-amyloid production and methods of identifying the compounds |
EP2461673A4 (de) | 2009-08-05 | 2013-08-07 | Intra Cellular Therapies Inc | Neue regulatorproteine und hemmer |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4372888A (en) † | 1980-08-26 | 1983-02-08 | The United States Of America As Represented By The Secretary Of The Department Of Health & Human Services | Nondenaturing zwitterionic detergents |
CA2191924A1 (en) * | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production |
GB9608657D0 (en) * | 1996-04-26 | 1996-07-03 | Smithkline Beecham Plc | Novel treatment |
WO1998015828A1 (en) | 1996-10-07 | 1998-04-16 | Scios Inc. | Method to identify direct inhibitors of the beta-amyloid forming enzyme gamma-secretase |
US6313268B1 (en) † | 1998-10-16 | 2001-11-06 | Vivian Y. H. Hook | Secretases related to Alzheimer's dementia |
DE19941039A1 (de) * | 1999-08-28 | 2001-03-01 | Boehringer Ingelheim Pharma | gamma-Sekretase in vitro Testsystem |
DE10000161A1 (de) * | 2000-01-06 | 2001-07-19 | Boehringer Ingelheim Pharma | Verfahren zur Identifikation eines Proteaseinhibitors |
JP2004505608A (ja) * | 2000-04-03 | 2004-02-26 | ブリストル−マイヤーズ スクイブ カンパニー | 機能的に活性なガンマ−セクレターゼタンパク質複合体の単離およびその活性およびインヒビターの検出法 |
-
2001
- 2001-05-09 US US09/852,914 patent/US6579689B2/en not_active Expired - Lifetime
- 2001-05-09 JP JP2001582513A patent/JP2003532413A/ja active Pending
- 2001-05-09 DK DK01935260.8T patent/DK1305406T4/en active
- 2001-05-09 AU AU2001261368A patent/AU2001261368A1/en not_active Abandoned
- 2001-05-09 WO PCT/US2001/015089 patent/WO2001085924A2/en active IP Right Grant
- 2001-05-09 DE DE60123074.4T patent/DE60123074T3/de not_active Expired - Lifetime
- 2001-05-09 EP EP01935260.8A patent/EP1305406B2/de not_active Expired - Lifetime
- 2001-05-09 AT AT01935260T patent/ATE339496T1/de not_active IP Right Cessation
-
2003
- 2003-06-17 US US10/464,036 patent/US20030211559A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DK1305406T4 (en) | 2015-02-02 |
WO2001085924A3 (en) | 2003-02-27 |
WO2001085924A2 (en) | 2001-11-15 |
EP1305406B2 (de) | 2014-11-12 |
DE60123074T2 (de) | 2007-03-01 |
US20010055782A1 (en) | 2001-12-27 |
DK1305406T3 (da) | 2007-01-08 |
JP2003532413A (ja) | 2003-11-05 |
AU2001261368A1 (en) | 2001-11-20 |
US20030211559A1 (en) | 2003-11-13 |
EP1305406B1 (de) | 2006-09-13 |
EP1305406A2 (de) | 2003-05-02 |
US6579689B2 (en) | 2003-06-17 |
ATE339496T1 (de) | 2006-10-15 |
DE60123074T3 (de) | 2015-01-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8363 | Opposition against the patent |