ATE437652T1 - Verwendung von hmgb1 zur aktivierung dendritischer zellen - Google Patents
Verwendung von hmgb1 zur aktivierung dendritischer zellenInfo
- Publication number
- ATE437652T1 ATE437652T1 AT02775057T AT02775057T ATE437652T1 AT E437652 T1 ATE437652 T1 AT E437652T1 AT 02775057 T AT02775057 T AT 02775057T AT 02775057 T AT02775057 T AT 02775057T AT E437652 T1 ATE437652 T1 AT E437652T1
- Authority
- AT
- Austria
- Prior art keywords
- hmgb1
- dendritic cells
- activate dendritic
- activate
- apc
- Prior art date
Links
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 title abstract 2
- 102000055207 HMGB1 Human genes 0.000 title abstract 2
- 108700010013 HMGB1 Proteins 0.000 title abstract 2
- 101150021904 HMGB1 gene Proteins 0.000 title abstract 2
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Marine Sciences & Fisheries (AREA)
- Gastroenterology & Hepatology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001MI001986A ITMI20011986A1 (it) | 2001-09-25 | 2001-09-25 | Metodo e composizione per l'attivazione di cellule presentanti l'antigene |
| PCT/IB2002/004080 WO2003026691A2 (en) | 2001-09-25 | 2002-09-25 | Use of hmgb1 for the activation of dendritic cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE437652T1 true ATE437652T1 (de) | 2009-08-15 |
Family
ID=11448420
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02775057T ATE437652T1 (de) | 2001-09-25 | 2002-09-25 | Verwendung von hmgb1 zur aktivierung dendritischer zellen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040242481A1 (de) |
| EP (1) | EP1432441B1 (de) |
| JP (1) | JP2005508913A (de) |
| AT (1) | ATE437652T1 (de) |
| AU (1) | AU2002341266B2 (de) |
| CA (1) | CA2461091A1 (de) |
| DE (1) | DE60233147D1 (de) |
| IT (1) | ITMI20011986A1 (de) |
| WO (1) | WO2003026691A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050112121A1 (en) * | 1992-04-30 | 2005-05-26 | Yale University | Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids |
| GB0226251D0 (en) * | 2002-11-11 | 2002-12-18 | San Raffaele Centro Fond | Acetylated protein |
| US8354106B2 (en) | 2005-06-16 | 2013-01-15 | The Feinstein Institute For Medical Research | Antibodies against HMGB1 and fragments thereof |
| WO2007130725A2 (en) * | 2006-02-06 | 2007-11-15 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Use of hmgb1 for protection against ischemia reperfusion injury |
| JP5308161B2 (ja) * | 2006-10-30 | 2013-10-09 | 株式会社ジェノミックス | 損傷組織の機能的再生促進医薬 |
| WO2008099913A1 (ja) * | 2007-02-15 | 2008-08-21 | Kumamoto University | ヒトhmgb-1に特異的に結合する抗体を有効成分として含有する治療剤 |
| TW200846366A (en) * | 2007-02-15 | 2008-12-01 | Univ Fukuoka | Agent for suppressing rejection in organ transplantation comprising anti-hmgb-1 antibody |
| WO2008099920A1 (ja) | 2007-02-15 | 2008-08-21 | Kyushu University, National University Corporation | 抗hmgb-1抗体を含む間質性肺疾患治療剤 |
| PT2214701T (pt) | 2007-11-01 | 2016-11-02 | Univ Guelph | Composições e métodos de potenciar respostas imunes a eimeria |
| CN102076351A (zh) * | 2008-04-30 | 2011-05-25 | 吉诺米克斯股份有限公司 | 损伤组织的功能性再生促进药物 |
| RU2519714C2 (ru) * | 2008-04-30 | 2014-06-20 | Дженомикс Ко., Лтд. | Средство для вовлечения происходящей из костного мозга плюрипотентной стволовой клетки в периферический кровоток |
| ES2654542T3 (es) | 2008-04-30 | 2018-02-14 | Genomix Co., Ltd. | Procedimiento de recolección de células funcionales in vivo con alta eficiencia |
| JP5865703B2 (ja) | 2009-10-28 | 2016-02-17 | 株式会社ジェノミックス | 骨髄間葉系および／または多能性幹細胞の血中動員による組織再生促進剤 |
| WO2011091255A1 (en) | 2010-01-21 | 2011-07-28 | The Board Of Trustees Of The University Of Arkansas | Vaccine vectors and methods of enhancing immune responses |
| MX2012010793A (es) | 2010-03-29 | 2013-05-09 | Univ Southern California | Composiciones y metodos para la eliminacion de biopeliculas. |
| CA2800830C (en) | 2010-06-09 | 2020-09-08 | The Board Of Trustees Of The University Of Arkansas | Vaccine and methods to reduce campylobacter infection |
| WO2012034090A1 (en) * | 2010-09-09 | 2012-03-15 | University Of Southern California | Compositions and methods for the removal of biofilms |
| KR101992807B1 (ko) | 2011-04-26 | 2019-06-26 | 가부시키가이샤 스템림 | 조직 재생을 유도하기 위한 펩티드 및 그의 이용 |
| US9244074B2 (en) | 2011-06-07 | 2016-01-26 | University Of Hawaii | Biomarker of asbestos exposure and mesothelioma |
| US9561274B2 (en) | 2011-06-07 | 2017-02-07 | University Of Hawaii | Treatment and prevention of cancer with HMGB1 antagonists |
| SG11201503236RA (en) | 2012-10-25 | 2015-06-29 | Genomix Co Ltd | Novel method for treating cardiac infarction using hmgb1 fragment |
| MX365899B (es) | 2012-10-25 | 2019-06-19 | Univ Osaka | Composición farmacéutica que comprende un fragmento de péptido de hmgb1 para usarse en tratamiento de daño a la medula espinal. |
| ES2758759T3 (es) | 2013-02-14 | 2020-05-06 | Univ Arkansas | Composiciones y métodos para potenciar las respuestas inmunitarias a eimeria o limitar la infección por eimeria |
| CN105142653B (zh) | 2013-03-15 | 2019-11-15 | 阿肯色大学评议会 | 增强对肠病原体免疫应答的组合物和方法 |
| US11274144B2 (en) | 2013-06-13 | 2022-03-15 | Research Institute At Nationwide Children's Hospital | Compositions and methods for the removal of biofilms |
| US9745366B2 (en) | 2013-09-23 | 2017-08-29 | University Of Southern California | Compositions and methods for the prevention of microbial infections |
| US11248040B2 (en) | 2013-09-26 | 2022-02-15 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
| US10233234B2 (en) | 2014-01-13 | 2019-03-19 | Trellis Bioscience, Llc | Binding moieties for biofilm remediation |
| HK1255383A1 (zh) | 2015-07-31 | 2019-08-16 | The Research Institute At Nationwide Children's Hospital | 去除生物膜的肽及抗體 |
| GB201600075D0 (en) | 2016-01-03 | 2016-02-17 | Glaxosmithkline Biolog Sa | Immunogenci composition |
| JP7467027B2 (ja) | 2016-05-03 | 2024-04-15 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 免疫刺激性ポリペプチドおよび抗原性ポリペプチドを含む酵母ワクチンベクター並びにそれを使用する方法 |
| WO2018047917A1 (ja) * | 2016-09-09 | 2018-03-15 | 国立大学法人 東京大学 | Ｈｍｇタンパク質と抗ｃｄ４抗体又は免疫チェックポイント制御剤との組み合わせによる相乗的抗腫瘍効果 |
| US11969459B2 (en) | 2017-01-27 | 2024-04-30 | StemRIM Inc. | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
| US11746136B2 (en) | 2017-03-15 | 2023-09-05 | Research Institute At Nationwide Children's Hospital | Composition and methods for disruption of bacterial biofilms without accompanying inflammation |
| CN111868231B (zh) | 2017-12-01 | 2024-05-31 | 斯特姆里姆有限公司 | 外胚层间充质干细胞及其产生方法 |
| JPWO2019107530A1 (ja) | 2017-12-01 | 2020-11-26 | 株式会社ステムリム | 炎症性腸疾患の治療薬 |
| WO2019156137A1 (ja) | 2018-02-08 | 2019-08-15 | 株式会社ステムリム | 乾癬の治療薬 |
| US12304933B2 (en) | 2018-10-05 | 2025-05-20 | StemRIM Inc. | Disease treatment drug based on mesenchymal-stem-cell mobilization |
| MX2021003838A (es) | 2018-10-05 | 2021-05-27 | Res Inst Nationwide Childrens Hospital | Derivados de proteina hmgb1 para la eliminacion de biopeliculas. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5214131A (en) * | 1988-05-06 | 1993-05-25 | Sumitomo Pharmaceuticals Company, Limited | Polyethylene glycol derivatives, modified peptides and production thereof |
| US5091176A (en) * | 1988-11-02 | 1992-02-25 | W. R. Grace & Co.-Conn. | Polymer-modified peptide drugs having enhanced biological and pharmacological activities |
| JPH04218000A (ja) * | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5811512A (en) * | 1991-08-22 | 1998-09-22 | The Trustees Of The University Of Pennsylvania | Non-peptide peptidomimetics and related cyclic hexapeptides |
| US5580853A (en) * | 1994-03-22 | 1996-12-03 | New England Deaconess Hospital | Modified polypeptides with increased biological activity |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| FR2739292B1 (fr) * | 1995-09-28 | 1997-10-31 | Rhone Poulenc Rorer Sa | Composition pharmaceutique utile pour la transfection d'acides nucleiques et ses utilisations |
| IT1299583B1 (it) * | 1998-05-19 | 2000-03-16 | Vander Way Limited | Uso di proteine hmg-i per la preparazione di medicamenti ad attivita' citotossica |
| US6100090A (en) * | 1999-06-25 | 2000-08-08 | Isis Pharmaceuticals Inc. | Antisense inhibition of PI3K p85 expression |
| US6303321B1 (en) * | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
-
2001
- 2001-09-25 IT IT2001MI001986A patent/ITMI20011986A1/it unknown
-
2002
- 2002-09-25 WO PCT/IB2002/004080 patent/WO2003026691A2/en not_active Ceased
- 2002-09-25 US US10/489,878 patent/US20040242481A1/en not_active Abandoned
- 2002-09-25 JP JP2003530326A patent/JP2005508913A/ja active Pending
- 2002-09-25 AT AT02775057T patent/ATE437652T1/de not_active IP Right Cessation
- 2002-09-25 AU AU2002341266A patent/AU2002341266B2/en not_active Ceased
- 2002-09-25 CA CA002461091A patent/CA2461091A1/en not_active Abandoned
- 2002-09-25 EP EP02775057A patent/EP1432441B1/de not_active Expired - Lifetime
- 2002-09-25 DE DE60233147T patent/DE60233147D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005508913A (ja) | 2005-04-07 |
| US20040242481A1 (en) | 2004-12-02 |
| WO2003026691A2 (en) | 2003-04-03 |
| EP1432441B1 (de) | 2009-07-29 |
| CA2461091A1 (en) | 2003-04-03 |
| ITMI20011986A0 (it) | 2001-09-25 |
| DE60233147D1 (de) | 2009-09-10 |
| AU2002341266B2 (en) | 2007-11-15 |
| EP1432441A2 (de) | 2004-06-30 |
| WO2003026691A3 (en) | 2003-05-30 |
| ITMI20011986A1 (it) | 2003-03-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |