DE60121928T2 - Verfahren zur herstellung von den trans-4-n-butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)-dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung - Google Patents
Verfahren zur herstellung von den trans-4-n-butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)-dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung Download PDFInfo
- Publication number
- DE60121928T2 DE60121928T2 DE60121928T DE60121928T DE60121928T2 DE 60121928 T2 DE60121928 T2 DE 60121928T2 DE 60121928 T DE60121928 T DE 60121928T DE 60121928 T DE60121928 T DE 60121928T DE 60121928 T2 DE60121928 T2 DE 60121928T2
- Authority
- DE
- Germany
- Prior art keywords
- dimethyl
- bucyclate
- compound
- hydroxy
- estrene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
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- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
- C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
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Landscapes
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- Organic Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicinal Preparation (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19353000P | 2000-03-31 | 2000-03-31 | |
| US193530P | 2000-03-31 | ||
| US19444000P | 2000-04-04 | 2000-04-04 | |
| US194440P | 2000-04-04 | ||
| PCT/US2001/010293 WO2001074839A2 (en) | 2000-03-31 | 2001-03-30 | Methods of making the 4-n-butylcyclohexanoic and the undecanoic acid esters of (7 alpha, 11 beta)-dimethyl-17 beta-hydroxy-4-estren-3-one and their medical use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60121928D1 DE60121928D1 (de) | 2006-09-14 |
| DE60121928T2 true DE60121928T2 (de) | 2007-03-01 |
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| DE60121928T Expired - Lifetime DE60121928T2 (de) | 2000-03-31 | 2001-03-30 | Verfahren zur herstellung von den trans-4-n-butylcyclohexanoicsaüre- und undecanoicsaüreestern von (7-alpha,11-beta)-dimethyl-17 beta -hydroxy-4-estren-3-one und deren medizynische anwendung |
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| EP (1) | EP1272196B1 (https=) |
| JP (1) | JP4845320B2 (https=) |
| AT (1) | ATE334682T1 (https=) |
| AU (2) | AU2001249661B2 (https=) |
| CA (1) | CA2402524C (https=) |
| DE (1) | DE60121928T2 (https=) |
| WO (1) | WO2001074839A2 (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5952319A (en) | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
| US20030069215A1 (en) * | 2001-03-30 | 2003-04-10 | The Government Of The United States Of America, | Methods of making and using 7a,11b-dimethyl-17b-hydroxy-4-estren-3-one 17b-trans-4-n-butylcyclohexane carboxylate and 7a,11b-dimethyl-17b-hydroxyestr-4-en-3-one 17-undecanoate |
| GB0025221D0 (en) * | 2000-10-14 | 2000-11-29 | Astrazeneca Ab | New process |
| AU2006211907B2 (en) * | 2005-02-04 | 2011-09-08 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Nandrolone 17beta-carbonates |
| WO2008039482A2 (en) * | 2006-09-26 | 2008-04-03 | The Regents Of The University Of California | Methods and compositions for cancer prevention and treatment |
| US9517240B2 (en) | 2006-09-26 | 2016-12-13 | The Regents Of The University Of California | Methods and compositions for cancer prevention and treatment |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10050658B2 (en) | 2014-02-24 | 2018-08-14 | National Products, Inc. | Docking sleeve with electrical adapter |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
| US9931349B2 (en) | 2016-04-01 | 2018-04-03 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
| US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
| US20230227492A1 (en) * | 2020-06-11 | 2023-07-20 | The Usa As Represented By The Secretary, Department Of Health And Human Services | Monomeric and oligomeric compound embodiments as contraceptives and therapies and methods of making and using the same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2837517A (en) * | 1955-08-08 | 1958-06-03 | Upjohn Co | 9, 11beta-epoxy-17-alkyltestosterones |
| US3160644A (en) * | 1955-08-08 | 1964-12-08 | Upjohn Co | 1-dehydro-11-keto-9alpha-fluoro-17alpha-methyl testosterones |
| US2806863A (en) * | 1956-03-19 | 1957-09-17 | Upjohn Co | 9alpha-halo-11beta, 17beta-dihydroxy-17alpha-methylandrostane-3-ones |
| US3438783A (en) * | 1965-08-16 | 1969-04-15 | Monsanto Co | Improving egg quality in poultry by orally administering androgens |
| US3577410A (en) | 1968-07-30 | 1971-05-04 | American Home Prod | 13beta-alkyl-17-hydroxygona-4,14-dien-3-ones |
| DE2031849C3 (de) | 1970-06-27 | 1978-11-16 | Bosch Gmbh Robert | Flüssigkeitsdichte Verbindung eines Deckels aus thermoplastischem Material mit einem Kasten aus thermoplastischem Material |
| ZA712312B (en) | 1970-04-28 | 1972-01-26 | Ochsner Med Found Alton | 4,14-estradiene compounds |
| IL36628A (en) | 1970-04-28 | 1978-08-31 | Ochsner Med Found Alton | 4, 14-estradiene compounds and processes for their preparation |
| ES2053714T3 (es) * | 1987-12-12 | 1994-08-01 | Akzo Nv | Proceso para la preparacion de 11-arilesteroides. |
| FR2747680B1 (fr) * | 1996-04-18 | 1998-07-03 | Roussel Uclaf | Nouveaux steroides, leur application a titre de medicaments, leur procede de preparation, les intermediaires de ce procede et les compositions pharmaceutiques les renfermant |
| DE19619045C1 (de) | 1996-05-02 | 1997-11-13 | Jenapharm Gmbh | Verwendung von Kombinationspräparaten zur Behandlung hypogonadaler Männer sowie Männern mit Hypophysenerkrankungen |
| US5952319A (en) * | 1997-11-26 | 1999-09-14 | Research Triangle Institute | Androgenic steroid compounds and a method of making and using the same |
| TW548277B (en) | 1999-07-16 | 2003-08-21 | Akzo Nobel Nv | Orally active androgens |
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2001
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- 2001-03-30 AU AU2001249661A patent/AU2001249661B2/en not_active Ceased
- 2001-03-30 AU AU4966101A patent/AU4966101A/xx active Pending
- 2001-03-30 WO PCT/US2001/010293 patent/WO2001074839A2/en not_active Ceased
- 2001-03-30 CA CA002402524A patent/CA2402524C/en not_active Expired - Lifetime
- 2001-03-30 DE DE60121928T patent/DE60121928T2/de not_active Expired - Lifetime
- 2001-03-30 JP JP2001572528A patent/JP4845320B2/ja not_active Expired - Fee Related
- 2001-03-30 EP EP01922911A patent/EP1272196B1/en not_active Expired - Lifetime
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Also Published As
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|---|---|
| AU2001249661B2 (en) | 2005-02-17 |
| WO2001074839A2 (en) | 2001-10-11 |
| EP1272196A2 (en) | 2003-01-08 |
| CA2402524A1 (en) | 2001-10-11 |
| JP4845320B2 (ja) | 2011-12-28 |
| WO2001074839A3 (en) | 2002-06-13 |
| CA2402524C (en) | 2009-11-17 |
| US20030130243A1 (en) | 2003-07-10 |
| JP2003531119A (ja) | 2003-10-21 |
| ATE334682T1 (de) | 2006-08-15 |
| DE60121928D1 (de) | 2006-09-14 |
| AU4966101A (en) | 2001-10-15 |
| US7196074B2 (en) | 2007-03-27 |
| EP1272196B1 (en) | 2006-08-02 |
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