DE60117858D1 - Zusammensetzung zur behandlung von entzündlichen erkrankungen - Google Patents

Zusammensetzung zur behandlung von entzündlichen erkrankungen

Info

Publication number
DE60117858D1
DE60117858D1 DE60117858T DE60117858T DE60117858D1 DE 60117858 D1 DE60117858 D1 DE 60117858D1 DE 60117858 T DE60117858 T DE 60117858T DE 60117858 T DE60117858 T DE 60117858T DE 60117858 D1 DE60117858 D1 DE 60117858D1
Authority
DE
Germany
Prior art keywords
vesicle
treatment
composition
inflammatory diseases
mole percent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60117858T
Other languages
English (en)
Other versions
DE60117858T2 (de
Inventor
Marca Henriette Michael Wauben
Josbert Maarten Metselaar
Gerrit Storm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enceladus Pharmaceuticals BV
Original Assignee
Universiteit Utrecht Holding Bv Utrecht
Universiteit Utrecht Holding BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universiteit Utrecht Holding Bv Utrecht, Universiteit Utrecht Holding BV filed Critical Universiteit Utrecht Holding Bv Utrecht
Publication of DE60117858D1 publication Critical patent/DE60117858D1/de
Application granted granted Critical
Publication of DE60117858T2 publication Critical patent/DE60117858T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/797—Lipid particle
    • Y10S977/798—Lipid particle having internalized material
    • Y10S977/799—Containing biological material
    • Y10S977/801—Drug
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60117858T 2000-12-07 2001-12-07 Zusammensetzung zur behandlung von entzündlichen erkrankungen Expired - Lifetime DE60117858T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00204372 2000-12-07
EP00204372 2000-12-07
PCT/EP2001/014633 WO2002045688A2 (en) 2000-12-07 2001-12-07 Composition for treatment of inflammatory disorders

Publications (2)

Publication Number Publication Date
DE60117858D1 true DE60117858D1 (de) 2006-05-04
DE60117858T2 DE60117858T2 (de) 2006-11-30

Family

ID=8172392

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60117858T Expired - Lifetime DE60117858T2 (de) 2000-12-07 2001-12-07 Zusammensetzung zur behandlung von entzündlichen erkrankungen

Country Status (11)

Country Link
US (1) US7955618B2 (de)
EP (1) EP1347743B1 (de)
JP (1) JP4623931B2 (de)
AT (1) ATE319428T1 (de)
AU (2) AU3169702A (de)
CA (1) CA2430897C (de)
DE (1) DE60117858T2 (de)
DK (1) DK1347743T3 (de)
ES (1) ES2260321T3 (de)
PT (1) PT1347743E (de)
WO (1) WO2002045688A2 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1347743T3 (da) 2000-12-07 2006-07-03 Univ Utrecht Holding Bv Præparat til behandling af inflammatoriske lidelser
US7635463B2 (en) * 2002-02-27 2009-12-22 Pharmain Corporation Compositions for delivery of therapeutics and other materials
EP1371362A1 (de) * 2002-06-12 2003-12-17 Universiteit Utrecht Holding B.V. Zusammensetzung zur Behandlung entzündlicher Erkrankungen
EP1393720A1 (de) * 2002-08-27 2004-03-03 Universiteit Utrecht Vesikel enthaltend Corticosteroide zur Behandlung von Krebs
WO2005011633A1 (ja) * 2003-08-01 2005-02-10 National Institute Of Advanced Industrial Science And Technology 標的指向性リポソームを含む炎症性疾患治療薬または診断薬
US20050255154A1 (en) 2004-05-11 2005-11-17 Lena Pereswetoff-Morath Method and composition for treating rhinitis
JP2008512445A (ja) 2004-09-09 2008-04-24 イッスム・リサーチ・ディベロップメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシティ・オブ・エルサレム 炎症状態の治療のためのリポソーム性グルココルチコイドの使用
ES2384641T3 (es) 2005-07-14 2012-07-10 Lithera, Inc. Formulación lipolítica que potencia la liberación mantenida para el tratamiento localizado del tejido adiposo
JP2010506941A (ja) * 2006-10-17 2010-03-04 リセラ，インク． 甲状腺眼症の治療のための方法、組成物及び製剤
US20090155207A1 (en) * 2007-11-29 2009-06-18 Hariri Robert J Use of Immunomodulatory Compounds for the Treatment of Transverse Myelitis, Multiple Sclerosis, and Other Disorders
EP2127639A1 (de) * 2008-05-26 2009-12-02 Universiteit Utrecht Holding B.V. Corticosteroid enthaltende Liposomen zur Behandlung von kardiovaskulären Erkrankungen
US20100016265A1 (en) * 2008-07-16 2010-01-21 Qaiser Yusuf Anti-inflammatory composition and method for preparation
US9132084B2 (en) * 2009-05-27 2015-09-15 Neothetics, Inc. Methods for administration and formulations for the treatment of regional adipose tissue
KR20120113267A (ko) * 2010-01-15 2012-10-12 리쎄라 인코오포레이티드 동결건조 케이크 제제
EA201270784A1 (ru) 2010-11-24 2013-04-30 ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НоваМедика" Монотерапевтические композиции селективного липофильного и бета-агониста длительного действия и способы косметического лечения ожирения и контурного выпячивания
TR201818978T4 (tr) 2011-11-04 2019-01-21 Enceladus Pharmaceuticals B V İnsanlardaki İnflamatuvar Rahatsızlıkların Tedavisine Yönelik Lipozomal Kortikosteroidler
US9186326B2 (en) * 2014-07-21 2015-11-17 Kimia Zist Parsian (Kzp) Method and system for synthesizing nanocarrier based long acting drug delivery system for dexamethasone
CA2997286A1 (en) * 2015-09-14 2017-03-23 Vgsk Technologies, Inc. A sterically stabilized carrier for subcutaneous, sublingual and oral therapeutics, compositions and methods for treating a mammal
WO2017188818A1 (en) 2016-04-29 2017-11-02 Enceladus Pharmaceuticals B.V. Liposomal corticosteroids for topical injection in inflamed lesions or areas

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002185A (en) * 1930-06-26 1935-05-21 Prosperity Co Inc Garment or ironing press
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
US4522803A (en) * 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4994443A (en) * 1982-12-20 1991-02-19 The Children's Medical Center Corporation Inhibition of angiogenesis
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
IL79114A (en) 1985-08-07 1990-09-17 Allergan Pharma Method and composition for making liposomes
DE3542773A1 (de) * 1985-12-04 1987-06-11 Roehm Pharma Gmbh Hautwirksame pharmaka mit liposomen als wirkstofftraeger
US4818537A (en) * 1986-10-21 1989-04-04 Liposome Technology, Inc. Liposome composition for treating dry eye
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US5139803A (en) * 1989-02-09 1992-08-18 Nabisco, Inc. Method and liposome composition for the stabilization of oxidizable substances
FR2648462B1 (fr) * 1989-06-15 1994-01-28 Oreal Procede pour ameliorer l'efficacite therapeutique de corticosteroides liposolubles et composition pour la mise en oeuvre de ce procede
US5356633A (en) * 1989-10-20 1994-10-18 Liposome Technology, Inc. Method of treatment of inflamed tissues
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
US5989586A (en) 1992-10-05 1999-11-23 Cygnus, Inc. Two-phase matrix for sustained release drug delivery device
CA2120197A1 (en) 1993-04-02 1994-10-03 Kenji Endo Stable aqueous dispersions containing liposomes
JPH07316040A (ja) * 1994-03-29 1995-12-05 Res Dev Corp Of Japan 再構成リポソームと物質導入方法
US5786344A (en) * 1994-07-05 1998-07-28 Arch Development Corporation Camptothecin drug combinations and methods with reduced side effects
JPH08198777A (ja) * 1995-01-25 1996-08-06 Taisho Pharmaceut Co Ltd 注射用脂肪乳剤
KR100506958B1 (ko) * 1995-12-15 2005-10-27 코닌클리케 필립스 일렉트로닉스 엔.브이. 액정디스플레이 장치
JPH09278672A (ja) * 1996-04-12 1997-10-28 Green Cross Corp:The 薬物含有脂肪乳剤
DK0850646T3 (da) * 1996-06-18 2008-05-13 Kyowa Hakko Kogyo Kk Liposompræparater af indolocarbazol-derivater
DK0929293T3 (da) * 1996-08-23 2004-02-02 Sequus Pharm Inc Liposomer indeholdende en cisplatinforbindelse
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6120751A (en) * 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US5758659A (en) 1997-03-26 1998-06-02 Thompson; Robert B. Wound tab condom and method of application
US20020159951A1 (en) 1997-05-06 2002-10-31 Unger Evan C. Novel targeted compositions for diagnostic and therapeutic use
WO1998050041A1 (en) 1997-05-06 1998-11-12 Imarx Pharmaceutical Corp. Novel prodrugs comprising fluorinated amphiphiles
US6506783B1 (en) * 1997-05-16 2003-01-14 The Procter & Gamble Company Cancer treatments and pharmaceutical compositions therefor
US6316260B1 (en) * 1997-08-22 2001-11-13 Bernina Biosystems Gmbh Tetraether lipid derivatives and liposomes and lipid agglomerates containing tetraether lipid derivatives, and use thereof
WO2000025748A1 (fr) * 1998-11-02 2000-05-11 Terumo Kabushiki Kaisha Liposomes
CZ20012038A3 (cs) 1998-12-23 2001-09-12 Idea Ag Zdokonalený přípravek pro topické, neinvazivní použití in vivo
US6270806B1 (en) * 1999-03-03 2001-08-07 Elan Pharma International Limited Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions
WO2001000174A1 (fr) 1999-06-25 2001-01-04 Terumo Kabushiki Kaisha Liposomes
ATE317869T1 (de) * 1999-07-14 2006-03-15 Alza Corp Neutrales lipopolymer und liposomale zusammensetzungen daraus
EP1072617A1 (de) 1999-07-30 2001-01-31 Universiteit van Utrecht Temperaturempfindliche Polymere
US6511676B1 (en) * 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
US20030050236A1 (en) * 2000-08-15 2003-03-13 The University Of Chicago Compounds that enhance tumor death
TWI230616B (en) * 2000-09-25 2005-04-11 Ind Tech Res Inst Liposome for incorporating large amounts of hydrophobic substances
DK1347743T3 (da) 2000-12-07 2006-07-03 Univ Utrecht Holding Bv Præparat til behandling af inflammatoriske lidelser
EP1371362A1 (de) 2002-06-12 2003-12-17 Universiteit Utrecht Holding B.V. Zusammensetzung zur Behandlung entzündlicher Erkrankungen
US20050152962A1 (en) * 2002-06-12 2005-07-14 Metselaar Josbert M. Composition for treatment of inflammatory disorders
EP1393720A1 (de) 2002-08-27 2004-03-03 Universiteit Utrecht Vesikel enthaltend Corticosteroide zur Behandlung von Krebs

Also Published As

Publication number Publication date
EP1347743A2 (de) 2003-10-01
WO2002045688A3 (en) 2002-11-14
CA2430897A1 (en) 2002-06-13
DK1347743T3 (da) 2006-07-03
PT1347743E (pt) 2006-06-30
ES2260321T3 (es) 2006-11-01
JP4623931B2 (ja) 2011-02-02
WO2002045688A2 (en) 2002-06-13
US20040037875A1 (en) 2004-02-26
ATE319428T1 (de) 2006-03-15
JP2004517835A (ja) 2004-06-17
CA2430897C (en) 2010-11-16
AU2002231697B2 (en) 2006-09-07
EP1347743B1 (de) 2006-03-08
US7955618B2 (en) 2011-06-07
AU3169702A (en) 2002-06-18
DE60117858T2 (de) 2006-11-30

Similar Documents

Publication Publication Date Title
ATE319428T1 (de) Zusammensetzung zur behandlung von entzündlichen erkrankungen
ATE406873T1 (de) Zusammensetzung zur behandlung entzündlicher erkrankungen
Dokka et al. Oxygen radical-mediated pulmonary toxicity induced by some cationic liposomes
FI971494A (fi) Eetterilipidiloposomit sekä niiden terapeuttinen käyttö
DE69033856D1 (de) Verabreichungssystem für phospholipide
AU2003258686A1 (en) Vesicle-encapsulated corticosteroids for the treatment of cancer
ATE337019T1 (de) Geladene lipide und deren verwendung
ES2173420T3 (es) Comprimidos que contienen un antibiotico de beta-lactamico y procedimiento para su produccion.
AU2003304237A1 (en) Gel-stabilized nanoparticulate active agent compositions
AR015919A1 (es) Formas de dosificacion de liberacion sostenida de sertralina, sales de sertralina ,composicion farmaceutica, procedimiento depreparacion y su uso en terapias.
TR200101307T2 (tr) Antranilik asit amidler ve ilaç olarak kullanılmaları.
PT850046E (pt) Microemulsoes para utilizacao como veiculos para administracao de compostos activos
ATE152614T1 (de) Mittel zur behandlung entzündeter gewebe
NO980047D0 (no) Blanding for tildeling av et polart medikament i kolon
CR7936A (es) Formulaciones parenterales de un peptido para el tratamiento de lupus sitemico eritematoso
FI956014A (fi) Nona- ja dekapeptidien käyttö lääkkeen valmistamiseksi AIDS-sairauden hoitoon
DK0873351T3 (da) Steroidnitrit/nitratesterderivater anvendelige som antiinflammatoriske lægemidler
SE9704833D0 (sv) New formulation
ATE310512T1 (de) Verwendung von lipoxinen zur inhibierung von tnf- alpha initiierter gegenreaktion
EA200300110A1 (ru) Композиция элетриптана в виде частиц
BR9712329A (pt) Veículos contendo um éter lipídio/combinação de lipídio formado complementarmente e os usos terapêuticos dos mesmos
ES8707111A1 (es) Procedimiento para obtencion de un preparado farmaceutico para tratamiento terapeutico de enfermedades reumaticas.
ES2084348T3 (es) N-((4,5-dihidroxi- y 4,5,8-trihidroxi-9,10-dihidro-9,10-dioxo-2-antracen-il)carbonil)aminoacidos utiles en la terapia de afecciones osteoarticulares.
GEP20053512B (en) S-Methyl-Dihydro-Ziprasidone for Treatment of Psychiatric and Ocular Disorders.
YU24603A (sh) Novi farmaceutski preparati koji sadrže epinastin i pseudoefedrin

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ENCELADUS PHARMACEUTICALS B.V., AMSTERDAM, NL