DE60115863T3 - Beta 1, 2-xylosyltransferase gen aus arabidopsis - Google Patents

Beta 1, 2-xylosyltransferase gen aus arabidopsis Download PDF

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Publication number
DE60115863T3
DE60115863T3 DE60115863.6T DE60115863T DE60115863T3 DE 60115863 T3 DE60115863 T3 DE 60115863T3 DE 60115863 T DE60115863 T DE 60115863T DE 60115863 T3 DE60115863 T3 DE 60115863T3
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Prior art keywords
xylosyltransferase
sequence
plant
dna
seq
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Expired - Lifetime
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DE60115863.6T
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German (de)
English (en)
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DE60115863T2 (de
DE60115863D1 (de
Inventor
Josef Glössl
Richard Strasser
Jan Mucha
Lukas Mach
Friedrich Altmann
Iain WILSON
Herta Steinkellner
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Publication of DE60115863D1 publication Critical patent/DE60115863D1/de
Publication of DE60115863T2 publication Critical patent/DE60115863T2/de
Publication of DE60115863T3 publication Critical patent/DE60115863T3/de
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/005Glycopeptides, glycoproteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1077Pentosyltransferases (2.4.2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y204/00Glycosyltransferases (2.4)
    • C12Y204/02Pentosyltransferases (2.4.2)
    • C12Y204/02038Glycoprotein 2-beta-D-xylosyltransferase (2.4.2.38)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024Alpha-mannosidase (3.2.1.24)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105Alpha-N-acetylglucosaminidase (3.2.1.50)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y302/00Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01052Beta-N-acetylhexosaminidase (3.2.1.52)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60115863.6T 2000-03-03 2001-03-02 Beta 1, 2-xylosyltransferase gen aus arabidopsis Expired - Lifetime DE60115863T3 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AT0035500A AT409381B (de) 2000-03-03 2000-03-03 Xylosyltransferase-gen
AT3552000 2000-03-03
PCT/EP2001/002352 WO2001064901A1 (en) 2000-03-03 2001-03-02 Beta 1, 2-xylosyltransferase-gene from arabidopsis
EP01919367.1A EP1263968B2 (en) 2000-03-03 2001-03-02 Beta 1, 2-xylosyltransferase-gene from arabidopsis

Publications (3)

Publication Number Publication Date
DE60115863D1 DE60115863D1 (de) 2006-01-19
DE60115863T2 DE60115863T2 (de) 2006-08-10
DE60115863T3 true DE60115863T3 (de) 2015-01-22

Family

ID=3672559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60115863.6T Expired - Lifetime DE60115863T3 (de) 2000-03-03 2001-03-02 Beta 1, 2-xylosyltransferase gen aus arabidopsis

Country Status (12)

Country Link
US (3) US7205137B2 (enExample)
EP (2) EP1263968B2 (enExample)
JP (2) JP5279976B2 (enExample)
KR (5) KR20090101981A (enExample)
AT (2) AT409381B (enExample)
AU (1) AU781010B2 (enExample)
CA (1) CA2402015C (enExample)
DE (1) DE60115863T3 (enExample)
DK (2) DK1263968T4 (enExample)
ES (2) ES2252208T5 (enExample)
PT (1) PT1621633E (enExample)
WO (1) WO2001064901A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1137789T3 (da) 1998-12-09 2010-11-08 Phyton Holdings Llc Fremgangsmåde til fremstilling af et glycoprotein med glycosylering af human type
DK1772518T3 (da) 1999-10-26 2010-11-22 Stichting Dienst Landbouwkundi Pattedyrsagtig glykosylering i planter
US20040214273A1 (en) 2001-01-19 2004-10-28 Kazuhito Fujiyama Method for secretory production of glycoprotein having human-type sugar chain using plant cell
WO2003078614A2 (en) 2002-03-19 2003-09-25 Plant Research International B.V. Gntiii (udp-n-acethylglucosamine:beta-d mannoside beta (1,4)-n-acethylglucosaminy ltransferase iii) expression in plants
KR101060361B1 (ko) 2002-03-19 2011-08-29 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서 글리칸 프로세싱의 최적화
AR042145A1 (es) 2002-11-27 2005-06-08 Dow Agrociences Llc Produccion de inmunoglobulinas en plantas con una fucocilacion reducida
ATE426033T1 (de) 2003-08-11 2009-04-15 Greenovation Biotech Gmbh Promoter sequenzen aus moos und dessen verwendung
DK1974040T3 (da) 2006-01-17 2012-12-17 Synthon Biopharmaceuticals Bv Sammensætninger og fremgangsmåder til humanisering og optimering af N-glycanet i planter.
US20090060921A1 (en) * 2006-01-17 2009-03-05 Biolex Therapeutics, Inc. Glycan-optimized anti-cd20 antibodies
JP2009529898A (ja) * 2006-03-23 2009-08-27 バイエル・バイオサイエンス・エヌ・ヴェー Nicotianaβ−1,2−キシロシルトランスフェラーゼをコードする新規なヌクレオチド配列
CN104195166B (zh) 2007-04-17 2017-01-11 基金会农业研究服务中心 植物通过表达非哺乳动物糖基转移酶而表现出哺乳动物类型的糖基化作用
BRPI0814244B1 (pt) 2007-06-07 2018-10-09 Agriculture And Agri Food Canada método para obtenção de uma planta geneticamente engenheirada
EP2789686A1 (en) 2013-04-11 2014-10-15 Greenovation Biotech GmbH Expression of phosphorylated glycoproteins in plants
JP6934666B2 (ja) * 2018-01-18 2021-09-15 国立研究開発法人産業技術総合研究所 植物細胞においてキシロース修飾タンパク質を製造する方法、コアオリゴ糖修飾タンパク質を製造する方法、及びプロテオグリカンを製造する方法
EP3871687A1 (en) 2020-02-27 2021-09-01 eleva GmbH Enzyme replacement therapy for treating pompe disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0858467B1 (en) * 1995-11-23 2004-02-11 Cancer Research Campaign Technology Limited Materials and methods relating to the identification and sequencing of the brca2 cancer susceptibility gene and uses thereof
WO1999029835A1 (en) * 1997-12-08 1999-06-17 Board Of Trustees Of The University Of Arkansas PURIFIED β1,2-XYLOSYLTRANSFERASE AND USES THEREOF
DE19754622A1 (de) 1997-12-09 1999-06-10 Antje Von Dr Schaewen Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität
DE69830074D1 (de) * 1997-12-19 2005-06-09 Upjohn Co Humane sel-10 polypeptiden und dafur kodierende polynukleotiden
US6207811B1 (en) * 1998-03-18 2001-03-27 Karl Tryggvason Nephrin gene and protein
CA2339409A1 (en) * 1998-08-11 2000-02-24 Darwin Discovery Ltd. Identification of the gene causing the mouse scurfy phenotype and its human ortholog
EP1033405A3 (en) * 1999-02-25 2001-08-01 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
CA2388432A1 (en) 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants

Also Published As

Publication number Publication date
KR100859919B1 (ko) 2008-09-23
CA2402015C (en) 2012-07-17
US7205137B2 (en) 2007-04-17
US20040121325A1 (en) 2004-06-24
ES2252208T3 (es) 2006-05-16
CA2402015A1 (en) 2001-09-07
JP2013116113A (ja) 2013-06-13
KR20070058018A (ko) 2007-06-07
EP1621633A3 (en) 2006-02-08
AU4649501A (en) 2001-09-12
EP1263968A1 (en) 2002-12-11
EP1263968B2 (en) 2014-09-10
ATA3552000A (de) 2001-12-15
AU781010B2 (en) 2005-04-28
KR101185123B1 (ko) 2012-09-21
US20070186311A1 (en) 2007-08-09
EP1621633B1 (en) 2014-04-16
JP5279976B2 (ja) 2013-09-04
ATE312931T1 (de) 2005-12-15
EP1263968B1 (en) 2005-12-14
DE60115863T2 (de) 2006-08-10
WO2001064901A1 (en) 2001-09-07
EP1621633A2 (en) 2006-02-01
KR20090101981A (ko) 2009-09-29
US20120331578A1 (en) 2012-12-27
PT1621633E (pt) 2014-07-18
AT409381B (de) 2002-07-25
KR20030030987A (ko) 2003-04-18
ES2460672T3 (es) 2014-05-14
KR20080077296A (ko) 2008-08-21
DK1621633T3 (da) 2014-05-19
DK1263968T3 (da) 2006-05-01
KR20100119005A (ko) 2010-11-08
DK1263968T4 (da) 2014-11-03
ES2252208T5 (es) 2014-11-04
DE60115863D1 (de) 2006-01-19
JP2004500096A (ja) 2004-01-08
KR100861437B1 (ko) 2008-10-02

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