PT1621633E - Glicoproteínas produzidas em plantas com supressão da expressão de beta 1,2-xilosiltransferase - Google Patents

Glicoproteínas produzidas em plantas com supressão da expressão de beta 1,2-xilosiltransferase Download PDF

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Publication number
PT1621633E
PT1621633E PT51080141T PT05108014T PT1621633E PT 1621633 E PT1621633 E PT 1621633E PT 51080141 T PT51080141 T PT 51080141T PT 05108014 T PT05108014 T PT 05108014T PT 1621633 E PT1621633 E PT 1621633E
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PT
Portugal
Prior art keywords
plants
xylosyltransferase
beta
glycoproteins produced
suppressed expression
Prior art date
Application number
PT51080141T
Other languages
English (en)
Inventor
Friedrich Altmann
Josef Glössl
Richard Strasser
Jan Mucha
Lukas Mach
Iain B Wilson
Herta Steinkellner
Original Assignee
Josef Glossl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3672559&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1621633(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Josef Glossl filed Critical Josef Glossl
Publication of PT1621633E publication Critical patent/PT1621633E/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1077—Pentosyltransferases (2.4.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/02—Pentosyltransferases (2.4.2)
    • C12Y204/02038—Glycoprotein 2-beta-D-xylosyltransferase (2.4.2.38)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01024—Alpha-mannosidase (3.2.1.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/0105—Alpha-N-acetylglucosaminidase (3.2.1.50)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01052—Beta-N-acetylhexosaminidase (3.2.1.52)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
PT51080141T 2000-03-03 2001-03-02 Glicoproteínas produzidas em plantas com supressão da expressão de beta 1,2-xilosiltransferase PT1621633E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0035500A AT409381B (de) 2000-03-03 2000-03-03 Xylosyltransferase-gen

Publications (1)

Publication Number Publication Date
PT1621633E true PT1621633E (pt) 2014-07-18

Family

ID=3672559

Family Applications (1)

Application Number Title Priority Date Filing Date
PT51080141T PT1621633E (pt) 2000-03-03 2001-03-02 Glicoproteínas produzidas em plantas com supressão da expressão de beta 1,2-xilosiltransferase

Country Status (12)

Country Link
US (3) US7205137B2 (pt)
EP (2) EP1621633B1 (pt)
JP (2) JP5279976B2 (pt)
KR (5) KR101185123B1 (pt)
AT (2) AT409381B (pt)
AU (1) AU781010B2 (pt)
CA (1) CA2402015C (pt)
DE (1) DE60115863T3 (pt)
DK (2) DK1263968T4 (pt)
ES (2) ES2252208T5 (pt)
PT (1) PT1621633E (pt)
WO (1) WO2001064901A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU771908C (en) 1998-12-09 2005-03-10 Phyton Holdings, Llc A method for manufacturing glycoproteins having human-type glycosylation
IL149271A0 (en) 1999-10-26 2002-11-10 Plant Res Int Bv Mammalian-type glycosylation in plants
ZA200306406B (en) 2001-01-19 2004-09-06 Dow Chemical Co Method for secretory production of glycoprotein having human-type sugar chain using plant cell.
KR101196023B1 (ko) 2002-03-19 2012-10-30 스티칭 디엔스트 랜드보위쿤디그 온데조에크 식물에서 글리칸 프로세싱의 최적화
NZ534881A (en) 2002-03-19 2006-09-29 Plant Res Internat B Mammalian GnTIII expression in plants
CL2003002461A1 (es) 2002-11-27 2005-01-07 Dow Chemical Company Agroscien Inmunoglobulina que comprende al menos un glicano afucosilado, composicion que la contiene, secuencia nucleotidica y vector que la comprende, procedimiento para producir dicha inmunoglobulina en plantas.
EP1510584B1 (en) 2003-08-11 2009-03-18 Greenovation Biotech GmbH Expression promoting sequences from mosses and their uses
AU2007205935B2 (en) * 2006-01-17 2013-07-11 Synthon Biopharmaceuticals B.V. Compositions and methods for humanization and optimization of N-glycans in plants
US20090060921A1 (en) * 2006-01-17 2009-03-05 Biolex Therapeutics, Inc. Glycan-optimized anti-cd20 antibodies
BRPI0709202A2 (pt) * 2006-03-23 2011-06-28 Bayer Bioscience Nv seqüências de nucleotìdeo que codificam nicotiana beta-1,2-xilosiltransferase
AU2008237632B2 (en) 2007-04-17 2014-01-16 Stichting Dienst Landbouwkundig Onderzoek Mammalian-type glycosylation in plants by expression of non-mammalian glycosyltransferases
BRPI0814244B1 (pt) 2007-06-07 2018-10-09 Agriculture And Agri Food Canada método para obtenção de uma planta geneticamente engenheirada
EP2789686A1 (en) 2013-04-11 2014-10-15 Greenovation Biotech GmbH Expression of phosphorylated glycoproteins in plants
JP6934666B2 (ja) * 2018-01-18 2021-09-15 国立研究開発法人産業技術総合研究所 植物細胞においてキシロース修飾タンパク質を製造する方法、コアオリゴ糖修飾タンパク質を製造する方法、及びプロテオグリカンを製造する方法
EP3871687A1 (en) 2020-02-27 2021-09-01 eleva GmbH Enzyme replacement therapy for treating pompe disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001507563A (ja) * 1995-11-23 2001-06-12 キャンサー リサーチ キャンペーン テクノロジー リミテッド Ｂｒｃａ２癌感受性遺伝子の同定及び配列決定に関する材料及び方法並びにそれらの使用
AU1808699A (en) * 1997-12-08 1999-06-28 Board Of Trustees Of The University Of Arkansas, The Purified beta1,2-xylosyltransferase and uses thereof
DE19754622A1 (de) * 1997-12-09 1999-06-10 Antje Von Dr Schaewen Pflanzliche GntI-Sequenzen und Verwendung derselben zur Gewinnung von Pflanzen mit verminderter oder fehlender N-Acetylglucosaminyltransferase I (GnTI)-Aktivität
EP1037990B8 (en) * 1997-12-19 2005-06-29 Pharmacia & Upjohn Company LLC Human sel-10 polypeptides and polynucleotides that encode them
US6207811B1 (en) * 1998-03-18 2001-03-27 Karl Tryggvason Nephrin gene and protein
JP4351807B2 (ja) * 1998-08-11 2009-10-28 ダーウィン・ディスカバリー・リミテッド マウスのｓｃｕｒｆｙの表現型を引き起こす遺伝子およびそのヒトのオルソログの同定
EP1033405A3 (en) 1999-02-25 2001-08-01 Ceres Incorporated Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
WO2001029242A2 (en) * 1999-10-21 2001-04-26 Monsanto Company Post-translational modification of recombinant proteins produced in plants

Also Published As

Publication number Publication date
KR101185123B1 (ko) 2012-09-21
ATA3552000A (de) 2001-12-15
KR100859919B1 (ko) 2008-09-23
ES2252208T5 (es) 2014-11-04
KR20030030987A (ko) 2003-04-18
KR100861437B1 (ko) 2008-10-02
AU781010B2 (en) 2005-04-28
JP2013116113A (ja) 2013-06-13
KR20080077296A (ko) 2008-08-21
ES2460672T3 (es) 2014-05-14
EP1263968A1 (en) 2002-12-11
JP5279976B2 (ja) 2013-09-04
AT409381B (de) 2002-07-25
KR20100119005A (ko) 2010-11-08
DE60115863T2 (de) 2006-08-10
EP1263968B1 (en) 2005-12-14
CA2402015A1 (en) 2001-09-07
US20040121325A1 (en) 2004-06-24
US7205137B2 (en) 2007-04-17
EP1621633A2 (en) 2006-02-01
US20070186311A1 (en) 2007-08-09
EP1621633B1 (en) 2014-04-16
CA2402015C (en) 2012-07-17
DK1263968T3 (da) 2006-05-01
ATE312931T1 (de) 2005-12-15
DE60115863D1 (de) 2006-01-19
ES2252208T3 (es) 2006-05-16
EP1621633A3 (en) 2006-02-08
WO2001064901A1 (en) 2001-09-07
KR20070058018A (ko) 2007-06-07
US20120331578A1 (en) 2012-12-27
EP1263968B2 (en) 2014-09-10
DK1621633T3 (da) 2014-05-19
KR20090101981A (ko) 2009-09-29
DK1263968T4 (da) 2014-11-03
DE60115863T3 (de) 2015-01-22
JP2004500096A (ja) 2004-01-08
AU4649501A (en) 2001-09-12

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