DE60103431D1 - Ein Verfahren zur chromatographischen Isolierung von Isomeren des Vitamins E - Google Patents

Ein Verfahren zur chromatographischen Isolierung von Isomeren des Vitamins E

Info

Publication number
DE60103431D1
DE60103431D1 DE60103431T DE60103431T DE60103431D1 DE 60103431 D1 DE60103431 D1 DE 60103431D1 DE 60103431 T DE60103431 T DE 60103431T DE 60103431 T DE60103431 T DE 60103431T DE 60103431 D1 DE60103431 D1 DE 60103431D1
Authority
DE
Germany
Prior art keywords
isomers
vitamin
chromatographic isolation
chromatographic
isolation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60103431T
Other languages
English (en)
Other versions
DE60103431T2 (de
Inventor
Choo Yuen May
Ma Ah Ngan
Yusof Basiron
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Palm Oil Research and Development Board
Original Assignee
Palm Oil Research and Development Board
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Palm Oil Research and Development Board filed Critical Palm Oil Research and Development Board
Application granted granted Critical
Publication of DE60103431D1 publication Critical patent/DE60103431D1/de
Publication of DE60103431T2 publication Critical patent/DE60103431T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/283—Porous sorbents based on silica
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/40—Selective adsorption, e.g. chromatography characterised by the separation mechanism using supercritical fluid as mobile phase or eluent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/287—Non-polar phases; Reversed phases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6
    • C07D311/72—3,4-Dihydro derivatives having in position 2 at least one methyl radical and in position 6 one oxygen atom, e.g. tocopherols
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/54—Improvements relating to the production of bulk chemicals using solvents, e.g. supercritical solvents or ionic liquids
DE60103431T 2000-02-02 2001-02-02 Ein Verfahren zur chromatographischen Isolierung von Isomeren des Vitamins E Expired - Lifetime DE60103431T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
MY0000368 2000-02-02
MYPI20000368A MY127451A (en) 1999-11-04 2000-02-02 A method of chromatographic isolation for vitamin e isomers

Publications (2)

Publication Number Publication Date
DE60103431D1 true DE60103431D1 (de) 2004-07-01
DE60103431T2 DE60103431T2 (de) 2005-06-16

Family

ID=19749442

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60103431T Expired - Lifetime DE60103431T2 (de) 2000-02-02 2001-02-02 Ein Verfahren zur chromatographischen Isolierung von Isomeren des Vitamins E

Country Status (8)

Country Link
US (1) US6656358B2 (de)
EP (1) EP1122250B1 (de)
JP (2) JP5051943B2 (de)
AU (1) AU783564B2 (de)
CA (1) CA2334068C (de)
DE (1) DE60103431T2 (de)
MY (1) MY127451A (de)
SG (1) SG99880A1 (de)

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MY127451A (en) 1999-11-04 2006-12-29 Malaysian Palm Oil Board A method of chromatographic isolation for vitamin e isomers
MY127954A (en) 1999-11-04 2007-01-31 Malaysian Palm Oil Board A method of chromatographic isolation for non-glyceride components
MY130618A (en) * 2002-11-27 2007-07-31 Malaysian Palm Oil Board A method of extracting and isolating minor components from vegetable oil
MY138963A (en) * 2003-08-27 2009-08-28 Malaysian Palm Oil Board One-stage and two-stage supercritical fluid extractions of carotenes concentrate, vitamin e concentrate and other minor components concentrates
MY146635A (en) * 2004-09-01 2012-09-14 Malaysian Palm Oil Board Specialty palm oil products and other specialty vegetable oil products
US7332159B2 (en) * 2004-09-30 2008-02-19 Board Of Regents Of The University Of Nebraska Method and composition for inhibiting reperfusion injury in the brain
EP2471530B1 (de) 2005-06-01 2017-01-11 Edison Pharmaceuticals, Inc. Redoxaktive therapeutik zur behandlung von mitochondrialen erkrankungen und anderen zuständen sowie modulation von energie-biomarkern
JP4943001B2 (ja) * 2005-12-27 2012-05-30 ライオン株式会社 トコトリエノール類含有組成物の製造方法
ES2345396T3 (es) * 2006-02-10 2010-09-22 Carotech Sdn. Bhd Proceso para la produccion de fracciones altamente enriquecidas de compuestos naturales de aceite de palma con fluidos supercriticos y proximos al estado critico.
JP5374162B2 (ja) 2006-02-22 2013-12-25 エジソン ファーマシューティカルズ， インコーポレイテッド ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節
MY148321A (en) * 2007-10-02 2013-03-29 Malaysian Palm Oil Board Mpob Vitamin e supplementation to tetanus toxoid
DE102007061436A1 (de) * 2007-12-20 2009-06-25 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Gewinnung von Fettbegleitstoffen aus Kraftstoffen und Verwendung dieses Verfahrens
CA2736250C (en) 2008-09-10 2016-12-20 Edison Pharmaceuticals, Inc. Treatment of pervasive developmental disorders with redox-active therapeutics
EP2963006B1 (de) 2008-10-28 2018-10-17 BioElectron Technology Corporation Zusammensetzung enthaltend alpha-tocotrienolchinon, und zwischenverbindungen davon
PL2424495T3 (pl) 2009-04-28 2018-06-29 Bioelectron Technology Corporation Leczenie dziedzicznej neuropatii nerwów wzrokowych lebera i dominującego zaniku nerwu wzrokowego chinonami tokotrienolu
JP2012531411A (ja) 2009-06-25 2012-12-10 アンペア ライフ サイエンシーズ，インコーポレイテッド トコトリエノールまたはトコトリエノール濃縮抽出物を用いた広汎性発達障害の処置
JP2011173949A (ja) * 2010-02-23 2011-09-08 Japan Polyethylene Corp ポリエチレン系樹脂組成物及びそれからなる食品包装容器
WO2013013078A1 (en) 2011-07-19 2013-01-24 Edison Pharmeceuticals, Inc. Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
US9039898B2 (en) 2011-11-15 2015-05-26 Engineering Research Associates, Inc. Method for separating components in natural oil
WO2014085486A2 (en) 2012-11-30 2014-06-05 Waters Technologies Corporation Methods and apparatus for the analysis of vitamin d metabolites
CN105492006B (zh) * 2013-08-30 2022-02-25 因温特国际有限公司 从脂类混合物中分离或纯化维生素e、生育酚和生育三烯酚的方法
US9512098B1 (en) 2014-02-03 2016-12-06 Board Of Trustees Of The University Of Arkansas Process of producing purified gamma- and delta-tocotrienols from tocol-rich oils or distillates
US10017712B2 (en) * 2014-02-11 2018-07-10 Evonik Degussa Gmbh Method for producing vitamin E-enriched, especially tocotrienol-enriched, compositions from natural oils
DE102014009237A1 (de) 2014-06-24 2015-12-24 Weylchem Wiesbaden Gmbh Verfahren zur Gewinnung von Vitamin E, Sterolen und/oder Terpenen aus öligen oder fettigen Gemischen biologischer Herkunft
US20180155311A1 (en) 2015-05-26 2018-06-07 Dsm Ip Assets B.V. Separation of chiral isomers by sfc
CN106317007B (zh) * 2015-06-15 2019-03-01 浙江医药股份有限公司新昌制药厂 一种从天然维生素E脚料回收d-α-生育酚的方法
CN106689422A (zh) * 2015-11-12 2017-05-24 中国石油天然气股份有限公司 抗氧化剂组合物及其应用
US10745371B2 (en) 2015-12-16 2020-08-18 Ptc Therapeutics, Inc. Methods for enriching alpha-tocotrienol from mixed tocol compositions
CN113024369A (zh) 2015-12-17 2021-06-25 Ptc医疗公司 用于治疗氧化应急障碍的化合物
US11154795B2 (en) 2016-10-21 2021-10-26 Novasep Equipment Solutions Use of compressed gas for moving eluent applied to chromatography
WO2018109780A1 (en) * 2016-12-16 2018-06-21 Praj Industries Limited Process for the preparation of tocols & squalene
CN108929303B (zh) * 2017-05-27 2020-12-15 浙江大学 一种利用聚离子液体从混合生育酚中分离单个生育酚的方法
MY184673A (en) * 2018-03-16 2021-04-15 Palm Nutraceuticals Sdn Bhd A process of preparing vitamin e concentrate
CN110412139A (zh) 2018-04-27 2019-11-05 株式会社岛津制作所 一种分析系统
CN110412189A (zh) * 2018-04-27 2019-11-05 株式会社岛津制作所 一种快速检测油脂或生物样品中的维生素d的方法

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Publication number Priority date Publication date Assignee Title
US4122094A (en) * 1976-06-09 1978-10-24 Lever Brothers Company Separation of the isomers of tocopherol by liquid/solid chromatography
JPS57144280A (en) * 1981-03-04 1982-09-06 Nisshin Oil Mills Ltd:The Preparation of tocopherol concentrate
JPS60149582A (ja) * 1984-01-14 1985-08-07 Mitsui Petrochem Ind Ltd トコフエロ−ルの精製方法
GB8729232D0 (en) 1987-12-15 1988-01-27 Palm Oil Research Inst Of Mala Recovery of carotenoids tocopherols tocotrienols & sterols from esterified palm oil
AU618791B2 (en) 1988-03-16 1992-01-09 Bioindustry Development Centre Production of high concentration tocopherols and tocotrienols from palm oil by-product
JPH02157274A (ja) * 1988-12-07 1990-06-18 Sumitomo Heavy Ind Ltd 植物油からビタミンｅを分離濃縮する方法
US4964995A (en) * 1989-06-16 1990-10-23 Midwest Research Institute Supercritical separation process for complex organic mixtures
US5157132A (en) * 1990-05-18 1992-10-20 Carotech Associates Integrated process for recovery of carotenoids and tocotrienols from oil
MY108071A (en) * 1990-05-23 1996-08-15 Pentad Foods Int Stabilization and recovery method for tocotrienol and tocopherol products.
DE69332946T2 (de) * 1992-10-16 2004-05-19 Suprex Corp. Automatisierte extrakion mittels eines superkritischen fluidum
US5972357A (en) * 1996-12-19 1999-10-26 Kikkoman Corporation Healthy foods and cosmetics
US6395915B1 (en) * 1999-09-10 2002-05-28 Technikrom, Inc. Method for producing purified tocotrienols and tocopherols using liquid chromatography
MY127954A (en) * 1999-11-04 2007-01-31 Malaysian Palm Oil Board A method of chromatographic isolation for non-glyceride components
MY127451A (en) 1999-11-04 2006-12-29 Malaysian Palm Oil Board A method of chromatographic isolation for vitamin e isomers

Also Published As

Publication number Publication date
CA2334068C (en) 2010-04-06
US20010044548A1 (en) 2001-11-22
CA2334068A1 (en) 2001-08-02
EP1122250B1 (de) 2004-05-26
SG99880A1 (en) 2003-11-27
MY127451A (en) 2006-12-29
AU1826001A (en) 2001-08-09
DE60103431T2 (de) 2005-06-16
JP5051943B2 (ja) 2012-10-17
JP2001261671A (ja) 2001-09-26
AU783564B2 (en) 2005-11-10
JP2012140467A (ja) 2012-07-26
EP1122250A1 (de) 2001-08-08
US6656358B2 (en) 2003-12-02

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