DE60102825T2 - Kinetische racematspaltung chiraler 2- und 3- substituierter carbonsäuren - Google Patents
Kinetische racematspaltung chiraler 2- und 3- substituierter carbonsäuren Download PDFInfo
- Publication number
- DE60102825T2 DE60102825T2 DE60102825T DE60102825T DE60102825T2 DE 60102825 T2 DE60102825 T2 DE 60102825T2 DE 60102825 T DE60102825 T DE 60102825T DE 60102825 T DE60102825 T DE 60102825T DE 60102825 T2 DE60102825 T2 DE 60102825T2
- Authority
- DE
- Germany
- Prior art keywords
- chiral
- dhqd
- dhq
- racemic
- nmr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 COC(CC(*C(O)O1)C1=O)=C Chemical compound COC(CC(*C(O)O1)C1=O)=C 0.000 description 6
- KZSNJWFQEVHDMF-BYPYZUCNSA-O CC(C)[C@@H](C([OH2+])=O)N Chemical compound CC(C)[C@@H](C([OH2+])=O)N KZSNJWFQEVHDMF-BYPYZUCNSA-O 0.000 description 1
- CEMZBWPSKYISTN-RXMQYKEDSA-N CC(C)[C@H](C(OC)=O)N Chemical compound CC(C)[C@H](C(OC)=O)N CEMZBWPSKYISTN-RXMQYKEDSA-N 0.000 description 1
- ARQIJEFZHPIVHK-UHFFFAOYSA-N CC(CN1)(O)OC1=O Chemical compound CC(CN1)(O)OC1=O ARQIJEFZHPIVHK-UHFFFAOYSA-N 0.000 description 1
- RNFBCJJCMLRNIG-UHFFFAOYSA-N CCOC(C(Cc(cc1)ccc1F)N)=O Chemical compound CCOC(C(Cc(cc1)ccc1F)N)=O RNFBCJJCMLRNIG-UHFFFAOYSA-N 0.000 description 1
- XWHHYOYVRVGJJY-UHFFFAOYSA-N NC(Cc(cc1)ccc1F)C(O)=O Chemical compound NC(Cc(cc1)ccc1F)C(O)=O XWHHYOYVRVGJJY-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B57/00—Separation of optically-active compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/34—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/42—Separation; Purification; Stabilisation; Use of additives
- C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/12—Preparation of carboxylic acid esters from asymmetrical anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
- Fertilizers (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22214500P | 2000-07-31 | 2000-07-31 | |
| US222145P | 2000-07-31 | ||
| US25317200P | 2000-11-27 | 2000-11-27 | |
| US253172P | 2000-11-27 | ||
| PCT/US2001/023953 WO2002010096A1 (en) | 2000-07-31 | 2001-07-31 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60102825D1 DE60102825D1 (de) | 2004-05-19 |
| DE60102825T2 true DE60102825T2 (de) | 2005-03-31 |
Family
ID=26916484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60102825T Expired - Fee Related DE60102825T2 (de) | 2000-07-31 | 2001-07-31 | Kinetische racematspaltung chiraler 2- und 3- substituierter carbonsäuren |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US6562966B2 (https=) |
| EP (1) | EP1305270B1 (https=) |
| JP (1) | JP2004505098A (https=) |
| KR (1) | KR100799789B1 (https=) |
| AT (1) | ATE264282T1 (https=) |
| AU (1) | AU2001277231A1 (https=) |
| CA (1) | CA2416303A1 (https=) |
| DE (1) | DE60102825T2 (https=) |
| WO (1) | WO2002010096A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1298127A4 (en) * | 2000-07-04 | 2004-12-08 | Mitsui Chemicals Inc | AMINO ACID N-CARBOXY ANHYDRIDE WITH SUBSTITUENTS ON NITROGEN |
| WO2002010096A1 (en) * | 2000-07-31 | 2002-02-07 | Brandeis University | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids |
| CA2456166A1 (en) * | 2001-07-31 | 2003-02-13 | Brandeis University | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids |
| TWI298067B (en) | 2002-01-31 | 2008-06-21 | Daiso Co Ltd | New optically active compound, method for kinetic resolution of carbonic acid derivatives and catalyst thereof |
| US7531662B2 (en) | 2003-06-11 | 2009-05-12 | Brandeis University | Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them |
| US8540755B2 (en) * | 2003-07-21 | 2013-09-24 | Robin C. Whitmore | Self-drilling self-tapping bone screw |
| JP4591998B2 (ja) * | 2004-07-30 | 2010-12-01 | 日本曹達株式会社 | 光学活性アルコール誘導体の製造方法 |
| US8345258B2 (en) * | 2006-09-07 | 2013-01-01 | 4 D Technology Corporation | Synchronous frequency-shift mechanism in fizeau interferometer |
| US7675628B2 (en) * | 2006-09-07 | 2010-03-09 | 4D Technology Corporation | Synchronous frequency-shift mechanism in Fizeau interferometer |
| MD20140044A2 (ro) | 2011-11-11 | 2014-08-31 | Pfizer Inc. | 2-Tiopirimidinone şi utilizarea lor pentru tratamentul afecţiunilor cardiovasculare |
| JP6649961B2 (ja) | 2015-03-17 | 2020-02-19 | レゲネロン ファーマシューティカルス，インコーポレーテッド | アミノ酸アシル化試薬及びその使用方法 |
| AU2016257179A1 (en) | 2015-05-05 | 2017-11-02 | Pfizer Inc. | 2-thiopyrimidinones |
| KR20170037240A (ko) * | 2015-09-25 | 2017-04-04 | 주식회사 아미노로직스 | 광학활성을 가진 티에닐알라닌의 제조 방법 |
| CN117800935B (zh) * | 2023-06-15 | 2025-10-14 | 河南师范大学 | 动态动力学拆分合成手性邻苯二甲酰酯类化合物的方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1240651B (it) * | 1990-05-17 | 1993-12-17 | Zambon Spa | Processo per la risoluzione di derivati glicidici |
| US6262278B1 (en) | 1995-03-14 | 2001-07-17 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
| US5665890A (en) | 1995-03-14 | 1997-09-09 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
| DE19617772A1 (de) * | 1996-05-03 | 1997-11-13 | Bayer Ag | Neues effizientes und hochenantioselektives Verfahren zur Herstellung von enantiomerenreinen Cyclopentan-beta-aminosäuren |
| US6521561B1 (en) * | 1998-05-01 | 2003-02-18 | President And Fellows Of Harvard College | Main-group metal based asymmetric catalysts and applications thereof |
| US6562967B2 (en) * | 2000-07-31 | 2003-05-13 | Brandeis University | Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids |
| WO2002010096A1 (en) * | 2000-07-31 | 2002-02-07 | Brandeis University | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids |
-
2001
- 2001-07-31 WO PCT/US2001/023953 patent/WO2002010096A1/en not_active Ceased
- 2001-07-31 AT AT01955023T patent/ATE264282T1/de not_active IP Right Cessation
- 2001-07-31 KR KR1020037001408A patent/KR100799789B1/ko not_active Expired - Fee Related
- 2001-07-31 EP EP01955023A patent/EP1305270B1/en not_active Expired - Lifetime
- 2001-07-31 US US09/919,371 patent/US6562966B2/en not_active Expired - Lifetime
- 2001-07-31 JP JP2002516229A patent/JP2004505098A/ja not_active Abandoned
- 2001-07-31 DE DE60102825T patent/DE60102825T2/de not_active Expired - Fee Related
- 2001-07-31 AU AU2001277231A patent/AU2001277231A1/en not_active Abandoned
- 2001-07-31 CA CA002416303A patent/CA2416303A1/en not_active Abandoned
-
2002
- 2002-11-20 US US10/300,704 patent/US6743914B2/en not_active Expired - Lifetime
-
2004
- 2004-05-26 US US10/854,737 patent/US7057038B2/en not_active Expired - Fee Related
-
2006
- 2006-06-05 US US11/447,237 patent/US7767811B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20060293536A1 (en) | 2006-12-28 |
| KR100799789B1 (ko) | 2008-01-31 |
| EP1305270A1 (en) | 2003-05-02 |
| DE60102825D1 (de) | 2004-05-19 |
| US20020165393A1 (en) | 2002-11-07 |
| ATE264282T1 (de) | 2004-04-15 |
| US20050020849A1 (en) | 2005-01-27 |
| AU2001277231A1 (en) | 2002-02-13 |
| JP2004505098A (ja) | 2004-02-19 |
| KR20030020430A (ko) | 2003-03-08 |
| US7767811B2 (en) | 2010-08-03 |
| US6562966B2 (en) | 2003-05-13 |
| WO2002010096A1 (en) | 2002-02-07 |
| US6743914B2 (en) | 2004-06-01 |
| US7057038B2 (en) | 2006-06-06 |
| CA2416303A1 (en) | 2002-02-07 |
| US20030166963A1 (en) | 2003-09-04 |
| EP1305270B1 (en) | 2004-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de | ||
| 8370 | Indication related to discontinuation of the patent is to be deleted | ||
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |