DE60037578T2 - Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen - Google Patents
Verwendung von triacetyluridin zur behandlung von mitochondrialen erkrankungen Download PDFInfo
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- DE60037578T2 DE60037578T2 DE60037578T DE60037578T DE60037578T2 DE 60037578 T2 DE60037578 T2 DE 60037578T2 DE 60037578 T DE60037578 T DE 60037578T DE 60037578 T DE60037578 T DE 60037578T DE 60037578 T2 DE60037578 T2 DE 60037578T2
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- syndrome
- mitochondrial
- deficiency
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| US20050203053A1 (en) * | 1999-07-30 | 2005-09-15 | Wurtman Richard J. | Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function |
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| US8314064B2 (en) * | 1998-07-31 | 2012-11-20 | Massachusetts Institute Of Technology | Uridine administration stimulates membrane production |
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| US7915233B1 (en) | 1998-08-31 | 2011-03-29 | Wellstat Therapeutics Corporation | Compositions and methods for treatment of mitochondrial diseases |
| IL144964A0 (en) | 1999-02-23 | 2002-06-30 | Pro Neuron Inc | Methods of treatment of mitochondrial disorders |
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| DE10110355A1 (de) * | 2001-03-03 | 2002-09-12 | Ulrich Walker | Bekämpfung von Nebenwirkungen |
| CA2444148A1 (en) * | 2001-04-11 | 2002-10-24 | Queen's University At Kingston | Pyrimidine compounds as anti-ictogenic and/or anti-epileptogenic agents |
| DE60213406T2 (de) * | 2001-05-29 | 2007-03-08 | The University Of British Columbia, Vancouver | Pharmakologische anwendungen von mitochondriellen dna assays |
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| US9278085B2 (en) | 2006-02-22 | 2016-03-08 | Edison Pharmaceuticals, Inc. | Side-chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| US8748405B2 (en) | 2007-01-26 | 2014-06-10 | City Of Hope | Methods and compositions for the treatment of cancer or other diseases |
| WO2009059306A1 (en) | 2007-11-02 | 2009-05-07 | Massachusetts Institute Of Technology | Uridine dietary supplementation compliance methods and use thereof |
| CN101612110B (zh) * | 2008-06-23 | 2012-07-25 | 欣凯医药化工中间体（上海）有限公司 | 三乙酰尿苷缓释制剂及其制备方法 |
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| RU2400221C2 (ru) * | 2008-11-11 | 2010-09-27 | ФГУ "Московский НИИ педиатрии и детской хирургии Росмедтехнологий" | Способ лечения врожденных структурных миопатий и врожденных мышечных дистрофий путем коррекции вторичных митохондриальных изменений |
| ES2640485T3 (es) | 2011-08-12 | 2017-11-03 | Universitätsklinikum Freiburg | Uridina y análogos de uridina para el uso en el tratamiento de la enfermedad pulmonar obstructiva crónica |
| WO2015106255A1 (en) | 2014-01-13 | 2015-07-16 | City Of Hope | Multivalent oligonucleotide assemblies |
| WO2016028894A1 (en) * | 2014-08-19 | 2016-02-25 | Wellstat Therapeutics Corportion | Treatment of glycosylation deficiency diseases |
| FR3027804A1 (fr) | 2014-10-31 | 2016-05-06 | Centre Nat Rech Scient | Utilisation d'un inhibiteur de transcriptase inverse dans la prevention et le traitement des maladies degeneratives |
| US10675293B2 (en) | 2015-05-29 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| BR112017025839A2 (en) * | 2015-06-05 | 2018-08-14 | Fundació Hospital Universitari Vall D'hebron - Institut De Recerca | treatment of mitochondrial diseases |
| JP6599484B2 (ja) * | 2015-06-17 | 2019-10-30 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | ミトコンドリアｄｎａ枯渇症候群を含む不均衡なヌクレオチドプールによって引き起こされる疾患のためのデオキシヌクレオシド療法 |
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| KR101981843B1 (ko) | 2016-09-13 | 2019-05-23 | 울산대학교 산학협력단 | 일산화탄소 또는 일산화탄소 공급체를 유효성분으로 함유하는 미토콘드리아 기능 개선용 조성물 |
| EP3773579A4 (en) | 2018-03-26 | 2022-03-09 | Clear Creek Bio, Inc. | COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE |
| US20230000894A1 (en) * | 2019-09-05 | 2023-01-05 | Mitorainbow Therapeutics, Inc. | Treating mitochondrial dna depletion disorders |
| US20210300873A1 (en) | 2020-03-20 | 2021-09-30 | Clear Creek Bio, Inc. | Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof |
| KR102290596B1 (ko) | 2020-09-10 | 2021-08-19 | 주식회사 파이안바이오테크놀로지 | 분리된 미토콘드리아를 포함하는 주사용 조성물 및 이의 용도 |
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| BR112023010517A2 (pt) * | 2020-12-01 | 2024-02-06 | Wellstat Therapeutics Corp | 5'-o-fenilacetil uridina e seu uso terapêutico |
| CN113116900B (zh) * | 2021-04-14 | 2022-07-08 | 兰州大学 | 一类核苷类似物在制备预防和/或治疗脑血管疾病药物中的应用 |
| BE1030026B1 (fr) * | 2022-06-14 | 2023-07-07 | Dendrogenix | Composés dérivés de stérols et composition pharmaceutique les comprenant pour leur utilisation dans la prévention, l’amélioration et/ou le traitement d’une pathologie liée à un déficit mitochondrial |
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2000
- 2000-02-23 IL IL14496400A patent/IL144964A0/xx unknown
- 2000-02-23 RU RU2005121711/14A patent/RU2394580C2/ru not_active IP Right Cessation
- 2000-02-23 PT PT00910321T patent/PT1171137E/pt unknown
- 2000-02-23 WO PCT/US2000/004663 patent/WO2000050043A1/en not_active Ceased
- 2000-02-23 MX MXPA01008549A patent/MXPA01008549A/es active IP Right Grant
- 2000-02-23 AU AU32434/00A patent/AU776437B2/en not_active Ceased
- 2000-02-23 CN CNB008041032A patent/CN1191835C/zh not_active Expired - Fee Related
- 2000-02-23 EP EP07008953.7A patent/EP1808177B1/en not_active Expired - Lifetime
- 2000-02-23 ES ES00910321T patent/ES2298130T3/es not_active Expired - Lifetime
- 2000-02-23 DE DE60037578T patent/DE60037578T2/de not_active Expired - Lifetime
- 2000-02-23 CN CNB2004100784053A patent/CN100379426C/zh not_active Expired - Fee Related
- 2000-02-23 EP EP00910321A patent/EP1171137B1/en not_active Expired - Lifetime
- 2000-02-23 DK DK00910321T patent/DK1171137T3/da active
- 2000-02-23 KR KR1020017010801A patent/KR100758712B1/ko not_active Expired - Fee Related
- 2000-02-23 KR KR1020077012846A patent/KR100879559B1/ko not_active Expired - Fee Related
- 2000-02-23 RU RU2001125913/14A patent/RU2268732C2/ru not_active IP Right Cessation
- 2000-02-23 AT AT00910321T patent/ATE381935T1/de active
- 2000-02-23 JP JP2000600654A patent/JP4776780B2/ja not_active Expired - Lifetime
- 2000-02-23 US US09/889,251 patent/US7638501B1/en not_active Expired - Fee Related
- 2000-02-23 NZ NZ513926A patent/NZ513926A/en not_active IP Right Cessation
- 2000-02-23 BR BR0008447-6A patent/BR0008447A/pt not_active Application Discontinuation
- 2000-02-23 CA CA2362925A patent/CA2362925C/en not_active Expired - Fee Related
- 2000-02-23 HU HU0400914A patent/HU230191B1/hu not_active IP Right Cessation
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2001
- 2001-08-19 IL IL144964A patent/IL144964A/en not_active IP Right Cessation
- 2001-09-19 ZA ZA200107727A patent/ZA200107727B/en unknown
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2007
- 2007-01-03 IL IL180528A patent/IL180528A/en not_active IP Right Cessation
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2009
- 2009-12-21 US US12/643,920 patent/US8748408B2/en not_active Expired - Fee Related
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