DE60037347D1 - Kombinationen enthaltend cGMP-PDE5-hemmer. - Google Patents

Kombinationen enthaltend cGMP-PDE5-hemmer.

Info

Publication number
DE60037347D1
DE60037347D1 DE60037347T DE60037347T DE60037347D1 DE 60037347 D1 DE60037347 D1 DE 60037347D1 DE 60037347 T DE60037347 T DE 60037347T DE 60037347 T DE60037347 T DE 60037347T DE 60037347 D1 DE60037347 D1 DE 60037347D1
Authority
DE
Germany
Prior art keywords
pde5 inhibitor
combinations containing
containing cgmp
cgmp
pde5
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60037347T
Other languages
English (en)
Other versions
DE60037347T2 (de
Inventor
Eliot Richard Forster
Nandan Parmanand Koppiker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9924958.3A external-priority patent/GB9924958D0/en
Priority claimed from GB0021520A external-priority patent/GB0021520D0/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Application granted granted Critical
Publication of DE60037347D1 publication Critical patent/DE60037347D1/de
Publication of DE60037347T2 publication Critical patent/DE60037347T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE60037347T 1999-10-21 2000-10-17 Kombinationen enthaltend cGMP-PDE5-hemmer. Expired - Fee Related DE60037347T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9924958 1999-10-21
GBGB9924958.3A GB9924958D0 (en) 1999-10-21 1999-10-21 Treatment of neuropathy
GB0021520A GB0021520D0 (en) 2000-09-01 2000-09-01 Treatment of neuropathy
GB0021520 2000-09-01

Publications (2)

Publication Number Publication Date
DE60037347D1 true DE60037347D1 (de) 2008-01-17
DE60037347T2 DE60037347T2 (de) 2008-11-27

Family

ID=26244947

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60037347T Expired - Fee Related DE60037347T2 (de) 1999-10-21 2000-10-17 Kombinationen enthaltend cGMP-PDE5-hemmer.

Country Status (16)

Country Link
US (2) US20030162782A1 (de)
EP (2) EP1129706A3 (de)
JP (2) JP2001122803A (de)
KR (1) KR20010051181A (de)
AT (1) ATE380049T1 (de)
AU (1) AU781550B2 (de)
CA (1) CA2323839C (de)
CO (1) CO5271711A1 (de)
CY (1) CY1107285T1 (de)
DE (1) DE60037347T2 (de)
DK (1) DK1440709T3 (de)
ES (1) ES2295726T3 (de)
HU (1) HUP0004120A3 (de)
IL (2) IL139073A0 (de)
PE (1) PE20010754A1 (de)
PT (1) PT1440709E (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001257146B2 (en) * 2000-04-19 2006-11-30 Johns Hopkins University Methods for prevention and treatment of gastrointestinal disorders
FR2809623B1 (fr) * 2000-06-05 2003-09-05 Sanjuan Benito Arranz Dans le traitement des maladies neurodegeneratives : (notamment alzheimer et parkinson), utilisation pour un medicament : du sildenafil (ou de ses derives)
DE10135815A1 (de) * 2001-07-23 2003-02-06 Bayer Ag Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen
US20030211040A1 (en) 2001-08-31 2003-11-13 Paul Greengard Phosphodiesterase activity and regulation of phosphodiesterase 1B-mediated signaling in brain
GB0129274D0 (en) * 2001-12-06 2002-01-23 Pfizer Ltd Novel kit
US20050143388A1 (en) * 2002-01-04 2005-06-30 Michael Chopp Nitric oxide donors for treatment of disease and injury
US7419981B2 (en) 2002-08-15 2008-09-02 Pfizer Inc. Synergistic combinations of an alpha-2-delta ligand and a cGMP phosphodieterse 5 inhibitor
GB0219024D0 (en) * 2002-08-15 2002-09-25 Pfizer Ltd Synergistic combinations
US7659305B2 (en) 2002-10-31 2010-02-09 Pfizer Inc. Therapeutic proline derivatives
CA2509605C (en) * 2002-12-13 2010-10-05 Warner-Lambert Company Llc Alpha-2-delta ligand to treat lower urinary tract symptoms
EP2308828A3 (de) 2003-04-23 2013-05-22 Japan Tobacco Inc. CaSR-Antagonist
DE10325813B4 (de) 2003-06-06 2007-12-20 Universitätsklinikum Freiburg Prophylaxe und/oder Therapie bei der portalen Hypertonie
ATE445402T1 (de) 2004-03-05 2009-10-15 Nycomed Gmbh Neue verwendung von pde5-hemmern
CN103467471A (zh) 2005-06-06 2013-12-25 武田药品工业株式会社 有机化合物
US20080194592A1 (en) * 2005-08-23 2008-08-14 Intra-Cellular Therapies, Inc. Organic Compounds
JP5453086B2 (ja) * 2006-06-06 2014-03-26 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
WO2008063505A1 (en) * 2006-11-13 2008-05-29 Intra-Cellular Therapies, Inc. Organic compounds
WO2008070095A1 (en) 2006-12-05 2008-06-12 Intra-Cellular Therapies, Inc. Novel uses
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
WO2008131256A1 (en) * 2007-04-19 2008-10-30 Trinity Laboratories Inc. Improved treatments for premature ejaculation in humans
BRPI0814294A2 (pt) 2007-07-19 2015-02-03 Metabolex Inc Agonistas de receptor heterocíclico ligado a n para o tratamento do diabetes e de desordens metabólicas.
KR101227738B1 (ko) * 2007-12-06 2013-01-29 다케다 야쿠힌 고교 가부시키가이샤 유기 화합물
US8846693B2 (en) * 2007-12-06 2014-09-30 Intra-Cellular Therapies, Inc. Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones
GEP20146046B (en) 2008-12-06 2014-02-25 Intracellular Therapies Inc Organic compounds
EP2367429B1 (de) 2008-12-06 2017-06-07 Intra-Cellular Therapies, Inc. Organische verbindungen
MA32940B1 (fr) 2008-12-06 2012-01-02 Intra Cellular Therapies Inc Composes organiques
EP2367428B1 (de) 2008-12-06 2016-04-06 Intra-Cellular Therapies, Inc. Organische verbindungen
MX2011005937A (es) 2008-12-06 2011-12-16 Intra Cellular Therapies Inc Compuestos organicos.
MX2011005936A (es) * 2008-12-06 2011-12-16 Intra Cellular Therapies Inc Compuestos organicos.
WO2010098839A1 (en) 2009-02-25 2010-09-02 Intra-Cellular Therapies, Inc. Pde 1 inhibitors for ophthalmic disorders
JP2012526810A (ja) 2009-05-13 2012-11-01 イントラ−セルラー・セラピーズ・インコーポレイテッド 有機化合物
EP2461673A4 (de) 2009-08-05 2013-08-07 Intra Cellular Therapies Inc Neue regulatorproteine und hemmer
WO2011041154A1 (en) 2009-10-01 2011-04-07 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
WO2011143607A1 (en) * 2010-05-14 2011-11-17 The Regents Of The University Of California Modulation of bioactive epoxy-fatty acid levels by phosphodiesterase inhibitors
EP2590657A4 (de) 2010-05-31 2014-02-12 Intra Cellular Therapies Inc Organische verbindungen
JP5879336B2 (ja) 2010-05-31 2016-03-08 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2011153138A1 (en) 2010-05-31 2011-12-08 Intra-Cellular Therapies, Inc. Organic compounds
TW201206937A (en) 2010-05-31 2012-02-16 Intra Cellular Therapies Inc Organic compounds
US20130143894A1 (en) * 2010-06-07 2013-06-06 vadel Pharma Inc. Oral spray formulations ad methods for administration of sildenafil
CN109674753A (zh) 2010-06-23 2019-04-26 希玛贝治疗股份有限公司 固态分散体
WO2012171016A1 (en) 2011-06-10 2012-12-13 Intra-Cellular Therapies, Inc. Organic compounds
CN102276511A (zh) * 2011-06-20 2011-12-14 兰州博实生化科技有限责任公司 1-叔丁氧羰基-3-碘氮杂环丁烷的合成方法
US8449565B2 (en) 2011-07-21 2013-05-28 Francis Duhay Approaches to venous occlusion for embolus management
WO2014127331A1 (en) 2013-02-17 2014-08-21 Intra-Cellular Therapies, Inc. Novel uses
MX2015013042A (es) 2013-03-15 2016-05-05 Intra Cellular Therapies Inc Compuestos organicos.
EP3479825B1 (de) 2013-03-15 2021-02-17 Intra-Cellular Therapies, Inc. Pde1-inhibitoren zur verwendung bei der behandlung und/oder prävention von zns- oder pns-krankheiten oder störungen
RU2549459C2 (ru) * 2013-08-20 2015-04-27 Константин Александрович Корейба Способ лечения нейропатических трофических язв при синдроме диабетической стопы
US9849132B2 (en) 2014-01-08 2017-12-26 Intra-Cellular Therapies, Inc. Products and pharmaceutical compositions
ES2732442T3 (es) 2014-06-20 2019-11-22 Intra Cellular Therapies Inc Compuestos orgánicos
US9546175B2 (en) 2014-08-07 2017-01-17 Intra-Cellular Therapies, Inc. Organic compounds
US10285992B2 (en) 2014-08-07 2019-05-14 Intra-Cellular Therapies, Inc. Combinations of PDE1 inhibitors and NEP inhibitors and associated methods
JP6591530B2 (ja) 2014-08-07 2019-10-16 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
US10150774B2 (en) 2014-09-17 2018-12-11 Intra-Cellular Therapies, Inc. Compounds and methods
KR102557603B1 (ko) 2014-12-06 2023-07-19 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
US10105349B2 (en) 2014-12-06 2018-10-23 Intra-Cellular Therapies, Inc. Organic compounds
US10813894B2 (en) 2015-02-20 2020-10-27 The Regents Of The University Of California Methods of inhibiting pain
WO2017172795A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
CA3032432A1 (en) 2016-08-03 2018-02-08 Charles A. Mcwherter Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
AU2017322427B2 (en) 2016-09-09 2021-12-23 Incyte Corporation Pyrazolopyridine derivatives as HPK1 modulators and uses thereof for the treatment of cancer
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
EP3509589B1 (de) 2016-09-12 2021-11-17 Intra-Cellular Therapies, Inc. Neuartige verwendungen
WO2018152220A1 (en) 2017-02-15 2018-08-23 Incyte Corporation Pyrazolopyridine compounds and uses thereof
WO2019051199A1 (en) 2017-09-08 2019-03-14 Incyte Corporation 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS
MX2017016930A (es) * 2017-12-19 2019-06-20 Malesil Research & Tech Llc Uso del maleato de sildenafil en el tratamiento de ulceras de pie diabetico.
JP7401442B2 (ja) 2018-01-31 2023-12-19 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規使用
US10745388B2 (en) 2018-02-20 2020-08-18 Incyte Corporation Indazole compounds and uses thereof
KR20200133747A (ko) 2018-02-20 2020-11-30 인사이트 코포레이션 암을 치료하기 위한 hpk1 억제제로서의 n-(페닐)-2-(페닐)피리미딘-4-카복스아미드 유도체 및 관련 화합물
US10752635B2 (en) 2018-02-20 2020-08-25 Incyte Corporation Indazole compounds and uses thereof
US11299473B2 (en) 2018-04-13 2022-04-12 Incyte Corporation Benzimidazole and indole compounds and uses thereof
US10899755B2 (en) 2018-08-08 2021-01-26 Incyte Corporation Benzothiazole compounds and uses thereof
WO2020068729A1 (en) 2018-09-25 2020-04-02 Incyte Corporation Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators
KR20220059480A (ko) 2019-08-06 2022-05-10 인사이트 코포레이션 고체 형태의 hpk1 억제제

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT100905A (pt) * 1991-09-30 1994-02-28 Eisai Co Ltd Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
AU722514B2 (en) * 1995-12-28 2000-08-03 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
USRE41920E1 (en) * 1996-07-24 2010-11-09 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
US6127418A (en) * 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
AU748352B2 (en) * 1998-04-20 2002-06-06 Pfizer Inc. Pyrazolopyrimidinone cGMP PDE5 inhibitors for the treatment of sexual dysfunction
US6331171B1 (en) * 1998-06-04 2001-12-18 Alcon Laboratories, Inc. Tip for a liquefracture handpiece
WO2000024745A1 (en) * 1998-10-23 2000-05-04 Pfizer Limited PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
GB9823101D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
GB9823103D0 (en) * 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
US6453237B1 (en) * 1999-04-23 2002-09-17 Global Locate, Inc. Method and apparatus for locating and providing services to mobile devices
US6411892B1 (en) * 2000-07-13 2002-06-25 Global Locate, Inc. Method and apparatus for locating mobile receivers using a wide area reference network for propagating ephemeris
IL137429A0 (en) * 1999-07-28 2001-07-24 Pfizer Prod Inc Methods and compsitions for treating diseases and conditions of the eye
AU779761C (en) * 1999-10-12 2005-09-22 Lilly Icos Llc Medicament for treatment of neuropathies
US7196660B2 (en) * 2000-11-17 2007-03-27 Global Locate, Inc Method and system for determining time in a satellite positioning system
US6560534B2 (en) * 2001-06-06 2003-05-06 Global Locate, Inc. Method and apparatus for distributing satellite tracking information

Also Published As

Publication number Publication date
KR20010051181A (ko) 2001-06-25
CA2323839A1 (en) 2001-04-21
EP1440709A3 (de) 2004-12-08
AU781550B2 (en) 2005-05-26
PE20010754A1 (es) 2001-07-18
EP1440709A2 (de) 2004-07-28
EP1129706A3 (de) 2002-01-02
PT1440709E (pt) 2008-02-06
HUP0004120A3 (en) 2003-11-28
CA2323839C (en) 2008-03-18
AU6665000A (en) 2001-04-26
EP1129706A2 (de) 2001-09-05
US20040122010A1 (en) 2004-06-24
DE60037347T2 (de) 2008-11-27
HUP0004120A2 (hu) 2002-11-28
ES2295726T3 (es) 2008-04-16
US20030162782A1 (en) 2003-08-28
CO5271711A1 (es) 2003-04-30
CY1107285T1 (el) 2012-11-21
JP2001122803A (ja) 2001-05-08
IL152925A (en) 2010-04-15
IL139073A0 (en) 2001-11-25
ATE380049T1 (de) 2007-12-15
HU0004120D0 (de) 2001-01-29
EP1440709B1 (de) 2007-12-05
DK1440709T3 (da) 2008-03-17
JP2003119131A (ja) 2003-04-23

Similar Documents

Publication Publication Date Title
DE60037347D1 (de) Kombinationen enthaltend cGMP-PDE5-hemmer.
MXPA03008968A (es) Fuente de iluminacion lineal.
ECSP034600A (es) Compuestos de lactama
GB2379798B (en) Light emitting diode and method for manufacturing the same
ATE404528T1 (de) 7,9 substituierte tetracyclinverbindungen
HK1105948A1 (en) Aspirin triggered lipid mediators
PL362558A1 (en) Xylanase variants having altered sensitivity to xylanase inhibitors
MXPA02012494A (es) Tiazina oxazolidinona.
DE50101648D1 (de) Endoskop
DK1489082T3 (da) Mellemprodukter
BR0102059B1 (pt) segmento retentor para conjunto turbilhonador.
MY138266A (en) Treatment of neuropathy
DK1390364T3 (da) Aryl-8-azabicyclo[3.2.1]octaner til behandling af depression
AU2000267392A1 (en) Improved generator and light emitting wheel having the generator
BR0210678A (pt) Carbamatos de 2-heterocìclicos-1,2-etanodióis
TWI319707B (en) Method of purifying pravastatin
ECSP972265A (es) Dihidrato de d-olanzapina
ITTO20020158U1 (it) Luce per veicoli.
RU2001103824A (ru) Средство для лечения острого мышьяковистого периодонтита
GB0111551D0 (en) F.R.at source
GB0116806D0 (en) Structured light source
TW515237U (en) The bobber having the emitting light
ES1023775Y (es) Camara-tunel para desinfeccion.
ES1049935Y (es) Colgante luminoso.
GB0120987D0 (en) V.p.c.o

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee