DE60027476D1 - Enantiomerentrennung von amlodipine - Google Patents

Enantiomerentrennung von amlodipine

Info

Publication number
DE60027476D1
DE60027476D1 DE60027476T DE60027476T DE60027476D1 DE 60027476 D1 DE60027476 D1 DE 60027476D1 DE 60027476 T DE60027476 T DE 60027476T DE 60027476 T DE60027476 T DE 60027476T DE 60027476 D1 DE60027476 D1 DE 60027476D1
Authority
DE
Germany
Prior art keywords
amlodipine
enantiomer
detection
enantiomer detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60027476T
Other languages
English (en)
Other versions
DE60027476T2 (de
Inventor
Xitian Zhang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=4576510&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60027476(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE60027476D1 publication Critical patent/DE60027476D1/de
Publication of DE60027476T2 publication Critical patent/DE60027476T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60027476T 2000-02-21 2000-12-08 Enantiomerentrennung von amlodipin Expired - Fee Related DE60027476T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN00102701 2000-02-21
CN00102701A CN1100038C (zh) 2000-02-21 2000-02-21 氨氯地平对映体的拆分
PCT/CN2000/000538 WO2001060799A1 (fr) 2000-02-21 2000-12-08 Resolution d'enantiomeres d'amlidipine

Publications (2)

Publication Number Publication Date
DE60027476D1 true DE60027476D1 (de) 2006-05-24
DE60027476T2 DE60027476T2 (de) 2006-12-07

Family

ID=4576510

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027476T Expired - Fee Related DE60027476T2 (de) 2000-02-21 2000-12-08 Enantiomerentrennung von amlodipin

Country Status (7)

Country Link
US (1) US6646131B2 (de)
EP (1) EP1258477B1 (de)
CN (1) CN1100038C (de)
AU (2) AU1849401A (de)
CA (1) CA2416062C (de)
DE (1) DE60027476T2 (de)
WO (1) WO2001060799A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005509637A (ja) 2001-10-24 2005-04-14 セプラコア インク． アムロジピンラセミ体の分離方法
CN1152013C (zh) * 2001-11-22 2004-06-02 张喜田 一类左旋氨氯地平盐的水合物及其制剂
KR100476636B1 (ko) * 2002-09-11 2005-03-17 한림제약(주) 엘-(+)-타르트레이트를 이용한 에스-(-)-암로디핀의 제조방법
CN1231469C (zh) * 2003-12-05 2005-12-14 石家庄制药集团欧意药业有限公司 一种光学活性氨氯地平的拆分方法
KR101130622B1 (ko) * 2004-10-20 2012-04-02 엠큐어 파마슈티컬즈 리미티드 높은 광학적 순도로 암로디핀의 광학이성질체를 제조하는방법
EP1831166B1 (de) * 2004-12-02 2010-10-20 SK Chemicals, Co., Ltd. Verfahren zur optischen auftrennung von amlodipin
KR101235116B1 (ko) * 2005-10-17 2013-02-20 에스케이케미칼주식회사 광학활성 암로디핀 겐티세이트 염의 제조방법
CN100436417C (zh) * 2006-04-11 2008-11-26 石药集团中奇制药技术（石家庄）有限公司 一种光学活性氨氯地平的拆分方法
KR100828883B1 (ko) * 2006-10-27 2008-05-09 씨제이제일제당 (주) 라세믹 암로디핀으로부터 ｓ-(-)-암로디핀의 분리방법
US20090247750A1 (en) * 2008-03-28 2009-10-01 Biocryst Pharmaceuticals, Inc. Process for preparing nucleoside analogs
CN101766611B (zh) 2010-02-09 2011-10-12 施慧达药业集团(吉林)有限公司 一种左旋氨氯地平或其可药用盐和β受体阻滞剂的药物组合物及其应用
CN104151229B (zh) * 2014-07-30 2015-04-22 施慧达药业集团(吉林)有限公司 一种(S)-(-)-氨氯地平-半-D-酒石酸-单-DMSO-d6配合物的制备方法
EP3960158A1 (de) 2016-10-07 2022-03-02 Silvergate Pharmaceuticals, Inc. Amlodipinformulierungen
JP7456933B2 (ja) 2018-04-11 2024-03-27 シルバーゲイト ファーマシューティカルズ，インク． アムロジピン製剤
KR20220005073A (ko) * 2019-05-02 2022-01-12 클로즈드 룹 메디신 엘티디 환자에게 개인 맞춤 약물을 제공하기 위한 방법 및 시스템
CN110882249B (zh) 2019-11-08 2021-04-30 北京吾为尔创科技有限公司 含苯磺酸左氨氯地平水合物的组合物及其制备方法
CN111100064B (zh) * 2020-01-08 2024-01-02 湖南理工学院 一种从废液中富集、回收和拆分碱性手性药物氨氯地平的方法
CN111777547B (zh) * 2020-07-17 2021-10-08 江西施美药业股份有限公司 一种诱导析晶拆分左旋氨氯地平的方法
CN112079770B (zh) * 2020-10-05 2024-01-02 湖南理工学院 用于高效手性拆分及母液原位再生的循环萃取和非对映体结晶耦合新方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8804630D0 (en) 1988-02-27 1988-03-30 Pfizer Ltd Preparation of r-& s-amlodipine
JPH01220075A (ja) * 1988-02-29 1989-09-01 Nippon Taisanbin Kogyo Kk 表示部読取方法
GB9405833D0 (en) * 1994-03-24 1994-05-11 Pfizer Ltd Separation of the enantiomers of amlodipine

Also Published As

Publication number Publication date
CN1267669A (zh) 2000-09-27
WO2001060799A1 (fr) 2001-08-23
EP1258477B1 (de) 2006-04-19
EP1258477A4 (de) 2003-04-02
DE60027476T2 (de) 2006-12-07
AU2001218494B2 (en) 2006-09-28
EP1258477A1 (de) 2002-11-20
CA2416062A1 (en) 2002-11-06
CA2416062C (en) 2009-02-17
AU1849401A (en) 2001-08-27
US20030028031A1 (en) 2003-02-06
US6646131B2 (en) 2003-11-11
CN1100038C (zh) 2003-01-29

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee