DE60027171D1 - Nanopartikelzusammensetzungen enthaltend amorphes cyclosporin und deren herstellungsverfahren und verwendungsverfahren - Google Patents

Nanopartikelzusammensetzungen enthaltend amorphes cyclosporin und deren herstellungsverfahren und verwendungsverfahren

Info

Publication number
DE60027171D1
DE60027171D1 DE60027171T DE60027171T DE60027171D1 DE 60027171 D1 DE60027171 D1 DE 60027171D1 DE 60027171 T DE60027171 T DE 60027171T DE 60027171 T DE60027171 T DE 60027171T DE 60027171 D1 DE60027171 D1 DE 60027171D1
Authority
DE
Germany
Prior art keywords
cyclosporine
amorphic
production process
compositions containing
nanoparticle compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60027171T
Other languages
English (en)
Other versions
DE60027171T2 (de
Inventor
William Bosch
D Ostrander
C Hovey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharma International Ltd
Original Assignee
Elan Pharma International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharma International Ltd filed Critical Elan Pharma International Ltd
Publication of DE60027171D1 publication Critical patent/DE60027171D1/de
Application granted granted Critical
Publication of DE60027171T2 publication Critical patent/DE60027171T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE60027171T 1999-09-09 2000-09-07 Nanopartikelzusammensetzungen enthaltend amorphes cyclosporin und deren herstellungsverfahren und verwendungsverfahren Expired - Lifetime DE60027171T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US392557 1989-08-11
US09/392,557 US6656504B1 (en) 1999-09-09 1999-09-09 Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
PCT/US2000/024505 WO2001017546A1 (en) 1999-09-09 2000-09-07 Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions

Publications (2)

Publication Number Publication Date
DE60027171D1 true DE60027171D1 (de) 2006-05-18
DE60027171T2 DE60027171T2 (de) 2007-01-04

Family

ID=23551058

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027171T Expired - Lifetime DE60027171T2 (de) 1999-09-09 2000-09-07 Nanopartikelzusammensetzungen enthaltend amorphes cyclosporin und deren herstellungsverfahren und verwendungsverfahren

Country Status (8)

Country Link
US (1) US6656504B1 (de)
EP (1) EP1210104B1 (de)
JP (2) JP2003508492A (de)
AT (1) ATE322281T1 (de)
AU (1) AU7119500A (de)
CA (1) CA2384670C (de)
DE (1) DE60027171T2 (de)
WO (1) WO2001017546A1 (de)

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Also Published As

Publication number Publication date
JP2003508492A (ja) 2003-03-04
JP2011006450A (ja) 2011-01-13
CA2384670A1 (en) 2001-03-15
WO2001017546A1 (en) 2001-03-15
EP1210104A1 (de) 2002-06-05
DE60027171T2 (de) 2007-01-04
CA2384670C (en) 2011-01-04
AU7119500A (en) 2001-04-10
ATE322281T1 (de) 2006-04-15
US6656504B1 (en) 2003-12-02
EP1210104B1 (de) 2006-04-05

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