DE60027039T2 - Cisplatin- und andere Wirkstoffe oder Gene eingekapselt in Liposomen zur menschlichen Krebstherapie - Google Patents

Cisplatin- und andere Wirkstoffe oder Gene eingekapselt in Liposomen zur menschlichen Krebstherapie Download PDF

Info

Publication number
DE60027039T2
DE60027039T2 DE60027039T DE60027039T DE60027039T2 DE 60027039 T2 DE60027039 T2 DE 60027039T2 DE 60027039 T DE60027039 T DE 60027039T DE 60027039 T DE60027039 T DE 60027039T DE 60027039 T2 DE60027039 T2 DE 60027039T2
Authority
DE
Germany
Prior art keywords
cisplatin
encapsulated
human
tumor
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60027039T
Other languages
German (de)
English (en)
Other versions
DE60027039D1 (de
Inventor
Teni Palo Alto Boulikas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regulon Inc
Original Assignee
Regulon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regulon Inc filed Critical Regulon Inc
Publication of DE60027039D1 publication Critical patent/DE60027039D1/de
Application granted granted Critical
Publication of DE60027039T2 publication Critical patent/DE60027039T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6907—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a microemulsion, nanoemulsion or micelle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Professional, Industrial, Or Sporting Protective Garments (AREA)
DE60027039T 1999-11-05 2000-10-27 Cisplatin- und andere Wirkstoffe oder Gene eingekapselt in Liposomen zur menschlichen Krebstherapie Expired - Lifetime DE60027039T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US434345 1982-10-14
US09/434,345 US6511676B1 (en) 1999-11-05 1999-11-05 Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
PCT/US2000/029723 WO2001034130A1 (en) 1999-11-05 2000-10-27 Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes

Publications (2)

Publication Number Publication Date
DE60027039D1 DE60027039D1 (de) 2006-05-18
DE60027039T2 true DE60027039T2 (de) 2007-04-12

Family

ID=23723848

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60027039T Expired - Lifetime DE60027039T2 (de) 1999-11-05 2000-10-27 Cisplatin- und andere Wirkstoffe oder Gene eingekapselt in Liposomen zur menschlichen Krebstherapie

Country Status (15)

Country Link
US (3) US6511676B1 (https=)
EP (1) EP1156789B9 (https=)
JP (2) JP2003513911A (https=)
CN (1) CN100562311C (https=)
AT (1) ATE321541T1 (https=)
AU (1) AU777151B2 (https=)
CA (1) CA2358948C (https=)
CY (1) CY1105628T1 (https=)
DE (1) DE60027039T2 (https=)
DK (1) DK1156789T3 (https=)
ES (1) ES2261251T3 (https=)
GR (1) GR1004168B (https=)
PT (1) PT1156789E (https=)
TW (1) TWI259770B (https=)
WO (1) WO2001034130A1 (https=)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE397066T1 (de) * 1993-10-27 2008-06-15 Univ Columbia Methode zur bildung einer subtrahierten cdna bank und ihre verwendung
US5710137A (en) 1996-08-16 1998-01-20 The Trustees Of Columbia University In The City Of New York Use of a melanoma differentiation associated gene (mda 7) for reversing a cancerous phenotype
US6511676B1 (en) * 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
CA2396431A1 (en) * 1999-11-29 2001-05-31 Advanced Research And Technology Institute, Inc. Sustained percutaneous delivery of a biologically active substance
US20030072794A1 (en) * 2000-06-09 2003-04-17 Teni Boulikas Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
US20040220100A1 (en) * 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems
EP1301213B1 (en) * 2000-07-21 2017-01-18 ReVance Therapeutics, Inc. Multi-component biological transport systems
CA2430897C (en) * 2000-12-07 2010-11-16 Universiteit Utrecht Holding B.V. Liposomal composition comprising water-soluble corticosteroids for the treatment of inflammatory disorders
US8658202B2 (en) 2001-04-25 2014-02-25 Western University Of Health Sciences Coated drug delivery formulations
US6759058B1 (en) * 2001-04-25 2004-07-06 Western Center For Drug Development College Of Pharmacy Western University Of Health Sciences Enteric-coated proliposomal formulations for poorly water soluble drugs
JP2005502653A (ja) * 2001-08-20 2005-01-27 トランセーヴ・インコーポレーテッド 肺ガンの治療方法
CA2457148A1 (en) * 2001-08-20 2003-02-27 Transave, Inc. Treatment of cancers by inhalation of stable platinum-containing formulations
WO2003028696A2 (en) * 2001-10-03 2003-04-10 Celator Technologies Inc. Compositions for delivery of drug combinations
CA2383259A1 (en) 2002-04-23 2003-10-23 Celator Technologies Inc. Synergistic compositions
US7850990B2 (en) 2001-10-03 2010-12-14 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
WO2003075889A1 (en) * 2002-03-05 2003-09-18 Transave, Inc. An inhalation system for prevention and treatment of intracellular infections
US20030180348A1 (en) * 2002-03-22 2003-09-25 Levinson R. Saul Transcellular drug delivery system
US20090060992A1 (en) * 2002-05-08 2009-03-05 University Of Central Florida Research Foundation, Inc., Preparation of magneto-vesicles with DOPE/DDAB layers
US20050152962A1 (en) * 2002-06-12 2005-07-14 Metselaar Josbert M. Composition for treatment of inflammatory disorders
US9186322B2 (en) * 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
JP2006502233A (ja) * 2002-08-02 2006-01-19 トランセーブ，インク． 白金凝集物およびその製造方法
EP1393720A1 (en) * 2002-08-27 2004-03-03 Universiteit Utrecht Vesicle-encapsulated corticosteroids for treatment of cancer
US7718189B2 (en) 2002-10-29 2010-05-18 Transave, Inc. Sustained release of antiinfectives
US7879351B2 (en) * 2002-10-29 2011-02-01 Transave, Inc. High delivery rates for lipid based drug formulations, and methods of treatment thereof
EP1581236B1 (en) * 2002-10-29 2013-10-16 Insmed Incorporated Sustained release of antiinfectives
JP4874547B2 (ja) * 2002-11-26 2012-02-15 ギリアード サイエンシーズ， インコーポレイテッド 勾配によるリポソームへの薬物充填方法
US7670604B2 (en) 2002-12-13 2010-03-02 Aurelium Biopharma, Inc. Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
US7413851B2 (en) * 2002-12-13 2008-08-19 Aurelium Biopharma, Inc. Nucleophosmin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
US7550256B2 (en) * 2002-12-13 2009-06-23 Aurelium Biopharma, Inc. Vimentin directed diagnostics and therapeutics for multidrug resistant neoplastic disease
AU2003300676A1 (en) * 2003-01-03 2004-07-29 Aurelium Biopharma Inc. Hsc70 directed diagnostics and therapeutics for multidrug resistant neoplastic disease
WO2004080819A2 (en) * 2003-03-14 2004-09-23 Aurelium Biopharma Inc. Triosephosphate isomerase directed diagnostics and therapeutics for multidrug resistant neoplastic disease
WO2004087105A1 (en) * 2003-04-02 2004-10-14 Celator Pharmaceuticals, Inc. Combination formulations of platinum agents and fluoropyrimidines
EP1643971A2 (en) * 2003-05-22 2006-04-12 Neopharm, Inc. Liposomal formulations comprising a combination of two or more active agents
CA2535584A1 (en) * 2003-08-13 2005-02-24 University Of South Florida Platinum complexes for the treatment of tumors
CA2538729A1 (en) * 2003-09-12 2005-03-31 Avi Biopharma, Inc. Compound and method for treating androgen-independent prostate cancer
US20050095283A1 (en) * 2003-09-16 2005-05-05 Aphios Corporation Compositions and methods for topically treating diseases
US20090208478A1 (en) * 2003-10-24 2009-08-20 Gencia Corporation Transducible polypeptides for modifying metabolism
US8133733B2 (en) 2003-10-24 2012-03-13 Gencia Corporation Nonviral vectors for delivering polynucleotides to target tissues
US20090123468A1 (en) 2003-10-24 2009-05-14 Gencia Corporation Transducible polypeptides for modifying metabolism
US8507277B2 (en) 2003-10-24 2013-08-13 Gencia Corporation Nonviral vectors for delivering polynucleotides
US8062891B2 (en) 2003-10-24 2011-11-22 Gencia Corporation Nonviral vectors for delivering polynucleotides to plants
EP1687017B1 (en) 2003-10-24 2013-03-06 Gencia Corporation Methods and compositions for delivering polynucleotides
CN100471493C (zh) * 2003-12-17 2009-03-25 梅比欧法姆股份有限公司 含有奥沙利铂的脂质体制剂
CA2558676C (en) 2004-03-03 2019-04-16 Essentia Biosystems, Inc. Compositions and methods for topical diagnostic and therapeutic transport
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US8784881B2 (en) * 2004-03-05 2014-07-22 Board Of Regents, The University Of Texas System Liposomal curcumin for treatment of diseases
WO2005089448A2 (en) * 2004-03-18 2005-09-29 Transave, Inc. Administration of cisplatin by inhalation
CA2928387A1 (en) 2004-05-03 2005-11-17 Merrimack Pharmaceuticals, Inc. Drug delivery liposomes containing anionic polyols or anionic sugars
CN101001633A (zh) * 2004-05-21 2007-07-18 特兰萨夫公司 肺病和肺病前期病症的治疗
US20060246124A1 (en) * 2004-11-08 2006-11-02 Pilkiewicz Frank G Methods of treating cancer with lipid-based platinum compound formulations administered intraperitoneally
SG160357A1 (en) * 2005-03-03 2010-04-29 Revance Therapeutics Inc Compositions and methods for topical application and transdermal delivery of botulinum toxins
US20060283742A1 (en) * 2005-06-16 2006-12-21 Canel Lightning Co. Ltd. Multi-lamp display packaging for lamps with collapsible lampshades
US20080088046A1 (en) * 2006-10-13 2008-04-17 Steffen Panzner Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome
CA2523032A1 (en) 2005-10-07 2007-04-07 Immunovaccine Technologies Inc. Vaccines for cancer therapy
CA2891996A1 (en) 2005-10-18 2007-04-26 Duke University Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity
WO2007056263A2 (en) * 2005-11-08 2007-05-18 Transave, Inc. Methods of treating cancer with high potency lipid-based platinum compound formulations administered intravenously
US20070190181A1 (en) * 2005-11-08 2007-08-16 Pilkiewicz Frank G Methods of treating cancer with lipid-based platinum compound forumulations administered intravenously
US9107824B2 (en) * 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
WO2007056264A2 (en) * 2005-11-08 2007-05-18 Transave, Inc. Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
US20070122350A1 (en) * 2005-11-30 2007-05-31 Transave, Inc. Safe and effective methods of administering therapeutic agents
US20090304766A1 (en) * 2005-11-30 2009-12-10 Lawrence Mayer Localized delivery of drug combinations
HUE029994T2 (en) 2005-12-08 2017-04-28 Insmed Inc Lipid-based compositions of antiinfectives for treating pulmonary infections
GR20060100144A (el) * 2006-03-03 2007-10-17 Θεραπεια του καρκινου με χρηση οξαλιπλατινης εγκλεισμενης μεσα σε λιποσωματα και απο κοινου εγκλεισμος στο λιποσωμιακο μοριο περισσοτερων απο ενος φαρμακευτικου παρασκευασματος h gene
DE102006040647A1 (de) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Handwerkzeugmaschine
NZ578164A (en) 2007-01-16 2011-12-22 Musc Found For Res Dev Compositions and methods for diagnosing, treating, and preventing prostate conditions
WO2008137717A1 (en) * 2007-05-04 2008-11-13 Transave, Inc. Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof
US9119783B2 (en) 2007-05-07 2015-09-01 Insmed Incorporated Method of treating pulmonary disorders with liposomal amikacin formulations
US9114081B2 (en) 2007-05-07 2015-08-25 Insmed Incorporated Methods of treating pulmonary disorders with liposomal amikacin formulations
US9333214B2 (en) 2007-05-07 2016-05-10 Insmed Incorporated Method for treating pulmonary disorders with liposomal amikacin formulations
US20100215582A1 (en) * 2007-05-14 2010-08-26 Konica Minolta Holdings, Inc. Liposome and method for producing liposome
ES2550759T3 (es) 2007-08-17 2015-11-12 Celator Pharmaceuticals, Inc. Formulaciones farmacológicas de platino mejoradas
CA2700808C (en) 2007-09-27 2017-11-14 Immunovaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
US20100209452A1 (en) * 2007-10-03 2010-08-19 Immunovaccine Technologies, Inc Compositions comprising an antigen, an amphipathic compound and a hydrophobic carrier, and uses thereof
EP2209420A4 (en) 2007-10-09 2014-01-22 Univ St Louis PARTICULARS FOR IMAGING
US9468607B2 (en) 2007-10-09 2016-10-18 Washington University Ligand directed toroidal nanoparticles for therapy and diagnostic imaging
EP2215223B1 (en) 2007-10-31 2013-05-01 Precision Biosciences, Inc. Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
KR100890317B1 (ko) 2008-05-08 2009-03-26 고려대학교 산학협력단 플라티늄 항암제 조성물 및 제제
ES2524699T3 (es) * 2008-06-05 2014-12-11 Immunovaccine Technologies Inc. Composiciones que comprenden liposomas, un antígeno, un polinucleótido y un vehículo que comprende una fase continua de una sustancia hidrófoba
WO2009156706A1 (en) * 2008-06-27 2009-12-30 University Of Strathclyde Pulmonary drug delivery with vesicles comprising non-ionic surfactants
US20100068302A1 (en) * 2008-09-17 2010-03-18 Traslational Cancer Drugs Pharma, S.L. Methods and compositions for the treatment of cancer
WO2010114922A1 (en) * 2009-03-31 2010-10-07 Agios Pharmaceuticals, Inc. Methods of treating cancer having an aberrant egfr or kras genotype
TWI437001B (zh) * 2009-04-06 2014-05-11 Food Industry Res & Dev Inst 氮雜芬酮（ａｚａｐｈｉｌｏｎｅ）化合物於調節核荷爾蒙受體活性之用途
WO2010135714A2 (en) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
CN102038640B (zh) * 2009-10-26 2013-11-13 石药集团中奇制药技术（石家庄）有限公司 一种含有胆固醇的peg修饰物的脂质体药物及其制备方法
JP2013514999A (ja) 2009-12-17 2013-05-02 ワシントン・ユニバーシティ 抗血栓性ナノ粒子
US9808500B2 (en) 2009-12-17 2017-11-07 Washington University Antithrombotic nanoparticle
AU2011239414A1 (en) * 2010-04-15 2012-11-08 The Washington University Prodrug compositions, prodrug nanoparticles, and methods of use thereof
BR112013005202B1 (pt) * 2010-09-02 2021-07-27 The Scripps Research Institute Lipídeo legumaína-alvo, composição de nanopartículas de legumaína-alvo e usos dos mesmos
PL220281B1 (pl) 2011-09-23 2015-09-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA
JP6240077B2 (ja) 2011-10-06 2017-11-29 イムノバクシーン・テクノロジーズ・インコーポレイテッドＩｍｍｕｎｏｖａｃｃｉｎｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． Ｔｌｒ２を活性化するか、またはその活性を増加させるアジュバントを含むリポソーム組成物およびその使用
CN102525928B (zh) * 2012-02-20 2014-04-02 中国药科大学 一种顺铂长循环脂质体及其制备方法
MX369828B (es) 2012-05-21 2019-11-22 Insmed Inc Sistemas para tratar infecciones pulmonares.
AU2013202947B2 (en) 2012-06-13 2016-06-02 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan
US9717724B2 (en) 2012-06-13 2017-08-01 Ipsen Biopharm Ltd. Methods for treating pancreatic cancer using combination therapies
SG11201501147WA (en) * 2012-08-13 2015-04-29 Regulon Inc Methods for treatment of cancer using lipoplatin
CN121606602A (zh) 2012-09-04 2026-03-06 埃莱森制药股份有限公司 用顺铂脂质复合物预防癌症的肺部复发
CN104884065B (zh) 2012-09-21 2019-01-01 强烈治疗剂公司 治疗癌症的方法
CA2925687A1 (en) * 2012-09-27 2014-04-03 The University Of North Carolina At Chapel Hill Lipid coated nanoparticles containing agents having low aqueous and lipid solubilities and methods thereof
US10113151B2 (en) 2012-10-29 2018-10-30 The Regents Of The University Of California Composition of viral vectors in lecithin liposomes, preparation method and treatment methods
RU2018135921A (ru) 2012-11-29 2019-02-05 Инсмед Инкорпорейтед Стабилизированные составы ванкомицина
LT4095130T (lt) 2013-10-18 2024-04-25 Novartis Ag Žymėti prostatos specifinio membranos antigeno (psma) inhibitoriai, jų naudojimas kaip vizualizavimo medžiagų ir farmacinių medžiagų prostatos vėžiui gydyti
SMT202000516T1 (it) 2014-05-15 2020-11-10 Insmed Inc Metodi per trattamento di infezioni micobatteriche polmonati non tubercolari
US11318131B2 (en) 2015-05-18 2022-05-03 Ipsen Biopharm Ltd. Nanoliposomal irinotecan for use in treating small cell lung cancer
EP3337467B1 (en) 2015-08-20 2020-12-09 Ipsen Biopharm Ltd. Combination therapy using liposomal irinotecan and a parp inhibitor for cancer treatment
MX385425B (es) 2015-08-21 2025-03-18 Ipsen Biopharm Ltd Irinotecán liposomal y oxaliplatino, 5-fluoroacilo y leucovorina para usarse en el tratamiento de cáncer pancreático metastásico.
JP6924431B2 (ja) * 2015-10-13 2021-08-25 株式会社ケーナインラボ ヒトを除く哺乳動物への薬剤の投与方法
MX382522B (es) 2015-10-16 2025-03-13 Ipsen Biopharm Ltd Composiciones farmaceuticas estabilizantes de camptotecina.
FI127460B (en) 2016-01-15 2018-06-29 Targovax Oy Combining adenovirus and chemotherapeutic agents for treating cancer
US10987353B2 (en) 2016-05-04 2021-04-27 The Wistar Institute Of Anatomy And Biology Methods of treating cancers overexpressing CARM1 with EZH2 inhibitors and platinum-based antineoplastic drugs
FR3051674B1 (fr) * 2016-05-31 2019-11-08 Universite De Bourgogne Lipoproteines chargees en complexes de platine pour le traitement du cancer
EP3535026A1 (en) 2016-11-02 2019-09-11 Ipsen Biopharm Limited Treating gastric cancer using combination therapies comprising liposomal irinotecan, oxaliplatin, 5-fluoruracil (and leucovorin)
US20190231690A1 (en) * 2017-11-08 2019-08-01 L.E.A.F. Holdings Group Llc Platinum complexes and uses thereof
CN108042490B (zh) * 2018-01-10 2020-09-15 华中科技大学 纳米载药系统、其制备方法、药物组合物及在治疗癌症中的应用
EP3773505B1 (en) 2018-03-30 2026-04-29 Insmed Incorporated Methods for continuous manufacture of liposomal drug products
JP7197106B2 (ja) * 2018-04-27 2022-12-27 国立大学法人北海道大学 脂質ナノ粒子
WO2019213398A1 (en) 2018-05-02 2019-11-07 Insmed Incorporated Methods for the manufacture of liposomal drug formulations
US11246945B2 (en) 2019-06-07 2022-02-15 National Defense Medical Center Cisplatin-loaded microbubbles, pharmaceutical composition for treatment of cancer, method for preparing pharmaceutical compositions and method for treating cancer
JP2023521400A (ja) * 2020-04-09 2023-05-24 デファイメッド 医療デバイス用の膜
CN118127042B (zh) * 2024-03-18 2024-10-22 安阳工学院 GhBC1基因及其相关生物材料在调控植物油脂积累中的应用
CN118873677B (zh) * 2024-07-08 2025-12-30 北京化工大学 病原体相关分子模式表面修饰的抗肿瘤脂质体纳米载药系统及其制备方法与应用

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2862498A (en) * 1957-06-14 1958-12-02 Don J Weekes Endotracheal tube
US3554673A (en) * 1969-01-31 1971-01-12 Sage Instr Inc Syringe pump
US3683908A (en) * 1969-10-20 1972-08-15 Tantrimudalige Anthony Don Mic Apparatus for sealing the oesophagus and providing artificial respiration
US4104357A (en) * 1973-01-10 1978-08-01 Monster Molding, Inc. Method of rotational molding about plural axes at low rotational speeds
US3931822A (en) * 1974-02-26 1976-01-13 Marici Frank N Automatic alternating cuff endo tracheal tube inflator
US4231365A (en) * 1978-01-30 1980-11-04 Scarberry Eugene N Emergency resuscitation apparatus
DE2816203C2 (de) * 1978-04-14 1982-07-15 Dr.Ing.H.C. F. Porsche Ag, 7000 Stuttgart Schalteinrichtung für ein elektrisch gesteuertes Brennstoff-Einspritzsystem bei Brennkraftmaschinen
GB2111394B (en) * 1981-12-16 1985-09-11 Archibald Ian Jeremy Brain Artificial airway device
US4553540A (en) * 1983-08-16 1985-11-19 Straith Richard E Airway
US4793327A (en) * 1986-01-21 1988-12-27 Frankel Alfred R Device for opening a patient's airway during automatic intubation of the trachea
MX9203808A (es) 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5203320A (en) * 1987-03-24 1993-04-20 Augustine Medical, Inc. Tracheal intubation guide
US4832020A (en) * 1987-03-24 1989-05-23 Augustine Scott D Tracheal intubation guide
US5042469A (en) * 1987-03-24 1991-08-27 Augustine Medical, Inc. Tracheal intubation guide
US4872483A (en) * 1987-12-31 1989-10-10 International Medical Products, Inc. Conveniently hand held self-contained electronic manometer and pressure modulating device
US4953547A (en) * 1989-01-26 1990-09-04 Poole Jr Samuel E Drug administering endotracheal respiration systems
GB2229367A (en) * 1989-03-22 1990-09-26 Archibald Ian Jeremy Brain Artificial airway device
US5549910A (en) 1989-03-31 1996-08-27 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
DE69026820T2 (de) * 1989-03-31 1996-11-28 Univ California Zubereitung von liposomen- und lipid-komplexzusammensetzungen
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5038766A (en) * 1989-11-08 1991-08-13 Parker Jeffrey D Blind orolaryngeal and oroesophageal guiding and aiming device
US5174283A (en) * 1989-11-08 1992-12-29 Parker Jeffrey D Blind orolaryngeal and oroesophageal guiding and aiming device
IS1685B (is) 1990-12-11 1998-02-24 Bracco International B.V. Aðferð við að búa til fitukúlur (liposomes) sem eru gæddar auknum hæfileika til að draga í sig og halda í sér aðskotaefnum
GB9102821D0 (en) * 1991-02-11 1991-03-27 Brain Archibald Ian Jeremy An intubating laryngeal mask airway
US5747469A (en) 1991-03-06 1998-05-05 Board Of Regents, The University Of Texas System Methods and compositions comprising DNA damaging agents and p53
US5339808A (en) * 1991-04-02 1994-08-23 Don Michael T Anthony Endotracheal-esophageal intubation devices
US5235973A (en) * 1991-05-15 1993-08-17 Gary Levinson Tracheal tube cuff inflation control and monitoring system
GB9119703D0 (en) * 1991-09-14 1991-10-30 Dingley John Medico-surgical device
MX9301163A (es) * 1992-03-05 1994-07-29 Brain Archibald Ian Jeremy Mascara laringea y metodo para su fabricacion.
GB9204754D0 (en) * 1992-03-05 1992-04-15 Brain Archibald Ian Jeremy Mould for manufacture of a laryngeal mask
US5249571A (en) * 1992-05-21 1993-10-05 Brain Archibald Ian Jeremy Laryngeal clamp airway
CN1079385A (zh) * 1992-06-01 1993-12-15 丛繁滋 抗癌药物脂质体的制备方法
US5297547A (en) * 1992-07-30 1994-03-29 Brain Archibald Ian Jeremy Laryngeal mask construction
US5334761A (en) * 1992-08-28 1994-08-02 Life Technologies, Inc. Cationic lipids
US5355879A (en) * 1992-09-28 1994-10-18 Brain Archibald Ian Jeremy Laryngeal-mask construction
US5443063A (en) * 1993-08-31 1995-08-22 The Johns Hopkins University Cuffed oro-pharyngeal airway
US5599301A (en) * 1993-11-22 1997-02-04 Advanced Cardiovascular Systems, Inc. Motor control system for an automatic catheter inflation system
GB2285765B (en) * 1994-01-12 1997-10-29 Archibald Ian Jeremy Brain Forming tool for use with a laryngeal mask
US5529582A (en) * 1994-02-01 1996-06-25 Fukuhara; Tomio Apparatus for inserting laryngeal mask
US5582167A (en) * 1994-03-02 1996-12-10 Thomas Jefferson University Methods and apparatus for reducing tracheal infection using subglottic irrigation, drainage and servoregulation of endotracheal tube cuff pressure
JP3782123B2 (ja) * 1994-05-31 2006-06-07 住友ベークライト株式会社 咽腔用エアウエイ
US5569219A (en) * 1994-09-13 1996-10-29 Hakki; A-Hamid Collapsible catheter
GB9422224D0 (en) * 1994-11-03 1994-12-21 Brain Archibald Ian Jeremy A laryngeal mask airway device modified to detect and/or stimulate mescle or nerve activity
US5477851A (en) * 1995-01-26 1995-12-26 Callaghan; Eric B. Laryngeal mask assembly and method for removing same
GB9504657D0 (en) * 1995-03-08 1995-04-26 Neil Michael J O An improved artificial airway device
GB9505134D0 (en) * 1995-03-14 1995-05-03 Smiths Industries Plc Laryngeal mask airways
GB9505399D0 (en) * 1995-03-17 1995-05-03 Smiths Industries Plc Medico-surgical devices
US5908777A (en) 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
GB9513860D0 (en) * 1995-07-07 1995-09-06 Smiths Industries Plc Securing devices
MY115052A (en) * 1995-10-03 2003-03-31 Archibald Ian Jeremy Brain Laryngeal mask airway incorporating an epiglottic elevating mechanism
US5791341A (en) * 1995-12-19 1998-08-11 Bullard; James Roger Oropharyngeal stent with laryngeal aditus shield and nasal airway with laryngeal aditus shield
US5694929A (en) * 1996-02-26 1997-12-09 Christopher; Kent L. Method and apparatus for ventilation/oxygenation during guided insertion of an endotracheal tube
US5623921A (en) * 1996-04-10 1997-04-29 Kinsinger; J. William Laryngeal mask airway and method for its use
US5894060A (en) 1996-06-28 1999-04-13 Boulikas; Teni Cloning method for trapping human origins of replication
US5682880A (en) * 1996-07-26 1997-11-04 Brain; Archibald Ian Jeremy Laryngeal-mask airway with guide element, stiffener, and fiberoptic access
CA2263455C (en) 1996-08-23 2002-10-29 Sequus Pharmaceuticals, Inc. Liposomes containing a cisplatin compound
US5738094A (en) * 1996-08-30 1998-04-14 Hoftman; Moshe Anesthesia/respirator mask with reduced nasal section enclosure and inflatable cuff
GB9619432D0 (en) * 1996-09-18 1996-10-30 Smiths Industries Plc Laryngeal mask assemblies
GB2318297B (en) * 1996-10-16 2000-04-12 Smiths Industries Plc A tracheal shield assembly
GB9622880D0 (en) * 1996-11-02 1997-01-08 Smiths Industries Plc Laryngeal mask airways and thier manufacture
GB9624029D0 (en) * 1996-11-19 1997-01-08 Smiths Industries Ltd Laryngeal mask airways and their manufacture
US5843475A (en) * 1996-12-06 1998-12-01 Board Of Regents, The University Of Texas System Delivery and activation through liposome incorporation of diaminocyclohexane platinum (II) complexes
GB9702337D0 (en) * 1997-02-05 1997-03-26 Smiths Industries Plc Laryngeal mask airways and their manufacture
US5827533A (en) 1997-02-06 1998-10-27 Duke University Liposomes containing active agents aggregated with lipid surfactants
GB9705585D0 (en) * 1997-03-18 1997-05-07 Smiths Industries Plc Laryngeal mask assemlies
US5743254A (en) * 1997-03-18 1998-04-28 Parker Medical Limited Partnership Orotracheal intubation guide
GB9705586D0 (en) * 1997-03-18 1997-05-07 Smiths Industries Plc Laryngeal mask assemblies
GB9705537D0 (en) * 1997-03-18 1997-05-07 Smiths Industries Plc Laryngeal mask assemblies
US6090800A (en) * 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US5937860A (en) * 1997-04-10 1999-08-17 Cook; Daniel J. Laryngeal mask
GB9708568D0 (en) * 1997-04-29 1997-06-18 Smiths Industries Ltd Cuffed medico-surgical tubes
US5988167A (en) * 1997-05-02 1999-11-23 Kamen; Jack M. Foam cuff for laryngeal mask airway
US5850832A (en) * 1997-06-23 1998-12-22 Chu; Kyo Y. Laryngeal mask airway insertion guide
GB9721840D0 (en) * 1997-10-16 1997-12-17 Smiths Industries Plc Laryngeal mask assemblies
US6003510A (en) * 1997-12-04 1999-12-21 Anunta; Boonchuay Hand tool for introducing a laryngeal mask
GB9817537D0 (en) * 1998-08-13 1998-10-07 Brain Archibald Ian Jeremy A laryngear mask airway with mutually independant laterally-placed ultra-flexible eastric access/discharge and airway tubes
US6705318B1 (en) * 1999-04-09 2004-03-16 Archibald I. J. Brain Disposable LMA
US6390093B1 (en) * 1999-04-14 2002-05-21 Vital Signs, Inc. Artificial airway device and method of its use
US6511676B1 (en) * 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
US6427688B1 (en) * 2000-02-01 2002-08-06 Dura Pharmaceuticals, Icn. Dry powder inhaler
GB2383755B (en) * 2002-01-04 2004-02-25 Future Top Medical Environment Obturator for use with a laryngeal mask airway

Also Published As

Publication number Publication date
JP5711099B2 (ja) 2015-04-30
DK1156789T3 (da) 2006-08-07
CA2358948C (en) 2010-01-05
JP2003513911A (ja) 2003-04-15
TWI259770B (en) 2006-08-11
US20030185879A1 (en) 2003-10-02
PT1156789E (pt) 2006-08-31
AU777151B2 (en) 2004-10-07
DE60027039D1 (de) 2006-05-18
CY1105628T1 (el) 2010-12-22
WO2001034130A1 (en) 2001-05-17
ES2261251T3 (es) 2006-11-16
US6511676B1 (en) 2003-01-28
AU1104801A (en) 2001-06-06
EP1156789B9 (en) 2006-06-28
GR20000100384A (el) 2001-07-31
CA2358948A1 (en) 2001-05-17
CN100562311C (zh) 2009-11-25
US7393478B2 (en) 2008-07-01
EP1156789A4 (en) 2002-08-07
EP1156789B1 (en) 2006-03-29
EP1156789A1 (en) 2001-11-28
US20090280164A1 (en) 2009-11-12
CN1343118A (zh) 2002-04-03
GR1004168B (el) 2003-02-26
WO2001034130A9 (en) 2001-12-06
ATE321541T1 (de) 2006-04-15
JP2012041364A (ja) 2012-03-01

Similar Documents

Publication Publication Date Title
DE60027039T2 (de) Cisplatin- und andere Wirkstoffe oder Gene eingekapselt in Liposomen zur menschlichen Krebstherapie
DE69207603T2 (de) Zusammensetzung und verfahren zur behandlung von zystischer fibrose
DE69736432T2 (de) Hemmung der bcl-2 protein expression durch liposomale antisense-oligodeoxynukleotide
Wang et al. Nanopreparations for mitochondria targeting drug delivery system: current strategies and future prospective
Tamam et al. Development of liposomal gemcitabine with high drug loading capacity
US9655848B2 (en) Liposomes for in-vivo delivery
Zhang et al. Cell-permeable NF-κB inhibitor-conjugated liposomes for treatment of glioma
EP0774959B1 (en) A liposomal delivery system for biologically active agents
EP2314285B1 (en) Lipophilic drug delivery vehicle and methods of use thereof
DE69631149T2 (de) Formulierungen in form von emulsionen zur verabreichung von nukleinsäuren an zellen
US20030072794A1 (en) Encapsulation of plasmid DNA (lipogenes™) and therapeutic agents with nuclear localization signal/fusogenic peptide conjugates into targeted liposome complexes
US20030228355A1 (en) Novel hydrogel-isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules
KR101085203B1 (ko) 의약 전달용 인지질 나노입자
DE69830249T2 (de) Zielgerichtete liposomen zur verabreichung von genen
AU2008221633A1 (en) Compositions and methods for intracellular delivery
AU2005204689A2 (en) Lipid compositions and use thereof
AU2002345322A1 (en) Compositions and methods for intracellular delivery
US20200129434A1 (en) Liposome compositions and uses thereof
MXPA01006862A (en) Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
Law et al. Antitumor effect of mitoxantrone-containing liposomes
WO2007014150A2 (en) Method of administering liposomes containing oligonucleotides
Pattni Cell toxicity evaluation of lipid-based nanoparticles delivering survivin-siRNA and Doxil in sensitive and resistant human carcinoma