DE60025398D1 - Kombination aus einem serotonin-wiederaufnahme-inhibitor und einem 5-ht2c-antagonist, -inverse agonist oder einem -partiellen agonisten - Google Patents

Kombination aus einem serotonin-wiederaufnahme-inhibitor und einem 5-ht2c-antagonist, -inverse agonist oder einem -partiellen agonisten

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Publication number
DE60025398D1
DE60025398D1 DE60025398T DE60025398T DE60025398D1 DE 60025398 D1 DE60025398 D1 DE 60025398D1 DE 60025398 T DE60025398 T DE 60025398T DE 60025398 T DE60025398 T DE 60025398T DE 60025398 D1 DE60025398 D1 DE 60025398D1
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DE
Germany
Prior art keywords
agonist
particulate
combination
inverse
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60025398T
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English (en)
Other versions
DE60025398T2 (de
Inventor
Ivo Cremers
Wilhelm Wikstroem
Boer Antonie Den
Jan Bosker
Hendrik Westerink
Peter Bogeso
Sandra Hogg
Arne Mork
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
H Lundbeck AS
Original Assignee
H Lundbeck AS
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Application filed by H Lundbeck AS filed Critical H Lundbeck AS
Publication of DE60025398D1 publication Critical patent/DE60025398D1/de
Application granted granted Critical
Publication of DE60025398T2 publication Critical patent/DE60025398T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/942—Serotonin, i.e. 5-hydroxy-tryptamine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/36—Arsenic; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G01N33/9413—Dopamine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Cell Biology (AREA)
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  • Psychiatry (AREA)
  • Emergency Medicine (AREA)
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  • Diabetes (AREA)
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DE60025398T 1999-12-06 2000-12-06 Kombination aus einem serotonin-wiederaufnahme-inhibitor und einem 5-ht2c-antagonist, -inverse agonist oder einem -partiellen agonisten Expired - Fee Related DE60025398T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16924599P 1999-12-06 1999-12-06
US169245P 1999-12-06
PCT/DK2000/000671 WO2001041701A2 (en) 1999-12-06 2000-12-06 The combination of a serotonin reuptake inhibitor and a 5-ht2c antagonist, inverse agonist or partial agonist

Publications (2)

Publication Number Publication Date
DE60025398D1 true DE60025398D1 (de) 2006-03-30
DE60025398T2 DE60025398T2 (de) 2006-08-03

Family

ID=22614803

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60025398T Expired - Fee Related DE60025398T2 (de) 1999-12-06 2000-12-06 Kombination aus einem serotonin-wiederaufnahme-inhibitor und einem 5-ht2c-antagonist, -inverse agonist oder einem -partiellen agonisten

Country Status (33)

Country Link
US (4) US20020103249A1 (de)
EP (2) EP2036564A1 (de)
JP (1) JP2003516326A (de)
KR (1) KR100832026B1 (de)
CN (2) CN1433313A (de)
AT (1) ATE314849T1 (de)
AU (2) AU1850801A (de)
BG (1) BG106895A (de)
BR (1) BR0016385A (de)
CA (1) CA2393470A1 (de)
CO (1) CO5251409A1 (de)
CY (1) CY1105014T1 (de)
CZ (1) CZ20021961A3 (de)
DE (1) DE60025398T2 (de)
DK (1) DK1237553T3 (de)
EA (1) EA006391B1 (de)
ES (1) ES2255519T3 (de)
HR (1) HRP20020527A2 (de)
HU (1) HUP0203586A3 (de)
IL (2) IL149994A0 (de)
IS (1) IS2227B (de)
ME (1) MEP6208A (de)
MX (1) MXPA02005613A (de)
NO (1) NO20022657L (de)
NZ (1) NZ545907A (de)
PL (1) PL356402A1 (de)
PT (1) PT1237553E (de)
SK (1) SK7962002A3 (de)
TR (1) TR200201512T2 (de)
UA (1) UA77650C2 (de)
WO (2) WO2001041766A1 (de)
YU (1) YU41902A (de)
ZA (1) ZA200204391B (de)

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US20050234093A1 (en) * 2003-06-25 2005-10-20 H. Lundbeck A/S Treatment of depression and other affective disorders
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EA200801812A1 (ru) 2003-09-17 2009-06-30 Янссен Фармацевтика Н.В. Сопряженные гетероциклические соединения
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WO2007107165A1 (en) * 2006-03-22 2007-09-27 H. Lundbeck A/S Method for identifying compounds for the treatment of depression
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US20080081067A1 (en) * 2006-10-03 2008-04-03 Gupta Manishkumar Sustained release pharmaceutical compositions of venlafaxine and process for preparation thereof
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WO2009082268A2 (ru) 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ
WO2010006231A1 (en) * 2008-07-10 2010-01-14 Ore Pharmaceuticals Inc. Treating inflammation and related conditions with irindalone
JP5722891B2 (ja) 2010-07-15 2015-05-27 大日本住友製薬株式会社 ピラゾール化合物
EP2629615B1 (de) 2010-10-22 2018-10-10 Duke University Retardformulierungen aus 5-hydroxytryptophan als zusatz für pro-serotonergische therapien
US10039813B2 (en) 2012-02-07 2018-08-07 Massachusetts Institute Of Technology Use of antagonists of ghrelin or ghrelin receptor to prevent or treat stress-sensitive psychiatric illness
WO2014046544A1 (en) 2012-09-21 2014-03-27 Aapa B.V. Substituted 3-heteroaryloxy-3-(hetero)aryl-propylamines as serotonin transporter and serotonin ht2c receptor modulators
WO2014144231A1 (en) 2013-03-15 2014-09-18 Massachusetts Institute Of Technology Use of antagonists of growth hormone or growth hormone receptor to prevent or treat stress-sensitive psychiatric illness
WO2016138099A1 (en) 2015-02-24 2016-09-01 Massachusetts Institute Of Technology Use of ghrelin or functional ghrelin receptor agonists to prevent and treat stress-sensitive psychiatric illness
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WO2001041766A1 (en) 2001-06-14
IL149994A0 (en) 2002-12-01
NO20022657D0 (no) 2002-06-05
KR20020060987A (ko) 2002-07-19
TR200201512T2 (tr) 2002-09-23
US20070105843A1 (en) 2007-05-10
JP2003516326A (ja) 2003-05-13
CA2393470A1 (en) 2001-06-14
HUP0203586A3 (en) 2005-02-28
MXPA02005613A (es) 2002-12-13
ZA200204391B (en) 2003-11-26
AU1851101A (en) 2001-06-18
HUP0203586A2 (hu) 2003-03-28
US20030032636A1 (en) 2003-02-13
EP2036564A1 (de) 2009-03-18
UA77650C2 (en) 2007-01-15
EP1237553A2 (de) 2002-09-11
SK7962002A3 (en) 2002-09-10
US20020103249A1 (en) 2002-08-01
NZ545907A (en) 2007-07-27
ES2255519T3 (es) 2006-07-01
WO2001041701A3 (en) 2001-12-13
IS6404A (is) 2002-05-31
YU41902A (sh) 2005-06-10
EP1237553B1 (de) 2006-01-04
DK1237553T3 (da) 2006-05-15
EA006391B1 (ru) 2005-12-29
ATE314849T1 (de) 2006-02-15
CY1105014T1 (el) 2009-11-04
IL149994A (en) 2007-07-24
EA200200649A1 (ru) 2002-12-26
PL356402A1 (en) 2004-06-28
PT1237553E (pt) 2006-05-31
DE60025398T2 (de) 2006-08-03
AU1850801A (en) 2001-06-18
IS2227B (is) 2007-04-15
CZ20021961A3 (cs) 2002-11-13
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BR0016385A (pt) 2003-02-18
CO5251409A1 (es) 2003-02-28
NO20022657L (no) 2002-07-26
BG106895A (bg) 2003-04-30
US20090176808A1 (en) 2009-07-09
WO2001041701A2 (en) 2001-06-14
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HRP20020527A2 (en) 2004-12-31
KR100832026B1 (ko) 2008-05-23

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