DE60019894T2 - Phenantrhridin-n-oxides mit pde-iv hemmender wirkung - Google Patents
Phenantrhridin-n-oxides mit pde-iv hemmender wirkung Download PDFInfo
- Publication number
- DE60019894T2 DE60019894T2 DE60019894T DE60019894T DE60019894T2 DE 60019894 T2 DE60019894 T2 DE 60019894T2 DE 60019894 T DE60019894 T DE 60019894T DE 60019894 T DE60019894 T DE 60019894T DE 60019894 T2 DE60019894 T2 DE 60019894T2
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- Prior art keywords
- alkoxy
- alkyl
- substituted
- hydrogen
- compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Junction Field-Effect Transistors (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100693 | 1999-01-15 | ||
| EP99100693 | 1999-01-15 | ||
| PCT/EP2000/000192 WO2000042034A1 (en) | 1999-01-15 | 2000-01-13 | Phenanthridine-n-oxides with pde-iv inhibiting activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60019894D1 DE60019894D1 (de) | 2005-06-09 |
| DE60019894T2 true DE60019894T2 (de) | 2006-01-12 |
Family
ID=8237350
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60019894T Expired - Fee Related DE60019894T2 (de) | 1999-01-15 | 2000-01-13 | Phenantrhridin-n-oxides mit pde-iv hemmender wirkung |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6534519B1 (https=) |
| EP (1) | EP1147103B1 (https=) |
| JP (1) | JP2003502278A (https=) |
| AT (1) | ATE294793T1 (https=) |
| AU (1) | AU2290000A (https=) |
| CA (1) | CA2359449A1 (https=) |
| DE (1) | DE60019894T2 (https=) |
| DK (1) | DK1147103T3 (https=) |
| ES (1) | ES2241571T3 (https=) |
| PT (1) | PT1147103E (https=) |
| SI (1) | SI1147103T1 (https=) |
| WO (1) | WO2000042034A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1650193A3 (en) * | 1999-01-15 | 2006-10-04 | ALTANA Pharma AG | 6-Phenylphenanthridines with PDE-IV inhibiting activity |
| CA2396026A1 (en) | 2000-01-11 | 2001-07-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides |
| PT1303506E (pt) | 2000-07-14 | 2005-06-30 | Altana Pharma Ag | 6-heteroarilfenantridinas |
| CA2495827C (en) * | 2002-08-29 | 2012-05-08 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| ES2281658T3 (es) | 2002-08-29 | 2007-10-01 | Nycomed Gmbh | 3-hidroxi-6-fenilfenantridinas como inhibidores de pde-4. |
| EP1658270A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenantridines |
| CA2533636A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
| US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
| WO2005023253A1 (en) * | 2003-09-05 | 2005-03-17 | Altana Pharma Ag | Use of pde4 inhibitors for the treatment of diabetes mellitus |
| AU2005212857B2 (en) | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| CN104803974A (zh) | 2004-03-03 | 2015-07-29 | 塔科达有限责任公司 | 新的羟基-6-杂芳基菲啶及其作为pde4抑制剂的用途 |
| JP2007527901A (ja) * | 2004-03-10 | 2007-10-04 | アルタナ ファルマ アクチエンゲゼルシャフト | アミド置換された新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用 |
| ES2337083T3 (es) | 2005-03-02 | 2010-04-20 | Nycomed Gmbh | (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1. |
| AU2006222060B2 (en) | 2005-03-08 | 2011-09-01 | Takeda Gmbh | Roflumilast for the treatment of diabetes mellitus |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
| US5475003A (en) * | 1994-03-03 | 1995-12-12 | Syntex (U.S.A.) Inc. | 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives |
| CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
| US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
| UA48216C2 (uk) | 1996-01-31 | 2002-08-15 | Бік Гулден Ломберг Кеміше Фабрік Гмбх | Фенантридини та лікарський засіб для лікування захворювань дихальних шляхів |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| WO1997035854A1 (de) * | 1996-03-26 | 1997-10-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Neue in 6-position substituierte phenanthridine |
| GB9622386D0 (en) | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
| EE03829B1 (et) | 1996-11-11 | 2002-08-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Bensonaftüridiinid, nende kasutamine bronhiaalravimi valmistamiseks ning neid sisaldav ravim |
| GB9626643D0 (en) | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
| JP2001514640A (ja) | 1997-03-07 | 2001-09-11 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規のテトラゾール |
| CA2291153A1 (en) | 1997-06-03 | 1998-12-10 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine |
| DE69822162T2 (de) | 1997-07-25 | 2005-01-27 | Altana Pharma Ag | Neue tetrazolderivate |
| AU5970199A (en) | 1998-08-31 | 2000-03-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
-
2000
- 2000-01-13 AT AT00901539T patent/ATE294793T1/de not_active IP Right Cessation
- 2000-01-13 JP JP2000593602A patent/JP2003502278A/ja not_active Withdrawn
- 2000-01-13 ES ES00901539T patent/ES2241571T3/es not_active Expired - Lifetime
- 2000-01-13 US US09/889,146 patent/US6534519B1/en not_active Expired - Fee Related
- 2000-01-13 PT PT00901539T patent/PT1147103E/pt unknown
- 2000-01-13 CA CA002359449A patent/CA2359449A1/en not_active Abandoned
- 2000-01-13 DK DK00901539T patent/DK1147103T3/da active
- 2000-01-13 DE DE60019894T patent/DE60019894T2/de not_active Expired - Fee Related
- 2000-01-13 AU AU22900/00A patent/AU2290000A/en not_active Abandoned
- 2000-01-13 WO PCT/EP2000/000192 patent/WO2000042034A1/en not_active Ceased
- 2000-01-13 EP EP00901539A patent/EP1147103B1/en not_active Expired - Lifetime
- 2000-01-13 SI SI200030713T patent/SI1147103T1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK1147103T3 (da) | 2005-08-29 |
| JP2003502278A (ja) | 2003-01-21 |
| DE60019894D1 (de) | 2005-06-09 |
| CA2359449A1 (en) | 2000-07-20 |
| EP1147103B1 (en) | 2005-05-04 |
| WO2000042034A1 (en) | 2000-07-20 |
| ES2241571T3 (es) | 2005-11-01 |
| PT1147103E (pt) | 2005-08-31 |
| SI1147103T1 (en) | 2005-10-31 |
| ATE294793T1 (de) | 2005-05-15 |
| EP1147103A1 (en) | 2001-10-24 |
| US6534519B1 (en) | 2003-03-18 |
| AU2290000A (en) | 2000-08-01 |
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| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: NYCOMED GMBH, 78467 KONSTANZ, DE |
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| 8339 | Ceased/non-payment of the annual fee |