DE60019116T2 - Neue omeprazole und (s)-omeprazole zusammensetzung - Google Patents
Neue omeprazole und (s)-omeprazole zusammensetzung Download PDFInfo
- Publication number
- DE60019116T2 DE60019116T2 DE60019116T DE60019116T DE60019116T2 DE 60019116 T2 DE60019116 T2 DE 60019116T2 DE 60019116 T DE60019116 T DE 60019116T DE 60019116 T DE60019116 T DE 60019116T DE 60019116 T2 DE60019116 T2 DE 60019116T2
- Authority
- DE
- Germany
- Prior art keywords
- dosage form
- form according
- omeprazole
- core material
- coated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229960000381 omeprazole Drugs 0.000 title claims abstract description 40
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 title claims abstract description 31
- 239000000203 mixture Substances 0.000 title claims description 23
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 title 1
- 229960004770 esomeprazole Drugs 0.000 title 1
- 239000011162 core material Substances 0.000 claims abstract description 53
- 239000002552 dosage form Substances 0.000 claims abstract description 44
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- 239000004480 active ingredient Substances 0.000 claims abstract description 19
- 159000000011 group IA salts Chemical class 0.000 claims abstract description 14
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 3
- 229910000406 trisodium phosphate Inorganic materials 0.000 claims description 3
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- 229910019142 PO4 Inorganic materials 0.000 description 2
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 description 2
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9902386 | 1999-06-22 | ||
| SE9902386A SE9902386D0 (sv) | 1999-06-22 | 1999-06-22 | New formulation |
| PCT/SE2000/001310 WO2000078293A1 (en) | 1999-06-22 | 2000-06-20 | New formulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60019116D1 DE60019116D1 (de) | 2005-05-04 |
| DE60019116T2 true DE60019116T2 (de) | 2006-02-09 |
Family
ID=20416209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60019116T Expired - Lifetime DE60019116T2 (de) | 1999-06-22 | 2000-06-20 | Neue omeprazole und (s)-omeprazole zusammensetzung |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP1191926B1 (https=) |
| JP (1) | JP2003502359A (https=) |
| KR (1) | KR100717661B1 (https=) |
| CN (1) | CN1243547C (https=) |
| AT (1) | ATE291901T1 (https=) |
| AU (1) | AU778158B2 (https=) |
| BR (1) | BR0011894A (https=) |
| CA (1) | CA2376226C (https=) |
| CZ (1) | CZ20014579A3 (https=) |
| DE (1) | DE60019116T2 (https=) |
| DK (1) | DK1191926T3 (https=) |
| EE (1) | EE200100693A (https=) |
| ES (1) | ES2235912T3 (https=) |
| HK (1) | HK1044480B (https=) |
| HU (1) | HUP0201489A3 (https=) |
| IL (2) | IL146818A0 (https=) |
| IS (1) | IS6209A (https=) |
| MX (1) | MXPA01012636A (https=) |
| NO (1) | NO20016346L (https=) |
| NZ (1) | NZ516186A (https=) |
| PL (1) | PL352873A1 (https=) |
| PT (1) | PT1191926E (https=) |
| RU (1) | RU2240110C2 (https=) |
| SE (1) | SE9902386D0 (https=) |
| SK (1) | SK285326B6 (https=) |
| TR (1) | TR200103693T2 (https=) |
| UA (1) | UA73302C2 (https=) |
| WO (1) | WO2000078293A1 (https=) |
| ZA (1) | ZA200109803B (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US8206741B2 (en) | 2001-06-01 | 2012-06-26 | Pozen Inc. | Pharmaceutical compositions for the coordinated delivery of NSAIDs |
| CA2480826C (fr) | 2002-04-09 | 2012-02-07 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
| SI21402A (sl) | 2003-02-12 | 2004-08-31 | LEK farmacevtska dru�ba d.d. | Obloženi delci in farmacevtske oblike |
| CA2517289A1 (en) * | 2003-02-28 | 2004-09-10 | Ranbaxy Laboratories Limited | Stable pharmaceutical composition of rabeprazole and processes for their preparation |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| WO2005027876A1 (en) * | 2003-08-28 | 2005-03-31 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of benzimidazole and processes for their preparation |
| WO2005020954A2 (en) * | 2003-09-03 | 2005-03-10 | Agi Therapeutics Limited | Proton pump inhibitor formulations, and methods of preparing and using such formulations |
| US7699964B2 (en) | 2004-02-09 | 2010-04-20 | Abbott Diabetes Care Inc. | Membrane suitable for use in an analyte sensor, analyte sensor, and associated method |
| US8165651B2 (en) | 2004-02-09 | 2012-04-24 | Abbott Diabetes Care Inc. | Analyte sensor, and associated system and method employing a catalytic agent |
| US8906940B2 (en) | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| CA2578404A1 (en) * | 2004-08-23 | 2006-03-02 | Auckland Uniservices Limited | Gastric therapies and compositions therefor |
| US7981908B2 (en) | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
| US7803817B2 (en) | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
| FR2885526B1 (fr) * | 2005-05-13 | 2007-07-27 | Flamel Technologies Sa | Medicament oral a base d'inhibiteur de pompe a protons |
| CN101534808A (zh) | 2005-06-27 | 2009-09-16 | 拜维尔实验室国际有限公司 | 丁氨苯丙酮盐的改良释放配制品 |
| US20090175959A1 (en) * | 2005-12-28 | 2009-07-09 | Takeda Pharmaceutical Company Limited | Controlled Release Solid Preparation |
| US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
| PL2046334T3 (pl) | 2006-07-25 | 2015-02-27 | Vecta Ltd | Kompozycje i sposoby hamowania wydzielania kwasów żołądkowych z wykorzystaniem pochodnych małych kwasów dikarboksylowych w połączeniu z PPI |
| US20100055173A1 (en) * | 2006-10-10 | 2010-03-04 | Adel Penhasi | Release of statins in the intestine |
| BRPI0918492A2 (pt) | 2008-09-09 | 2015-12-01 | Astrazeneca Ab | uso de naproxen, ou sal farmaceuticamente aceitável do mesmo, e esomeprazol, ou sal farmaceuticamente aceitável do mesmo |
| EP2445499A4 (en) | 2009-06-25 | 2013-02-27 | Astrazeneca Ab | METHOD FOR TREATING A PATIENT WITH RISK OF DEVELOPING A NSAID-ASSOCIATED SPURGE |
| KR102158948B1 (ko) | 2011-05-13 | 2020-09-24 | 이비 아이피 하이브리탭스 비.브이. | 약물 전달 시스템 |
| EP2586429A1 (en) * | 2011-10-26 | 2013-05-01 | Freund Pharmatec Ltd. | Multi-unit drug delivery device for pulsatile or sustained release |
| UA115139C2 (uk) | 2011-12-28 | 2017-09-25 | Поузен Інк. | Спосіб доставки фармацевтичної композиції, яка містить омепразол й ацетилсаліцилову кислоту, пацієнту |
| WO2013122554A1 (en) | 2012-02-14 | 2013-08-22 | Mahmut Bilgic | Pellet formulations comprising esomeprazole |
| CN103127026B (zh) * | 2013-02-05 | 2017-02-15 | 悦康药业集团有限公司 | 一种奥美拉唑肠溶胶囊及其制备方法 |
| US11229382B2 (en) | 2013-12-31 | 2022-01-25 | Abbott Diabetes Care Inc. | Self-powered analyte sensor and devices using the same |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| RU2614730C1 (ru) * | 2016-02-05 | 2017-03-28 | Игорь Юрьевич Чичерин | Антибактериальное средство и способ лечения кишечного иерсиниоза, или псевдотуберкулеза, или эшерихиоза |
| WO2017145146A1 (en) * | 2016-02-25 | 2017-08-31 | Dexcel Pharma Technologies Ltd. | Compositions comprising proton pump inhibitors |
| JP6426115B2 (ja) * | 2016-04-06 | 2018-11-21 | ニプロ株式会社 | カルシウムブロッカーを含有する固形医薬組成物 |
| JP6462625B2 (ja) * | 2016-04-06 | 2019-01-30 | ニプロ株式会社 | カルシウムブロッカーを含有する錠剤 |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| CN109125282B (zh) * | 2018-09-05 | 2020-07-14 | 珠海润都制药股份有限公司 | 一种奥美拉唑肠溶胶囊及其制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327010C (en) * | 1986-02-13 | 1994-02-15 | Tadashi Makino | Stabilized solid pharmaceutical composition containing antiulcer benzimidazole compound and its production |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| YU48263B (sh) * | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
| SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| AU5179898A (en) * | 1996-11-06 | 1998-05-29 | Sharmatek, Inc. | Delayed delivery system for acid-sensitive drugs |
| SE9702000D0 (sv) * | 1997-05-28 | 1997-05-28 | Astra Ab | New pharmaceutical formulation |
| ATE500815T1 (de) * | 1997-12-08 | 2011-03-15 | Dietrich Rango | Neue suppositoriumsform mit säureempfindlichem wirkstoff |
| JP4988088B2 (ja) * | 1998-08-12 | 2012-08-01 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ピリジン−２−イルメチルスルフィニル−１ｈ−ベンズイミダゾール、もしくはピリジン−２−イルメチルスルフィニル−１ｈ−ベンズイミダゾールの骨格を有する化合物、またはその薬学的に許容される塩の経口投与形組成物を固定的に組み合わせた組成物 |
-
1999
- 1999-06-22 SE SE9902386A patent/SE9902386D0/xx unknown
-
2000
- 2000-06-20 HK HK02106171.6A patent/HK1044480B/en not_active IP Right Cessation
- 2000-06-20 EP EP00946614A patent/EP1191926B1/en not_active Expired - Lifetime
- 2000-06-20 NZ NZ516186A patent/NZ516186A/en unknown
- 2000-06-20 PT PT00946614T patent/PT1191926E/pt unknown
- 2000-06-20 UA UA2001128420A patent/UA73302C2/uk unknown
- 2000-06-20 MX MXPA01012636A patent/MXPA01012636A/es active IP Right Grant
- 2000-06-20 CN CNB008093369A patent/CN1243547C/zh not_active Expired - Fee Related
- 2000-06-20 PL PL00352873A patent/PL352873A1/xx unknown
- 2000-06-20 DE DE60019116T patent/DE60019116T2/de not_active Expired - Lifetime
- 2000-06-20 SK SK1825-2001A patent/SK285326B6/sk not_active IP Right Cessation
- 2000-06-20 EE EEP200100693A patent/EE200100693A/xx unknown
- 2000-06-20 JP JP2001504358A patent/JP2003502359A/ja active Pending
- 2000-06-20 WO PCT/SE2000/001310 patent/WO2000078293A1/en not_active Ceased
- 2000-06-20 KR KR1020017016442A patent/KR100717661B1/ko not_active Expired - Fee Related
- 2000-06-20 AT AT00946614T patent/ATE291901T1/de not_active IP Right Cessation
- 2000-06-20 HU HU0201489A patent/HUP0201489A3/hu unknown
- 2000-06-20 RU RU2001132861/15A patent/RU2240110C2/ru not_active IP Right Cessation
- 2000-06-20 CA CA002376226A patent/CA2376226C/en not_active Expired - Fee Related
- 2000-06-20 CZ CZ20014579A patent/CZ20014579A3/cs unknown
- 2000-06-20 ES ES00946614T patent/ES2235912T3/es not_active Expired - Lifetime
- 2000-06-20 AU AU60344/00A patent/AU778158B2/en not_active Ceased
- 2000-06-20 DK DK00946614T patent/DK1191926T3/da active
- 2000-06-20 IL IL14681800A patent/IL146818A0/xx active IP Right Grant
- 2000-06-20 TR TR2001/03693T patent/TR200103693T2/xx unknown
- 2000-06-20 BR BR0011894-0A patent/BR0011894A/pt not_active Application Discontinuation
-
2001
- 2001-11-28 ZA ZA200109803A patent/ZA200109803B/en unknown
- 2001-11-29 IL IL146818A patent/IL146818A/en not_active IP Right Cessation
- 2001-12-21 IS IS6209A patent/IS6209A/is unknown
- 2001-12-21 NO NO20016346A patent/NO20016346L/no not_active Application Discontinuation
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