DE60017285D1 - Direktkomprimierter tablettenkern auf polymerbasis - Google Patents

Direktkomprimierter tablettenkern auf polymerbasis

Info

Publication number
DE60017285D1
DE60017285D1 DE60017285T DE60017285T DE60017285D1 DE 60017285 D1 DE60017285 D1 DE 60017285D1 DE 60017285 T DE60017285 T DE 60017285T DE 60017285 T DE60017285 T DE 60017285T DE 60017285 D1 DE60017285 D1 DE 60017285D1
Authority
DE
Germany
Prior art keywords
polymer based
tablet core
directly compressed
based tablet
compressed polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017285T
Other languages
English (en)
Other versions
DE60017285T2 (de
Inventor
Joseph Tyler
S Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of DE60017285D1 publication Critical patent/DE60017285D1/de
Application granted granted Critical
Publication of DE60017285T2 publication Critical patent/DE60017285T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60017285T 1999-10-19 2000-10-13 Direktkomprimierter tablettenkern auf polymerbasis Expired - Lifetime DE60017285T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16025899P 1999-10-19 1999-10-19
US160258P 1999-10-19
US17422700P 2000-01-03 2000-01-03
US174227P 2000-01-03
PCT/US2000/028548 WO2001028527A2 (en) 1999-10-19 2000-10-13 Direct compression polymer tablet core

Publications (2)

Publication Number Publication Date
DE60017285D1 true DE60017285D1 (de) 2005-02-10
DE60017285T2 DE60017285T2 (de) 2005-12-08

Family

ID=26856737

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017285T Expired - Lifetime DE60017285T2 (de) 1999-10-19 2000-10-13 Direktkomprimierter tablettenkern auf polymerbasis

Country Status (29)

Country Link
EP (1) EP1239837B1 (de)
JP (4) JP4942271B2 (de)
KR (1) KR100794427B1 (de)
CN (1) CN1202812C (de)
AR (1) AR026067A1 (de)
AT (1) ATE286386T1 (de)
AU (1) AU778262B2 (de)
BG (1) BG106626A (de)
BR (1) BRPI0015061B8 (de)
CA (1) CA2387915C (de)
CZ (1) CZ20021344A3 (de)
DE (1) DE60017285T2 (de)
EA (1) EA200200387A1 (de)
EE (1) EE200200209A (de)
ES (1) ES2235969T3 (de)
HK (1) HK1049451B (de)
HU (1) HUP0203334A2 (de)
IL (1) IL149146A0 (de)
IS (1) IS6343A (de)
MX (1) MXPA02003684A (de)
MY (1) MY125495A (de)
NO (1) NO20021827L (de)
NZ (1) NZ518334A (de)
PL (1) PL364888A1 (de)
PT (1) PT1239837E (de)
SK (1) SK5412002A3 (de)
TR (1) TR200201087T2 (de)
TW (1) TWI225413B (de)
WO (1) WO2001028527A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TR200201087T2 (tr) * 1999-10-19 2002-08-21 Geltex Pharmaceuticals,Inc. Doğrudan sıkıştırmalı polimer tablet
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
CA2551528A1 (en) * 2003-12-31 2005-07-21 Genzyme Corporation Enteric coated aliphatic amine polymer bile acid sequestrants
EP3219312B1 (de) 2004-03-30 2019-01-30 Relypsa, Inc. Ionenbindende polymere und verwendungen davon
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
AU2012200480B2 (en) * 2004-11-01 2014-10-16 Genzyme Corporation "Aliphatic amine polymer salts for tableting"
US20060276534A1 (en) * 2005-03-17 2006-12-07 Amgen Inc. Methods of decreasing calcification
WO2007027566A2 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
PT1924246E (pt) * 2005-09-15 2016-02-10 Genzyme Corp Formulação sachê para polímeros com funcionalidade amina
EP2064252A2 (de) * 2006-09-01 2009-06-03 Usv Limited Verfahren zur herstellung von sevelamerhydrochlorid und formulierung daraus
US8425887B2 (en) 2006-09-29 2013-04-23 Genzyme Corporation Amide dendrimer compositions
EP2120972A1 (de) 2006-12-14 2009-11-25 Genzyme Corporation Amido-amin-polymerzusammensetzungen
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
DE102008030046A1 (de) * 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
KR20110059750A (ko) 2008-09-02 2011-06-03 유에스브이 리미티드 가교 폴리머
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
ES2350999B1 (es) * 2009-06-26 2011-12-07 Combino Pharm, S.L. Nueva composición farmacéutica comprendiendo hidrocloruro de poli (alilamin-co-n,n'-dialil-1,3-diamino-2-hidroxi propano).
WO2010149794A2 (en) 2009-06-26 2010-12-29 Combino Pharm, S.L. Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane)
DK2490675T3 (en) * 2009-10-22 2019-04-29 Synthon Bv Pharmaceutical compositions with sevelamer
EP2545907A1 (de) 2011-07-15 2013-01-16 Combino Pharm, S.L. Verfahren zur wässrig-nassen Granulation für vernetzte Polyallylaminpolymere
TW201400146A (zh) * 2012-06-05 2014-01-01 Takeda Pharmaceutical 有核錠
CN102908325B (zh) * 2012-11-12 2014-07-30 南京生命能科技开发有限公司 一种碳酸司维拉姆药用片剂组合物及其制备方法
CN107412166B (zh) * 2017-08-08 2020-03-24 同济大学 一种纳米复合吸附磷材料及其制备与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ286958B6 (cs) * 1991-07-03 2000-08-16 Pharmacia & Upjohn Company Tabletování lékových směsí hydrochloridu colestipolu
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
TW592727B (en) * 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
JP3389493B2 (ja) * 1997-04-04 2003-03-24 中外製薬株式会社 リン酸結合性ポリマー製剤
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
TR200201087T2 (tr) * 1999-10-19 2002-08-21 Geltex Pharmaceuticals,Inc. Doğrudan sıkıştırmalı polimer tablet

Also Published As

Publication number Publication date
WO2001028527A2 (en) 2001-04-26
CN1202812C (zh) 2005-05-25
JP5583110B2 (ja) 2014-09-03
SK5412002A3 (en) 2002-09-10
EP1239837A2 (de) 2002-09-18
JP5903111B2 (ja) 2016-04-13
PL364888A1 (en) 2004-12-27
KR100794427B1 (ko) 2008-01-16
HK1049451B (zh) 2005-12-16
JP2016000753A (ja) 2016-01-07
IL149146A0 (en) 2002-11-10
JP2014065749A (ja) 2014-04-17
NZ518334A (en) 2003-08-29
JP2012067132A (ja) 2012-04-05
EP1239837B1 (de) 2005-01-05
TR200201087T2 (tr) 2002-08-21
TWI225413B (en) 2004-12-21
BR0015061A (pt) 2002-07-23
WO2001028527A3 (en) 2002-01-03
EA200200387A1 (ru) 2002-10-31
NO20021827D0 (no) 2002-04-18
CZ20021344A3 (cs) 2002-08-14
BRPI0015061B8 (pt) 2021-05-25
CN1382041A (zh) 2002-11-27
AR026067A1 (es) 2002-12-26
EE200200209A (et) 2003-06-16
DE60017285T2 (de) 2005-12-08
ES2235969T3 (es) 2005-07-16
PT1239837E (pt) 2005-05-31
CA2387915C (en) 2007-04-17
HK1049451A1 (en) 2003-05-16
ATE286386T1 (de) 2005-01-15
HUP0203334A2 (hu) 2003-02-28
AU1088701A (en) 2001-04-30
AU778262B2 (en) 2004-11-25
KR20020059629A (ko) 2002-07-13
BG106626A (bg) 2003-03-31
NO20021827L (no) 2002-05-29
BRPI0015061B1 (pt) 2016-03-22
MXPA02003684A (es) 2002-08-30
IS6343A (is) 2002-04-15
JP2003512317A (ja) 2003-04-02
MY125495A (en) 2006-08-30
CA2387915A1 (en) 2001-04-26
JP4942271B2 (ja) 2012-05-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition