DE60017285D1 - DIRECTLY COMPRESSED POLYMER BASED TABLET CORE - Google Patents

DIRECTLY COMPRESSED POLYMER BASED TABLET CORE

Info

Publication number
DE60017285D1
DE60017285D1 DE60017285T DE60017285T DE60017285D1 DE 60017285 D1 DE60017285 D1 DE 60017285D1 DE 60017285 T DE60017285 T DE 60017285T DE 60017285 T DE60017285 T DE 60017285T DE 60017285 D1 DE60017285 D1 DE 60017285D1
Authority
DE
Germany
Prior art keywords
polymer based
tablet core
directly compressed
based tablet
compressed polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017285T
Other languages
German (de)
Other versions
DE60017285T2 (en
Inventor
Joseph Tyler
S Petersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Application granted granted Critical
Publication of DE60017285D1 publication Critical patent/DE60017285D1/en
Publication of DE60017285T2 publication Critical patent/DE60017285T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60017285T 1999-10-19 2000-10-13 DIRECTLY COMPRESSED POLYMER BASED TABLET CORE Expired - Lifetime DE60017285T2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16025899P 1999-10-19 1999-10-19
US160258P 1999-10-19
US17422700P 2000-01-03 2000-01-03
US174227P 2000-01-03
PCT/US2000/028548 WO2001028527A2 (en) 1999-10-19 2000-10-13 Direct compression polymer tablet core

Publications (2)

Publication Number Publication Date
DE60017285D1 true DE60017285D1 (en) 2005-02-10
DE60017285T2 DE60017285T2 (en) 2005-12-08

Family

ID=26856737

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017285T Expired - Lifetime DE60017285T2 (en) 1999-10-19 2000-10-13 DIRECTLY COMPRESSED POLYMER BASED TABLET CORE

Country Status (29)

Country Link
EP (1) EP1239837B1 (en)
JP (4) JP4942271B2 (en)
KR (1) KR100794427B1 (en)
CN (1) CN1202812C (en)
AR (1) AR026067A1 (en)
AT (1) ATE286386T1 (en)
AU (1) AU778262B2 (en)
BG (1) BG106626A (en)
BR (1) BRPI0015061B8 (en)
CA (1) CA2387915C (en)
CZ (1) CZ20021344A3 (en)
DE (1) DE60017285T2 (en)
EA (1) EA200200387A1 (en)
EE (1) EE200200209A (en)
ES (1) ES2235969T3 (en)
HK (1) HK1049451B (en)
HU (1) HUP0203334A2 (en)
IL (1) IL149146A0 (en)
IS (1) IS6343A (en)
MX (1) MXPA02003684A (en)
MY (1) MY125495A (en)
NO (1) NO20021827L (en)
NZ (1) NZ518334A (en)
PL (1) PL364888A1 (en)
PT (1) PT1239837E (en)
SK (1) SK5412002A3 (en)
TR (1) TR200201087T2 (en)
TW (1) TWI225413B (en)
WO (1) WO2001028527A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202812C (en) * 1999-10-19 2005-05-25 基酶有限公司 Direct comperession polymer tablet core
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
CA2551528A1 (en) * 2003-12-31 2005-07-21 Genzyme Corporation Enteric coated aliphatic amine polymer bile acid sequestrants
ES2339571T3 (en) 2004-03-30 2010-05-21 Relypsa, Inc. POLYMERS OF UNION TO POTASSIUM AND USES OF THE SAME.
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
AU2012200480B2 (en) * 2004-11-01 2014-10-16 Genzyme Corporation "Aliphatic amine polymer salts for tableting"
MX2007011153A (en) * 2005-03-17 2007-12-12 Amgen Inc Methods of decreasing calcification.
JP2009507019A (en) 2005-09-02 2009-02-19 ジェンザイム・コーポレーション Method for removing phosphate and polymer used therein
HUE026628T2 (en) * 2005-09-15 2016-06-28 Genzyme Corp Sachet formulation for amine polymers
CA2749074A1 (en) * 2006-09-01 2008-05-29 Usv Limited Process for the preparation of sevelamer hydrochloride and formulation thereof
US8425887B2 (en) 2006-09-29 2013-04-23 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
DE102008030046A1 (en) * 2008-06-25 2009-12-31 Ratiopharm Gmbh Preparation of tablets comprising polyallylamine polymer, useful for treating e.g. hyperphosphatemia, comprises mixing polyallylamine polymer and additives, compacting to slug, granulating the slug and compressing the granules into tablets
CA2735962A1 (en) 2008-09-02 2010-04-15 Usv Limited Crosslinked polymers
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
ES2350999B1 (en) * 2009-06-26 2011-12-07 Combino Pharm, S.L. NEW PHARMACEUTICAL COMPOSITION UNDERSTANDING POLY HYDROCHLORIDE (ALILAMIN-CO-N, N'-DIALIL-1,3-DIAMINO-2-PROPANE HYDROXY).
WO2010149794A2 (en) 2009-06-26 2010-12-29 Combino Pharm, S.L. Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane)
EP2490675B1 (en) * 2009-10-22 2019-01-23 Synthon B.V. Pharmaceutical compositions of sevelamer
EP2545907A1 (en) 2011-07-15 2013-01-16 Combino Pharm, S.L. Aqueous wet granulation process for cross-linked polyallylamine polymers
US9693962B2 (en) * 2012-06-05 2017-07-04 Takeda Pharmaceutical Limited Dry-coated tablet
CN102908325B (en) * 2012-11-12 2014-07-30 南京生命能科技开发有限公司 Sevelamer carbonate medical tablet composition and preparation method thereof
CN107412166B (en) * 2017-08-08 2020-03-24 同济大学 Nano composite phosphorus adsorption material and preparation and application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69227773T2 (en) * 1991-07-03 1999-05-20 Pharmacia & Upjohn Co., Kalamazoo, Mich. TABLETS HIGH IN COLESTIPOLHYDROCHLORIDE
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
JP3389493B2 (en) * 1997-04-04 2003-03-24 中外製薬株式会社 Phosphate-binding polymer preparation
TW592727B (en) * 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
CN1202812C (en) * 1999-10-19 2005-05-25 基酶有限公司 Direct comperession polymer tablet core

Also Published As

Publication number Publication date
BRPI0015061B8 (en) 2021-05-25
JP5903111B2 (en) 2016-04-13
CN1382041A (en) 2002-11-27
WO2001028527A3 (en) 2002-01-03
HK1049451A1 (en) 2003-05-16
EP1239837A2 (en) 2002-09-18
IS6343A (en) 2002-04-15
NO20021827L (en) 2002-05-29
JP2016000753A (en) 2016-01-07
MY125495A (en) 2006-08-30
IL149146A0 (en) 2002-11-10
PL364888A1 (en) 2004-12-27
SK5412002A3 (en) 2002-09-10
MXPA02003684A (en) 2002-08-30
JP4942271B2 (en) 2012-05-30
KR100794427B1 (en) 2008-01-16
NZ518334A (en) 2003-08-29
AU1088701A (en) 2001-04-30
JP2012067132A (en) 2012-04-05
HUP0203334A2 (en) 2003-02-28
BR0015061A (en) 2002-07-23
EP1239837B1 (en) 2005-01-05
AU778262B2 (en) 2004-11-25
KR20020059629A (en) 2002-07-13
CA2387915C (en) 2007-04-17
EE200200209A (en) 2003-06-16
ES2235969T3 (en) 2005-07-16
AR026067A1 (en) 2002-12-26
EA200200387A1 (en) 2002-10-31
DE60017285T2 (en) 2005-12-08
JP5583110B2 (en) 2014-09-03
TR200201087T2 (en) 2002-08-21
TWI225413B (en) 2004-12-21
JP2003512317A (en) 2003-04-02
BG106626A (en) 2003-03-31
HK1049451B (en) 2005-12-16
BRPI0015061B1 (en) 2016-03-22
JP2014065749A (en) 2014-04-17
ATE286386T1 (en) 2005-01-15
CZ20021344A3 (en) 2002-08-14
CA2387915A1 (en) 2001-04-26
PT1239837E (en) 2005-05-31
CN1202812C (en) 2005-05-25
NO20021827D0 (en) 2002-04-18
WO2001028527A2 (en) 2001-04-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition