NO20021827L - Direkte kompresjons-polymer tablettkjerne - Google Patents

Direkte kompresjons-polymer tablettkjerne

Info

Publication number
NO20021827L
NO20021827L NO20021827A NO20021827A NO20021827L NO 20021827 L NO20021827 L NO 20021827L NO 20021827 A NO20021827 A NO 20021827A NO 20021827 A NO20021827 A NO 20021827A NO 20021827 L NO20021827 L NO 20021827L
Authority
NO
Norway
Prior art keywords
tablet core
aliphatic amine
amine polymer
direct compression
approx
Prior art date
Application number
NO20021827A
Other languages
English (en)
Other versions
NO20021827D0 (no
Inventor
Joseph Tyler
John S Petersen
Original Assignee
Geltex Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geltex Pharma Inc filed Critical Geltex Pharma Inc
Publication of NO20021827D0 publication Critical patent/NO20021827D0/no
Publication of NO20021827L publication Critical patent/NO20021827L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Det beskrives en tablettkjerne som omfatter minst ca. 95 vekt% av en alifatisk aminpolymer. Det beskrives også en fremgangsmåte for fremstilling av en tablett- kjerne som omfatter minst ca. 95 vekt% av en alifatisk aminpolymerharpiks. Frem- gangsmåten omfatter det trinn å presse den alifatiske aminpolymer slik at tablett- kjernen dannes. Tablettkjemen kan videre innbefatte ett eller flere hjelpestoffer. Denne fremgangsmåte for fremstilling av tablettkjemen omfatter trinnene: (1) hydratisering av den alifatiske aminpolymer til det ønskede fuktighetsnivå; (2) blanding av den alifatiske aminpolymer med hjelpestoffene i slike mengder at polymeren omfatter minst ca. 95 vekt% av den resulterende blanding; og (3) pressing av blandingen for å danne tablettkjemen. Det beskrives videre en drasjert tablett som omfatter en alifatisk aminpolymerkjeme, hvor drasjeringen er en vann- basert drasjering.
NO20021827A 1999-10-19 2002-04-18 Direkte kompresjons-polymer tablettkjerne NO20021827L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16025899P 1999-10-19 1999-10-19
US17422700P 2000-01-03 2000-01-03
PCT/US2000/028548 WO2001028527A2 (en) 1999-10-19 2000-10-13 Direct compression polymer tablet core

Publications (2)

Publication Number Publication Date
NO20021827D0 NO20021827D0 (no) 2002-04-18
NO20021827L true NO20021827L (no) 2002-05-29

Family

ID=26856737

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20021827A NO20021827L (no) 1999-10-19 2002-04-18 Direkte kompresjons-polymer tablettkjerne

Country Status (29)

Country Link
EP (1) EP1239837B1 (no)
JP (4) JP4942271B2 (no)
KR (1) KR100794427B1 (no)
CN (1) CN1202812C (no)
AR (1) AR026067A1 (no)
AT (1) ATE286386T1 (no)
AU (1) AU778262B2 (no)
BG (1) BG106626A (no)
BR (1) BRPI0015061B8 (no)
CA (1) CA2387915C (no)
CZ (1) CZ20021344A3 (no)
DE (1) DE60017285T2 (no)
EA (1) EA200200387A1 (no)
EE (1) EE200200209A (no)
ES (1) ES2235969T3 (no)
HK (1) HK1049451B (no)
HU (1) HUP0203334A2 (no)
IL (1) IL149146A0 (no)
IS (1) IS6343A (no)
MX (1) MXPA02003684A (no)
MY (1) MY125495A (no)
NO (1) NO20021827L (no)
NZ (1) NZ518334A (no)
PL (1) PL364888A1 (no)
PT (1) PT1239837E (no)
SK (1) SK5412002A3 (no)
TR (1) TR200201087T2 (no)
TW (1) TWI225413B (no)
WO (1) WO2001028527A2 (no)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1202812C (zh) * 1999-10-19 2005-05-25 基酶有限公司 直接压缩聚合物片剂核
US7767768B2 (en) 2003-11-03 2010-08-03 Ilypsa, Inc. Crosslinked amine polymers
US7385012B2 (en) 2003-11-03 2008-06-10 Ilypsa, Inc. Polyamine polymers
US7335795B2 (en) 2004-03-22 2008-02-26 Ilypsa, Inc. Crosslinked amine polymers
US7449605B2 (en) 2003-11-03 2008-11-11 Ilypsa, Inc. Crosslinked amine polymers
US7608674B2 (en) 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
US7459502B2 (en) 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
AU2004311849B2 (en) * 2003-12-31 2009-04-02 Genzyme Corporation Enteric coated aliphatic amine polymer bile acid sequestrants
KR101269766B1 (ko) 2004-03-30 2013-05-30 리립사, 인크. 이온 결합 중합체 및 이의 용도
US7985418B2 (en) * 2004-11-01 2011-07-26 Genzyme Corporation Aliphatic amine polymer salts for tableting
AU2012200480B2 (en) * 2004-11-01 2014-10-16 Genzyme Corporation "Aliphatic amine polymer salts for tableting"
MX2007011153A (es) * 2005-03-17 2007-12-12 Amgen Inc Metodos para reducir la calcificacion.
WO2007027566A2 (en) 2005-09-02 2007-03-08 Genzyme Corporation Method for removing phosphate and polymer used therefore
CA2622693C (en) * 2005-09-15 2015-05-05 Genzyme Corporation Sachet formulation for amine polymers
WO2008062437A2 (en) * 2006-09-01 2008-05-29 Usv Limited Process for the preparation of sevelamer hydrochloride and formulation thereof
EP2066293A2 (en) 2006-09-29 2009-06-10 Genzyme Corporation Amide dendrimer compositions
US8163799B2 (en) 2006-12-14 2012-04-24 Genzyme Corporation Amido-amine polymer compositions
WO2009034540A1 (en) * 2007-09-11 2009-03-19 Ranbaxy Laboratories Limited Pharmaceutical composition of sevelamer
DE102008030046A1 (de) 2008-06-25 2009-12-31 Ratiopharm Gmbh Kompaktiertes Polyallylamin-Polymer
KR20110059750A (ko) 2008-09-02 2011-06-03 유에스브이 리미티드 가교 폴리머
US20100330175A1 (en) * 2009-06-24 2010-12-30 Jobdevairakkam Christopher N Cross-linked polyallylamine tablet core
ES2350999B1 (es) * 2009-06-26 2011-12-07 Combino Pharm, S.L. Nueva composición farmacéutica comprendiendo hidrocloruro de poli (alilamin-co-n,n'-dialil-1,3-diamino-2-hidroxi propano).
WO2010149794A2 (en) 2009-06-26 2010-12-29 Combino Pharm, S.L. Novel pharmaceutical composition comprising poly (allylamin-co-n,n'-diallyl- 1,3-diamino-2-hydroxypropane)
WO2011047700A1 (en) * 2009-10-22 2011-04-28 Synthon B.V. Pharmaceutical compositions of sevelamer
EP2545907A1 (en) 2011-07-15 2013-01-16 Combino Pharm, S.L. Aqueous wet granulation process for cross-linked polyallylamine polymers
JP6289367B2 (ja) * 2012-06-05 2018-03-07 武田薬品工業株式会社 有核錠
CN102908325B (zh) * 2012-11-12 2014-07-30 南京生命能科技开发有限公司 一种碳酸司维拉姆药用片剂组合物及其制备方法
CN107412166B (zh) * 2017-08-08 2020-03-24 同济大学 一种纳米复合吸附磷材料及其制备与应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2124736T3 (es) * 1991-07-03 1999-02-16 Upjohn Co Comprimidos con alto contenido de clorhidrato de colestipol.
US5496545A (en) * 1993-08-11 1996-03-05 Geltex Pharmaceuticals, Inc. Phosphate-binding polymers for oral administration
JP3389493B2 (ja) * 1997-04-04 2003-03-24 中外製薬株式会社 リン酸結合性ポリマー製剤
TW592727B (en) * 1997-04-04 2004-06-21 Chugai Pharmaceutical Co Ltd Phosphate-binding polymer preparations
US6083497A (en) * 1997-11-05 2000-07-04 Geltex Pharmaceuticals, Inc. Method for treating hypercholesterolemia with unsubstituted polydiallylamine polymers
TW568788B (en) * 1998-10-12 2004-01-01 Chugai Pharmaceutical Co Ltd Polymer combining with phosphoric acid and preparation containing the same
CN1202812C (zh) * 1999-10-19 2005-05-25 基酶有限公司 直接压缩聚合物片剂核

Also Published As

Publication number Publication date
EE200200209A (et) 2003-06-16
WO2001028527A2 (en) 2001-04-26
JP2003512317A (ja) 2003-04-02
PL364888A1 (en) 2004-12-27
KR100794427B1 (ko) 2008-01-16
NO20021827D0 (no) 2002-04-18
BRPI0015061B8 (pt) 2021-05-25
BG106626A (bg) 2003-03-31
NZ518334A (en) 2003-08-29
ES2235969T3 (es) 2005-07-16
AR026067A1 (es) 2002-12-26
JP2012067132A (ja) 2012-04-05
MY125495A (en) 2006-08-30
AU778262B2 (en) 2004-11-25
HK1049451A1 (en) 2003-05-16
MXPA02003684A (es) 2002-08-30
TR200201087T2 (tr) 2002-08-21
TWI225413B (en) 2004-12-21
CN1382041A (zh) 2002-11-27
HUP0203334A2 (hu) 2003-02-28
IL149146A0 (en) 2002-11-10
KR20020059629A (ko) 2002-07-13
BRPI0015061B1 (pt) 2016-03-22
JP4942271B2 (ja) 2012-05-30
CA2387915C (en) 2007-04-17
BR0015061A (pt) 2002-07-23
SK5412002A3 (en) 2002-09-10
JP5903111B2 (ja) 2016-04-13
EP1239837A2 (en) 2002-09-18
HK1049451B (zh) 2005-12-16
DE60017285D1 (de) 2005-02-10
CA2387915A1 (en) 2001-04-26
PT1239837E (pt) 2005-05-31
JP5583110B2 (ja) 2014-09-03
CN1202812C (zh) 2005-05-25
CZ20021344A3 (cs) 2002-08-14
AU1088701A (en) 2001-04-30
EP1239837B1 (en) 2005-01-05
EA200200387A1 (ru) 2002-10-31
JP2016000753A (ja) 2016-01-07
JP2014065749A (ja) 2014-04-17
DE60017285T2 (de) 2005-12-08
ATE286386T1 (de) 2005-01-15
WO2001028527A3 (en) 2002-01-03
IS6343A (is) 2002-04-15

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