DE60017159D1 - In vivo assay zur prüfung der phänotypischen stabilität - Google Patents

In vivo assay zur prüfung der phänotypischen stabilität

Info

Publication number
DE60017159D1
DE60017159D1 DE60017159T DE60017159T DE60017159D1 DE 60017159 D1 DE60017159 D1 DE 60017159D1 DE 60017159 T DE60017159 T DE 60017159T DE 60017159 T DE60017159 T DE 60017159T DE 60017159 D1 DE60017159 D1 DE 60017159D1
Authority
DE
Germany
Prior art keywords
chondrocytes
vivo assay
outcome
phenotypic stability
stability
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017159T
Other languages
English (en)
Other versions
DE60017159T2 (de
Inventor
Frank Luyten
Bari Cosimo De
Accio Francesco Dell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tigenix NV
Original Assignee
Tigenix NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tigenix NV filed Critical Tigenix NV
Publication of DE60017159D1 publication Critical patent/DE60017159D1/de
Application granted granted Critical
Publication of DE60017159T2 publication Critical patent/DE60017159T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0006—Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE60017159T 1999-10-06 2000-10-06 In vivo assay zur prüfung der phänotypischen stabilität Expired - Lifetime DE60017159T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99203273 1999-10-06
EP99203273 1999-10-06
PCT/BE2000/000118 WO2001024833A2 (en) 1999-10-06 2000-10-06 In vivo assay for testing the phenotypic stability

Publications (2)

Publication Number Publication Date
DE60017159D1 true DE60017159D1 (de) 2005-02-03
DE60017159T2 DE60017159T2 (de) 2006-05-04

Family

ID=8240723

Family Applications (3)

Application Number Title Priority Date Filing Date
DE122010000021C Pending DE122010000021I1 (de) 1999-10-06 2000-10-06 In vivo assay zur prüfung der phänotypischen stabilität
DE20023659U Expired - Lifetime DE20023659U1 (de) 1999-10-06 2000-10-06 Molekulare Marker zum Testen der phänotypischen Stabilität von Zellpopulationen und Zellpopulationen für die autologe Transplantation
DE60017159T Expired - Lifetime DE60017159T2 (de) 1999-10-06 2000-10-06 In vivo assay zur prüfung der phänotypischen stabilität

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DE122010000021C Pending DE122010000021I1 (de) 1999-10-06 2000-10-06 In vivo assay zur prüfung der phänotypischen stabilität
DE20023659U Expired - Lifetime DE20023659U1 (de) 1999-10-06 2000-10-06 Molekulare Marker zum Testen der phänotypischen Stabilität von Zellpopulationen und Zellpopulationen für die autologe Transplantation

Country Status (12)

Country Link
US (2) US7479367B1 (de)
EP (2) EP1218037B1 (de)
AT (1) ATE285797T1 (de)
AU (1) AU7764200A (de)
CA (1) CA2397610C (de)
CY (1) CY2010007I2 (de)
DE (3) DE122010000021I1 (de)
DK (1) DK1218037T3 (de)
ES (2) ES2234673T3 (de)
LU (1) LU91672I2 (de)
PT (1) PT1218037E (de)
WO (1) WO2001024833A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001024833A2 (en) * 1999-10-06 2001-04-12 Tigenix N.V. In vivo assay for testing the phenotypic stability
US7482114B2 (en) 1999-10-06 2009-01-27 Tigenix N.V. In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation
WO2001095860A2 (en) * 2000-06-14 2001-12-20 Case Western Reserve University Probes for chondrogenesis
WO2004013606A2 (en) * 2002-08-02 2004-02-12 Stratatech Corporation Species specific dna detection
EP2004806A2 (de) 2006-03-20 2008-12-24 Tigenix N.V. Verfahren zur aufrechterhaltung, verbesserung und wiederherstellung des knorpelphänotyps von chondrozyten
CN101616693A (zh) 2006-11-24 2009-12-30 泰根尼克斯股份有限公司 用于鉴定软骨细胞表型稳定性以及筛选软骨形成影响因子的标记基因
CN101215565B (zh) * 2008-01-11 2011-04-27 华中农业大学 一种作为猪标记辅助选择的与免疫性状相关的分子标记的克隆及应用
GB0902793D0 (en) 2009-02-20 2009-04-08 Univ Gent GDF15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes
EP3872168A1 (de) * 2020-02-28 2021-09-01 Cline Scientific AB Chondrozytendifferenzierung
EP4200019A1 (de) 2020-08-21 2023-06-28 Genzyme Corporation Fgfr3-antikörper und verfahren zur verwendung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837258A (en) * 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US5723331A (en) * 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
US5902785A (en) 1995-06-06 1999-05-11 Genetics Institute, Inc. Cartilage induction by bone morphogenetic proteins
AU721773B2 (en) 1995-06-12 2000-07-13 Yeda Research And Development Co. Ltd. FGF9 as a specific ligand for FGFR3
AU742342B2 (en) 1997-05-21 2001-12-20 Clontech Laboratories, Inc. Nucleic acid arrays
AU7984498A (en) 1997-06-25 1999-01-04 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Serum-free cell growth medium
WO2001024833A2 (en) * 1999-10-06 2001-04-12 Tigenix N.V. In vivo assay for testing the phenotypic stability
US7482114B2 (en) 1999-10-06 2009-01-27 Tigenix N.V. In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation
ATE283349T1 (de) * 1999-10-06 2004-12-15 Tigenix Nv Isolierung von vorläuferzellen und deren verwendung zum wiederaufbau von bindegewebe

Also Published As

Publication number Publication date
US7479367B1 (en) 2009-01-20
US9089598B2 (en) 2015-07-28
DE20023659U1 (de) 2005-07-07
CA2397610C (en) 2012-07-03
EP1218037B1 (de) 2004-12-29
ES2234673T3 (es) 2005-07-01
AU7764200A (en) 2001-05-10
DE122010000021I1 (de) 2012-09-06
CY2010007I1 (el) 2010-07-28
LU91672I2 (fr) 2010-06-02
DK1218037T3 (da) 2005-04-25
US20090162328A1 (en) 2009-06-25
EP1218037A2 (de) 2002-07-03
EP1498146A2 (de) 2005-01-19
ES2488240T1 (es) 2014-08-26
WO2001024833A3 (en) 2001-12-20
EP1498146A3 (de) 2007-01-24
CA2397610A1 (en) 2001-04-12
DE60017159T2 (de) 2006-05-04
WO2001024833A2 (en) 2001-04-12
ATE285797T1 (de) 2005-01-15
CY2010007I2 (el) 2010-07-28
PT1218037E (pt) 2005-05-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: EX VIVO EXPANDIERTE SPEZIFISCHE MARKERPROTEINE EXPRIMIERENDE CHARAKTERISIERTE LEBENSFAEHIGE AUTOLOGE KNORPELZELLEN; REGISTRATION NO/DATE: EU/1/09/563/001, 20091005

Spc suppl protection certif: 12 2010 000 021

Filing date: 20100401