ATE306559T1 - Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben - Google Patents

Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben

Info

Publication number
ATE306559T1
ATE306559T1 AT99907122T AT99907122T ATE306559T1 AT E306559 T1 ATE306559 T1 AT E306559T1 AT 99907122 T AT99907122 T AT 99907122T AT 99907122 T AT99907122 T AT 99907122T AT E306559 T1 ATE306559 T1 AT E306559T1
Authority
AT
Austria
Prior art keywords
bioactivity
screening compounds
organ tissues
compound
biological parameter
Prior art date
Application number
AT99907122T
Other languages
English (en)
Inventor
Herman H Vandenburgh
Robert F Valentini
Original Assignee
Herman H Vandenburgh
Robert F Valentini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Herman H Vandenburgh, Robert F Valentini filed Critical Herman H Vandenburgh
Application granted granted Critical
Publication of ATE306559T1 publication Critical patent/ATE306559T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99907122T 1998-02-18 1999-02-18 Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben ATE306559T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7505498P 1998-02-18 1998-02-18
US8637098P 1998-05-22 1998-05-22
PCT/US1999/003459 WO1999042604A1 (en) 1998-02-18 1999-02-18 Methods of screening compounds for bioactivity in organized tissue

Publications (1)

Publication Number Publication Date
ATE306559T1 true ATE306559T1 (de) 2005-10-15

Family

ID=26756388

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99907122T ATE306559T1 (de) 1998-02-18 1999-02-18 Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben

Country Status (6)

Country Link
US (3) US20020106627A1 (de)
EP (1) EP1088096B1 (de)
AT (1) ATE306559T1 (de)
AU (1) AU2685699A (de)
DE (1) DE69927685T2 (de)
WO (1) WO1999042604A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003068979A2 (en) * 2001-08-06 2003-08-21 Vanderbilt University System and methods for discriminating an agent
DE102014003465A1 (de) 2014-03-11 2015-09-17 NeuroProof GmbH Gewinnung von Gehirnregion-spezifischen neuronalen Kulturen aus dreidimensionalen Gewebekulturen von Stammzellen
EP3525584B1 (de) * 2016-10-14 2023-05-03 Wake Forest University Health Sciences Multiorgan- körper-auf-einem-chip -vorrichtung unter verwendung eines gemeinsamen mediums
EP3746785A4 (de) 2018-02-02 2022-05-11 Wake Forest University Health Sciences, Inc. Mit einer immuntherapie verwandte organoide und verfahren zur herstellung und verwendung davon

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863531A (en) * 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
US5153136A (en) * 1988-07-22 1992-10-06 Vandenburgh Herman H Apparatus for growing tissue specimens in vitro
US4940853A (en) * 1988-07-22 1990-07-10 Vandenburgh Herman H Method for growing tissue specimens in vitro
US5521087A (en) * 1989-05-10 1996-05-28 Massachusetts Institute Of Technology Method for producing oriented connective tissue cells in a ligament configuration
US5340736A (en) * 1991-05-13 1994-08-23 The President & Fellows Of Harvard College ATP-dependent protease and use of inhibitors for same in the treatment of cachexia and muscle wasting
US5661133B1 (en) * 1991-11-12 1999-06-01 Univ Michigan Collateral blood vessel formation in cardiac muscle by injecting a dna sequence encoding an angiogenic protein
US5618718A (en) * 1994-12-30 1997-04-08 Universite Laval Production of a contractile smooth muscle
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US5888982A (en) * 1996-04-01 1999-03-30 President And Fellows Of Harvard College Regulation of vascular smooth muscle cell heme oxygenase-1
US6008010A (en) * 1996-11-01 1999-12-28 University Of Pittsburgh Method and apparatus for holding cells
US6114164A (en) * 1998-12-07 2000-09-05 The Regents Of The University Of Michigan System and method for emulating an in vivo environment of a muscle tissue specimen

Also Published As

Publication number Publication date
US20020106627A1 (en) 2002-08-08
EP1088096A4 (de) 2002-02-06
US20100190165A1 (en) 2010-07-29
US20030027202A1 (en) 2003-02-06
AU2685699A (en) 1999-09-06
DE69927685D1 (de) 2006-02-23
WO1999042604A1 (en) 1999-08-26
EP1088096B1 (de) 2005-10-12
WO1999042604A8 (en) 1999-10-28
EP1088096A1 (de) 2001-04-04
DE69927685T2 (de) 2006-07-13

Similar Documents

Publication Publication Date Title
ATE111228T1 (de) Verfahren zur überwachung des kollagenabbaus.
DE69938662D1 (de) Spurendetektion von analyten mit hilfe artifizieller olfaktometrie
ATE179521T1 (de) Verfahren zum in-vivo-nachweis von kollagenabbau
DE59903915D1 (de) Verfahren zur frühen diagnose von carcinomen
ATE400219T1 (de) Verfahren zur quantifizierung von menschlicher wachsamkeit
DE69128362D1 (de) Zusammensetzungen und verfahren zur identifizierung von molekülen mit biologischer wirksamkeit
DE69528848D1 (de) Vorrichtung zur Auswertung von Gewebe-Eigenschaften
DE69633312D1 (de) Verfahren zur Verbesserung der Verschleissfestigkeit von biokompatiblen Polymerkomponenten
ATE455554T1 (de) Verfahren zur erhöhung der mageren fleischmasse mit fettleibigkeitsprotein (ob) zusammensetzungen
DE69838434D1 (de) Luziferase und verfahren zur bestimmung von intrazellulärem atp unter verwendung derselben
WO2003039491A8 (en) Novel isoforms of vascular endothelial cell growth inhibitor
DE69636749D1 (de) Methode zur bestimmung von proteinfragmenten in körperflüssigkeiten
ATE367819T1 (de) Isolierte stromazellen und methoden zu deren verwendung
ATE395433T1 (de) Screeningverfahren für geeignete wirkstoffe
ATE422334T1 (de) System und verfahren zur gewebeanalyse
ATE306559T1 (de) Verfahren zum screenen von verbindungen mit bioaktivität in organgeweben
DE69939723D1 (de) Verwendung von Intereferon Gamma zur Behandlung von Herzhypertrophie
DE59009364D1 (de) Verfahren zur quantitativen Bestimmung zumindest eines chemischen Parameters eines Probenmediums.
DE60038614D1 (de) Verfahren zur diagnose von synovialen oder osteoartikulären erkrankungen
DE69941317D1 (de) Verfahren zur Untersuchung von Gasen
DE60016951D1 (de) Zellulosefilme zur durchfuehrung von screening-verfahren
ATE212083T1 (de) Verfahren zum einarbeiten eines wirkstoffes in ein kunstoffbauteil
ATE253223T1 (de) Verfahren und materialien zur diagnose instabiler angina
DE69023710D1 (de) Verfahren zur bestimmung von enzymatischer wirksamkeit.
ATA124192A (de) Verfahren zur bestimmung, quantifizierung und/oder ojektivierung von geruchsimmissionen, anordnung zur durchführung des verfahrens und verwendung desselben

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties