ES2488240T1 - Ensayos in vivo y marcadores moleculares para comprobar la estabilidad fenotípica - Google Patents
Ensayos in vivo y marcadores moleculares para comprobar la estabilidad fenotípica Download PDFInfo
- Publication number
- ES2488240T1 ES2488240T1 ES04077642.9T ES04077642T ES2488240T1 ES 2488240 T1 ES2488240 T1 ES 2488240T1 ES 04077642 T ES04077642 T ES 04077642T ES 2488240 T1 ES2488240 T1 ES 2488240T1
- Authority
- ES
- Spain
- Prior art keywords
- phenotypic stability
- check
- cartilage
- procedure
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000005462 in vivo assay Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 5
- 210000000845 cartilage Anatomy 0.000 abstract 3
- 238000001727 in vivo Methods 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 241000699670 Mus sp. Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000006285 cell suspension Substances 0.000 abstract 1
- 210000001612 chondrocyte Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0006—Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pathology (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Un método para evaluar si un cierto tratamiento o procedimiento aumenta la estabilidad fenotípica de una suspensión de células aisladas o expandidas, dicho método comprende: a) someter dicha suspensión de células a dicho tratamiento o procedimiento b) inyectar por vía intramuscular o subcutánea en un mamífero no humano dicha suspensión que comprende un equivalente de al menos 1x106 condrocitos articulares aplicados a ratones inmunodeficientes c) evaluar el cartílago formado in vivo histológicamente respecto si es estable, cartílago desprovisto de cualquier signo de vascularización, y d) identificar si o no dicho tratamiento o procedimiento afecta a la formación de cartílago estable in vivo.
Claims (1)
-
imagen1
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99203273 | 1999-10-06 | ||
EP99203273 | 1999-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2488240T1 true ES2488240T1 (es) | 2014-08-26 |
Family
ID=8240723
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00967443T Expired - Lifetime ES2234673T3 (es) | 1999-10-06 | 2000-10-06 | Prueba in vivo para verificar la estabilidad fenotipica. |
ES04077642.9T Pending ES2488240T1 (es) | 1999-10-06 | 2000-10-06 | Ensayos in vivo y marcadores moleculares para comprobar la estabilidad fenotípica |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00967443T Expired - Lifetime ES2234673T3 (es) | 1999-10-06 | 2000-10-06 | Prueba in vivo para verificar la estabilidad fenotipica. |
Country Status (12)
Country | Link |
---|---|
US (2) | US7479367B1 (es) |
EP (2) | EP1218037B1 (es) |
AT (1) | ATE285797T1 (es) |
AU (1) | AU7764200A (es) |
CA (1) | CA2397610C (es) |
CY (1) | CY2010007I1 (es) |
DE (3) | DE20023659U1 (es) |
DK (1) | DK1218037T3 (es) |
ES (2) | ES2234673T3 (es) |
LU (1) | LU91672I2 (es) |
PT (1) | PT1218037E (es) |
WO (1) | WO2001024833A2 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7764200A (en) * | 1999-10-06 | 2001-05-10 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cellpopulations, and selecting cell populations for autologous transplantation |
US7482114B2 (en) | 1999-10-06 | 2009-01-27 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation |
WO2001095860A2 (en) * | 2000-06-14 | 2001-12-20 | Case Western Reserve University | Probes for chondrogenesis |
EP1546392A4 (en) * | 2002-08-02 | 2006-05-24 | Stratatech Corp | DETECTION OF SPECIFIC DNA FROM SPECIES |
WO2007107330A2 (en) | 2006-03-20 | 2007-09-27 | Tigenix N.V. | Methods to maintain, improve and restore the cartilage phenotype of chondrocytes |
WO2008061804A2 (en) | 2006-11-24 | 2008-05-29 | Tigenix N.V. | Marker genes for use in the identification of chondrocyte phenotypic stability and in the screening of factors influencing cartilage production |
CN101215565B (zh) * | 2008-01-11 | 2011-04-27 | 华中农业大学 | 一种作为猪标记辅助选择的与免疫性状相关的分子标记的克隆及应用 |
GB0902793D0 (en) | 2009-02-20 | 2009-04-08 | Univ Gent | GDF15 as molecular tool to monitor and enhance phenotypic stability of articular chondrocytes |
EP3872168A1 (en) * | 2020-02-28 | 2021-09-01 | Cline Scientific AB | Chondrocyte differentiation |
JP2023538098A (ja) | 2020-08-21 | 2023-09-06 | ジェンザイム・コーポレーション | Fgfr3抗体および使用の方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5837258A (en) * | 1991-08-30 | 1998-11-17 | University Of South Florida | Induction of tissue, bone or cartilage formation using connective tissue growth factor |
US5723331A (en) | 1994-05-05 | 1998-03-03 | Genzyme Corporation | Methods and compositions for the repair of articular cartilage defects in mammals |
US5902785A (en) * | 1995-06-06 | 1999-05-11 | Genetics Institute, Inc. | Cartilage induction by bone morphogenetic proteins |
ATE225652T1 (de) | 1995-06-12 | 2002-10-15 | Yeda Res & Dev | Fgfr3 als signal für die vorläufer der mesenchymzellen des skeletts |
EP0988398A4 (en) | 1997-05-21 | 2005-05-18 | Clontech Lab Inc | Nucleic Acid Arrays |
WO1998059035A2 (en) * | 1997-06-25 | 1998-12-30 | The Goverment Of The United States Of America, Represented By The Secretary, Dept. Of Health And Human Services, National Institutes Of Health | Serum-free cell growth medium |
AU7764200A (en) * | 1999-10-06 | 2001-05-10 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cellpopulations, and selecting cell populations for autologous transplantation |
AU7634400A (en) * | 1999-10-06 | 2001-05-10 | Tigenix N.V. | Isolation of precursor cells and their use for tissue repair |
US7482114B2 (en) | 1999-10-06 | 2009-01-27 | Tigenix N.V. | In vivo assay and molecular markers for testing the phenotypic stability of cell populations, and selected cell populations for autologous transplantation |
-
2000
- 2000-10-06 AU AU77642/00A patent/AU7764200A/en not_active Abandoned
- 2000-10-06 ES ES00967443T patent/ES2234673T3/es not_active Expired - Lifetime
- 2000-10-06 EP EP00967443A patent/EP1218037B1/en not_active Expired - Lifetime
- 2000-10-06 DE DE20023659U patent/DE20023659U1/de not_active Expired - Lifetime
- 2000-10-06 WO PCT/BE2000/000118 patent/WO2001024833A2/en active IP Right Grant
- 2000-10-06 CA CA2397610A patent/CA2397610C/en not_active Expired - Lifetime
- 2000-10-06 DE DE60017159T patent/DE60017159T2/de not_active Expired - Lifetime
- 2000-10-06 ES ES04077642.9T patent/ES2488240T1/es active Pending
- 2000-10-06 AT AT00967443T patent/ATE285797T1/de active
- 2000-10-06 US US10/089,932 patent/US7479367B1/en not_active Expired - Fee Related
- 2000-10-06 DE DE122010000021C patent/DE122010000021I1/de active Pending
- 2000-10-06 DK DK00967443T patent/DK1218037T3/da active
- 2000-10-06 EP EP20040077642 patent/EP1498146A3/en not_active Withdrawn
- 2000-10-06 PT PT00967443T patent/PT1218037E/pt unknown
-
2008
- 2008-11-25 US US12/323,185 patent/US9089598B2/en not_active Expired - Fee Related
-
2010
- 2010-03-31 CY CY2010007C patent/CY2010007I1/el unknown
- 2010-04-02 LU LU91672C patent/LU91672I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
ES2234673T3 (es) | 2005-07-01 |
EP1218037A2 (en) | 2002-07-03 |
PT1218037E (pt) | 2005-05-31 |
ATE285797T1 (de) | 2005-01-15 |
EP1498146A3 (en) | 2007-01-24 |
DE20023659U1 (de) | 2005-07-07 |
US9089598B2 (en) | 2015-07-28 |
WO2001024833A2 (en) | 2001-04-12 |
WO2001024833A3 (en) | 2001-12-20 |
CA2397610A1 (en) | 2001-04-12 |
DE60017159D1 (de) | 2005-02-03 |
DE60017159T2 (de) | 2006-05-04 |
DK1218037T3 (da) | 2005-04-25 |
AU7764200A (en) | 2001-05-10 |
CY2010007I2 (el) | 2010-07-28 |
CA2397610C (en) | 2012-07-03 |
EP1498146A2 (en) | 2005-01-19 |
LU91672I2 (fr) | 2010-06-02 |
US20090162328A1 (en) | 2009-06-25 |
EP1218037B1 (en) | 2004-12-29 |
CY2010007I1 (el) | 2010-07-28 |
DE122010000021I1 (de) | 2012-09-06 |
US7479367B1 (en) | 2009-01-20 |
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