DE60008790T3 - Medizinische verbände enthaltend gelartigen honig - Google Patents
Medizinische verbände enthaltend gelartigen honig Download PDFInfo
- Publication number
- DE60008790T3 DE60008790T3 DE60008790T DE60008790T DE60008790T3 DE 60008790 T3 DE60008790 T3 DE 60008790T3 DE 60008790 T DE60008790 T DE 60008790T DE 60008790 T DE60008790 T DE 60008790T DE 60008790 T3 DE60008790 T3 DE 60008790T3
- Authority
- DE
- Germany
- Prior art keywords
- composition
- honey
- wound
- medical
- medical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 235000012907 honey Nutrition 0.000 claims abstract description 118
- 239000000203 mixture Substances 0.000 claims abstract description 105
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 90
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 38
- 229920000615 alginic acid Polymers 0.000 claims abstract description 38
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 15
- 206010052428 Wound Diseases 0.000 claims description 89
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical group O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 25
- 229940072056 alginate Drugs 0.000 claims description 24
- 239000000463 material Substances 0.000 claims description 24
- 239000003349 gelling agent Substances 0.000 claims description 21
- 230000000845 anti-microbial effect Effects 0.000 claims description 11
- 210000000416 exudates and transudate Anatomy 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 230000003385 bacteriostatic effect Effects 0.000 claims description 7
- 239000000835 fiber Substances 0.000 claims description 6
- 150000002978 peroxides Chemical class 0.000 claims description 6
- 230000002745 absorbent Effects 0.000 claims description 4
- 239000002250 absorbent Substances 0.000 claims description 4
- 210000001124 body fluid Anatomy 0.000 claims description 3
- 239000010839 body fluid Substances 0.000 claims description 3
- 241001112695 Clostridiales Species 0.000 claims description 2
- 239000004599 antimicrobial Substances 0.000 claims description 2
- 239000012779 reinforcing material Substances 0.000 claims 3
- 239000000499 gel Substances 0.000 abstract description 33
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 28
- 230000000694 effects Effects 0.000 abstract description 9
- 230000001965 increasing effect Effects 0.000 abstract description 8
- 229920001817 Agar Polymers 0.000 abstract description 7
- 235000010419 agar Nutrition 0.000 abstract description 7
- 239000000853 adhesive Substances 0.000 abstract description 4
- 239000002674 ointment Substances 0.000 abstract 2
- 208000007117 Oral Ulcer Diseases 0.000 abstract 1
- 206010037888 Rash pustular Diseases 0.000 abstract 1
- 208000029561 pustule Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 description 27
- 239000000047 product Substances 0.000 description 18
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- 150000001768 cations Chemical class 0.000 description 11
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- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 230000035876 healing Effects 0.000 description 7
- 239000008272 agar Substances 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 238000007792 addition Methods 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000001879 gelation Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 150000002772 monosaccharides Chemical class 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 238000005096 rolling process Methods 0.000 description 4
- 239000000661 sodium alginate Substances 0.000 description 4
- 235000010413 sodium alginate Nutrition 0.000 description 4
- 229940005550 sodium alginate Drugs 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- 240000003553 Leptospermum scoparium Species 0.000 description 3
- 235000016887 Leptospermum scoparium Nutrition 0.000 description 3
- 230000001070 adhesive effect Effects 0.000 description 3
- -1 ammonium ions Chemical class 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 239000000416 hydrocolloid Substances 0.000 description 3
- 239000000017 hydrogel Substances 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000000543 intermediate Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000036407 pain Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000011236 particulate material Substances 0.000 description 3
- AZUYLZMQTIKGSC-UHFFFAOYSA-N 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one Chemical compound ClC=1C(=C2C=NNC2=CC=1C)C=1C(=NN(C=1C)C1CC2(CN(C2)C(C=C)=O)C1)C=1C=C2C=NN(C2=CC=1)C AZUYLZMQTIKGSC-UHFFFAOYSA-N 0.000 description 2
- 208000008960 Diabetic foot Diseases 0.000 description 2
- 241001495479 Knightia excelsa Species 0.000 description 2
- 241001514662 Leptospermum Species 0.000 description 2
- 244000062939 Leptospermum ericoides Species 0.000 description 2
- 235000017763 Leptospermum ericoides Nutrition 0.000 description 2
- 208000032536 Pseudomonas Infections Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 239000004568 cement Substances 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000000451 tissue damage Effects 0.000 description 2
- 231100000827 tissue damage Toxicity 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- CVOFKRWYWCSDMA-UHFFFAOYSA-N 2-chloro-n-(2,6-diethylphenyl)-n-(methoxymethyl)acetamide;2,6-dinitro-n,n-dipropyl-4-(trifluoromethyl)aniline Chemical compound CCC1=CC=CC(CC)=C1N(COC)C(=O)CCl.CCCN(CCC)C1=C([N+]([O-])=O)C=C(C(F)(F)F)C=C1[N+]([O-])=O CVOFKRWYWCSDMA-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 241001112696 Clostridia Species 0.000 description 1
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 235000015001 Cucumis melo var inodorus Nutrition 0.000 description 1
- 240000002495 Cucumis melo var. inodorus Species 0.000 description 1
- 240000001879 Digitalis lutea Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 240000000731 Fagus sylvatica Species 0.000 description 1
- 235000010099 Fagus sylvatica Nutrition 0.000 description 1
- 241001138389 Fuscospora solandri Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000005230 Leg Ulcer Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 206010040943 Skin Ulcer Diseases 0.000 description 1
- 229920001938 Vegetable gum Polymers 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000003638 chemical reducing agent Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- 231100000433 cytotoxic Toxicity 0.000 description 1
- 230000001472 cytotoxic effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000002657 fibrous material Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 229940124600 folk medicine Drugs 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000009740 moulding (composite fabrication) Methods 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000001338 necrotic effect Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000002105 tongue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Inorganic Chemistry (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ50168799A NZ501687A (en) | 1999-12-09 | 1999-12-09 | A medical composition comprising a combination of one or more honeys with one or more gelling agents to form a pliable solid |
| NZ50168799 | 1999-12-09 | ||
| NZ50174899 | 1999-12-13 | ||
| NZ50174899 | 1999-12-13 | ||
| PCT/NZ2000/000248 WO2001041776A2 (en) | 1999-12-09 | 2000-12-11 | Use of honey in medical dressings |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE60008790D1 DE60008790D1 (de) | 2004-04-08 |
| DE60008790T2 DE60008790T2 (de) | 2005-03-10 |
| DE60008790T3 true DE60008790T3 (de) | 2009-12-10 |
Family
ID=26652142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60008790T Expired - Lifetime DE60008790T3 (de) | 1999-12-09 | 2000-12-11 | Medizinische verbände enthaltend gelartigen honig |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US6956144B2 (enExample) |
| EP (1) | EP1237561B2 (enExample) |
| JP (2) | JP2003516357A (enExample) |
| CN (1) | CN1409636A (enExample) |
| AT (1) | ATE260669T1 (enExample) |
| AU (1) | AU781878B2 (enExample) |
| CA (1) | CA2397614C (enExample) |
| DE (1) | DE60008790T3 (enExample) |
| ES (1) | ES2217000T5 (enExample) |
| WO (1) | WO2001041776A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070009586A1 (en) * | 2000-02-29 | 2007-01-11 | Cohen Kelman I | Wound dressings containing complexes of transition metals and alginate for elastase sequestering |
| NZ505514A (en) | 2000-06-30 | 2003-02-28 | Bee & Herbal New Zealand Ltd | Method of manufacturing a wound dressing for the application of honey |
| GB0110715D0 (en) * | 2001-05-02 | 2001-06-27 | Acordis Speciality Fibres Ltd | Wound dressing |
| GB2382527A (en) | 2001-12-03 | 2003-06-04 | Acordis Speciality Fibres Ltd | Wound dressings |
| JP2007526209A (ja) * | 2003-04-14 | 2007-09-13 | エフ エム シー コーポレーション | 均一かつ熱可逆性低粘度ポリマンナンフィルムの伝達システム |
| KR101165658B1 (ko) * | 2004-04-28 | 2012-07-17 | 히사미쓰 세이야꾸 가부시키가이샤 | 첩부제 |
| NZ533121A (en) * | 2004-05-21 | 2006-02-24 | Apimed Medical Honey Ltd | Wound dressing comprising adhesive portions linked by non-elastic threads, and a treatment composition positioned between the adhesive portions |
| NZ542258A (en) * | 2005-09-06 | 2010-05-28 | Comvita New Zealand Ltd | A medical composition comprising honey or sugar syrup and a viscosity increasing agent for use on wounds |
| JP4990150B2 (ja) * | 2005-09-20 | 2012-08-01 | 久光製薬株式会社 | 貼付剤 |
| EP1948254B1 (en) | 2005-10-26 | 2014-04-30 | Medihoney Pty Ltd | Hydrocolloid composition |
| US20070098671A1 (en) * | 2005-11-02 | 2007-05-03 | Martin Gregory D | Composition and method of treatment for irritated skin |
| DE202005019670U1 (de) | 2005-12-14 | 2006-04-27 | Riesinger, Birgit | Wundbehandlungsvorrichtung mit elastisch verformbarem Unterdruckerzeugungselement |
| FR2899479B1 (fr) * | 2006-04-10 | 2009-07-24 | Agelys Lab | Composition cicatrisante |
| EP2040721B1 (en) | 2006-05-31 | 2013-05-08 | Medihoney Pty Ltd | Medicinal compositions containing honey |
| WO2008064272A2 (en) * | 2006-11-20 | 2008-05-29 | Promedtek, Inc. | Method of treating a severe diabetic ulcer |
| WO2008117019A1 (en) * | 2007-03-24 | 2008-10-02 | University College Cardiff Consultants Limited | Tlr4 ligand isolated from honey |
| JP5313132B2 (ja) * | 2007-04-16 | 2013-10-09 | 喜久二 山口 | ヘリコバクター・ピロリ除菌剤 |
| GB0810404D0 (en) * | 2008-06-06 | 2008-07-09 | Manuka Medical Ltd | Compositions |
| GB0813541D0 (en) * | 2008-07-24 | 2008-08-27 | Brightwake Ltd | Honey wound dressing |
| WO2010082846A1 (en) * | 2008-12-24 | 2010-07-22 | Comvita New Zealand Limited | Medical and nutritional formulations |
| US20110171284A1 (en) * | 2010-01-11 | 2011-07-14 | Gilman Miles E | Povidone-iodine and sucrose wound healing dressing |
| KR101242579B1 (ko) * | 2010-09-20 | 2013-03-19 | 한국원자력연구원 | 방사선을 이용한 꿀을 포함하는 궤양 치료용 페이스트의 제조방법 및 이에 따라 제조되는 궤양 치료용 페이스트 |
| KR101242573B1 (ko) * | 2010-09-20 | 2013-03-19 | 한국원자력연구원 | 꿀을 포함하는 궤양 치료용 겔의 제조방법 및 이에 따라 제조되는 궤양 치료용 겔 |
| WO2012134770A1 (en) * | 2011-03-25 | 2012-10-04 | Avery Dennison Corporation | Honey composition |
| JP5896348B2 (ja) * | 2011-07-12 | 2016-03-30 | 株式会社Ａｒｔｓ | 貼り薬貼り具 |
| CN102406958B (zh) * | 2011-12-02 | 2014-04-09 | 褚加冕 | 一种杀菌蜂蜜敷料的制备方法 |
| ITMI20120180A1 (it) * | 2012-02-09 | 2013-08-10 | Marco Gandini | Composizione per la prevenzione delle aderenze post-operatorie |
| EP2838543B1 (en) | 2012-04-17 | 2018-05-30 | Apimed Medical Honey Limited | Immunostimulatory compositions from honey and methods of manufacture |
| USD745690S1 (en) | 2013-07-11 | 2015-12-15 | Links Medical Products, Inc. | Honey patterned foam structure for holding medical grade manuka honey |
| US9107974B2 (en) | 2013-07-11 | 2015-08-18 | Links Medical Products, Inc | Honey impregnated composite dressing having super absorbency and intelligent management of wound exudate and method of making same |
| US20150030688A1 (en) * | 2013-07-25 | 2015-01-29 | Saint Louis University | Honey and growth factor eluting scaffold for wound healing and tissue engineering |
| CA2922955C (en) * | 2013-09-02 | 2020-09-22 | Honeylab Limited | Honey compositions |
| US10342891B2 (en) | 2013-09-19 | 2019-07-09 | Medline Industries, Inc. | Wound dressing containing saccharide and collagen |
| US10086017B2 (en) * | 2013-09-19 | 2018-10-02 | Medline Industries, Inc. | Wound dressing containing polysaccharides |
| GB2519072B (en) * | 2013-10-07 | 2019-12-04 | Welland Medical Ltd | Composition comprising collagen and honey |
| GB2522416B (en) * | 2014-01-22 | 2020-07-22 | Welland Medical Ltd | Flange extender comprising honey |
| GB2535666B (en) * | 2014-04-30 | 2017-03-29 | Matoke Holdings Ltd | Antimicrobial compositions |
| WO2015173547A1 (en) * | 2014-05-14 | 2015-11-19 | Brightwake Limited | Wound dressing |
| GB201408553D0 (en) * | 2014-05-14 | 2014-06-25 | Brightwake Ltd | Wound dressing |
| PL4035635T3 (pl) | 2014-05-14 | 2025-09-01 | Brightwake Limited | Opatrunek na ranę |
| WO2015183228A1 (en) | 2014-05-27 | 2015-12-03 | Duymuş Ethem | Nano fiber cover for wounds and ambustions with an additive containing natural antiseptic |
| CA2957263A1 (en) | 2014-08-05 | 2016-02-11 | The University Of Memphis | Compositions and methods for enhancing healing and regeneration of bone and soft tissue |
| US10500235B2 (en) | 2015-01-29 | 2019-12-10 | San Melix Laboratories, Inc. | Wound healing compositions comprising buckwheat honey and methylglyoxal and methods of use |
| CN105169464B (zh) * | 2015-09-24 | 2018-05-15 | 中国人民解放军军事医学科学院放射与辐射医学研究所 | 一种天然蜂蜜伤口敷料及其制备方法与应用 |
| GB201518348D0 (en) * | 2015-10-16 | 2015-12-02 | Systagenix Wound Man Ip Co Bv | Composition |
| US20190038569A1 (en) * | 2016-08-01 | 2019-02-07 | Carlos A. Alvarado | Multifunctional-reinforced dressing |
| WO2018156730A1 (en) | 2017-02-22 | 2018-08-30 | Cornell University | Mechanical vacuum dressing for mechanically managing, protecting and suctioning small incisional wounds |
| GB201716986D0 (en) | 2017-10-16 | 2017-11-29 | Matoke Holdings Ltd | Antimicrobial compositions |
| CN107899061A (zh) * | 2017-11-13 | 2018-04-13 | 广东泰宝医疗科技股份有限公司 | 一种藻酸盐创面修复敷料及其制备方法 |
| JP7424638B2 (ja) | 2017-12-06 | 2024-01-30 | コーネル ユニヴァーシティー | 改善されたポンプ効率、自動圧力インジケータおよび自動圧力リミッタを有する手動操作式陰圧閉鎖療法（ｎｐｗｔ）包帯 |
| IL270762B (en) | 2019-11-19 | 2021-10-31 | Sion Biotext Medical Ltd | Wound dressing comprising a combination of hydrogel and honey, method of preparation and uses thereof |
| WO2021188651A1 (en) | 2020-03-19 | 2021-09-23 | Friedman Joel M | Novel approach to sustained production and delivery of nitric oxide and s-nitrosothiols |
| US12059493B2 (en) | 2020-11-09 | 2024-08-13 | Albert Einstein College Of Medicine | Transdermal delivery formulations |
| US12151019B2 (en) | 2020-11-09 | 2024-11-26 | Albert Einstein College Of Medicine | Compositions for blood storage and transfusions |
| EP4240365A4 (en) | 2020-11-09 | 2024-07-10 | Albert Einstein College of Medicine | FORMULATIONS FOR TRANSDERMAL ADMINISTRATION |
| US12419917B2 (en) | 2021-04-23 | 2025-09-23 | Ndal Mfg Inc | Compositions and methods for treatment of conditions using fractionated honey |
| CN113318129A (zh) * | 2021-06-24 | 2021-08-31 | 中国人民大学 | 一种高效抗菌的蜂蜜膏剂及其制备方法 |
| US11786712B2 (en) | 2021-08-30 | 2023-10-17 | Albert Einstein College Of Medicine | Nitric oxide-releasing device |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU536885B2 (en) * | 1979-04-18 | 1984-05-31 | R. A. Knutson | Wound and burn dressing |
| CA1287584C (en) † | 1986-09-02 | 1991-08-13 | Seiichi Komori | Wound-healing preparations |
| DE3827561C1 (enExample) * | 1988-08-13 | 1989-12-28 | Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De | |
| LU87320A1 (fr) | 1988-08-24 | 1990-03-13 | Arbed | Charpente metallique antisismique |
| DE4018247A1 (de) * | 1990-06-07 | 1991-12-12 | Lohmann Therapie Syst Lts | Herstellungsverfahren fuer schnellzerfallende folienfoermige darreichungsformen |
| DE69029969T2 (de) * | 1990-12-04 | 1997-06-05 | Zenoderm Ltd | Kunsthaut |
| JP3254013B2 (ja) * | 1991-09-10 | 2002-02-04 | ジョンソン・アンド・ジョンソン・メディカル・インコーポレイテッド | 包帯材料およびその製造方法 |
| GB9218749D0 (en) | 1992-09-04 | 1992-10-21 | Courtaulds Plc | Alginate gels |
| AUPN907496A0 (en) * | 1996-04-02 | 1996-04-26 | Byron Australia Pty Ltd | Spreadable gelled food product |
| US5980875A (en) * | 1996-04-12 | 1999-11-09 | Mousa; Mahmoud A. | Honey preparations |
| GB9609474D0 (en) * | 1996-05-08 | 1996-07-10 | Innovative Tech Ltd | Hydrogels |
| GB9618573D0 (en) * | 1996-09-05 | 1996-10-16 | Courtaulds Fibres Holdings Ltd | Wound dressings and manufacture thereof |
| US5785972A (en) * | 1997-01-10 | 1998-07-28 | Tyler; Kathleen A. | Colloidal silver, honey, and helichrysum oil antiseptic composition and method of application |
| US6146655A (en) | 1997-08-29 | 2000-11-14 | Softy-Flex Inc. | Flexible intra-oral bandage and drug delivery system |
| FR2769504B1 (fr) * | 1997-10-13 | 2000-03-10 | Oreal | Utilisation du miel en tant qu'agent diminuant l'adhesion des micro-organismes |
| AT406731B (de) * | 1998-04-24 | 2000-08-25 | Dado Suleiman | Stoffgemisch zur topischen anwendung |
| NZ505514A (en) * | 2000-06-30 | 2003-02-28 | Bee & Herbal New Zealand Ltd | Method of manufacturing a wound dressing for the application of honey |
| GB2382527A (en) * | 2001-12-03 | 2003-06-04 | Acordis Speciality Fibres Ltd | Wound dressings |
-
2000
- 2000-12-11 US US10/149,116 patent/US6956144B2/en not_active Ceased
- 2000-12-11 WO PCT/NZ2000/000248 patent/WO2001041776A2/en not_active Ceased
- 2000-12-11 DE DE60008790T patent/DE60008790T3/de not_active Expired - Lifetime
- 2000-12-11 CA CA002397614A patent/CA2397614C/en not_active Expired - Lifetime
- 2000-12-11 EP EP00981937A patent/EP1237561B2/en not_active Expired - Lifetime
- 2000-12-11 CN CN00816916A patent/CN1409636A/zh active Pending
- 2000-12-11 US US12/420,344 patent/USRE42755E1/en not_active Expired - Lifetime
- 2000-12-11 AU AU19038/01A patent/AU781878B2/en not_active Expired
- 2000-12-11 JP JP2001543121A patent/JP2003516357A/ja active Pending
- 2000-12-11 ES ES00981937T patent/ES2217000T5/es not_active Expired - Lifetime
- 2000-12-11 AT AT00981937T patent/ATE260669T1/de not_active IP Right Cessation
-
2011
- 2011-09-16 JP JP2011203171A patent/JP2012006971A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012006971A (ja) | 2012-01-12 |
| WO2001041776A3 (en) | 2001-11-08 |
| EP1237561B1 (en) | 2004-03-03 |
| AU781878B2 (en) | 2005-06-16 |
| ES2217000T5 (es) | 2009-10-01 |
| ES2217000T3 (es) | 2004-11-01 |
| AU1903801A (en) | 2001-06-18 |
| CA2397614A1 (en) | 2001-06-14 |
| WO2001041776A2 (en) | 2001-06-14 |
| US6956144B2 (en) | 2005-10-18 |
| CN1409636A (zh) | 2003-04-09 |
| ATE260669T1 (de) | 2004-03-15 |
| DE60008790D1 (de) | 2004-04-08 |
| USRE42755E1 (en) | 2011-09-27 |
| EP1237561A2 (en) | 2002-09-11 |
| JP2003516357A (ja) | 2003-05-13 |
| US20040054313A1 (en) | 2004-03-18 |
| WO2001041776B1 (en) | 2002-02-28 |
| CA2397614C (en) | 2009-11-10 |
| AU781878C (en) | 2001-06-18 |
| EP1237561B2 (en) | 2009-04-22 |
| DE60008790T2 (de) | 2005-03-10 |
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| 8363 | Opposition against the patent | ||
| 8366 | Restricted maintained after opposition proceedings | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: COMVITA LTD., PAENGAROA, TE PUKE, NZ |