DE577785T1 - Fluorinierte verbindungen als sauerstofftransportmittel. - Google Patents

Fluorinierte verbindungen als sauerstofftransportmittel.

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Publication number
DE577785T1
DE577785T1 DE92923941T DE92923941T DE577785T1 DE 577785 T1 DE577785 T1 DE 577785T1 DE 92923941 T DE92923941 T DE 92923941T DE 92923941 T DE92923941 T DE 92923941T DE 577785 T1 DE577785 T1 DE 577785T1
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DE
Germany
Prior art keywords
compound
compound according
oxygen transport
atoms
hydrophilic group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE92923941T
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English (en)
Inventor
Stephen Cooper
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oxford University Innovation Ltd
Original Assignee
Oxford University Innovation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford University Innovation Ltd filed Critical Oxford University Innovation Ltd
Publication of DE577785T1 publication Critical patent/DE577785T1/de
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/39—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups
    • C07C205/40—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by esterified hydroxy groups having nitro groups and esterified hydroxy groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C07C309/66—Methanesulfonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/04—Saturated ethers
    • C07C43/10—Saturated ethers of polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (9)

EPA 92.923941.6 ISIS INNOVATION LTD. Patentansprüche
1. Verbindung zur Verwendung in vivo als ein Sauerstofftransportmittel, wobei besagte Verbindung mindestens eine Verbindungsgruppe umfaßt, die mindestens drei stark fluorierte Arme aufweist.
2. Verbindung nach Anspruch 1, wobei die Verbindung die Struktur LRn hat, worin R ein stark fluorierter Arm, &eegr; 3 oder 4 und L eine Verbindungsgruppe ist.
3. Verbindung nach Anspruch 2, wobei die Gruppen R gleich oder verschieden sein können und jede ein C4-C15-Kohlenwasserstoff, gesättigt oder ungesättigt, geradkettig oder verzweigt oder cyclisch, aromatisch oder heterocyclisch ist, worin mehr als die Hälfte der H-Atome durch F-Atome ersetzt ist.
4. Verbindung nach einem der Ansprüche 1 bis 3, die auch eine im wesentlichen nicht hämolytische, hydrophile Gruppe enthält.
5. Verbindung nach Anspruch 4, wobei die hydrophile Gruppe eine oder mehrere Alkohol-, Ether-, Carboxamid-, Sulfonamid-, Phosphoramid- oder N-Oxidgruppen in linearer, verzweigter oder cyclischer Konfiguration umfaßt.
6. Verbindung nach Anspruch 4 oder Anspruch 5 mit der Struktur
worin Z eine hydrophile Gruppe und R ein stark fluorierter Arm ist.
7. Verbindung nach Anspruch 6 mit der Struktur a), worin Z -CONH(CH2)3N(O)(CH3)2 oder -CON(CH2CH2OCH3)2 ist.
8. Wäßrige Emulsion enthaltend 5-70 Volumen-% der in einem der Ansprüche 1 bis 7 definierten Verbindung.
9. Verwendung der in einem der Ansprüche 1 bis 7 definierten Verbindung zur Herstellung eines in vivo Sauerstofftransportmittels .
DE92923941T 1991-11-29 1992-11-27 Fluorinierte verbindungen als sauerstofftransportmittel. Pending DE577785T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919125454A GB9125454D0 (en) 1991-11-29 1991-11-29 Oxygen transport agents
PCT/GB1992/002208 WO1993011098A1 (en) 1991-11-29 1992-11-27 Fluorinated compounds as oxygen transport agents

Publications (1)

Publication Number Publication Date
DE577785T1 true DE577785T1 (de) 1994-04-28

Family

ID=10705469

Family Applications (2)

Application Number Title Priority Date Filing Date
DE92923941T Pending DE577785T1 (de) 1991-11-29 1992-11-27 Fluorinierte verbindungen als sauerstofftransportmittel.
DE69228058T Expired - Fee Related DE69228058T2 (de) 1991-11-29 1992-11-27 Fluorinierte verbindungen als sauerstofftransportmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69228058T Expired - Fee Related DE69228058T2 (de) 1991-11-29 1992-11-27 Fluorinierte verbindungen als sauerstofftransportmittel

Country Status (7)

Country Link
EP (1) EP0577785B1 (de)
JP (1) JPH06504797A (de)
AT (1) ATE175189T1 (de)
DE (2) DE577785T1 (de)
ES (1) ES2049692T1 (de)
GB (1) GB9125454D0 (de)
WO (1) WO1993011098A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201521524D0 (en) 2015-12-07 2016-01-20 Mexichem Fluor Sa De Cv Compound

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1618090A1 (de) * 1967-02-03 1970-11-05 Boehringer Sohn Ingelheim Verfahren zur Herstellung herbizid wirksamer Ester von Polyalkoholen
US3600415A (en) * 1968-08-01 1971-08-17 Allied Chem Fluorinated amides
GB1338430A (en) * 1970-11-04 1973-11-21 Allied Chem Fluorocarbon diols diols dicarboxylic acids and derivatives thereof
DE2731226A1 (de) * 1977-07-11 1979-01-25 Dow Chemical Co Trifluormethansulfonate
FR2602774B1 (fr) * 1986-07-29 1990-10-19 Atta Nouvelles molecules amphiphiles polyhydroxylees et perfluoroalkylees ayant des proprietes tensioactives

Also Published As

Publication number Publication date
JPH06504797A (ja) 1994-06-02
ES2049692T1 (es) 1994-05-01
DE69228058T2 (de) 1999-05-20
ATE175189T1 (de) 1999-01-15
EP0577785B1 (de) 1998-12-30
WO1993011098A1 (en) 1993-06-10
GB9125454D0 (en) 1992-01-29
EP0577785A1 (de) 1994-01-12
DE69228058D1 (de) 1999-02-11

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