DE4337600A1 - N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen - Google Patents

N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen

Info

Publication number
DE4337600A1
DE4337600A1 DE4337600A DE4337600A DE4337600A1 DE 4337600 A1 DE4337600 A1 DE 4337600A1 DE 4337600 A DE4337600 A DE 4337600A DE 4337600 A DE4337600 A DE 4337600A DE 4337600 A1 DE4337600 A1 DE 4337600A1
Authority
DE
Germany
Prior art keywords
general formula
group
compounds
optionally
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4337600A
Other languages
German (de)
English (en)
Inventor
Hartmut Dr Spies
Paul-Eberhard Dr Schulze
Bernd Dr Noll
Steffi Dr Noll
Ludger Dr Dinkelborg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Institut fuer Diagnostikforschung GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut fuer Diagnostikforschung GmbH filed Critical Institut fuer Diagnostikforschung GmbH
Priority to DE4337600A priority Critical patent/DE4337600A1/de
Priority to ZA948411A priority patent/ZA948411B/xx
Priority to EP95900059A priority patent/EP0726909A1/de
Priority to JP7512959A priority patent/JPH09508351A/ja
Priority to CN94193990A priority patent/CN1134158A/zh
Priority to HU9601140A priority patent/HUT74881A/hu
Priority to AU81038/94A priority patent/AU681919B2/en
Priority to CA002173844A priority patent/CA2173844A1/en
Priority to PCT/DE1994/001295 priority patent/WO1995012610A1/de
Publication of DE4337600A1 publication Critical patent/DE4337600A1/de
Priority to KR1019960702247A priority patent/KR960705842A/ko
Priority to NO961743A priority patent/NO961743L/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/26—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE4337600A 1993-11-01 1993-11-01 N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen Withdrawn DE4337600A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE4337600A DE4337600A1 (de) 1993-11-01 1993-11-01 N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen
ZA948411A ZA948411B (en) 1993-11-01 1994-10-26 N-alkyl peptide chelating agents
HU9601140A HUT74881A (en) 1993-11-01 1994-10-27 N-alkyl peptide chelate formers, their metal comlexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds
JP7512959A JPH09508351A (ja) 1993-11-01 1994-10-27 Ｎ‐アルキルペプチドキレート化剤、その放射性核種との金属錯体、その製造方法、およびこの化合物を含む放射性医薬
CN94193990A CN1134158A (zh) 1993-11-01 1994-10-27 N-烷基肽螯合剂、它们与放射性核素的金属配合物、它们的制备方法及含有这些化合物的放射性药物
EP95900059A EP0726909A1 (de) 1993-11-01 1994-10-27 N-alkyl-peptidchelatbildner, deren metallkomplexe mit radionukliden, verfahren zu ihrer herstellung und diese verbindungen enthaltende radiopharmazeutische zusammensetzungen
AU81038/94A AU681919B2 (en) 1993-11-01 1994-10-27 N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds
CA002173844A CA2173844A1 (en) 1993-11-01 1994-10-27 N-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compounds
PCT/DE1994/001295 WO1995012610A1 (de) 1993-11-01 1994-10-27 N-alkyl-peptidchelatbildner, deren metallkomplexe mit radionukliden, verfahren zu ihrer herstellung und diese verbindungen enthaltende radiopharmazeutische zusammensetzungen
KR1019960702247A KR960705842A (ko) 1993-11-01 1996-04-30 N-알킬 펩티드 킬레이트 형성제, 방사핵종을 갖는 그의 금속 착물, 이들의 제조방법 및 이들 화합물을 함유한 방사성의약 조성물(n-alkyl peptide chelate formers, their metal complexes with radionuclides, processes for producing them and radio-pharmaceutical compositions containing these compound)
NO961743A NO961743L (no) 1993-11-01 1996-04-30 N-alkyl-peptid-chelatdannere, deres metallkomplekser med radionuklider, fremgangsmåte ved deres fremstilling og radiofarmasöytiske sammensetninger inneholdende disse forbindelser

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4337600A DE4337600A1 (de) 1993-11-01 1993-11-01 N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen

Publications (1)

Publication Number Publication Date
DE4337600A1 true DE4337600A1 (de) 1995-05-04

Family

ID=6501750

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4337600A Withdrawn DE4337600A1 (de) 1993-11-01 1993-11-01 N-Alkyl-Peptidchelatbildner, deren Metallkomplexe mit Radionukliden, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Zusammesetzungen

Country Status (11)

Country Link
EP (1) EP0726909A1 (zh)
JP (1) JPH09508351A (zh)
KR (1) KR960705842A (zh)
CN (1) CN1134158A (zh)
AU (1) AU681919B2 (zh)
CA (1) CA2173844A1 (zh)
DE (1) DE4337600A1 (zh)
HU (1) HUT74881A (zh)
NO (1) NO961743L (zh)
WO (1) WO1995012610A1 (zh)
ZA (1) ZA948411B (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980860A (en) * 1995-10-19 1999-11-09 The Trustees Of University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6162378A (en) * 1999-02-25 2000-12-19 3D Systems, Inc. Method and apparatus for variably controlling the temperature in a selective deposition modeling environment
US6171578B1 (en) 1999-04-14 2001-01-09 Diatide, Inc. Benzodiazepine derivatives for imaging thrombi
EP1294699B1 (en) * 2000-05-12 2016-04-13 Genzyme Corporation Modulators of tnf- alpha signalling

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA811340B (en) * 1980-06-09 1982-03-31 Morton Norwich Products Inc N-(cycloalkyl)amino acid compounds
WO1992019274A1 (en) * 1991-05-08 1992-11-12 Mallinckrodt Medical, Inc. Technetium chelates to be used for determining the renal function
JPH0570484A (ja) * 1991-09-12 1993-03-23 Hitachi Chem Co Ltd ペプチドおよびその塩
WO1993015771A1 (en) * 1992-02-06 1993-08-19 Mallinckrodt Medical, Inc. Ligands for improving metal chelate formation kinetics
DK0641222T3 (da) * 1992-05-21 2000-12-11 Diatide Inc Peptider mærket med technetium-99m til trombeafbildning
DE4311021A1 (de) * 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980860A (en) * 1995-10-19 1999-11-09 The Trustees Of University Of Pennsylvania Dopamine and serotonin transporter ligands and imaging agents

Also Published As

Publication number Publication date
NO961743D0 (no) 1996-04-30
KR960705842A (ko) 1996-11-08
HUT74881A (en) 1997-02-28
EP0726909A1 (de) 1996-08-21
WO1995012610A1 (de) 1995-05-11
NO961743L (no) 1996-04-30
CA2173844A1 (en) 1995-05-11
JPH09508351A (ja) 1997-08-26
AU8103894A (en) 1995-05-23
CN1134158A (zh) 1996-10-23
AU681919B2 (en) 1997-09-11
HU9601140D0 (en) 1996-07-29
ZA948411B (en) 1995-06-30

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Legal Events

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8130 Withdrawal