DE4230470A1 - Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung - Google Patents

Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Info

Publication number
DE4230470A1
DE4230470A1 DE4230470A DE4230470A DE4230470A1 DE 4230470 A1 DE4230470 A1 DE 4230470A1 DE 4230470 A DE4230470 A DE 4230470A DE 4230470 A DE4230470 A DE 4230470A DE 4230470 A1 DE4230470 A1 DE 4230470A1
Authority
DE
Germany
Prior art keywords
group
carbon atoms
alkyl
phenyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4230470A
Other languages
German (de)
English (en)
Inventor
Frank Dipl Chem Dr Himmeslbach
Volkhard Dipl Chem Dr Austel
Guenter Dipl Chem Dr Linz
Helmut Dipl Chem Dr Pieper
Brian Dr Guth
Thomas Dipl Chem Dr Mueller
Johannes Dipl Che Weisenberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Priority to DE4230470A priority Critical patent/DE4230470A1/de
Priority to DE19934302052 priority patent/DE4302052A1/de
Priority to DE19934309213 priority patent/DE4309213A1/de
Priority to SK943-93A priority patent/SK94393A3/sk
Priority to EP19930114401 priority patent/EP0587134A3/de
Priority to TW082107365A priority patent/TW239135B/zh
Priority to FI933942A priority patent/FI933942A7/fi
Priority to BG98103A priority patent/BG98103A/bg
Priority to IL106955A priority patent/IL106955A0/xx
Priority to HU9302577A priority patent/HUT71496A/hu
Priority to CZ931881A priority patent/CZ188193A3/cs
Priority to MX9305566A priority patent/MX9305566A/es
Priority to ZA936689A priority patent/ZA936689B/xx
Priority to AU46249/93A priority patent/AU4624993A/en
Priority to CA002105934A priority patent/CA2105934A1/en
Priority to NO933248A priority patent/NO933248L/no
Priority to NZ248633A priority patent/NZ248633A/en
Priority to PL93300347A priority patent/PL300347A1/xx
Priority to US08/120,008 priority patent/US5681841A/en
Priority to KR1019930018293A priority patent/KR940007023A/ko
Priority to CN 93114711 priority patent/CN1092769A/zh
Priority to JP5226864A priority patent/JPH06263740A/ja
Publication of DE4230470A1 publication Critical patent/DE4230470A1/de
Priority to US08/864,528 priority patent/US5880284A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/36—One oxygen atom with hydrocarbon radicals, substituted by nitrogen atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/70—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE4230470A 1992-09-11 1992-09-11 Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung Withdrawn DE4230470A1 (de)

Priority Applications (23)

Application Number Priority Date Filing Date Title
DE4230470A DE4230470A1 (de) 1992-09-11 1992-09-11 Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19934302052 DE4302052A1 (de) 1992-09-11 1993-01-26 Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19934309213 DE4309213A1 (de) 1992-09-11 1993-03-22 Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
SK943-93A SK94393A3 (en) 1992-09-11 1993-09-06 Cyclic derivatives of urea, process for their production and their pharmaceutical agents with the content of those
EP19930114401 EP0587134A3 (en) 1992-09-11 1993-09-08 Cyclic urea derivatives, medicaments containing them and process for their preparation
TW082107365A TW239135B (enrdf_load_stackoverflow) 1992-09-11 1993-09-08
FI933942A FI933942A7 (fi) 1992-09-11 1993-09-09 Sykliset ureajohdokset, näitä yhdisteitä sisältävät lääkeaineet ja menetelmä niiden valmistamiseksi
BG98103A BG98103A (bg) 1992-09-11 1993-09-09 Циклични карбамидни производни, лекарствени средства съдържащи тези съединения и метод за техното получаване
IL106955A IL106955A0 (en) 1992-09-11 1993-09-09 Cyclic urea derivatives
MX9305566A MX9305566A (es) 1992-09-11 1993-09-10 Derivados de urea ciclicos, medicamentos que contienen estos compuestos y procedimientos para su preparacion.
NZ248633A NZ248633A (en) 1992-09-11 1993-09-10 Substituted imidazole and triazole derivatives and pharmaceutical compositions
HU9302577A HUT71496A (en) 1992-09-11 1993-09-10 Cyclic carbamide derivatives, pharmaceutical compositions containing them and process for preparing them
ZA936689A ZA936689B (en) 1992-09-11 1993-09-10 Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
AU46249/93A AU4624993A (en) 1992-09-11 1993-09-10 Cyclic urea derivatives
CA002105934A CA2105934A1 (en) 1992-09-11 1993-09-10 Cyclic urea derivatives
NO933248A NO933248L (no) 1992-09-11 1993-09-10 Cykliske urinstoffderivater, legemidler inneholdende disse forbindelser, og fremgangsmåte for deres fremstilling
CZ931881A CZ188193A3 (en) 1992-09-11 1993-09-10 Cyclic derivatives of urea, process of their preparation and pharmaceutical preparations in which they are comprised
PL93300347A PL300347A1 (en) 1992-09-11 1993-09-10 Cyclic urea derivatives, therapeutic agents containing them and method of obtaining sames
US08/120,008 US5681841A (en) 1992-09-11 1993-09-10 Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them
KR1019930018293A KR940007023A (ko) 1992-09-11 1993-09-11 사이클릭 우레아 유도체, 이를 함유하는 약제학적 조성물 및 이의 제조방법
CN 93114711 CN1092769A (zh) 1992-09-11 1993-09-11 环脲衍生物，含有这些化合物的药物组合物以及制备它们的方法
JP5226864A JPH06263740A (ja) 1992-09-11 1993-09-13 環状尿素誘導体、これらの化合物を含む医薬組成物及びそれらの調製方法
US08/864,528 US5880284A (en) 1992-09-11 1997-05-28 Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4230470A DE4230470A1 (de) 1992-09-11 1992-09-11 Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
DE4230470A1 true DE4230470A1 (de) 1994-04-14

Family

ID=6467761

Family Applications (1)

Application Number Title Priority Date Filing Date
DE4230470A Withdrawn DE4230470A1 (de) 1992-09-11 1992-09-11 Cyclische Harnstoffderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung

Country Status (3)

Country Link
DE (1) DE4230470A1 (enrdf_load_stackoverflow)
TW (1) TW239135B (enrdf_load_stackoverflow)
ZA (1) ZA936689B (enrdf_load_stackoverflow)

Also Published As

Publication number Publication date
TW239135B (enrdf_load_stackoverflow) 1995-01-21
ZA936689B (en) 1995-03-10

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