DE4119544C1 - - Google Patents

Info

Publication number
DE4119544C1
DE4119544C1 DE19914119544 DE4119544A DE4119544C1 DE 4119544 C1 DE4119544 C1 DE 4119544C1 DE 19914119544 DE19914119544 DE 19914119544 DE 4119544 A DE4119544 A DE 4119544A DE 4119544 C1 DE4119544 C1 DE 4119544C1
Authority
DE
Germany
Prior art keywords
amino acid
building block
group
amino
protected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE19914119544
Other languages
German (de)
English (en)
Inventor
Ralf Bartl
Ronald Dr. 3300 Braunschweig De Frank
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GESELLSCHAFT fur BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) 3300 BRAUNSCHWEIG DE
Original Assignee
GESELLSCHAFT fur BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) 3300 BRAUNSCHWEIG DE
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GESELLSCHAFT fur BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) 3300 BRAUNSCHWEIG DE filed Critical GESELLSCHAFT fur BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) 3300 BRAUNSCHWEIG DE
Priority to DE19914119544 priority Critical patent/DE4119544C1/de
Priority to JP51124692A priority patent/JP3296434B2/ja
Priority to PCT/EP1992/001280 priority patent/WO1992022566A1/de
Priority to EP92911418A priority patent/EP0589927A1/de
Application granted granted Critical
Publication of DE4119544C1 publication Critical patent/DE4119544C1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19914119544 1991-06-13 1991-06-13 Expired - Fee Related DE4119544C1 (enrdf_load_stackoverflow)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE19914119544 DE4119544C1 (enrdf_load_stackoverflow) 1991-06-13 1991-06-13
JP51124692A JP3296434B2 (ja) 1991-06-13 1992-06-05 保護されたアミノ酸構成単位、生産と使用
PCT/EP1992/001280 WO1992022566A1 (de) 1991-06-13 1992-06-05 Geschützter aminosäurebaustein, herstellung und verwendung
EP92911418A EP0589927A1 (de) 1991-06-13 1992-06-05 Geschützter aminosäurebaustein, herstellung und verwendung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19914119544 DE4119544C1 (enrdf_load_stackoverflow) 1991-06-13 1991-06-13

Publications (1)

Publication Number Publication Date
DE4119544C1 true DE4119544C1 (enrdf_load_stackoverflow) 1992-10-15

Family

ID=6433885

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19914119544 Expired - Fee Related DE4119544C1 (enrdf_load_stackoverflow) 1991-06-13 1991-06-13

Country Status (4)

Country Link
EP (1) EP0589927A1 (enrdf_load_stackoverflow)
JP (1) JP3296434B2 (enrdf_load_stackoverflow)
DE (1) DE4119544C1 (enrdf_load_stackoverflow)
WO (1) WO1992022566A1 (enrdf_load_stackoverflow)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033765A1 (en) * 1994-06-08 1995-12-14 Peptor Ltd. Conformationally constrained backbone cyclized peptide analog
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US7060679B2 (en) 1998-06-19 2006-06-13 Develogen Israel Ltd. Conformationally constrained backbone cyclized somatostatin analogs
US7084244B2 (en) 1994-06-08 2006-08-01 Develogen Israel Ltd. Conformationally constrained backbone cyclized peptide analogs
CN103025165A (zh) * 2010-05-05 2013-04-03 普罗林科斯有限责任公司 自大分子共轭物的控释

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6117974A (en) * 1991-10-02 2000-09-12 Peptor Limited Libraries of backbone-cyclized peptidomimetics
AU724386B2 (en) * 1994-06-08 2000-09-21 Peptor Ltd Conformationally constrained backbone cyclized peptide analogs
DE4431513A1 (de) * 1994-09-03 1996-03-07 Carsten Goldammer Racemisierungsfreie Herstellung und Verwendung von N-Methoxy- oder -Hydroxy-benzyl-Aminosäurederivaten und -Dipeptiden
US6051554A (en) * 1995-06-07 2000-04-18 Peptor Limited Conformationally constrained backbone cyclized somatostatin analogs
WO2023219152A1 (ja) * 2022-05-13 2023-11-16 中外製薬株式会社 リチウム塩の析出工程を含む、アミノ酸の塩若しくはペプチド化合物の塩又はこれらの溶媒和物の製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH516523A (fr) * 1969-11-25 1971-12-15 Sogespar S A Procédé de préparation des dérivés des acides a-aminés N-disubstitués par benzoylation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ECKERT, H., u. SEIDEL, Ch.: Angew. Chem. 98(1986), Nr, 2, S. 168-170 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995033765A1 (en) * 1994-06-08 1995-12-14 Peptor Ltd. Conformationally constrained backbone cyclized peptide analog
US5811392A (en) * 1994-06-08 1998-09-22 Yissum Research Development Co. Of The Hebrew University Conformationally constrained backbone cyclized peptide analogs
US6265375B1 (en) 1994-06-08 2001-07-24 Yissum Research Development Co. Of The Hebrew University Conformationally constrained backbone cyclized peptide analogs
WO2004074316A1 (en) * 1994-06-08 2004-09-02 Chaim Gilon Conformationally constrained backbone cyclized peptide analogs
US7084244B2 (en) 1994-06-08 2006-08-01 Develogen Israel Ltd. Conformationally constrained backbone cyclized peptide analogs
US5770687A (en) * 1995-06-07 1998-06-23 Peptor Limited Comformationally constrained backbone cyclized somatostatin analogs
US6841533B1 (en) 1995-12-07 2005-01-11 Peptor Limited Conformationally constrained backbone cyclized interleukin-6 antagonists
US7060679B2 (en) 1998-06-19 2006-06-13 Develogen Israel Ltd. Conformationally constrained backbone cyclized somatostatin analogs
CN103025165A (zh) * 2010-05-05 2013-04-03 普罗林科斯有限责任公司 自大分子共轭物的控释
EP2566335A4 (en) * 2010-05-05 2013-10-30 Prolynx Llc TAXED RELEASE FROM MACROMOLECULAR CONJUGATES
US8754190B2 (en) 2010-05-05 2014-06-17 Prolynx Llc Controlled release from macromolecular conjugates

Also Published As

Publication number Publication date
JPH07501312A (ja) 1995-02-09
WO1992022566A1 (de) 1992-12-23
JP3296434B2 (ja) 2002-07-02
EP0589927A1 (de) 1994-04-06

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Legal Events

Date Code Title Description
8100 Publication of the examined application without publication of unexamined application
D1 Grant (no unexamined application published) patent law 81
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee