DE4005711C1 - - Google Patents
Info
- Publication number
- DE4005711C1 DE4005711C1 DE4005711A DE4005711A DE4005711C1 DE 4005711 C1 DE4005711 C1 DE 4005711C1 DE 4005711 A DE4005711 A DE 4005711A DE 4005711 A DE4005711 A DE 4005711A DE 4005711 C1 DE4005711 C1 DE 4005711C1
- Authority
- DE
- Germany
- Prior art keywords
- weight
- phosphatidylcholine
- inorganic
- aqueous
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 claims abstract description 34
- 239000000203 mixture Substances 0.000 claims abstract description 32
- 239000006185 dispersion Substances 0.000 claims abstract description 29
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims abstract description 28
- 239000002537 cosmetic Substances 0.000 claims abstract description 18
- 150000003904 phospholipids Chemical class 0.000 claims abstract description 15
- 239000012528 membrane Substances 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000000787 lecithin Substances 0.000 claims description 9
- 235000010445 lecithin Nutrition 0.000 claims description 9
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims description 7
- 238000000265 homogenisation Methods 0.000 claims description 7
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000005486 organic electrolyte Substances 0.000 claims description 7
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims description 7
- 150000003905 phosphatidylinositols Chemical class 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 claims description 6
- 150000007529 inorganic bases Chemical class 0.000 claims description 4
- 150000007530 organic bases Chemical class 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims 1
- 238000011068 loading method Methods 0.000 abstract description 6
- 230000002349 favourable effect Effects 0.000 abstract 1
- 239000003921 oil Substances 0.000 description 22
- 235000019198 oils Nutrition 0.000 description 22
- 239000002502 liposome Substances 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000000463 material Substances 0.000 description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 239000002585 base Substances 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000009826 distribution Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- 239000010775 animal oil Substances 0.000 description 2
- 239000010516 ayurvedic herbal oil Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000013020 final formulation Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical class CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 230000003204 osmotic effect Effects 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000010496 thistle oil Substances 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- ASWBNKHCZGQVJV-UHFFFAOYSA-N (3-hexadecanoyloxy-2-hydroxypropyl) 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COP([O-])(=O)OCC[N+](C)(C)C ASWBNKHCZGQVJV-UHFFFAOYSA-N 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 235000004977 Brassica sinapistrum Nutrition 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- 206010012438 Dermatitis atopic Diseases 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 244000004005 Nypa fruticans Species 0.000 description 1
- 235000005305 Nypa fruticans Nutrition 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 201000008937 atopic dermatitis Diseases 0.000 description 1
- 150000003841 chloride salts Chemical class 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
- 229940093541 dicetylphosphate Drugs 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- DGLRDKLJZLEJCY-UHFFFAOYSA-L disodium hydrogenphosphate dodecahydrate Chemical compound O.O.O.O.O.O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O DGLRDKLJZLEJCY-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000019197 fats Nutrition 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000002356 laser light scattering Methods 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 150000008105 phosphatidylcholines Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- DQAKJEWZWDQURW-UHFFFAOYSA-N pyrrolidonecarboxylic acid Chemical compound OC(=O)N1CCCC1=O DQAKJEWZWDQURW-UHFFFAOYSA-N 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Colloid Chemistry (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4005711A DE4005711C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-02-23 | 1990-02-23 | |
| ES91903914T ES2078510T3 (es) | 1990-02-23 | 1991-02-11 | Dispersion acuosa de vesiculas de fosfolipidos, procedimiento para su fabricacion y su uso. |
| DK91903914.9T DK0629128T3 (da) | 1990-02-23 | 1991-02-11 | Vandig phospholipidvesikeldispersion, fremgangsmåde til fremstilling deraf samt anvendelse deraf |
| EP91903914A EP0629128B1 (en) | 1990-02-23 | 1991-02-11 | Aqueous phospholipid vesicle dispersion, process for its manufacture and use thereof |
| PCT/EP1991/000267 WO1991012794A1 (en) | 1990-02-23 | 1991-02-11 | Aqueous phospholipid vesicle dispersion, process for its manufacture and use thereof |
| DE69112849T DE69112849T2 (de) | 1990-02-23 | 1991-02-11 | Wässrige phospholipidvesikeldispersion, verfahren zu deren herstellung sowie deren verwendung. |
| JP91503964A JPH05506397A (ja) | 1990-02-23 | 1991-02-11 | リン脂質小胞の水性懸濁液、その製造法及びその使用 |
| AT91903914T ATE127336T1 (de) | 1990-02-23 | 1991-02-11 | Wässrige phospholipidvesikeldispersion, verfahren zu deren herstellung sowie deren verwendung. |
| CA002076625A CA2076625A1 (en) | 1990-02-23 | 1991-02-11 | Aqueous phospholipid vesicle dispersion, process for its manufacture and use thereof |
| GR950403162T GR3018064T3 (en) | 1990-02-23 | 1995-11-10 | Aqueous phospholipid vesicle dispersion, process for its manufacture and use thereof. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4005711A DE4005711C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-02-23 | 1990-02-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE4005711C1 true DE4005711C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1991-06-13 |
Family
ID=6400805
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE4005711A Expired - Lifetime DE4005711C1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1990-02-23 | 1990-02-23 | |
| DE69112849T Expired - Fee Related DE69112849T2 (de) | 1990-02-23 | 1991-02-11 | Wässrige phospholipidvesikeldispersion, verfahren zu deren herstellung sowie deren verwendung. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69112849T Expired - Fee Related DE69112849T2 (de) | 1990-02-23 | 1991-02-11 | Wässrige phospholipidvesikeldispersion, verfahren zu deren herstellung sowie deren verwendung. |
Country Status (9)
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4338046A1 (de) * | 1993-11-08 | 1995-05-11 | Dietl Hans | Fettlösliche Arzneimittel erhaltende flüssige pharmazeutische Zubereitung zur oralen Anwendung |
| WO1995034279A1 (en) * | 1994-06-15 | 1995-12-21 | Rovi Gmbh Handelsgesellschaft Für Rohstoffe | NON-IRRITANT AQUEOUS LIPOSOME DISPERSIONS CONTAINING α-HYDROXYCARBOXYLIC ACIDS, α-KETOCARBOXYLIC ACIDS AND/OR SALICYCLIC ACID IN THEIR SALT FORMS |
| EP0728459A1 (fr) * | 1995-02-23 | 1996-08-28 | L'oreal | Composition acide à base de vésicules lipidiques et son utilisation en application topique |
| DE19703368C1 (de) * | 1997-01-30 | 1998-10-01 | Klaus Dr Goebel | Verfahren zur Herstellung von Cremes |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811119A (en) * | 1987-05-19 | 1998-09-22 | Board Of Regents, The University Of Texas | Formulation and use of carotenoids in treatment of cancer |
| US5160669A (en) * | 1988-03-03 | 1992-11-03 | Micro Vesicular Systems, Inc. | Method of making oil filled paucilamellar lipid vesicles |
| ES2128417T3 (es) * | 1992-01-16 | 1999-05-16 | Univ Texas | Formulacion y utilizacion de carotenoides en el tratamiento del cancer. |
| US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
| US6977085B2 (en) | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
| US7193084B2 (en) | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
| US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6951656B2 (en) | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
| US6884436B2 (en) | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
| US8067032B2 (en) | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
| JP2005504090A (ja) | 2001-09-26 | 2005-02-10 | バクスター・インターナショナル・インコーポレイテッド | 分散体および溶媒相または液相の除去によるサブミクロンサイズ−ナノ粒子の調製 |
| US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
| US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| US20070082042A1 (en) * | 2004-08-06 | 2007-04-12 | Deok-Hoon Park | Multiple-layered liposome and preparation method thereof |
| JP5412078B2 (ja) * | 2008-10-06 | 2014-02-12 | ドクタープログラム株式会社 | 皮膚外用剤 |
| JP2013136038A (ja) * | 2011-12-28 | 2013-07-11 | Miyoshi Oil & Fat Co Ltd | リポソームおよびその製造方法 |
| CH714305B1 (de) | 2017-11-06 | 2022-07-15 | Cosmetolab Ag | Verfahren zur Herstellung von topischen Formulierungen und hergestellte Formulierungen. |
| CN116019778B (zh) * | 2021-10-27 | 2025-04-04 | 嘉药学校财团法人嘉南药理大学 | 牡丹花蕊复合微晶囊体组合物的制作方法及其抗蓝光、保护细胞、抗过敏、与抗老化的用途 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016976A1 (de) * | 1979-05-02 | 1980-11-13 | Kureha Chemical Ind Co Ltd | Liposom mit einem gehalt an einer aktiven substanz und verfahren zu dessen herstellung |
| DE3125953A1 (de) * | 1980-07-01 | 1982-01-28 | L'Oreal, 75008 Paris | "verfahren zur herstellung von in waessriger phase stabilen dispersionen mindestens einer mit wasser nicht mischbaren fluessigen phase und danach erhaltene dispersionen" |
| EP0095591A1 (de) * | 1982-05-13 | 1983-12-07 | A. Nattermann & Cie. GmbH | Phospholipidlösungen |
| EP0299937A1 (en) * | 1987-07-06 | 1989-01-18 | LARSSON, Kare | A composition based on phosphatidylcholine and medical uses thereof |
| WO1990012565A1 (en) * | 1989-04-25 | 1990-11-01 | Nattermann, A. & Cie. Gmbh | Water-containing formulations with phospholipids |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3374837D1 (en) * | 1982-02-17 | 1988-01-21 | Ciba Geigy Ag | Lipids in the aqueous phase |
-
1990
- 1990-02-23 DE DE4005711A patent/DE4005711C1/de not_active Expired - Lifetime
-
1991
- 1991-02-11 CA CA002076625A patent/CA2076625A1/en not_active Abandoned
- 1991-02-11 EP EP91903914A patent/EP0629128B1/en not_active Expired - Lifetime
- 1991-02-11 JP JP91503964A patent/JPH05506397A/ja active Pending
- 1991-02-11 WO PCT/EP1991/000267 patent/WO1991012794A1/en active IP Right Grant
- 1991-02-11 DE DE69112849T patent/DE69112849T2/de not_active Expired - Fee Related
- 1991-02-11 DK DK91903914.9T patent/DK0629128T3/da active
- 1991-02-11 ES ES91903914T patent/ES2078510T3/es not_active Expired - Lifetime
- 1991-02-11 AT AT91903914T patent/ATE127336T1/de not_active IP Right Cessation
-
1995
- 1995-11-10 GR GR950403162T patent/GR3018064T3/el unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016976A1 (de) * | 1979-05-02 | 1980-11-13 | Kureha Chemical Ind Co Ltd | Liposom mit einem gehalt an einer aktiven substanz und verfahren zu dessen herstellung |
| DE3125953A1 (de) * | 1980-07-01 | 1982-01-28 | L'Oreal, 75008 Paris | "verfahren zur herstellung von in waessriger phase stabilen dispersionen mindestens einer mit wasser nicht mischbaren fluessigen phase und danach erhaltene dispersionen" |
| EP0095591A1 (de) * | 1982-05-13 | 1983-12-07 | A. Nattermann & Cie. GmbH | Phospholipidlösungen |
| EP0299937A1 (en) * | 1987-07-06 | 1989-01-18 | LARSSON, Kare | A composition based on phosphatidylcholine and medical uses thereof |
| WO1990012565A1 (en) * | 1989-04-25 | 1990-11-01 | Nattermann, A. & Cie. Gmbh | Water-containing formulations with phospholipids |
Non-Patent Citations (2)
| Title |
|---|
| Ann. Rev. Biophys. Bioeng. 1980, 9: 467-476 * |
| Seifen, Öle, Fette, Wachse, 114, 14, 531-534, 1988 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4338046A1 (de) * | 1993-11-08 | 1995-05-11 | Dietl Hans | Fettlösliche Arzneimittel erhaltende flüssige pharmazeutische Zubereitung zur oralen Anwendung |
| WO1995034279A1 (en) * | 1994-06-15 | 1995-12-21 | Rovi Gmbh Handelsgesellschaft Für Rohstoffe | NON-IRRITANT AQUEOUS LIPOSOME DISPERSIONS CONTAINING α-HYDROXYCARBOXYLIC ACIDS, α-KETOCARBOXYLIC ACIDS AND/OR SALICYCLIC ACID IN THEIR SALT FORMS |
| EP0728459A1 (fr) * | 1995-02-23 | 1996-08-28 | L'oreal | Composition acide à base de vésicules lipidiques et son utilisation en application topique |
| FR2730928A1 (fr) * | 1995-02-23 | 1996-08-30 | Oreal | Composition a base de vesicules lipidiques a ph acide et son utilisation en application topique |
| US5804216A (en) * | 1995-02-23 | 1998-09-08 | L'oreal | Acidic composition based on lipid vesicles and its use in topical application |
| DE19703368C1 (de) * | 1997-01-30 | 1998-10-01 | Klaus Dr Goebel | Verfahren zur Herstellung von Cremes |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69112849D1 (de) | 1995-10-12 |
| JPH05506397A (ja) | 1993-09-22 |
| ES2078510T3 (es) | 1995-12-16 |
| EP0629128B1 (en) | 1995-09-06 |
| WO1991012794A1 (en) | 1991-09-05 |
| ATE127336T1 (de) | 1995-09-15 |
| EP0629128A1 (en) | 1994-12-21 |
| CA2076625A1 (en) | 1991-08-24 |
| DK0629128T3 (da) | 1995-10-16 |
| GR3018064T3 (en) | 1996-02-29 |
| DE69112849T2 (de) | 1996-11-07 |
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| 8365 | Fully valid after opposition proceedings | ||
| 8339 | Ceased/non-payment of the annual fee |